ライフサイエンスコーパス: paternal

1 DNMs in the offspring after controlling for paternal age (0.51 additional mutations per year, 95% CI

2 32; 95% CI: 0.11, 0.54; P < 0.01), and older paternal age (adjusted coefficient: 33.27; 95% CI: 4.10,

3 c risk for schizophrenia was associated with paternal age (R(2) = 0.002; P = 1e-04), and offspring ed

4 The association was similar for paternal age and present even among individuals older th

5 (including sex, year of birth, maternal and paternal age at birth, and parity), for smoking 10 or mo

6 In humans, the effect of paternal age at conception (PAC) on offspring leukocyte

7 We test for maternal (MAC) and paternal age at conception effects on offspring LTL in S

8 autosomal dominant disorders show a dramatic paternal age effect due to selfish mutations: substituti

9 s are important in adequately explaining the paternal age effect.

10 The mutation rate increased with paternal age in all families, but the number of addition

11 Paternal age or body mass index (BMI) were not associate

12 mia and central nervous system tumors, older paternal age was not associated with risk of either type

13 Paternal age was not associated with TL in newborns.

14 Associations with paternal age were strongly, but not completely, attenuat

15 There was a joint effect of maternal and paternal age with increasing risk of ASD for couples wit

16 of DNMs in offspring increases not only with paternal age, but also with maternal age, and that some

17 age, maternal body mass index, maternal age, paternal age, newborn sex, newborn ethnicity, season of

18 ed for calendar year, age, sex, maternal and paternal age, place of residence at birth, and somatic c

19 ber of DNMs increases at a constant rate for paternal age, the contribution from the mother increases

20 psychiatric disorder (lifetime PD); and (3) paternal age.

21 on rates are a function of both maternal and paternal ages in humans.

22 n spectra between the sexes and at different paternal ages.

23 investigated the association of maternal and paternal alcohol drinking before and early in pregnancy

24 t pattern of association between maternal or paternal alcohol intake before or during pregnancy and o

25 Mice with paternal allele deletion of Gnas (Gnas(+/p-)) have defec

26 le silencing are monoallelic versus 56% with paternal allele expression-this cardiac-specific phenome

27 the brain of Ube3a(m-/p+) mice, because the paternal allele is epigenetically silenced in most neuro

28 anscriptional up-regulation of the remaining paternal allele of both Peg3 and Usp29, causing the incr

29 y be a suppressor antagonistic to the active paternal allele of the ICR, suggesting a potential intra

30 re expressed monoallelically from either the paternal allele or maternal allele as a result of epigen

31 w that only 5% of known imprinted genes with paternal allele silencing are monoallelic versus 56% wit

32 ed double-strand breaks (DSBs) at the mutant paternal allele were predominantly repaired using the ho

33 pression on the maternal allele, but not the paternal allele, in the dorsomedial nucleus of the hypot

34 ollowed by sequencing identify 76 genes with paternal allele-specific DNase I hypersensitive sites th

35 ing at the Xist gene is essential to achieve paternal allele-specific imprinted X-chromosome inactiva

36 al expression of a gene from its maternal or paternal allele.

37 h increased expression bias in favour of the paternal allele.

38 in neural stem cells (NSCs) solely from the paternal allele.

39 ng stably transcribed either the maternal or paternal allele.

40 rential DNA methylation between maternal and paternal alleles(1).

41 hylated maternal alleles and hypermethylated paternal alleles, respectively.

42 sion, evidence about the association between paternal and adolescent depression is inconclusive, and

43 We aimed to assess the association between paternal and adolescent depressive symptoms in two large

44 Advancing paternal and maternal age have both been associated with

45 Advancing paternal and maternal age were each associated with incr

46 tient (IQ) and adaptive function, as well as paternal and maternal age.

47 This study tests if advancing paternal and maternal ages are independently associated

48 printing refers to the unequal expression of paternal and maternal alleles of a gene in sexually repr

49 methylation and H3K4me3 specifically marked paternal and maternal alleles, respectively.

50 ' between the numbers of reads mapped to the paternal and maternal chromosomes.

