ライフサイエンスコーパス: paternally

1 tely 80% perinatal lethality, when inherited paternally.

2 chieved only if the transgene is transmitted paternally.

3 red by their affected siblings and inherited paternally.

4 was found more often when the haplotype was paternally (70%) rather than maternally transmitted (14%

5 germline interactions, and how they transmit paternally acquired phenotypes by shaping early embryoni

6 al exposures or experiences and that certain paternally acquired traits can be 'memorized' in the spe

7 ic interaction between an endosymbiont and a paternally acting locus on the X chromosome.

8 patibility in SLE families was compared with paternally affected offspring compatibility and with ind

9 demonstrated that trophoblast expresses both paternally and maternally inherited HLA-C surface protei

10 pstream Nesp and Nespas/Gnasxl promoters are paternally and maternally methylated, respectively.

11 aternally expressed Igf2 locus, H3K79me3 was paternally biased at the maternally expressed H19 locus,

12 e genes exhibited evidence for maternally or paternally biased expression at multiple stages of endos

13 he paternal, but not maternal, allele of the paternally-biased Bcl-x, (Bcl2l1) results in loss of spe

14 in pregnancies where its ligand, HLA-C2, was paternally but not maternally inherited by a fetus (p =

15 [OR], 1.92; P = 4.1 x 10(-12)), but not when paternally derived (OR, 0.93; P = 0.47; P = 9.9 x 10(-6)

16 Methylation is then lost specifically on the paternally derived allele during the latter stages of em

17 re occupied in vivo only on the unmethylated paternally derived allele.

18 opoietic tissues and is transcribed from the paternally derived allele.

19 nt is not obvious because the maternally and paternally derived alleles at a locus have equal probabi

20 s on the conflict between the maternally and paternally derived alleles at an imprinted locus.

21 esults from the absence of expression of the paternally derived alleles of maternally imprinted genes

22 found on chromosome 5 (LOD(MO) = 1.7) and to paternally derived alleles on chromosome 10p (LOD(FA) =

23 a network of relatedness for maternally and paternally derived alleles through identical-by-descent

24 5Gc antibodies are also capable of targeting paternally derived antigens and mediate cytotoxicity aga

25 vouring the expression of either maternal or paternally derived autosomal alleles depending on the pa

26 ion sites upstream of Nap1l5 are used on the paternally derived chromosome, from which Nap1l5 is expr

27 pring that carry a mixture of maternally and paternally derived copies of the genome; a type of heter

28 uals could carry a mixture of maternally and paternally derived copies of the mitochondrial genome, a

29 Children with Prader-Willi syndrome lack a paternally derived copy of the proximal long arm of chro

30 Female mice carrying the deletion in the paternally derived Dkc1 show extreme skewing of X-inacti

31 vestigate differences between maternally and paternally derived DNMs and study the underlying mutatio

32 (MLPA) showed the presence of an intragenic paternally derived duplication involving exons 7-11 of t

33 n inhibitory maternal KIR AA genotype with a paternally derived fetal HLA-C2 ligand.

34 gene showing no detectable expression of the paternally derived fie1 allele during kernel development

35 er-Willi syndrome (PWS) is caused by lack of paternally derived gene expression from the imprinted ge

36 qually related to the actor's maternally and paternally derived genes (unless a gene also has pleiotr

37 of the female developmental pathway requires paternally derived genes.

38 care for offspring is appropriate, with the paternally derived genome favoring greater care.

39 Contrary to the paternally derived genome, the PSR chromosome was visibl

40 Both the maternally and paternally derived genomes in the embryo favor maintenan

41 n be disagreement between the maternally and paternally derived genomes of mothers over how much care

42 rauterine environment from NOS3 deficiency), paternally derived heterozygous NOS3(+/-) (KOP: mother w

43 In somatic cells, the maternally and paternally derived ICRs are hypo- and hypermethylated, r

44 cumulating evidence indicates the absence of paternally derived miRNAs, piwiRNAs, and proteins may be

45 Although mechanisms that eliminate paternally derived mitochondria from the zygote have bee

46 Here, we assess maternally and paternally derived protection in a monarch butterfly-pro

47 born (HDFN) is caused by alloimmunization to paternally derived RBC antigens.

