ライフサイエンスコーパス: pathfinding

1 tracellular matrix collagen XV in motor axon pathfinding.

2 Robo class proteins and participates in axon pathfinding.

3 f its function disrupts axonal extension and pathfinding.

4 wn effect on neuron survival, regulates axon pathfinding.

5 ation, transducing signals required for axon pathfinding.

6 lar retention resulting in aberrant neuronal pathfinding.

7 nd in parallel to ced-10/Rac, to control DTC pathfinding.

8 such as LTP, LTD, spine motility, and axonal pathfinding.

9 in wiring events that follow successful axon pathfinding.

10 ns rely on guidance molecules to direct axon pathfinding.

11 direct olfactory sensory neuron (OSN) axonal pathfinding.

12 ncies may differentially modulate motoneuron pathfinding.

13 s defects in commissural axon projection and pathfinding.

14 ty of Slit function during intraretinal axon pathfinding.

15 guidance cues provide the basis for neuronal pathfinding.

16 n, promoting its outgrowth, and guiding axon pathfinding.

17 active oxygen species that also affects axon pathfinding.

18 ements that steer directional changes during pathfinding.

19 developmental function in ocular motor axon pathfinding.

20 ncreased VAB-1 levels elicited aberrant axon pathfinding.

21 norhabditis elegans L1CAM, functions in axon pathfinding.

22 al axons and proper anterior-posterior (A-P) pathfinding.

23 t this antagonism is important during axonal pathfinding.

24 generally Mmp2 plays the predominant role in pathfinding.

25 oning of the cell bodies and peripheral axon pathfinding.

26 g CNS and is required for motor and CNS axon pathfinding.

27 including germ cell development and neuronal pathfinding.

28 e growth cone (GC) during axon outgrowth and pathfinding.

29 on in all of these processes except neuronal pathfinding.

30 branching morphogenesis, as well as neuronal pathfinding.

31 w players utilized by the growth cone during pathfinding.

32 ion in synapse formation rather than in axon pathfinding.

33 in the lateral CNS and also, later, in axon pathfinding.

34 her to specify cell fate or to direct axonal pathfinding.

35 ons, possibly in the growth cone during axon pathfinding.

36 in parallel to Rac/MIG-15 signaling in axon pathfinding.

37 oliferation, neuronal positioning and axonal pathfinding.

38 re locally translated and have roles in axon pathfinding.

39 and may play a role in axonal elongation or pathfinding.

40 ny molecules underlying axonal outgrowth and pathfinding.

41 utgrowth as well as axonal fasciculation and pathfinding.

42 europilin-2 is required for precrossing axon pathfinding.

43 rin ligands regulate cell migration and axon pathfinding.

44 nvolved in cardiac valve maturation and axon pathfinding.

45 evidence that they are essential for axonal pathfinding.

46 that retinal axons encounter during in vivo pathfinding.

47 ghting the important role pseudopods play in pathfinding.

48 vo, but, unexpectedly, does not disrupt axon pathfinding.

49 iple guidance cues is integrated during axon pathfinding.

50 collaboratively regulate SAX-3-mediated axon pathfinding.

51 spinal cord commissural axon projection and pathfinding.

52 nd that NMD acts locally to influence axonal pathfinding.

53 influencing neuronal growth, inhibition, and pathfinding.

54 ance molecule receptor in regulation of axon pathfinding.

55 r axons and play important roles during axon pathfinding.

56 her to regulate synapse development and axon pathfinding.

57 activity of pioneer axons and regulate axon pathfinding.

58 ical signals as important regulators of axon pathfinding.

59 ance information to orchestrate ocular motor pathfinding.

60 utaneous pathways, conversely, would enhance pathfinding abilities.

61 e Bax and type III Nrg1 double mutants, axon pathfinding abnormalities were seen for TrkA(+) neurons

62 ing at their targets, developing axons cease pathfinding and begin instead to arborize and form synap

63 tes Fmrf expression by controlling both axon pathfinding and BMP signaling, but cannot trigger Fmrf e

64 verse developmental processes such as axonal pathfinding and cell adhesion.