51 Here we use autosomal, paternal and maternal DNA markers to (1) test the hypoth

52 iminate analysis (PLS-DA; P < 0.01), whereas paternal and maternal IUGR (IUGR(pat)/IUGR(mat), respect

53 zygote transition in mice and is distinct in paternal and maternal nuclei within single-cell zygotes.

54 According to the results, paternal and maternal transmission of the mutant allele

55 rapidly with the spatial separation between paternal and maternal trees.

56 y underlines the importance of investigating paternal and secondhand smoking in addition to maternal

57 time tree that accounts for unique maternal, paternal, and biparental evolutionary histories.

58 Transgenerational effects of paternal Areca catechu nut chewing on offspring metaboli

59 d hazard ratio, 1.95; 95% CI, 1.26-3.04) for paternal areca nut usage from 20 to 29 years of age, ver

60 ring MetS risks increased with prefatherhood paternal areca nutusage (adjusted hazard ratio, 1.77; 95

61 gh infancy and at 7 y of age exceed those of paternal associations.

62 y (OR, 4.27; 95% CI, 2.33-7.83; P for sex by paternal asthma interaction = .02), whereas being black

63 s (OR, 1.53; 95% CI, 1.19-1.96; P for sex by paternal asthma interaction = .03), whereas being black

64 Paternal asthma was a stronger predictor of ever wheezin

65 ed with persistent wheeze in both sexes, but paternal asthma was associated with persistent wheeze in

66 Paternal atopic status did not affect the risk of atopic

67 in male reproductive disorders and possibly paternal-based DOHaD diseases.

68 tio, 3.28; 95% CI, 1.67-6.43) with >10 years paternal betel chewing, 1.62 (95% CI, 0.88-2.96) for 5 t

69 Longer duration of paternal betel quid chewing and smoking, prefatherhood,

70 drives bi-allelic expression of Peg3 with a paternal bias only in the neonatal-stage brain.

71 In contrast, paternal birth season predicted offspring HAZ at 24 mo (

72 Paternal blood pressure was not associated with childhoo

73 In contrast, higher paternal BMI (P < 0.001), maternal prepregnancy BMI (P <

74 ions were present for maternal compared with paternal BMI across these associations; however, there w

75 by comparing the effects of maternal versus paternal BMI and incorporating genetic variation.

76 was collected at 15 weeks of gestation, and paternal BMI was assessed when the child was 18 months o

77 g trios) showed that increasing maternal and paternal BMI was associated with an adverse cardio-metab

78 egnancy and postpartum BMI z scores and with paternal BMI z scores.

79 ved with mothers' BMI at birth [maternal and paternal BMI z scores: 0.143 (95% CI: 0.130, 0.155) and

80 MI z score at child age 7 y per maternal and paternal BMI z scores: 0.208 (95% CI: 0.196, 0.220) and

81 (IPD) meta-analysis, and a negative-control (paternal BMI) to examine the association between materna

82 MI with maternal BMI were stronger than with paternal BMI.

83 body mass index (BMI) with associations for paternal BMI.

84 mass index at the first antenatal visit, and paternal body mass index at the time of conscription int

85 , no studies have investigated the impact of paternal body weight on daughters' risk of this disease.

86 her odds of microcephaly at birth for higher paternal, but not maternal, alcohol consumption before p

87 Finally, brain-specific deletion of the paternal, but not maternal, allele of the paternally-bia

88 tics, socioeconomic status, and maternal and paternal cardiovascular disease.

89 ategies - multiple mating, mate guarding and paternal care - in response to partner availability.

90 The evolution of monogamy and paternal care in humans is often argued to have resulted

91 maternal behavior and also promoted unusual paternal care in rats, as measured by pup-retrieval test

92 we find that male mate guarding, rather than paternal care, drives the evolution of monogamy, as it s

93 iological mechanisms underlying maternal and paternal care, especially in rodents, and discuss the re

94 When comparing maternal-child and paternal-child BMI z score associations, the strongest a

95 Paternal chromatin accessibility is quickly reprogrammed

96 PSR prevents the paternal chromatin from forming chromosomes during the f

97 discovered distinct effects on maternal and paternal chromatin loop sizes, likely reflecting differe

98 ene expression in the resulting embryos in a paternal chromatin-dependent manner.

99 Patient P7 carried the mutation in the paternal chromosome.

100 date and facilitate the sequential exodus of paternal chromosomes following fertilization.

