ライフサイエンスコーパス: pathobiology

1 ays an important role in viral bronchiolitis pathobiology.

2 aches are often limited by a complex disease pathobiology.

3 ropagation that is intimately linked to KSHV pathobiology.

4 toxic oligomer species contributing to brain pathobiology.

5 ingly, blood pressure, shedding light on ALS pathobiology.

6 cell-cell fusion, a hallmark of the disease pathobiology.

7 e basis of biomarkers, advanced imaging, and pathobiology.

8 and that inflammation may play a role in the pathobiology.

9 tabolite profile that would impinge on tumor pathobiology.

10 rrent understanding of REM sleep biology and pathobiology.

11 Cysteine proteases play important roles in pathobiology.

12 relationships relevant to early valve lesion pathobiology.

13 e association of IgG4 with APS, and possible pathobiology.

14 -CSC interactions in glioblastoma multiforme pathobiology.

15 ivated cellular signaling relevant to asthma pathobiology.

16 ominantly inherited provide insight into ALS pathobiology.

17 lead to medically actionable discoveries of pathobiology.

18 characterize a mouse model of papillomavirus pathobiology.

19 TBI) and predispose the brain to a PTSD-like pathobiology.

20 CM share mechanisms that contribute to their pathobiology.

21 zoan evolution, development, physiology, and pathobiology.

22 naling as it relates to liver physiology and pathobiology.

23 or-stromal interactions in pancreatic cancer pathobiology.

24 heterogeneous disorder, composed of varying pathobiology.

25 te studies of the role of NER in prokaryotic pathobiology.

26 ategy to reactivate BAI1 and suppress glioma pathobiology.

27 may be an important determinant of lymphoma pathobiology.

28 role of metabolic diversity in Campylobacter pathobiology.

29 s that can engender new insights into cancer pathobiology.

30 de a basis for a better understanding of HBV pathobiology.

31 it ignores all prior knowledge about disease pathobiology.

32 liary epithelium, and contributions to liver pathobiology.

33 overy, and an increased understanding of ALS pathobiology.

34 is involved in amyotrophic lateral sclerosis pathobiology.

35 a means for future studies addressing rabies pathobiology.

36 ntribute to many aspects of host biology and pathobiology.

37 de novel insights into NPM/ALK-positive ALCL pathobiology.

38 TH2 responses are implicated in asthma pathobiology.

39 culture system to investigate FT epithelial pathobiology.

40 opoietin signaling contributes to glomerular pathobiology.

41 a vital yet underdeveloped aspect of cancer pathobiology.

42 cidate previously unknown mechanisms of DIPG pathobiology.

43 wth factor 1 receptor (IGF1R) affects asthma pathobiology.

44 ine the association between FXIII and asthma pathobiology.

45 ation may play an important role in melanoma pathobiology.

46 sign of preventive strategies and inform CUA pathobiology.

47 play a central role in liver homeostasis and pathobiology.

48 ands, as well as new insights into glandular pathobiology.

49 and catabolism might be of importance in VKH pathobiology.

50 ich is suggestive of its diverse roles in PC pathobiology.

51 representing an early genetic lesion in CLL pathobiology.

52 aluate the function of pVir in Campylobacter pathobiology.

53 c disorders that may represent insights into pathobiology.

54 g to a poor mechanistic understanding of the pathobiology.

55 tant role for the miR-143/145 cluster in PAH pathobiology.

56 Because of the dissimilar pathobiology and clinical course between hemangioblastom

57 tions to examine pancreatic cell biology and pathobiology and could help screen for potential treatme

58 ystems biology description for understanding pathobiology and developing therapies, quantitative expe

59 usly impeded functional investigation of its pathobiology and development of effective targeted thera

60 ar mechanisms could be relevant to human ALS pathobiology and disease treatment.

61 tional structure, developmental biology, and pathobiology and explores the implications of key insigh

62 advance our molecular understanding of lung pathobiology and facilitate the development of new diagn

63 h the significance of SOX9 in gastric cancer pathobiology and heterogeneity, with implications for ta

64 rlap between FTD, AD and PD to assess shared pathobiology and identify novel genetic variants associa

65 eneity presents an opportunity to understand pathobiology and improve patient care.

