ライフサイエンスコーパス: paternally-expressed

1 he Dlk1 gene as a new imprinted gene that is paternally expressed.

2 IGF2, a fetal-specific growth factor that is paternally expressed.

3 e evidence suggesting that this locus may be paternally expressed.

4 signed to 7q32 and shown to be imprinted and paternally expressed.

5 15 ancient imprinted genes, of which 10 were paternally expressed.

6 ing antisense transcript, Kcnq1ot1, which is paternally expressed.

7 ns and a common promoter, and both genes are paternally expressed.

8 PEG3 gene, including a novel transcript, are paternally expressed.

9 e sequencing of cDNA libraries to identify 9 paternally expressed and 34 maternally expressed imprint

10 ur results demonstrate that Pref-1 is indeed paternally expressed and is important for normal develop

11 insulin-like growth factor II (IGF2) gene is paternally expressed and is surrounded by maternally exp

12 ently suggest that the gene is imprinted, is paternally expressed and maps to 6q22-q23.

13 The other exon, 14 kb further 3', is paternally expressed, and encodes XL(alpha)s (extra larg

14 ow that the region contains a promoter for a paternally expressed anti-sense transcript, Kcnq1ot1, an

15 he murine Ube3a locus includes an imprinted, paternally expressed antisense transcript.

16 alleles in normal tissues, where the IGF2 is paternally expressed, as well as in normal liver where g

17 expressed X-linked PO locus and an imprinted paternally expressed autosomal BW locus.

18 The five genes include all paternally expressed autosomal imprinted genes previousl

19 This L1 signature overlaps the paternally expressed domain of the locus, excluding the

20 PN maps to human chromosome 15q11-q13 and is paternally expressed, each cistron is a candidate for a

21 oduction; extralarge G(s)alpha (XLalphas), a paternally expressed G(s)alpha isoform; and neuroendocri

22 olute carrier family 38 member 4), and Peg1 (paternally expressed gene 1)--both MBD1 and H3K9me3 bind

23 actor receptor-bound protein 10), Peg1/Mest (paternally expressed gene 1/mesoderm-specific transcript

24 -/- cells showed aberrant methylation of the paternally expressed gene 3 (Peg3) tumor suppressor gene

25 Notably, allelic imbalance in paternally expressed gene 3 (PEG3) was associated with i

26 tment of breast carcinoma xenografts induces paternally expressed gene 3 (Peg3), an imprinted gene en

27 We found that decorin induced paternally expressed gene 3 (Peg3), an imprinted tumor s

28 hin 3 maternally methylated imprinted genes: paternally expressed gene 3 (PEG3), insulin-like growth

29 receptor 2 (VEGFR2) signaling that requires paternally expressed gene 3 (PEG3).

30 ICR (Imprinting Control Region) of the Peg3 (Paternally Expressed Gene 3) domain contains an unusual

31 ation status of the CpG islands of the PEG3 (Paternally expressed gene 3) imprinted domain in the mou

32 Peg3 (paternally expressed gene 3) is an imprinted gene locali

33 Peg3 (paternally expressed gene 3) is the first imprinted gene

34 (H19 fetal liver mRNA), p57(Kip2), Peg3/Pw1 (paternally expressed gene 3), and Zac1 (zinc finger-bind

35 d domain), located 25 kb downstream of PEG3 (paternally expressed gene 3).

36 ithin 30 kb of a known imprinted gene, Peg3 (paternally expressed gene 3).

37 IPW, a paternally expressed gene cloned from this region, is no

38 e previously identified Peg1/Mest as a novel paternally expressed gene in the developing mouse embryo

39 The paternally expressed gene insulin-like growth-factor 2 (

40 determined that Pw1 is identical to Peg3, a paternally expressed gene of unknown function (and will

41 osome 6q, believed to contain an exclusively paternally expressed gene or genes that cause transient

42 d the expression and methylation status of a paternally expressed gene Peg3, in germ cells from sex-r

43 LK1 (delta, Drosophila, homolog-like 1) is a paternally expressed gene that encodes for a transmembra

44 mprinting disorder caused by a deficiency of paternally expressed gene(s) in the 15q11-q13 chromosoma

45 stigate the role of the maternally imprinted/paternally expressed gene, Peg3, in several aspects of b

46 wn (CypA-KD) P19 cells, we observed a silent paternally expressed gene, Peg3.