65 Many genes that affect axon pathfinding and cell migration have been identified.

66 ED-10 Rac, RAC-2 Rac, and UNC-34 Ena in axon pathfinding and cell migration, also acts with MIG-15 in

67 have all been implicated in regulating axon pathfinding and cell migration.

68 t that APP overexpression may perturb axonal pathfinding and circuit formation in developing DS brain

69 t prenatally displayed major defects in axon pathfinding and cortical interneuron migration.

70 llular cues thereby ensuring correct neurite pathfinding and development of the nervous system.

71 In addition, we find that axonal pathfinding and fasciculation are abnormal in corticospi

72 is required during DTC migration for proper pathfinding and for cessation of DTC migration at the en

73 fate proteoglycans (HSPGs and CSPGs) in axon pathfinding and have linked HSPGs to specific signaling

74 sential role for lactosamine in sensory axon pathfinding and in the formation of OB synaptic connecti

75 (ckn) is necessary for embryonic motor axon pathfinding and interacts genetically and physically wit

76 n of molecular mechanisms that underlie axon pathfinding and map formation.

77 cogenic transformation and perhaps even axon pathfinding and memory consolidation.

78 Thus, extensive pathfinding and morphological rearrangement of central a

79 Moreover, by linking axon pathfinding and neural progenitor behaviors, our results

80 and novel role for collagen XV in motor axon pathfinding and neuromuscular development.

81 We found that hypoxia caused specific axon pathfinding and neuronal migration defects in C. elegans

82 ted guidance factors are known to guide axon pathfinding and neuronal migration.

83 uding C&E, cochlear cell orientation, axonal pathfinding and neuronal migration.

84 at regulate axon branching, commissural axon pathfinding and neuronal migration.

85 factors released from myelin may impair axon pathfinding and neuroregeneration after injury.

86 ng the dorso-ventral axis but also in axonal pathfinding and organisation of the axonal scaffold.

87 orrelates with early defects in neural crest pathfinding and peripheral ganglion formation.

88 edgehog (Hh) signaling for intraretinal axon pathfinding and show that Shh acts to pattern the optic

89 plays an important role in neurite extension/pathfinding and survival providing a causal link between

90 control neuronal fate determination, axonal pathfinding and synaptic communication and plasticity.

91 culate from other axons is critical for axon pathfinding and target innervation.

92 Axon pathfinding and target recognition are highly dynamic an

93 elles of developing neurons that enable axon pathfinding and target recognition for precise wiring of

94 Glia signal to neurons to direct pathfinding and targeting of axons, as well as to stabil

95 lating larval and adult locomotion, and axon pathfinding and targeting of embryonic motoneurons.

96 ap neurons can be subdivided based upon axon pathfinding and their expression of neuropeptidergic mar

97 that ANG plays an important role in neurite pathfinding and this has implications for ALS.

98 ronal migration, neurite outgrowth, neuronal pathfinding, and axonal fasciculation.

99 neurite outgrowth and differentiation, axon pathfinding, and dendritic spine formation and maintenan

100 trophic support to neurons, modulating axon pathfinding, and driving nerve fasciculation.

101 Rs, with subsequent effects on axon sorting, pathfinding, and extension, and glomerulus development.

102 c shRNA impedes axon initiation, elongation, pathfinding, and fasciculation.

103 motor neuron specification, axon growth and pathfinding, and mRNA expression, are unaffected in Munc

104 vertebrate tissue boundary formation, axonal pathfinding, and stem cell regeneration by steering cell

105 ranched dynamically and profusely throughout pathfinding, and successive branches oriented growth con

106 ee redundant pathways that each control axon pathfinding, and that the NIK kinase MIG-15 acts in each

107 r, the RNA-binding proteins involved in axon pathfinding, and their corresponding mRNA targets, are s

108 e, lamination, thalamus, and thalamocortical pathfinding are normal in homozygous nestin-Emx2 mice.

109 ed by these transcription factors to control pathfinding are poorly defined.

110 aling pathways employed in axonal growth and pathfinding are similar to those in mammals.