66 ss their unmet potential in reflecting human pathobiology and in facilitating disease monitoring and

67 oundly altering our understanding of disease pathobiology and leading to the emergence of new biologi

68 contribute to a better understanding of COPD pathobiology and may open new therapeutic opportunities

69 enhances our understanding of RDS-associated pathobiology and our ability to design rational treatmen

70 ole of myocyte PDE5 regulation to myocardial pathobiology and PDE5 targeting therapy in vivo and reve

71 ar regulators could provide new insight into pathobiology and possible new therapeutic strategies for

72 been implicated in interstitial lung disease pathobiology and proposed as a diagnostic and prognostic

73 phenotypes help to understand the underlying pathobiology and provide clinicians with directions for

74 chanisms of AKI, focusing on epithelial cell pathobiology and related cell-cell interactions, using i

75 atory leukotrienes might be important in the pathobiology and severity of asthma.

76 s of N-glycosylation of the F protein on NDV pathobiology and suggest that the N-glycans in HR1 and H

77 yperdynamic contraction is essential for HCM pathobiology and that inhibitors of sarcomere contractio

78 should facilitate the study of human immune pathobiology and the development of targeted therapeutic

79 e revisitation of many open questions in PCA pathobiology and the exploration of new avenues for futu

80 stuzumab, but the impact of d16HER2 on tumor pathobiology and therapeutic response remains uncertain.

81 ive mechanism, carrying implications for the pathobiology and therapy of asthma.

82 l be a valuable tool in the study of ALS/FTD pathobiology and therapy.

83 eeded to examine the role of pSer-324 in tau pathobiology and to determine whether therapeutically mo

84 otential implications for understanding TNBC pathobiology and treatment.

85 manized mouse model for the studies of HIV-1 pathobiology and virus-specific immunity.

86 The authors review the pathophysiology, pathobiology, and emerging clinical perspectives on pulm

87 ications in molecular biology, cell biology, pathobiology, and high-throughput screens.

88 UC4 mucin expression is associated with TNBC pathobiology, and its knockdown reduced aggressiveness i

89 on in the understanding of the epidemiology, pathobiology, and mechanisms underlying infectious colit

90 ew light on our understanding of the disease pathobiology, and provide opportunities to design novel

91 ides new insights into the mechanisms of tau pathobiology, and we speculate that this scheme will pro

92 d molecular mechanisms implicated in disease pathobiology are good therapeutic targets.

93 hese effector-host interactions and roles in pathobiology are incompletely understood.

94 e interactions and their roles in ehrlichial pathobiology are not well defined.

95 e, but the molecular bases of their distinct pathobiology are still poorly understood.

96 ied in Ehrlichia species, but their roles in pathobiology are unknown.

97 ghlight some aspects of macrodomain roles in pathobiology as well as their emerging potential as ther

98 ssociated with congenital cataracts, but the pathobiology awaits elucidation.

99 -chronic and aggressive-lack an unequivocal, pathobiology-based foundation.

100 have emerged as a testing platform for HIV-1 pathobiology by reflecting natural human disease process

101 ted the impact of miR-122 depletion on liver pathobiology by treating liver-specific miR-122 knockout

102 rable advances have since been made into the pathobiology (changes in organ function, morphology, cel

103 Our understanding of asthma onset, pathobiology, classification, and management has evolved

104 task force (n = 19) with expertise in sepsis pathobiology, clinical trials, and epidemiology was conv

105 However, ZIKV's unique pathobiology demands an explanation of how its structure

106 hese studies extend our understanding of CLL pathobiology, demonstrating that reduced differentiation

107 stigations further elucidated the pancreatic pathobiology due to alcohol, onset of diabetes mellitus

108 nowledge are identified regarding how sickle pathobiology evokes pain, pathways specific to chronic a

109 Consequently, exploring PAX-related pathobiology generates insights into both normal develop

110 nding of human exocrine pancreas biology and pathobiology has been hampered by a lack of suitable pre

111 pediatric acute lymphoblastic leukemia (ALL) pathobiology has led to dramatic improvements in patient

112 al target genes which are implicated in VSMC pathobiology, highlighting new disease mechanisms.