48 We show that a paternally derived targeted deletion of the germline dif

49 Here we show that a paternally derived targeted deletion of the germline dif

50 bution of cells, approximately half with the paternally derived X chromosome inactive and half with t

51 by exclusive, but leaky inactivation of the paternally derived X chromosome.

52 Consequently, females harboring a paternally derived Xist mutation (X/X(Xist-)) die owing

53 adic, and new mutations are virtually always paternally derived.

54 al crosses revealed that maternally, but not paternally, derived AtLETM2 was absolutely required for

55 CYK-4 is enriched within sperm, and paternally donated CYK-4 is required for polarity.

56 f over 100 megabases along the maternally or paternally duplicated distal chromosome 7 (Chr7) and Chr

57 omes to its offspring so that maternally and paternally encoded information is expressed equally.

58 one H3 lysine-27 di- and tri-methylation are paternally enriched at the imprinted loci Mez1, ZmFie1 a

59 y juxtaposed maternally expressed (Nesp) and paternally expressed (Nespas, Gnasxl, Exon 1A) transcrip

60 e sequencing of cDNA libraries to identify 9 paternally expressed and 34 maternally expressed imprint

61 ur results demonstrate that Pref-1 is indeed paternally expressed and is important for normal develop

62 ow that the region contains a promoter for a paternally expressed anti-sense transcript, Kcnq1ot1, an

63 he murine Ube3a locus includes an imprinted, paternally expressed antisense transcript.

64 The five genes include all paternally expressed autosomal imprinted genes previousl

65 This L1 signature overlaps the paternally expressed domain of the locus, excluding the

66 oduction; extralarge G(s)alpha (XLalphas), a paternally expressed G(s)alpha isoform; and neuroendocri

67 olute carrier family 38 member 4), and Peg1 (paternally expressed gene 1)--both MBD1 and H3K9me3 bind

68 -/- cells showed aberrant methylation of the paternally expressed gene 3 (Peg3) tumor suppressor gene

69 Notably, allelic imbalance in paternally expressed gene 3 (PEG3) was associated with i

70 tment of breast carcinoma xenografts induces paternally expressed gene 3 (Peg3), an imprinted gene en

71 We found that decorin induced paternally expressed gene 3 (Peg3), an imprinted tumor s

72 hin 3 maternally methylated imprinted genes: paternally expressed gene 3 (PEG3), insulin-like growth

73 receptor 2 (VEGFR2) signaling that requires paternally expressed gene 3 (PEG3).

74 ICR (Imprinting Control Region) of the Peg3 (Paternally Expressed Gene 3) domain contains an unusual

75 ation status of the CpG islands of the PEG3 (Paternally expressed gene 3) imprinted domain in the mou

76 Peg3 (paternally expressed gene 3) is an imprinted gene locali

77 The paternally expressed gene insulin-like growth-factor 2 (

78 d the expression and methylation status of a paternally expressed gene Peg3, in germ cells from sex-r

79 mprinting disorder caused by a deficiency of paternally expressed gene(s) in the 15q11-q13 chromosoma

80 stigate the role of the maternally imprinted/paternally expressed gene, Peg3, in several aspects of b

81 wn (CypA-KD) P19 cells, we observed a silent paternally expressed gene, Peg3.

82 The product of the imprinted gene paternally expressed gene-10 (PEG10) has been reported t

83 ressed genes (MEGs) and approximately 29% of paternally expressed genes (PEGs) in C. rubella were com

84 the mechanism by which PWS-IC activates the paternally expressed genes (PEGs) using transgenes that

85 ic crosses, whereas approximately 90% of 272 paternally expressed genes (PEGs) were found only in one

86 162 maternally expressed genes (MEGs) and 95 paternally expressed genes (PEGs), which were associated

87 and H3K36me3 peaks mostly co-localized with paternally expressed genes (PEGs), while endosperm-speci

88 54 maternally expressed genes (MEGs) and 46 paternally expressed genes (PEGs).

89 ssed genes, activated expression of silenced paternally expressed genes and resulted in methylation o

90 er-Willi syndrome (PWS) is caused by loss of paternally expressed genes at an imprinted locus on chro

91 oter regions and transcriptional termini and paternally expressed genes at promoters and gene bodies,

92 sults from loss of function of 10 clustered, paternally expressed genes in a 1.5-Mb region of chromos

93 -Willi syndrome (PWS) is caused by a loss of paternally expressed genes in an imprinted region of chr

94 the two parental alleles of SNRPN and other paternally expressed genes in the region by using a chro

95 Transcription of paternally expressed genes in the region depends upon an

96 portant for regulation of SNRPN and of other paternally expressed genes in the region.