101 Collectively, these results demonstrate that paternal cocaine exposure produces epigenetic remodeling

102 arisons, timing of exposure comparisons, and paternal comparisons, were used to examine the associati

103 chr5:60195556, NM_000082:c.618-2A > G) and a paternal complex deletion/inversion/deletion rearrangeme

104 for all Malagasy individuals with a limited paternal contribution from Europe and the Middle East.

105 trol over this remodeling is well described, paternal contributions are virtually unknown.

106 The maternal and paternal copies of the genome are both required for mamm

107 use of ASOs to activate the normally silent paternal copy of the imprinted UBE3A gene in neurons as

108 yses controlling for pregnancy, maternal and paternal covariates, as well as sibling comparisons, tim

109 Maternal depression and paternal depression at any time before the final compuls

110 Both maternal depression and paternal depression at different periods (before birth,

111 Elevated postnatal paternal depression symptoms affected 153 (4.3%) of fath

112 Elevated antenatal paternal depression symptoms affected 82 fathers (2.3%)

113 djustments, a 1 SD (three-point) increase in paternal depressive symptoms was associated with an incr

114 work, we investigate the mechanism by which paternal diet affects offspring metabolism.

115 cent observations have shown that changes in paternal diet may result in transgenerational inheritanc

116 ploid O. punctata with O. punctata being the paternal donor.

117 Associations with paternal drinking before pregnancy were unexpected and s

118 Thus, paternal drug exposure induces a protective phenotype in

119 Among the confounders, paternal eczema and race/ethnicity (Hispanic vs White) w

120 emic achievement independent of SES factors (paternal education and income, maternal education and in

121 R, 3.1, P = .02; African American, P < .001; paternal education less than college (OR, 1.4, P = .05);

122 very, Apgar score at 5 minutes, maternal and paternal educational levels, annual taxable household in

123 Here, we establish a paternal effect model based on nicotine exposure in mice

124 gh doses of either, which suggests that such paternal effects are generic, rather than being a respon

125 ting effort) or offspring number or fitness (paternal effort).

126 pothesis, few studies have found support for paternal effort.

127 benefit from self-sacrifice behavior through paternal effort.

128 We used two experiments to test the paternal-effort hypothesis in the dark fishing spider, D

129 In support of the paternal-effort predictions, when females were allowed t

130 Paternal environmental conditions can influence phenotyp

131 Paternal environmental perturbations including exposure

132 Hence, sperm tsRNAs represent a paternal epigenetic factor that may mediate intergenerat

133 Long-term paternal exercise also altered expression of several met

134 These findings suggest that paternal exercise produces offspring with a thrifty phen

135 The effect of paternal exposure during pregnancy and infancy on infect

136 cific responses to particular aspects of the paternal exposure history, or a generic response to pate

137 In mice, paternal exposure to cigarette smoke condensate (CSC) ca

138 Paternal exposure to dLAN decreased splenic endocrine re

139 Maternal and paternal exposure to dLAN reduced DTH responses in femal

140 Paternal exposure to MPA did not increase the risk of ad

141 Paternal exposure to nicotine prior to reproduction indu

142 (e.g. comparing the effects of maternal and paternal exposure) could help disentangle causal effects

143 relative risk was higher for maternal versus paternal exposure, in studies that assessed benzene vers

144 xicants, but the impact of both maternal and paternal exposures on offspring birth size is largely un

145 ns recapitulates the switch from maternal to paternal expression observed during neuronal development

146 stral to extant octoploid strawberries and a paternal, extinct Fragaria iinumae-like diploid progenit

147 rnal dispensations before pregnancy and with paternal first-trimester dispensations were consistent w

148 ybp, suggests it to be one of the Ashkenazi paternal founders; to have expanded as part of the overa

149 orming and after it matures and receives the paternal gamete.

150 F1 crosses, suggesting a role for disrupted paternal gene expression in seed abortion that varies in

151 suggest that maternal epigenetic factors and paternal gene expression play important roles in the pos

152 terns, resulting from predominantly European paternal gene flow.

153 nicotine exposure induced depression in the paternal generation, but reduced depression and promoted

154 ritance of DNA methylation patterns from the paternal generation.