113 opportunities) in existing knowledge of COPD pathobiology, how systems biology and network medicine c

114 ecular features of the underlying aggressive pathobiology in -7 AML patients.

115 a component of corticosteroid nonresponsive pathobiology in adults with SA that may differ in childr

116 that FRNK loss has been shown to modify the pathobiology in any animal disease model.

117 hanges in a peripheral cell model with brain pathobiology in autism.

118 t cancer, which suggests a new concept of ER pathobiology in breast cancer.

119 alterations in collagen V expression in the pathobiology in classic Ehlers-Danlos syndrome.

120 e information is needed about S. Enteritidis pathobiology in comparison to that of S. Typhimurium.

121 P. gingivalis pathobiology in Drosophila did not result from uncontrol

122 to greater understanding of mediators of the pathobiology in neuronal, cardiovascular, intestinal, re

123 discuss the emerging concepts of right heart pathobiology in PAH.

124 been shown to regulate normal functions and pathobiology in the digestive system.

125 g to acquire information on both anatomy and pathobiology in the same imaging session using either hy

126 designed small molecules that target the DM1 pathobiology in vitro in three distinct ways by acting s

127 functionally connect them to alpha-synuclein pathobiology in yeast, worms, and mouse.

128 the utility of murine models to study LukED pathobiology, including development and testing of strat

129 ational processing of proteins central to AD pathobiology, including tau, amyloid-beta (Abeta), and t

130 These disparate pathobiologies intersect and overlap, so it is probable

131 ese themes in pulmonary vascular biology and pathobiology involved: 1) pulmonary vascular development

132 seases, including Parkinson's disease, whose pathobiology is conserved from yeast to man.

133 a specific chromosome translocation, and its pathobiology is considered comparatively well understood

134 the contribution of complement activation to pathobiology is largely ancillary.

135 generation (AMD); however, its impact on AMD pathobiology is unresolved.

136 atenin pathway plays multiple roles in liver pathobiology, it is critical to identify gene targets th

137 le of B cell receptor (BcR) signaling in CLL pathobiology, it is notable that IkappaBepsilon loss was

138 eptides, does not require prior knowledge of pathobiology, it may be broadly useful for de novo disco

139 a pressing need to better understand how the pathobiology leads to severe disease in some patients ve

140 An important novel property of IL-27 in skin pathobiology may be to counter-regulate IL-18 activities

141 e the realm of adaptive immunity and impacts pathobiology more broadly than previously known.

142 Our understanding of the pathobiology, natural history, and treatment of these di

143 ovide fundamental insights into the distinct pathobiologies of these two viruses.

144 Cytokine-driven inflammation underlies the pathobiology of a wide array of infectious and immune-re

145 Advances in our understanding of the pathobiology of acute lymphoblastic leukaemia, fuelled b

146 these modifiers may provide insight into the pathobiology of AD and potential therapeutic measures.

147 nt implications for our understanding of the pathobiology of age-associated diseases and may guide ta

148 sregulated inflammation is implicated in the pathobiology of aging, yet platelet-leukocyte interactio

149 ALL-MSC communication gives insight into the pathobiology of ALL and opens new avenues to develop mor

150 ls and their receptors may contribute to the pathobiology of Alzheimer disease.

151 sms involved in progenitor expansion and the pathobiology of AML.

152 This article reviews the biology and pathobiology of AR actions.

153 y may reveal important new insights into the pathobiology of AS in humans.

154 ssociated with differences in the underlying pathobiology of asthma.

155 -depth mechanistic knowledge of the cellular pathobiology of atherosclerosis can lead to new ideas fo

156 sculature is an important contributor to the pathobiology of atherosclerotic cardiovascular disease.