97 The largest proportion of paternally expressed genes was at 7 DAP, mainly due to t

98 mplete abolition of the transcription of two paternally expressed genes, Peg3 and Usp29, causing the

99 ched for coexpressed pairs of maternally and paternally expressed genes, showed accelerated expressio

100 y expressed genes and repression of silenced paternally expressed genes.

101 for bidirectional activation of a number of paternally expressed genes.

102 cal crosses, resembling either maternally or paternally expressed genes.

103 r-Willi syndrome results from the absence of paternally expressed genes.

104 nts in which the expression of all the known paternally expressed Gnasxl proteins (XLalphas, XLN1 and

105 ression is still unclear, as is the role for paternally expressed Grb10 in neurons.

106 In contrast, the paternally expressed growth factor Igf2 is essential for

107 played a paternal-specific enrichment at the paternally expressed Igf2 locus, H3K79me3 was paternally

108 ation and has been recently reported to be a paternally expressed imprinted gene at human chromosome

109 ically examine the functional requirement of paternally expressed imprinted genes (PEGs) during seed

110 nces in methylation features associated with paternally expressed imprinted genes (PEGs).

111 -regulated expression of both maternally and paternally expressed imprinted genes and microRNAs, incl

112 Our results reveal that paternally expressed imprinted genes, in the absence of

113 CI in the trophectoderm, rather than loss of paternally expressed imprinted genes, is the primary cau

114 rs, certain noncoding RNAs, and generally to paternally expressed imprinted loci, but not paternally

115 associated with overexpression of genes at a paternally expressed imprinted locus on chromosome 6q24.

116 The paternally expressed imprinted retrotransposon-like 1 (R

117 is normally caused by deficiency of several paternally expressed imprinted transcripts within chromo

118 PWS) is caused by deficiency for one or more paternally expressed imprinted transcripts within chromo

119 in mice, we find the human GRB10 gene to be paternally expressed in brain.

120 Here, we show that Kcnq1ot1 is paternally expressed in preimplantation embryos from the

121 Interestingly, these genes are paternally expressed in preimplantation embryos, and ect

122 insulin-like growth factor II gene (Igf2) is paternally expressed in the fetus and placenta.

123 The paternally expressed long noncoding RNA (ncRNA) Kcnq1ot1

124 Transcripts from the imprinted, paternally expressed Magel2 gene, which maps to the chro

125 The 5'-ends of two paternally expressed mouse genes, Peg3 and Usp29, are jo

126 transcript is the candidate for Oed and the paternally expressed mutant Gnasxl transcript is the can

127 on the frequency of the favored allele: the paternally expressed pattern permits faster genetic chan

128 s faster genetic change than the reciprocal, paternally expressed pattern.

129 now been shown to target degradation of the paternally expressed Peg11 mRNA by an RNAi-mediated mech

130 The opposing effects of maternally and paternally expressed products of the Gnas locus provide

131 some, is necessary for the repression of the paternally expressed protein-coding genes and for activa

132 ified on distal chromosome 12 contains three paternally expressed protein-coding genes and multiple n

133 The 1-Mb cluster contains the paternally expressed protein-coding genes Dlk1 and Dio3

134 maternally expressed noncoding RNA genes and paternally expressed protein-coding genes.

135 rnally expressed non-coding RNAs and several paternally expressed protein-coding genes.

136 Relative contribution of paternally expressed proteins XLalphas, XLN1, and ALEX o

137 R loops and chromatin decondensation at the paternally expressed PWS Snord116 locus.

138 hromosome 7 recently identified Inpp5f_v2, a paternally expressed retrogene lying within an intron of

139 dystonic symptoms and caused by mutations in paternally expressed SGCE, which codes for epsilon-sarco

140 r RNAs (snoRNAs) encoded within the complex, paternally expressed SNRPN (small nuclear ribonuclear pr

141 Maternally and paternally expressed subgroups of imprinted genes were f

142 We disrupted a paternally expressed transcript at the Gnas locus, Gnasx

143 demonstrated that each is associated with a paternally expressed transcript.