155 ide data set supports the concept of delayed paternal genome activation in plant embryos.

156 t that germline chromothripsis arises in the paternal genome and may be transmitted maternally.

157 repair, is critical for reprogramming of the paternal genome during the oocyte-to-zygote transition.

158 approaches, we show that this group exhibits paternal genome elimination (PGE), an unusual mode of se

159 se findings strongly suggest that PSR causes paternal genome elimination by disrupting at least three

160 thesized to aid in the ordered exodus of the paternal genome following fertilization.

161 Overrepresentation of the paternal genome in sporadic hydatidiform moles (purely a

162 sized during spermiogenesis and condense the paternal genome into a transcriptionally inactive state

163 e postimplantation stage, methylation of the paternal genome is consistently lower than that of the m

164 Furthermore, demethylation of the paternal genome is much faster and thorough than that of

165 ed by PSR, suggesting that its effect on the paternal genome is specific to a subset of histone marks

166 nal genome inherited from the oocyte and the paternal genome provided by sperm coexist as separate ha

167 nt in angiosperms requires a 2:1 maternal-to-paternal genome ratio (2m:1p) in the endosperm.

168 ucture from a condensed maternal and a naive paternal genome to generate a totipotent embryo.

169 Transcription of the paternal genome was highly restricted but unexpectedly i

170 saturated linkage maps for the maternal and paternal genomes of an interspecific Brachiaria ruzizien

171 e the interaction of the fetal, maternal and paternal genomes.

172 ver, our analysis suggests that maternal and paternal genomic imprinting are equally rare events in A

173 conserve PGC-lineage erasure of maternal and paternal genomic imprints and DPPA3 (also known as STELL

174 th relevant data on maternal, offspring, and paternal genotype are required to obtain more precise (a

175 Paternal grandmothers smoking in pregnancy showed no ass

176 l grandmothers invest more in childcare than paternal grandmothers.

177 s (maternal half siblings, 1.10 [0.90-1.34]; paternal half siblings, 1.21 [0.98-1.49]; full cousins,

178 gical full siblings, maternal half siblings, paternal half siblings, full cousins, and half cousins.

179 The paternal haplogroup (hg) N is distributed from southeast

180 n excess of structural changes originated on paternal haplotypes.

181 phics, gestational weight gain, maternal and paternal height, and (for postdelivery outcomes) child s

182 Paternal (i.e., sperm-borne) RNAs isolated from paramuta

183 this study reveals evolutionarily divergent paternal imprinting at IC1 between mice and humans.

184 on of gene expression, splicing, DNA damage, paternal imprinting, cancer and metastasis.

185 s in mothers or infants were associated with paternal infections, except for sandbox exposure.

186 Accordingly, we argue that while paternal investment may be common across human societies

187 s of the chosen OR gene, the maternal or the paternal, is expressed per neuron.

188 ion, we propose that further analyses in the paternal knock-in H19(+/hIC1) mice will elucidate the mo

189 re reduced in hypothalami of fasted Snord116 paternal knockout (Snord116p-/m+) mice.

190 non-coding RNA emerges from the unmethylated paternal KvDMR in antisense direction, resulting in cis-

191 h geographic differences in the incidence of paternal leakage and/or the rates of nuclear restoration

192 Occasional paternal leakage could in principle promote recombinatio

193 genomes mitigates mutational erosion, while paternal leakage exacerbates the ratchet effect.

194 Paternal leakage may be important in the evolution of ma

195 own, and that homologous recombination under paternal leakage might not be needed.

196 Paternal leakage provides opportunity for recombination

197 locus near CHRNA3/5 differentially affecting paternal lifespan (P=4.8 x 10(-11), effect -0.86 years p

198 iRs in the transgenerational transmission of paternal lifetime experiences.

199 By contrast, the odds ratios for paternal lifetime smoking were 1.34 (95% CI: 1.11, 1.62)

200 gh diet-induced epigenetic reprogramming via paternal lineage has recently received much attention in

201 rodent models that specifically examine the paternal lineage, identifying epigenetic signatures in m

202 the phylogeographic features of maternal and paternal lineages of the Tyrolean Iceman within the cont

203 eny, coalescing similarly to other Ashkenazi paternal lineages, 1,743 ybp, suggests it to be one of

204 omic diversity (including maternal lineages, paternal lineages, and genome-wide data) across 257 vill

205 azi Levite R1a clade, other Ashkenazi Jewish paternal lineages, as well as non-Levite Jewish and non-

206 not leave a significant mark on the pool of paternal lineages.