157 e eosinophil is a pivotal immune cell in the pathobiology of atopic disease that is also found to acc

158 indings are crucial for the understanding of pathobiology of atopic diseases, including allergic asth

159 We focus on the pathophysiology and pathobiology of biomedical conditions that appear unique

160 anisms of normal aging may contribute to the pathobiology of both COPD and IPF.

161 or protein SUMOylation in the life cycle and pathobiology of C. glabrata.

162 results demonstrate that Ole1 regulates the pathobiology of C. parapsilosis via UFA and that the OLE

163 tial applications in vesicle physiology, the pathobiology of cancer and other diseases, diagnostics u

164 putational modeling to better understand the pathobiology of cancer and to better affect its cure.

165 ether, our findings provide insight into the pathobiology of CLL to suggest a more complex relationsh

166 It aims to help researchers understand the pathobiology of collagen-related diseases and create nov

167 These findings provide insight into the pathobiology of congenital lung diseases, such as alveol

168 ution of specific cellular components to the pathobiology of diabetic retinopathy remains to be defin

169 Progress has been made to understand the pathobiology of disease mechanisms for myotonic dystroph

170 damental to development, homeostasis and the pathobiology of diseases such as cancer.

171 The pathobiology of early squamous lung cancer is poorly und

172 ecific region of the protein critical to the pathobiology of EKC syndrome and to DSP function in the

173 erythrocytes, and implicate hypoxemia in the pathobiology of erythrocyte-based vascular signaling.

174 With a better understanding of the pathobiology of events following acute SCI, developing i

175 enes with a potentially critical role in the pathobiology of extranodal NK/T-cell lymphoma and aggres

176 ntral to HF pathogenesis and relevant to the pathobiology of failing human hearts.

177 r of normal repair, and a key element in the pathobiology of fibrotic lung diseases.

178 Food-specific IgE is central to the pathobiology of food allergy, but not sufficient to indu

179 s, which are strongly implicated in the root pathobiology of GBM.

180 The pathobiology of GVHD is complex and involves immune cell

181 A as a unique class of genes involved in the pathobiology of HCC.

182 cer stem cells play an important role in the pathobiology of head and neck squamous cell carcinomas (

183 ding of the role of cancer stem cells in the pathobiology of head and neck squamous cell carcinomas m

184 derstanding of HH signaling, its role in the pathobiology of hematological malignancies, and its pote

185 l mechanistic and clinical insights into the pathobiology of hepatocellular carcinoma.

186 ency renal nerve denervation (RF-RDN) on the pathobiology of HF and the interaction between the renal

187 confirms that microRNAs (miRNAs) impact the pathobiology of hormone-regulated malignancies.

188 cal and molecular alterations underlying the pathobiology of HPV-associated OPSCC (designated HPV(+)

189 etworks can enhance our understanding of the pathobiology of human periodontitis and, after appropria

190 In this article, we review the pathobiology of immune dysregulation in MDS and summariz

191 entists are elucidating the pathogenesis and pathobiology of individual cardiomyopathies.

192 Thus, there is an urgency to understand the pathobiology of influenza infection and the contribution

193 s on alterations in hematopoietic TFs in the pathobiology of inherited platelet defects.

194 To understand the pathobiology of interactions between the bacterium and h

195 This study provides insight into the pathobiology of IPF and identifies a novel epigenetic fe

196 The pathobiology of IPNB demonstrates geographic variation.

197 ontrast to experimental work elucidating the pathobiology of left ventricular failure, there is a pau

198 Our results provide insight into the basic pathobiology of LRRK2 and indicate an important role for

199 plementing the limited data available on the pathobiology of lung capillaries and small arteries; 3)

200 central role of the SRF/MRTF pathway in the pathobiology of lung fibrosis and suggest that its inhib

201 hese data support involvement of IER3 in the pathobiology of MDS.

202 cross-talk between secretion systems in the pathobiology of medically relevant Acinetobacter species

203 The indeterminate pathobiology of MGZL has led to uncertainty regarding th

204 Diaphanous formins and add insights into the pathobiology of microcephaly.

205 hts into conserved mechanisms and the shared pathobiology of mRNA dysregulation in disease.