111 s of these results, we investigated neuronal pathfinding at P5.

112 l substrate Enabled (Ena), all regulate axon pathfinding at the Drosophila embryonic CNS midline.

113 optic nerve astrocytes, and anomalous axonal pathfinding at the optic chiasm.

114 Hypoxia exerted its effect on axon pathfinding, at least in part, through HIF-1-dependent r

115 Pathfinding axons change responses to guidance cues at i

116 Wnt3 expression in the cingulate callosal pathfinding axons is developmentally regulated by anothe

117 st to show that ADCY8 is required for axonal pathfinding before axons reach their targets.

118 re-crossing CI growth cones exhibit distinct pathfinding behaviors compared to post-crossing axons an

119 ons are not precisely ordered during initial pathfinding but become corrected later, with missorted a

120 wn here not to affect these molecules or D-V pathfinding but to strongly perturb the anteroposterior

121 abundantly in most fiber tracts during axon pathfinding but were downregulated beginning in synaptog

122 hogenic proteins (BMPs) are involved in axon pathfinding, but how they guide growth cones remains elu

123 stream of Rac in Caenorhabditis elegans axon pathfinding, but the cellular role of UNC-115 in this pr

124 owing axon, and indeed, many proteins direct pathfinding by both structures.

125 yonic day 11.5, and that Fz3 is required for pathfinding by dopaminergic and serotonergic axons in th

126 e ribonucleolytic activity of hANG, affected pathfinding by P19-derived neurons but not neuronal diff

127 e receptor-like roles in the control of axon pathfinding by repulsion, although it is largely unknown

128 al developmental processes, such as neuronal pathfinding, cell adhesion and synaptogenesis.

129 es previously shown to be necessary for this pathfinding choice.

130 olution the detailed behaviors of individual pathfinding CI growth cones on the ipsilateral and contr

131 suggesting that their identity and neuronal pathfinding cues are both intact.

132 ein complexes that receive and transmit axon pathfinding cues during development are essential to cir

133 correctly executed the binary dorsal-ventral pathfinding decision but failed to make the subsequent p

134 ely execute their first major dorsal-ventral pathfinding decision.

135 d for the correct execution of an early axon pathfinding decision.

136 ctivity differentially affects the two major pathfinding decisions made by chick lumbosacral motoneur

137 cords differentially perturbed the two main pathfinding decisions made by motoneurons, dorsal-ventra

138 execution of several stereotyped motor axon pathfinding decisions.

139 ment of neural projections but not for early pathfinding decisions.

140 ilopodial PY levels may underlie growth cone pathfinding decisions.

141 uency differentially disrupt these two major pathfinding decisions.

142 racellular signaling cascades to direct axon pathfinding decisions.

143 rs, has been implicated in mediating midline pathfinding decisions; however, the complexity of these

144 very low, and this was correlated with axon pathfinding defects and cell death.

145 epithelium results in unexpectedly localized pathfinding defects at the caudal turn in the mid-optic

146 te appropriately, the HSNs also display axon pathfinding defects in ham-3 mutants.

147 Axon pathfinding defects included dysgenesis of the corpus ca

148 ted ablation of Ext1 causes commissural axon pathfinding defects that share similarities with those o

149 Corresponding axonal pathfinding defects were specific to NOVA2 deficiency: N

150 ic ablation of adaxial cells causes profound pathfinding defects, suggesting the existence of adaxial

151 iation as well a neuronal migration and axon pathfinding defects.

152 les for PlexB in central and peripheral axon pathfinding, define a functional ligand for PlexB, and i

153 Axon pathfinding depends on attractive and repulsive turning

154 Accurate retinotectal axon pathfinding depends upon the correct establishment of do

155 rphogen gradients also serve to guide axonal pathfinding during development of the nervous system.

156 studying the mechanisms that underlie axonal pathfinding during development, little is known about th

157 s study was to determine changes in neuronal pathfinding during early postnatal brain development of

158 ng pathway in motoneurons necessary for axon pathfinding during embryogenesis.

159 eted molecules, play important roles in axon pathfinding during nervous system development.

