ライフサイエンスコーパス: paternal age

1 in males than in females and increases with paternal age.

2 s were de novo and associated with increased paternal age.

3 proportion of mutants, which decreases with paternal age.

4 enetic alterations associated with advancing paternal age.

5 al evidence for an increase in mutation with paternal age.

6 Much less is known about the impact of paternal age.

7 of autism risk with increasing maternal and paternal age.

8 tism associated with increasing maternal and paternal age.

9 no association with ASD after adjusting for paternal age.

10 psychiatric disorder (lifetime PD); and (3) paternal age.

11 than female gametes and often increase with paternal age.

12 g habits, and they differed only slightly by paternal age.

13 no significant effects, after adjusting for paternal age.

14 n spectra between the sexes and at different paternal ages.

15 ce regarding the impact of both maternal and paternal ages.

16 DNMs in the offspring after controlling for paternal age (0.51 additional mutations per year, 95% CI

17 higher maternal age (1.13 [1.02-1.25]), and paternal age (1.12 [1.05-1.19]).

18 32; 95% CI: 0.11, 0.54; P < 0.01), and older paternal age (adjusted coefficient: 33.27; 95% CI: 4.10,

19 may play an important role in accounting for paternal age-AH4 associations.

20 here was a strong, positive association with paternal age among participants without siblings.

21 rved an inverse U-shaped association between paternal age and offspring AH4 score with the lowest sco

22 The association was similar for paternal age and present even among individuals older th

23 ant, monotonic association between advancing paternal age and risk of adult schizophrenia and schizop

24 cant monotonic association between advancing paternal age and risk of ASD.

25 association was also found between advancing paternal age and risk of autism in the offspring.

26 xamined the association between maternal and paternal age and subgroups of trisomy 21 defined by pare

27 Other variables, such as paternal age and subject's birth weight, were significan

28 anation for the association between advanced paternal age and various neurodevelopmental disorders bu

29 story of psychiatric disorders, maternal and paternal age, and parental educational and employment st

30 Advanced paternal age (APA) has been shown to be a significant ri

31 Maternal and paternal ages are associated with neurodevelopmental dis

32 es as well as additional reports of advanced paternal age associated with paternal origin of three sp

33 We observed a paternal age association with AH4 but not RT, a measure

34 to better understand the association between paternal age at birth and hematological malignancies.

35 ication were verbal IQ for the ASD/ID genes, paternal age at birth for the DBE genes and adaptive fun

36 ippines, we first replicate the finding that paternal age at birth is associated with longer TL in of

37 Paternal age at birth was obtained for most of the cohor

38 (including sex, year of birth, maternal and paternal age at birth, and parity), for smoking 10 or mo

39 The effects of advancing paternal age at childbearing on offspring morbidity rema

40 In humans, the effect of paternal age at conception (PAC) on offspring leukocyte

41 We test for maternal (MAC) and paternal age at conception effects on offspring LTL in S

42 ial confounders (maternal age at conception, paternal age at conception, parental psychiatric history

43 Paternal age at MI of <50, 50 to 59, 60 to 69, 70 to 79,

44 9, 1.64, 1.42, 1.16, and 0.92; in women, for paternal age at MI of <50, 50 to 59, and >/=60 years, th

45 The study examined the relation between paternal age at the time of birth and risk of schizophre

46 Advanced paternal age at the time of birth of the offspring may b

47 Maternal and paternal age at the time of offspring's birth.

48 rth cohort had prospective information about paternal age at the time of the offspring's birth.

49 of DNMs in offspring increases not only with paternal age, but also with maternal age, and that some

50 2.32, and 2.74 among those of each increased paternal age category (27-<32, 32-<38, and > or =38 year

51 in (4:1 bias) and positively correlated with paternal age, consistent with the modest increased risk

52 Our data on advanced paternal age corroborates and extends previous clinical

53 n association with rare disorders related to paternal age (e.g., Apert syndrome, achondroplasia), thi

54 tant sperm over time-explaining the observed paternal age effect associated with these disorders-and

55 autosomal dominant disorders show a dramatic paternal age effect due to selfish mutations: substituti

56 ts age, and thus selection could explain the paternal age effect for Apert syndrome and other genetic

57 This identifies the biological basis of the paternal age effect for new mutations previously suggest

58 We found no paternal age effect for the overall population nor when

59 A paternal age effect in spermatogenic cells is recognized

60 Although it is assumed that the paternal age effect is the result of an increasing frequ

61 estes suggests that the common factor in the paternal age effect lies in the dysregulation of spermat

62 n seven to eight times that of females and a paternal age effect of three mutations per year of fathe

63 syndrome (HRAS), which we collectively term "paternal age effect" (PAE) disorders, provides a good mo

64 deletions or rearrangements do not show the paternal age effect.