206 ow antibiotic resistance mutations shape the pathobiology of multidrug-resistant infections has the p

207 on has also been shown to play a role in the pathobiology of myriad cancers, one of which is glioblas

208 cal amyloid fold, play a central role in the pathobiology of neurodegenerative diseases.

209 the tumor suppressor NF1 contributes to the pathobiology of neurofibromatosis type 1, but a related

210 nding of both the normal development and the pathobiology of ocular neovascularization.

211 f altered lung macrophage populations on the pathobiology of ozone is poorly understood.

212 ver the past decades, knowledge of the basic pathobiology of PAH and its natural history, prognostic

213 hat serotonin plays an important role in the pathobiology of PAH per se.

214 ate developments in our understanding of the pathobiology of pain in SCD.

215 expression and T1172 phosphorylation in the pathobiology of pancreatic cancer.

216 nt, or stroma, is of major importance in the pathobiology of pancreatic ductal adenocarcinoma (PDA),

217 her members of this signaling cascade in the pathobiology of pediatric low-grade astrocytoma.

218 l processes with possible involvement in the pathobiology of periodontal disease.

219 ese findings expand our understanding of the pathobiology of PH in HF.

220 Emerging concepts are also relevant to the pathobiology of PH, including a role for bone marrow and

221 The pathobiology of primary cicatricial ("scarring") alopeci

222 Knowledge of the pathobiology of pulmonary hypertension (PH) continues to

223 important implications for understanding the pathobiology of renal disease.

224 This may have implications for the pathobiology of respiratory virus-induced airway disease

225 tanding of the role of the agr operon in the pathobiology of S. aureus.

226 This review addresses the pathobiology of SA and discusses the current limitations

227 rain development, has been implicated in the pathobiology of schizophrenia.

228 1C isoforms among phenotypes relevant to the pathobiology of schizophrenia.

229 ata indicate that trkB.T1 contributes to the pathobiology of SCI and SCI pain through modulation of c

230 t NK and CD8(+) T lymphocytes facilitate the pathobiology of septic shock.

231 GLI1 oncogene has been implicated in the pathobiology of several neoplasms including diffuse larg

232 suggest that in a subgroup of patients, the pathobiology of severe asthma is mediated by immune path

233 The vascular pathobiology of sickle cell anemia involves inflammation

234 insights into the clinical heterogeneity and pathobiology of sickle cell disease.

235 lial cell-secreted factors contribute to the pathobiology of squamous cell carcinoma (SCC) by enhanci

236 Intense investigation continues on the pathobiology of stent thrombosis (ST) because of its mor

237 ity and inflammation are key elements of the pathobiology of stroke, a devastating illness second onl

238 r transport across the peritoneum and of the pathobiology of structural and functional changes in the

239 a relevant platform to investigate both the pathobiology of such infections as well as novel approac

240 ell as serve as a platform for exploring the pathobiology of TDP-43, here we summarize the identified

241 protein changes could negatively affect the pathobiology of the 2010 derivative, its virulence defec

242 number of persons at risk of infection, the pathobiology of the disease is unknown, and no effective

243 A expression profiles that contribute to the pathobiology of the disease.

244 tion about how these cells contribute to the pathobiology of the disease.

245 symptom frequency, suggesting a role in the pathobiology of the late-onset phenotype.

246 as held on the topic of Vascular Biology and Pathobiology of the Liver.

247 provide important insights pertinent to the pathobiology of the P vivax infection.

248 de a strong foundation for understanding the pathobiology of the relapse.

249 Even though the pathobiology of the resulting retinal degeneration has b

250 vealing signatures consistent with the known pathobiology of these lesions, our observations provide

251 To demonstrate the involvement of UPR in the pathobiology of these lesions, we employed chemical chap

252 dels have led to better understanding of the pathobiology of these neuropathies, there continues to b

253 that might broaden our understanding of the pathobiology of this aggressive sarcoma.