160 use PlexB and PlexA, respectively, for axon pathfinding during neural development.

161 l for neuronal proliferation, migration, and pathfinding during the critical postnatal period of brai

162 Brn3b(KO) RGC axons show correct but delayed pathfinding during the early stages of embryonic develop

163 d reveal that it is required for normal axon pathfinding during vertebrate development.

164 t promotes axon outgrowth and regulates axon pathfinding, elevates cyclic AMP (cAMP) levels in growth

165 Apart from their role in axon pathfinding, emerging lines of evidence suggest that a w

166 cantly, the drugs used previously to produce pathfinding errors altered transient frequency but not d

167 tors, but since this occurred only after the pathfinding errors and alterations in guidance molecules

168 cause motoneurons to make dorsoventral (D-V) pathfinding errors and to alter the expression of molecu

169 l frequency allowed axons to correct the A-P pathfinding errors by altering their trajectories distal

170 s include mushroom body beta-lobe fusion and pathfinding errors by photoreceptor and subesophageal ne

171 These pathfinding errors can be corrected by the reexpression

172 r arising trkA(+) afferents make significant pathfinding errors in animals with reduced Shh function,

173 Loss and gain of col15a1b function provoke pathfinding errors in primary and secondary motoneuron a

174 d in motoneurons making dorsal-ventral (D-V) pathfinding errors in the limb and in the altered expres

175 the presence of picrotoxin prevented the D-V pathfinding errors in the limb and maintained the normal

176 SDF1 signaling in vivo rescues retinal axon pathfinding errors in zebrafish mutants that have a part

177 ic acid on NCAM, which may contribute to the pathfinding errors observed.

178 uption of viable ganglion formation leads to pathfinding errors of branchial motoneurons.

179 These pathfinding errors of spinal secondary motoneuron axons

180 ly and quantitatively identical intraretinal pathfinding errors to those reported previously in Slit

181 To distinguish whether the pathfinding errors were caused by perturbation of the no

182 addition, ventral motor neuron axons exhibit pathfinding errors within the VNC and along the dorsoven

183 ments resulted in aberrant axonal growth and pathfinding errors, suggesting that local tissue stiffne

184 ceptor expression and caused cell-autonomous pathfinding errors.

185 hypoplasia and a wide repertoire of RGC axon pathfinding errors.

186 nal cord, whereas those farther away display pathfinding errors.

187 enopus retinotectal system results in axonal pathfinding errors.

188 d a synergistic increase in the incidence of pathfinding errors.

189 axon guidance required for a subset of early pathfinding events in the developing Drosophila CNS.

190 ption factor Nerfin-1, required for CNS axon pathfinding events, is subject to post-transcriptional s

191 east and its receptors continue to provide a pathfinding experimental paradigm for investigating GPCR

192 on migration and thalamo-cortical axon (TCA) pathfinding follow similar trajectories and timing, sugg

193 No changes in corneal neurotrophin or nerve pathfinding gene expressions accompany corneal transitio

194 ds to determine molecular diffusion rates in pathfinding growth cones in vivo.

195 In the developing CNS, pathfinding growth cones use intermediate target- and pi

196 During axon pathfinding, growth cones commonly show changes in sensi

197 oordinated mechanism underlying the cellular pathfinding guided by signal gradients and the mechanist

198 ole of L1-CAMs in neurite extension and axon pathfinding has been extensively studied, much less is k

199 cification of motoneuron morphology and axon pathfinding has been studied extensively, implicating th

200 ile guidance cues contributing to motor axon pathfinding have been identified, the intracellular path

201 ated in guiding various steps of optic nerve pathfinding, however much less is known about transcript

202 plicated in retinal ganglion cell (RGC) axon pathfinding in a number of species.

203 for normal sensory neuron survival and axon pathfinding in both central and peripheral targets.

204 soderm, is required for embryonic motoneuron pathfinding in Drosophila.

205 for recessive alleles affecting motor neuron pathfinding in GFP reporter mice mutagenized with ENU.

206 ctive neuronal proliferation, migration, and pathfinding in response to Scn1b deletion may contribute

207 filopodial protrusions are non-essential for pathfinding in retinal axons.