47 The product of the imprinted gene paternally expressed gene-10 (PEG10) has been reported t

48 ene, rather than from absent expression of a paternally expressed gene.

49 ernally expressed genes (Igf2r, H19) and two paternally expressed genes (Igf2, U2af1-rs1) in ES cells

50 ressed genes (MEGs) and approximately 29% of paternally expressed genes (PEGs) in C. rubella were com

51 the mechanism by which PWS-IC activates the paternally expressed genes (PEGs) using transgenes that

52 ic crosses, whereas approximately 90% of 272 paternally expressed genes (PEGs) were found only in one

53 162 maternally expressed genes (MEGs) and 95 paternally expressed genes (PEGs), which were associated

54 and H3K36me3 peaks mostly co-localized with paternally expressed genes (PEGs), while endosperm-speci

55 54 maternally expressed genes (MEGs) and 46 paternally expressed genes (PEGs).

56 ssed genes, activated expression of silenced paternally expressed genes and resulted in methylation o

57 er-Willi syndrome (PWS) is caused by loss of paternally expressed genes at an imprinted locus on chro

58 oter regions and transcriptional termini and paternally expressed genes at promoters and gene bodies,

59 sults from loss of function of 10 clustered, paternally expressed genes in a 1.5-Mb region of chromos

60 -Willi syndrome (PWS) is caused by a loss of paternally expressed genes in an imprinted region of chr

61 y the inactivation or deletion of imprinted, paternally expressed genes in chromosome band 15q11.2.

62 nomic alterations that inactivate imprinted, paternally expressed genes in human chromosome region 15

63 the two parental alleles of SNRPN and other paternally expressed genes in the region by using a chro

64 Transcription of paternally expressed genes in the region depends upon an

65 portant for regulation of SNRPN and of other paternally expressed genes in the region.

66 The paternally expressed genes NDN, IPW, PWCR1 and MAGEL2 we

67 PWS is caused by the loss of one or more paternally expressed genes on chromosome 15q11-q13, whic

68 located adjacent to a cluster of imprinted, paternally expressed genes that are known to be positive

69 The largest proportion of paternally expressed genes was at 7 DAP, mainly due to t

70 Mash2, Kvlqt1, and p57(Kip2), as well as two paternally expressed genes, Igf2 and Ins2, and assess th

71 e required for the genomic imprinting of two paternally expressed genes, Ins-2 (encodes insulin-2) an

72 mplete abolition of the transcription of two paternally expressed genes, Peg3 and Usp29, causing the

73 ched for coexpressed pairs of maternally and paternally expressed genes, showed accelerated expressio

74 PWS involves loss of function of multiple paternally expressed genes, while mutations in a single

75 idespread relaxation of imprinting of mostly paternally expressed genes.

76 r-Willi syndrome results from the absence of paternally expressed genes.

77 y expressed genes and repression of silenced paternally expressed genes.

78 for bidirectional activation of a number of paternally expressed genes.

79 cal crosses, resembling either maternally or paternally expressed genes.

80 Surprisingly, paternally-expressed genes of the non-classical gene imp

81 nts in which the expression of all the known paternally expressed Gnasxl proteins (XLalphas, XLN1 and

82 ression is still unclear, as is the role for paternally expressed Grb10 in neurons.

83 In contrast, the paternally expressed growth factor Igf2 is essential for

84 Igf2 is a paternally expressed growth promoter, and H19 is a mater

85 o the mouse, the human IGF2-P0 transcript is paternally expressed; however, its expression is not lim

86 The paternally expressed Igf2 encodes a potent fetal growth

87 played a paternal-specific enrichment at the paternally expressed Igf2 locus, H3K79me3 was paternally

88 ation and has been recently reported to be a paternally expressed imprinted gene at human chromosome

89 ternally methylated region associated with a paternally expressed imprinted gene, Ras protein-specifi

90 ically examine the functional requirement of paternally expressed imprinted genes (PEGs) during seed

91 nces in methylation features associated with paternally expressed imprinted genes (PEGs).