254 he understanding of the genetic etiology and pathobiology of this disease.

255 substantive role for innate immunity in the pathobiology of this disease.

256 unbiased approach to further understand the pathobiology of this disease.

257 rgan targeting is of major relevance for the pathobiology of this disorder.

258 aise the profile of NTHi and to document the pathobiology of this microbe.

259 as been made in understanding the causes and pathobiology of this often life-threatening condition.

260 spective validation to further elucidate the pathobiology of this phenomenon.

261 In this Review we focus on the complex pathobiology of this side-effect.

262 kin and may improve our understanding of the pathobiology of tissue inflammatory diseases.

263 ary, our data reveal novel insights into the pathobiology of treatment failure and suggest CSF1R as a

264 iers and oncogenic pathways that reflect the pathobiology of tumor cells and their microenvironment w

265 system maturation, myelin stability, and the pathobiology of various de- and dys-myelinating disorder

266 lular protein presumed to be involved in the pathobiology of various fibrotic diseases, including gla

267 Although the underlying pathobiology of vision limiting processes in RD is not f

268 a framework for the genetic architecture and pathobiology of vitiligo, highlight relationships with o

269 splay exocrine pancreatic insufficiency, the pathobiology of which is unknown.

270 r telomerase and telomere dysfunction in the pathobiology of XP by comparing Xpc(-/-)-mutant mice and

271 nce of the involvement of SOX9 in neoplastic pathobiology, particularly, in colorectal cancer.

272 pping and to assess the relationship between pathobiology/pathophysiology and prognosis.

273 Heterogeneity in sepsis-related pathobiology presents a significant challenge.

274 le organ-culture studies to explore the main pathobiology principles and explain why chemotherapy-ind

275 Understanding the pathobiology related to the autoreactive T-cell and micr

276 ro However, the relevance of MIOX to tubular pathobiology remains enigmatic.

277 critical component in reflecting such human pathobiology rests in defining the tissue and cellular s

278 and they provide evidence of organ-specific pathobiology resulting from different mutations within G

279 the exposome, predictive health, and complex pathobiology serve to emphasize the central role of diet

280 exosomes as a potential target to attenuate pathobiology signals.

281 Typhimurium, S. Enteritidis is known to have pathobiology specific to chickens that impacts epidemiol

282 e definitive understanding of the underlying pathobiology, studies linking pathology to molecular mar

283 ined to supportive measures, but advances in pathobiology suggest that new stratified approaches will

284 these disorders, and insights into molecular pathobiology that have potential for clinical translatio

285 ied for complementary targets to inhibit the pathobiology that is specific to inflammatory breast can

286 lecular level about ischemia and reperfusion pathobiology that may be translated into future new ther

287 n ELN disruptions as not only the antecedent pathobiology that underlies beta-amyloidogenesis but als

288 approaches for the elucidation of neoplastic pathobiology, the identification of novel diagnostic bio

289 torial introduces this month's special Liver Pathobiology Theme Issue, a series of reviews that encom

290 multiple NLR inflammasomes attenuate disease pathobiology through modulating IL-1beta and IL-18 level

291 a focus ranging from clinical symptoms to PD pathobiology to molecular genetic mechanisms will be nec

292 alization of REEP1 and further elucidate the pathobiology underlying REEP1 mutations in patients.

293 We examined mutation pathobiology via expression of mutant GNA14 or GNA11 in

294 w discoveries with emerging models of asthma pathobiology, we aimed to test how genetic discoveries r

295 hitherto underappreciated aspects of keloid pathobiology, we took a laser capture microdissection-ba

296 Stat1, and CD48) associated with ehrlichial pathobiology were strongly upregulated during infection,

297 or pathway plays an important role in cancer pathobiology when it is dysregulated.

298 ast decade has been hallmarked by linkage of pathobiology with clinical expression of mucosal toxicit

299 hypersensitivity pneumonitis suggest shared pathobiology with IPF, and might help to stratify risk.

300 h has culminated in convergence of molecular pathobiology with models of symptom clusters, genetic-ba