208 ons, including neuronal migration and axonal pathfinding in the brain.

209 embrane receptors in regulating dorsolateral pathfinding in the chick trunk.

210 haperone BiP/GRP78 during axon outgrowth and pathfinding in the developing mammalian brain.

211 surface molecules essential for proper axon pathfinding in the developing nervous system, namely eph

212 developmental role of acetylcholine in axon pathfinding in the Drosophila visual system.

213 ication during development, including axonal pathfinding in the nervous system and cell-cell interact

214 ard the optic disc is the first step in axon pathfinding in the visual system.

215 ion of polarized Akt activity disrupted axon pathfinding in vitro and in vivo.

216 axon guidance in vitro and commissural axon pathfinding in vivo.

217 ctions are necessary for proper sensory axon pathfinding in vivo.

218 vitro, suggesting that FAK may control axon pathfinding in vivo.

219 fish primary motor neurons (PMN) during axon pathfinding in vivo.

220 aminin, and that it is likely to affect axon pathfinding in vivo.

221 ticularly well-characterized roles in axonal pathfinding, in the healing of damaged epithelia in Dros

222 l as mutants with specific defects in axonal pathfinding, including exit from the spinal cord and pat

223 gnaling through this isoform mediates axonal pathfinding, independent of the MuSK downstream componen

224 upport a model in which Shh acts in RGC axon pathfinding indirectly by regulating axon guidance cues

225 ial step of retinal ganglion cell (RGC) axon pathfinding involves directed growth of RGC axons toward

226 ish a previously unknown mechanism of axonal pathfinding involving vascular-derived endothelins, and

227 The current understanding of axon pathfinding is based mainly on chemical signaling.

228 Precise axon pathfinding is crucial for establishment of the initial

229 Strikingly, in hda-1(cw2) mutants, axon pathfinding is defective; specific axons often appear to

230 ion or by raphe neuron ablation, commissural pathfinding is disrupted.

231 Axon pathfinding is essential for the establishment of proper

232 Axon pathfinding is orchestrated by numerous guidance cues, i

233 diates neurite outgrowth, fasciculation, and pathfinding, is expressed on tumor vasculature.

234 as repellants in vertebrate embryonic axonal pathfinding may also inhibit regeneration.

235 sent the first demonstration of eye-specific pathfinding mediated by axon guidance cues and, taken wi

236 r cancer cells, and by inactivating the axon pathfinding molecule L1CAM, which metastatic cells expre

237 ults provide compelling evidence that during pathfinding, myotomal muscle cells communicate extensive

238 euronal development such as embryonic axonal pathfinding, neuroblast proliferation in the larval brai

239 uction of expression of Wnt3 by the callosal pathfinding neurons, which antagonize the inhibitory eff

240 ues, not only in nonneural cells but also in pathfinding neurons.

241 required for trunk neural crest migration or pathfinding, nor for the formation of dorsal root or sym

242 rin-B2 reverse signaling is required for the pathfinding of axons that form the posterior tract of th

243 ocyanine perchlorate) labeling to assess the pathfinding of commissural axons in the spinal cords of

244 us and its serotonergic projections regulate pathfinding of commissural axons in zebrafish.

245 gnaling protein previously implicated in the pathfinding of corticospinal axons in mice.

246 rgic projections from raphe neurons regulate pathfinding of crossing axons.

247 ellipsoid body (EB), where it influences the pathfinding of EB axons.

248 The pathfinding of motor axons is an important model system

249 acts (except for the corpus callosum) during pathfinding of pioneer axons.

250 Pathfinding of retinal ganglion cell (RGC) axons at the

251 Other developmental processes, such as pathfinding of RGCs at the optic chiasm and hippocampal

252 ls mouse SACMNs and can be used to trace the pathfinding of SACMN axons.

253 nt role in the specification, patterning and pathfinding of sensory neurons.