144 cation in mouse of four brain-specific novel paternally expressed transcripts and an additional three

145 unlike its positive effect on all the other paternally expressed transcripts in the region, the PWS-

146 associated with Igf2 and Igf2r both contain paternally expressed transcripts that act as enhancers o

147 omplex, containing biallelic, maternally and paternally expressed transcripts that share exons.

148 Here, we identify a novel paternally expressed variant of the Inpp5f gene (Inpp5f_

149 alleles in normal tissues, where the IGF2 is paternally expressed, as well as in normal liver where g

150 MKRN3 is a paternally expressed, imprinted gene located in the Prad

151 i syndrome (PWS) is caused by the absence of paternally expressed, maternally silenced genes at 15q11

152 ron 10 of Kcnq1, contains the promoter for a paternally expressed, noncoding, antisense transcript, K

153 ing antisense transcript, Kcnq1ot1, which is paternally expressed.

154 ns and a common promoter, and both genes are paternally expressed.

155 PEG3 gene, including a novel transcript, are paternally expressed.

156 15 ancient imprinted genes, of which 10 were paternally expressed.

157 o the mouse, the human IGF2-P0 transcript is paternally expressed; however, its expression is not lim

158 Surprisingly, paternally-expressed genes of the non-classical gene imp

159 strate that the gene encoding ASM (SMPD1) is paternally imprinted and that differential expression of

160 genes with trackable SNP variants) exhibited paternally imprinted expression, with nearly 100% of tra

161 aled that loss of neuronal expression of the paternally imprinted gene Ube3a in Angelman syndrome res

162 H19, a paternally imprinted gene, is postulated to have regulat

163 ESX1 is paternally imprinted in mice, but is not imprinted in hu

164 chromatin modification and compaction of the paternally imprinted Kcnq1 cluster.

165 rmatogonia lacked imprinting specifically at paternally imprinted loci but fully restored imprinting

166 It is generally accepted that paternally imprinted X inactivation occurs exclusively i

167 We found Zfp36l3 to be paternally imprinted, with profound parent-of-origin eff

168 d produced a tan abdomen only when inherited paternally in otherwise-black mice.

169 ween a woman's maternally inherited (MI) and paternally inherited (PI) genes, over the trade-off betw

170 inherited 1p, whereas 16 had deletion of the paternally inherited 1p (P = 0.58).

171 A paternally inherited activating mutation (N72S) in the A

172 t abnormal acquisition of methylation on the paternally inherited allele at intron 2.

173 The Peg3 gene is expressed only from the paternally inherited allele located on proximal mouse ch

174 This paternally inherited allele was also significantly assoc

175 Nap1l5 is a retrogene expressed from the paternally inherited allele, is situated within an intro

176 gene that is exclusively expressed from the paternally inherited allele.

177 expressed either from the maternally or the paternally inherited allele.

178 gene expression to either the maternally or paternally inherited allele.

179 y on an asymmetry between the maternally and paternally inherited alleles at a locus that favours the

180 there is no asymmetry between maternally and paternally inherited alleles in this model, other means

181 late the growth of body weight by expressing paternally inherited alleles were identified.

182 erentially expressed from the maternally and paternally inherited alleles.

183 s to differential behavior of maternally and paternally inherited alleles.

184 ic differential expression of maternally and paternally inherited alleles.

185 Acceptance of the fetus, which expresses paternally inherited alloantigens, by the mother during

186 sms suppress the maternal immune response to paternally inherited alloantigens.

187 en caused by deletions of the same region of paternally inherited and maternally inherited human chro

188 on females carrying embryos with overlapping paternally inherited antigens.

189 d thus traits or behaviors that are strictly paternally inherited are unlikely to be under strong cul

190 sociations occur when their HLA-C2 ligand is paternally inherited by a fetus.

191 y on the Z sex chromosome, which is strictly paternally inherited by daughters.

192 requires centrosomes that are assembled from paternally inherited centrioles and maternally inherited

193 r data supports the idea that, in zebrafish, paternally inherited centrosomes are required for the fi

194 al chromosome 1 and on both the maternal and paternally inherited chromosome 4.