207 We detected a significant paternal linkage of the 4q35 region to asthma and allerg

208 printed DMRs as sites where the maternal and paternal methylation levels diverge significantly from t

209 rall, our data support a crucial function of paternal miRNAs and/or endo-siRNAs in the control of the

210 ncoding a member of the calpain proteases: a paternal missense mutation (c.1511C>A; p.P504Q) and a ma

211 ia delays PME, whereas a defect in fusion of paternal mitochondria accelerates PME.

212 in mammalian cells and for the clearance of paternal mitochondria after embryonic fertilization in C

213 process is associated with depolarization of paternal mitochondria and additionally requires the mito

214 ion for the autophagy machinery with damaged paternal mitochondria and delayed PME.

215 Delayed removal of paternal mitochondria causes increased embryonic lethali

216 A defect in fission of paternal mitochondria delays PME, whereas a defect in fu

217 in Caenorhabditis elegans, we observed that paternal mitochondria rapidly lose their inner membrane

218 -6 relocates from the intermembrane space of paternal mitochondria to the matrix after fertilization

219 inner membranes, autophagosome enclosure of paternal mitochondria, and PME.

220 ion (PME) in Caenorhabditis elegans, but how paternal mitochondria, but not maternal mitochondria, ar

221 d about the cellular mechanism through which paternal mitochondria, delivered from sperm, are elimina

222 MUL1 play redundant roles in elimination of paternal mitochondria.

223 Thus, CPS-6 functions as a paternal mitochondrial degradation factor during animal

224 ost animals, but the mechanisms of selective paternal mitochondrial elimination (PME) are unknown.

225 The autophagy process is critical for paternal mitochondrial elimination (PME) in Caenorhabdit

226 a mitochondrial endonuclease G, serves as a paternal mitochondrial factor that is critical for PME.

227 ental inheritance at two levels, eliminating paternal mitochondrial genomes or destroying mitochondri

228 -dominant inheritance of variants, including paternal mosaicism in two affected sisters who inherited

229 In a paternal mouse model given a high-fat diet (HFD), we sho

230 e reassuring and support the continuation of paternal MPA treatment before, during, and after concept

231 oral phenotype of the F1 mice resulting from paternal nicotine exposure could be attenuated by viral

232 Paternal obesity was also associated with higher risk of

233 s between early life socioeconomic position (paternal occupation and parental education) and mean adu

234 Both maternal and paternal older ages were associated with risk of lymphom

235 aternal recombination rate is lower than the paternal one.

236 ses in ASD was not only limited to advancing paternal or maternal age alone but also to differences p

237 and reset during gametogenesis, resulting in paternal or maternal imprints, which lead to genomic imp

238 bility that our findings reflect the role of paternal or postnatal nicotine exposure, as opposed to m

239 pportunity for testing whether normal sperm (paternal) or oocyte (maternal) miRNA and endo-siRNA cont

240 Here, we show that diet-induced paternal overweight around the time of conception can ep

241 overweight and 1.96 (95% CI: 1.74, 2.21) by paternal overweight.

242 nd also from a mouse model of PWS carrying a paternal (p) deletion from small nuclear ribonucleoprote

243 r secondary deletions (32 maternal versus 14 paternal, p = 1.14 x 10(-2)).

244 on rate is much higher than the rates of the paternal PAR or autosomes, culminating in an elevated ch

245 This study provides evidence that paternal peri-conceptional body weight may affect daught

246 h attention in the literature, the effect of paternal physical activity on offspring metabolism has n

247 Ai knockdown of paternal Poc1, we found that paternal Poc1 enrichment is essential for the formation

248 during spermiogenesis, and RNAi knockdown of paternal Poc1, we found that paternal Poc1 enrichment is

249 rnal prepregnancy LDL-C levels compared with paternal prepregnancy and parental concurrent LDL-C leve

250 and significantly more expressed than in the paternal progenitor A. arenosa.