254 embryonic exposure to nicotine alters axonal pathfinding of spinal secondary motoneurons in zebrafish

255 optic nerve and retina, and abnormal axonal pathfinding of the ganglion cell axons at the optic chia

256 Focussing on the pathfinding of TrkA+ NGF-dependent axons, we demonstrate

257 ively little is known about commissural axon pathfinding on the contralateral side of the floor plate

258 he mechanisms that regulate commissural axon pathfinding on the contralateral side of the floor plate

259 sites in neurons, where it may regulate axon pathfinding or synapse remodeling through proteolysis of

260 affect neuronal identity specification, axon pathfinding, or EphA/ephrinA signaling during the develo

261 d membrane-bound proteins involved in neural pathfinding, organogenesis, and tumor progression, throu

262 during axonal development, including axonal pathfinding, orientation of axons in chemotactic gradien

263 icotine-induced changes in motoneuron axonal pathfinding persisted into adulthood.

264 In addition, Mmp2 overexpression pathfinding phenotypes depend on frac activity, indicati

265 ated protein, a crucial molecule involved in pathfinding, plasticity, and regeneration.

266 ests itself in axonal branching, turning and pathfinding, presynaptic differentiation, and growth con

267 o strongly perturb the anteroposterior (A-P) pathfinding process by which motoneurons fasciculate int

268 RGC laterality by repressing an ipsilateral pathfinding program unique to VTC RGCs and involving Zic

269 The fmi-1 mutants exhibit defective axon pathfinding, reduced synapse number, aberrant synapse si

270 his activity may play a major role in axonal pathfinding, refinement of topographic maps, dendritic m

271 Thus ray axon pathfinding relies on a variety of general and more ray

272 It is clear that axon pathfinding requires a growth cone to sample and integra

273 Successful axon pathfinding requires both correct patterning of tissues,

274 of many extracellular guidance cues on axon pathfinding requires Ca2+ influx at the growth cone, but

275 Axon pathfinding requires directional responses of growth con

276 Thus, efficacious pathfinding requires Phr1 activity for coordinating the

277 Proper axon pathfinding requires that growth cones execute appropria

278 We show that proper blood vessel pathfinding requires the endothelial receptor PlexinD1 a

279 rm prior to the sensory afferents, and their pathfinding show no dependence on sensory axons, as abla

280 rturbed dorsal-ventral but not pool-specific pathfinding, shows that modest changes in frequency diff

281 l streams join the segmental trajectories of pathfinding spinal motor axons, suggesting that interact

282 ntal processes, such as axonal outgrowth and pathfinding, synaptogenesis, and the maturation of ion c

283 lish Robo3 as a multifunctional regulator of pathfinding that simultaneously mediates NELL2 repulsion

284 membrane-bound proteins important for neural pathfinding, the class of proteins called Semaphorins ar

285 ules and receptors that regulate growth cone pathfinding, the signaling cascades underlying distinct

286 CNS is an indispensable phase of motor axon pathfinding, the underlying molecular mechanisms remain

287 Abl also regulates motor axon pathfinding through a non-overlapping set of functional

288 undamental cellular processes, from neuronal pathfinding to cell division.

289 olarization and migration to axon growth and pathfinding to dendrite growth and branching to synaptog

290 ging from neurotrophic modulation of neurite pathfinding to stimulation of cellular networks.

291 nce molecules for retinal ganglion cell axon pathfinding toward the optic nerve head and in midbrain

292 CaP motoneurons stalling along their ventral pathfinding trajectory.

293 Comparative profiling of "young" (pathfinding) versus "old" (target-arriving) Xenopus grow

294 layer structures were disrupted, and axonal pathfinding was impaired.

295 An in vivo correlate of altered TCA pathfinding was obtained by transient manipulation of 5-

296 to adopt serotonergic phenotype and correct pathfinding, whereas ADF are unaffected in unc-86-null m

297 Netrin-1 is critical for axonal pathfinding which shares similarities with formation of

298 n after injury depends on accuracy of axonal pathfinding, which is primarily believed to be influence

299 nes of cells to study their effects on nerve pathfinding within the peripheral nervous system.

300 cules and diffusible cues both regulate axon pathfinding, yet how these two modes of signaling intera