92 -regulated expression of both maternally and paternally expressed imprinted genes and microRNAs, incl

93 Our results reveal that paternally expressed imprinted genes, in the absence of

94 CI in the trophectoderm, rather than loss of paternally expressed imprinted genes, is the primary cau

95 oglycan gene (Sgce) and Zac1 (Lot1) are both paternally expressed imprinted genes.

96 ess contain different doses of maternally or paternally expressed imprinted loci affecting endosperm

97 rs, certain noncoding RNAs, and generally to paternally expressed imprinted loci, but not paternally

98 associated with overexpression of genes at a paternally expressed imprinted locus on chromosome 6q24.

99 The paternally expressed imprinted retrotransposon-like 1 (R

100 is normally caused by deficiency of several paternally expressed imprinted transcripts within chromo

101 PWS) is caused by deficiency for one or more paternally expressed imprinted transcripts within chromo

102 MKRN3 is a paternally expressed, imprinted gene located in the Prad

103 in mice, we find the human GRB10 gene to be paternally expressed in brain.

104 Here, we show that Kcnq1ot1 is paternally expressed in preimplantation embryos from the

105 Interestingly, these genes are paternally expressed in preimplantation embryos, and ect

106 insulin-like growth factor II gene (Igf2) is paternally expressed in the fetus and placenta.

107 In mice, Ins2 is imprinted and paternally expressed in the yolk sac.

108 The paternally expressed long noncoding RNA (ncRNA) Kcnq1ot1

109 Transcripts from the imprinted, paternally expressed Magel2 gene, which maps to the chro

110 i syndrome (PWS) is caused by the absence of paternally expressed, maternally silenced genes at 15q11

111 The 5'-ends of two paternally expressed mouse genes, Peg3 and Usp29, are jo

112 transcript is the candidate for Oed and the paternally expressed mutant Gnasxl transcript is the can

113 y juxtaposed maternally expressed (Nesp) and paternally expressed (Nespas, Gnasxl, Exon 1A) transcrip

114 ron 10 of Kcnq1, contains the promoter for a paternally expressed, noncoding, antisense transcript, K

115 on the frequency of the favored allele: the paternally expressed pattern permits faster genetic chan

116 s faster genetic change than the reciprocal, paternally expressed pattern.

117 now been shown to target degradation of the paternally expressed Peg11 mRNA by an RNAi-mediated mech

118 The paternally expressed Peg3 gene in mice encodes an unusua

119 The opposing effects of maternally and paternally expressed products of the Gnas locus provide

120 some, is necessary for the repression of the paternally expressed protein-coding genes and for activa

121 ified on distal chromosome 12 contains three paternally expressed protein-coding genes and multiple n

122 The 1-Mb cluster contains the paternally expressed protein-coding genes Dlk1 and Dio3

123 maternally expressed noncoding RNA genes and paternally expressed protein-coding genes.

124 rnally expressed non-coding RNAs and several paternally expressed protein-coding genes.

125 Relative contribution of paternally expressed proteins XLalphas, XLN1, and ALEX o

126 R loops and chromatin decondensation at the paternally expressed PWS Snord116 locus.

127 ducts NESP55 and XLalphas are maternally and paternally expressed, respectively.

128 hromosome 7 recently identified Inpp5f_v2, a paternally expressed retrogene lying within an intron of

129 dystonic symptoms and caused by mutations in paternally expressed SGCE, which codes for epsilon-sarco

130 r RNAs (snoRNAs) encoded within the complex, paternally expressed SNRPN (small nuclear ribonuclear pr

131 The data suggest the presence of a paternally expressed structural gene between Snrpn and I

132 Maternally and paternally expressed subgroups of imprinted genes were f

133 We disrupted a paternally expressed transcript at the Gnas locus, Gnasx

134 demonstrated that each is associated with a paternally expressed transcript.

135 cation in mouse of four brain-specific novel paternally expressed transcripts and an additional three

136 unlike its positive effect on all the other paternally expressed transcripts in the region, the PWS-

137 anonymous transcript, PAR-5, are two of the paternally expressed transcripts mapped to the Prader-Wi

138 associated with Igf2 and Igf2r both contain paternally expressed transcripts that act as enhancers o

139 omplex, containing biallelic, maternally and paternally expressed transcripts that share exons.

140 Here, we identify a novel paternally expressed variant of the Inpp5f gene (Inpp5f_