195 nes, Dlk1, Rtl1 and Dio3, expressed from the paternally inherited chromosome and several imprinted la

196 wn to be imprinted, being expressed from the paternally inherited chromosome homologue.

197 er of imprinted genes, is expressed from the paternally inherited chromosome.

198 All six de novo deletions originated on the paternally inherited chromosome.

199 and DHS2 within intron 1, exclusively on the paternally inherited chromosome.

200 lk1 to be expressed from both maternally and paternally inherited chromosomes.

201 ocally imprinted genes on the maternally and paternally inherited chromosomes.

202 ater for maternally inherited mtDNA than for paternally inherited cpDNA, though this difference was n

203 ches has been established for aneuploidy and paternally inherited dominant traits.

204 Paternally inherited Dp/+ (patDp/+) mice showed expected

205 showed strong evidence for the effect of the paternally inherited G allele of rs10009104 on AAR (P =

206 s expressed in mothers and by maternally and paternally inherited genes expressed in offspring.

207 pring extends to an offspring's genes, where paternally inherited genes favor demanding more from the

208 According to this "coadaptation theory," paternally inherited genes might be inactivated because

209 Our data indicate that paternally inherited HLA-associated odors influence odor

210 Understanding properties of maternally and paternally inherited imprints provides insight into the

211 Paternally inherited inactivating GNAS1 mutations cause

212 strated that Ashkenazi Levites, members of a paternally inherited Jewish priestly caste, display a di

213 sequence of somatic uniparental disomy for a paternally inherited K(ATP) channel mutation with enlarg

214 f a pathogenetic role for loss of the active paternally inherited locus.

215 eas males are heteroplasmic for this and the paternally inherited M mitotype.

216 interact synergistically with products from paternally inherited M' P elements.

217 igen-specific maternal T and B cells through paternally inherited major histocompatibility complex an

218 both parents but preferentially transmit the paternally inherited mtDNA to their sons.

219 hermore, an insulator was established on the paternally inherited mutated allele in vivo, reducing Ig

220 The paternally inherited mutation was present at 90% in lymp

221 s the maternal chromosome to behave like the paternally inherited one.

222 y relevant and deleterious alleles that were paternally inherited or had arisen as de novo germline m

223 Such significant disequilibria involving the paternally inherited organelle indicate that not only ar

224 Paternally inherited P element transposons thus escape s

225 he maternally inherited mtDNA genome and the paternally inherited portion of the nonrecombining Y chr

226 ave obtained robust evidence at rs941576 for paternally inherited risk of type 1 diabetes (T1D; ratio

227 Paternally inherited Sgce heterozygous knock-out (KO) mi

228 es, motor deficits or myoclonus, we produced paternally inherited striatum-specific Sgce conditional

229 y, we find that the Drosophila acrosome is a paternally inherited structure.

230 crosses are characterized by derepression of paternally inherited TE families that are rare or absent

231 metimes suffer from germline derepression of paternally inherited TE families, caused by a failure of

232 despread derepression of both maternally and paternally inherited TE families.

233 n control mice approximately half the litter paternally inherited the disrupted H19(Delta13), so the

234 e rejected only in mating combinations where paternally inherited tissue antigens elicited potent mat

235 embryogenesis, imprinted XCI inactivates the paternally inherited X chromosome (Xp) within the extra-

236 which undergo imprinted inactivation of the paternally inherited X chromosome.

237 ation resulting in silencing of genes on the paternally inherited X-chromosome.

238 Results from mice carrying a paternally inherited X-linked green fluorescent protein

239 In sharp contrast to this, the paternally inherited Y chromosome shows diversity simila

240 model has not been examined using data from paternally inherited Y chromosomes.

241 In contrast, for paternally inherited Y-chromosome variation each caste i

242 e are present in heterozygotes that harbor a paternally inherited, but not in those with a maternally

243 dependent on whether they are maternally or paternally inherited, is restricted to mammals and angio

244 e manifests itself only if the transposon is paternally inherited, suggesting maternal transmission o

245 ities about which alleles are maternally vs. paternally inherited.

246 t, occurring only when the Gct4(J) allele is paternally inherited.

247 re identified, exhibiting large effects when paternally inherited.

248 c.1433G>A, predicting p.Arg478His, that was paternally inherited.