65 s are important in adequately explaining the paternal age effect.

66 A paternal-age effect and the exclusive paternal origin of

67 Therefore, contributing factors to the paternal-age effect may include selection and a higher n

68 Maternal and paternal age effects were seen in subgroups defined by r

69 gic mechanisms are suggested by maternal and paternal age effects.

70 for the lower offspring scores in the oldest paternal age group.

71 interval: 1.1, 1.6; adjusted odds ratio for paternal age > or =40 years vs. 25-29 years = 1.4, 95% c

72 n the second, third, and oldest quartiles of paternal age had 1.2, 1.3, and 1.7 times increased risk

73 comparison analyses indicated that advancing paternal age had a dose-response relationship with every

74 Advanced paternal age has been associated with an increased risk

75 Advancing paternal age has been linked to autism.

76 crease in autism risk with both maternal and paternal age has potential implications for public healt

77 schizophrenia was associated with advancing paternal age in a population-based birth cohort of 87 90

78 The mutation rate increased with paternal age in all families, but the number of addition

79 dern humans and highlight a central role for paternal age in determining rates of mutation.

80 on rates are a function of both maternal and paternal ages in humans.

81 Advancing paternal age is associated with increased genetic mutati

82 Advancing paternal age is associated with increased risk of psychi

83 5.84) than did controls after adjustment for paternal age, low maternal education, race, residence, g

84 n-years among sons in the lowest quartile of paternal age (<27 years), to 2.00, 2.32, and 2.74 among

85 ma over time; a similar effect of increasing paternal age may be due to the same selection process.

86 Advanced paternal age may play a role in non-Hodgkin lymphoma eti

87 age, maternal body mass index, maternal age, paternal age, newborn sex, newborn ethnicity, season of

88 We explored paternal age-offspring cognition associations in 772 par

89 The effect of increased paternal age on prostate cancer risk may operate through

90 valuated independent effects of maternal and paternal age on risk of autism spectrum disorder.

91 no evidence to show an effect of maternal or paternal age on the frequency of nondisjunction.

92 here are independent effects of maternal and paternal age on the risk of autism.

93 Paternal age or body mass index (BMI) were not associate

94 ed for calendar year, age, sex, maternal and paternal age, place of residence at birth, and somatic c

95 observed to arise in fathers, and increasing paternal age positively correlates with the risk of new

96 d not differ in distributions of maternal or paternal age, previous livebirths, maternal smoking, or

97 c risk for schizophrenia was associated with paternal age (R(2) = 0.002; P = 1e-04), and offspring ed

98 nt with the clinical observation of advanced paternal age resulting in new cases of achondroplasia an

99 trend by adjusting for birth year, advanced paternal age showed no association with offspring IQ; ho

100 droplasia have been associated with advanced paternal age, suggesting that these mutations occur pref

101 ber of DNMs increases at a constant rate for paternal age, the contribution from the mother increases

102 academic morbidity associated with advancing paternal age using several quasi-experimental designs, i

103 oportional hazards regression, we found that paternal age was a strong and significant predictor of t

104 rval: 1.32, 1.44), and a 10-year increase in paternal age was associated with a 22% increase (odds ra

105 Advanced paternal age was associated with increased risk of ASD.

106 In the study population, advancing paternal age was associated with increased risk of some

107 Increased paternal age was associated with significant increases i

108 ternal age (> or =40 years) became null when paternal age was included in the statistical model.

109 In separate analyses, paternal age was modeled as a continuous variable and as

110 mia and central nervous system tumors, older paternal age was not associated with risk of either type

111 Paternal age was not associated with TL in newborns.

112 Advanced paternal age was noted for the fathers of patients with

113 Paternal age was positively associated with non-Hodgkin

114 Paternal age was significantly correlated with the sex r

115 radic AS births increases exponentially with paternal age, we hypothesized that the frequency of AS m

116 ion, and other covariates, both maternal and paternal age were independently associated with autism (

117 Associations with paternal age were strongly, but not completely, attenuat

118 There was a joint effect of maternal and paternal age with increasing risk of ASD for couples wit

119 We then show that this association of paternal age with offspring TL is cumulative across mult

120 The association of older paternal age with risk of early-onset prostate cancer (<