251 n, the nuclear envelopes of the maternal and paternal pronuclei disassemble, allowing both sets of ch

252 f H3.3K56 in efficient H2B incorporation and paternal pronuclei formation.

253 l exposure history, or a generic response to paternal 'quality of life'.

254 s, and base substitutions tend to go up with paternal reproductive age.

255 Paternal serum samples were tested for T. gondii antibod

256 and <18.5, 1.21; 95% CI, 1.01-1.45), as was paternal severe thinness (HR for BMI<16.0, 2.53; 95% CI,

257 non-essential, selfish B chromosome known as Paternal Sex Ratio (PSR) induces complete elimination of

258 ndicated selective expression of the mutated paternal SGCE allele.

259 Our analyses suggest an association between paternal smoking and childhood AML.

260 The neurobehavioral effects of paternal smoking and nicotine use have not been widely r

261 ated that effective interventions to prevent paternal smoking in the presence of children would reduc

262 MetS offspring risk for paternal smoking increased dosewise (Ptrend<0.0001) with

263 and diabetes mellitus experimentally, and of paternal smoking on offspring obesity, are reported, lik

264 Associations with paternal smoking varied by histological type.

265 We aimed to determine the effects of paternal smoking, and betel chewing, on the risks of ear

266 ning sessions were tested for the effects of paternal smoking, areca nut chewing, and their duration

267 SES indicators were paternal social class, participants' education, particip

268 the maternal egg and central cells with two paternal sperm cells, leading to the formation of embryo

269 h changes in the miRNA expression profile in paternal sperm.

270 reproductive trait characteristics of their paternal stock, (indicating enhanced activity of the pat

271 Transmission of preconception paternal stress exposure is associated with changes in e

272 strates the influence that both maternal and paternal stress exposures have in changing the course of

273 clinical manifestations were associated with paternal T. gondii infection status.

274 May 2010 in Nha Trang, Vietnam, to evaluate paternal tobacco smoking as a risk factor for infectious

275 Paternal tobacco smoking independently increased the ris

276 while adjusting for pregnancy, maternal, and paternal traits, first-trimester antidepressant exposure

277 The paternal transmission of the deletion resulted in comple

278 In contrast, the paternal transmission resulted in changes in the express

279 e evolved into the M-orf associated with the paternal transmission route in Hyrioidea and Unionoidea,

280 by dextran sodium sulphate (DSS), and their paternal transmission to offspring.

281 mbers who have inherited the variant through paternal transmission, a finding that is consistent with

282 l transmitted haplotype score as well as the paternal transmitted haplotype score.

283 demonstrated that strategies to activate the paternal Ube3a allele are feasible; however, a recent st

284 ns of the brain and spinal cord, whereas the paternal UBE3A allele is repressed by an extremely long

285 Paternal UBE3A also partially colocalizes with a marker

286 Due to neuron-specific imprinting, the paternal UBE3A copy is silenced.

287 Here we sought to examine maternal and paternal Ube3a expression in DRGs neurons and to evaluat

288 k proteins (PER2 and BMAL1), supporting that paternal UBE3A expression in the SCN is often of neurona

289 evidence in AS model mice (Ube3a(m-/p+)) of paternal UBE3A expression within the suprachiasmatic nuc

290 be rescued by pharmacologically unsilencing paternal UBE3A expression.

291 However, recent studies suggest that paternal Ube3a may escape silencing in certain neuron po

292 tions, allowing for persistent expression of paternal UBE3A protein.

293 ing that relaxed or incomplete imprinting of paternal Ube3a reflects an overall immature molecular ph

294 All patients carry at least one copy of paternal UBE3A, which is intact but silenced by a nuclea

295 ive DRG neurons expressed maternal Ube3a and paternal Ube3a-ATS In contrast, most small-diameter neur

296 Paternal UBE3A-positive cells in the SCN show partial co

297 ncRNA), UBE3A-ATS, has been shown to silence paternal UBE3A.

298 The paternal UBE3A/Ube3a allele becomes epigenetically silen

299 l conflicts driven by its growth-stimulating paternal versus growth-suppressing maternal alleles.

300 In mice, transcriptional repression of the paternal X-chromosome (Xp) and enrichment in epigenetic