249 ratio may reflect an epigenetic influence on paternally-inherited DNA.

250 ion of FREM1's full-length transcripts and a paternally-inherited splice site mutation that causes ac

251 Pups inheriting this mutation paternally lack detectable expression of all PWS genes a

252 In the imprinted form, Xist is paternally marked to be expressed in female embryos.

253 uch less known about egg-laying organisms or paternally-mediated effects.

254 and a 10% stronger allele-specific bias than paternally methylated DMRs that reside in intergenic reg

255 A paternally methylated imprinting control region (ICR) di

256 aternally expressed H19 locus, including the paternally methylated imprinting control region (ICR).

257 promoter (from upstream to downstream): the paternally methylated NESP55 promoter region, the matern

258 Both paternally (n = 205 males) and biparentally (n = 2,123 X

259 genes known to be biallelically expressed or paternally or maternally expressed were consistent with

260 the mice that inherited the KO allele either paternally or maternally.

261 Mammalian androgenones have two paternally or sperm-derived genomes.

262 Paternally preferred H3K4me3 and H3K36me3 peaks mostly c

263 pam-1 gene is expressed both maternally and paternally, providing additional evidence that sperm-don

264 ripts from the silent alleles of a subset of paternally repressed genes were present in Eed(-/-) embr

265 se distal chromosome 7 is flanked by several paternally repressed genes, with the more distant ones i

266 ally DNA methylated regions) controlling two paternally repressed imprinted genes, H19 and Gtl2, can

267 mainly biallelically expressed but is weakly paternally repressed in specific tissues.

268 paternally expressed imprinted loci, but not paternally repressed loci.

269 nd contains several imprinted genes that are paternally repressed.

270 to the expression of genes that are normally paternally repressed.

271 Pups inheriting this mutation paternally showed a complete loss of paternal gene expre

272 1 noncoding RNA and derepression of flanking paternally silenced genes.

273 To identify factors responsible for the paternally specific DNA methylation of the ICR, germ lin

274 al embryos with only maternally (oocyte-) or paternally (sperm-)derived genomes fail early in develop

275 When inherited paternally, there is no phenotype, suggesting that the L

276 equilibrium test) and both maternally versus paternally transmitted (parent-of-origin) and nontransmi

277 he hybrid being regulated exclusively by the paternally transmitted allele.

278 from that seen for premutation-size alleles: paternally transmitted alleles are far more stable than

279 s more marked when the premutation allele is paternally transmitted and expansions occur more frequen

280 zing sperm and that the risk of embryos with paternally transmitted chromosomal aberrations depends o

281 % of CHD trios; 10 out of 11 occurred on the paternally transmitted chromosome (p = 0.01).

282 Polymorphic variation in paternally transmitted fetal IGF2 is associated with inc

283 Using the minimum P value test, paternally transmitted fetal IGF2 polymorphisms were ass

284 ternal glucose concentrations; specifically, paternally transmitted fetal rs6578987 (P = 0.006), rs68

285 or 1A (MTNR1A) gene mediates the effect of a paternally transmitted genetic variant on the comorbidit

286 In contrast, paternally transmitted hIC1 leads to growth restriction,

287 ase chain reaction panel targeting unshared, paternally transmitted HLA sequences, a Y chromosome-spe

288 ally transmitted in 27 (49.1%) pedigrees and paternally transmitted in 28 (50.9%) pedigrees (P = non-

289 The effects of paternally transmitted T-alleles were greater than those

290 Paternally transmitted telomeric P elements reacquire re

291 The paternally transmitted variant predicted a premature sto

292 By contrast, when the mutation is paternally transmitted, a growth retardation (Sml) is se

293 Infantile SCA7, which is often paternally transmitted, can rarely arise by maternal tra

294 Although paternally transmitted, PSR evades self-elimination in o

295 anded ATTCT repeats are highly unstable when paternally transmitted, whereas maternal transmission re

296 a mitochondrial genome will be maternally or paternally transmitted.

297 ther, whereas in mammals the Y chromosome is paternally transmitted.

298 han those of maternally transmitted alleles (paternally transmitted: -250 g, P = 0.05; maternally tra

299 eased expansion rates of maternally, but not paternally, transmitted alleles.

300 results in preferential gene expression from paternally versus maternally inherited chromosomes.