ライフサイエンスコーパス: pathogenetic

1 ross GWAS datasets, to explore their "shared pathogenetics".

2 s of mutations is an important goal of human pathogenetics.

3 It is highly likely that these changes are pathogenetic, accounting for loss of glucose responsiven

4 roporation and to assess their antiviral and pathogenetic activity in vitro and in HBV-infected human

5 te PTLD often resembles tumors with distinct pathogenetic alterations and nodal appearance.

6 ome and observed conservation of the central pathogenetic alterations.

7 in the JAK-STAT pathway is important from a pathogenetic and diagnostic perspective, important quest

8 These data reveal a pathogenetic and molecular basis for glaucoma and demons

9 arkinson's disease (PD), both of which share pathogenetic and neurologic similarities with human immu

10 atency nor lytic replication, with important pathogenetic and therapeutic consequences.

11 ants were classified as "pathogenetic/likely pathogenetic" and two as "of uncertain significance." Co

12 This tool can be of great value in clinical, pathogenetic, and epidemiological research studies on ce

13 trial cultures, public-private partnerships, pathogenetic- and structure-led drug design, efficient d

14 biliary epithelial cells; this mechanism is pathogenetic, as shown by the protective effects of Src

15 nces have been made in understanding the key pathogenetic aspects of scleroderma, and these have led

16 is a disease with genetic and environmental pathogenetic background.

17 des, where novel insights into the molecular pathogenetic basis for sarcomas has dramatically (re)sha

18 A pathogenetic basis for the differing roles of skin and s

19 17, has transformed our understanding of the pathogenetic basis of an increasing number of chronic im

20 heme among myeloproliferative neoplasms, the pathogenetic basis of chronic neutrophilic leukemia (CNL

21 emains unclear but this new insight into the pathogenetic basis of L-ORD has implications for future

22 ss has been made in our understanding of the pathogenetic basis of myeloproliferative neoplasms.

23 ater appreciation of its diverse and complex pathogenetic basis.

24 rable advances in our understanding of their pathogenetic basis.

25 s and across GWASs, thereby revealing shared pathogenetics between diseases in an unsupervised fashio

26 of the peripheral nervous system in the ALS pathogenetic cascade.

27 We conclude that there may be a pathogenetic change in aged human brain arterioles that

28 accumulation of Abeta peptide and associated pathogenetic changes (eg, inflammation, oxidative stress

29 rall reduction in amyloidosis and associated pathogenetic changes in the brain resulted in decreased

30 atic diseases and periodontitis share common pathogenetic characteristics, such as proinflammatory tr

31 The goal of this review was to propose a pathogenetic classification of acute coronary syndromes

32 l organism." In parallel, however, we need a pathogenetic classification to describe the pathways and

33 unction of Htt is thought to be an important pathogenetic component of HD.

34 Thus, ER stress is a targetable pathogenetic component of the phenotypes caused by Droso

35 new clinical features in a more appropriate pathogenetic context.

36 The individual pathogenetic contribution of each gene variant is diffic

37 , IDH, IKZF1, or EZH2 mutations; the precise pathogenetic contribution of these mutations is under in

38 The latter seem to represent a pivotal pathogenetic, diagnostic, and prognostic factor in this

39 en HFpEF and HFrEF, supporting the notion of pathogenetic differences among HF subtypes.

40 fected in GCK-diabetes, reflecting important pathogenetic differences between the two MODY forms.

41 h basophils, mast cells constitute a central pathogenetic element of anaphylactic (IgE-dependent) and

42 nosomes into the brain parenchyma is a major pathogenetic event in African trypanosomiasis.

43 erization-a process postulated to be the key pathogenetic event in Alzheimer's disease.

44 the BCR-ABL tyrosine kinase is the critical pathogenetic event in CML and an ideal target for therap

45 HIF signaling pathway could be an important pathogenetic event in the development and progression of

46 ic program of the tumour cell of origin or a pathogenetic event.

47 nt major challenges in the identification of pathogenetic events driving the neoplastic transformatio

48 hereas chromosomal translocations are common pathogenetic events in cancer, mechanisms that promote t

49 mutation (EGFRvIII/DeltaEGFR) are signature pathogenetic events that are invariably expressed in a h

50 l allow this paradigm of targeting molecular pathogenetic events to be applied to many additional hem

51 s and is internalized, leading to a range of pathogenetic events.

52 orces that RTL is a marker and potentially a pathogenetic factor for CKD progression.

53 ature but also a novel prognostic marker and pathogenetic factor for this malignancy.

54 ANCE STATEMENT Amyloid-beta (Abeta) is a key pathogenetic factor in Alzheimer's disease.

55 Oxidative stress, a pathogenetic factor in many conditions, including chroni

56 predisposition is recognized as an important pathogenetic factor in otitis media (OM) and associated

57 lucidated that oxidative stress is a pivotal pathogenetic factor of age-related bone loss and strengt

58 e that high-level BKV replication is a major pathogenetic factor that may have implications for genom

59 stence has been suspected to be an important pathogenetic factor.

60 Herein, relevant pathogenetic factors and underlying mechanisms as well a

61 ntial diagnosis of childhood cholestasis and pathogenetic factors involved in fibrogenesis in chronic

62 ting that lenalidomide targets a fundamental pathogenetic feature of MDS that is more pronounced in t

63 ctive oxygen species in sickled AS RBCs is a pathogenetic feature shared by parasitized thalassemic a

64 The common pathogenetic features in STEC-HUS, aHUS, and secondary H

65 eir potential to alter the immunological and pathogenetic features of HLA-B27 as a function of the ER

66 isease lead to large kidney cysts that share pathogenetic features.

67 way are important for disease, informing the pathogenetic function of additional cytokines (such as t

68 (GRN+), compared with FTLD patients without pathogenetic GRN mutations (GRN-) and healthy controls (

69 Neuronal degeneration represents a pathogenetic hallmark after different brain insults, suc

70 her criterion emphasizes the etiology or the pathogenetic heterogeneity of acute decreases in kidney

71 peutic strategies are needed to address this pathogenetic heterogeneity.

72 The pathogenetic immune mechanisms involved (cell-mediated v

73 agnostic and possible prognostic utility and pathogenetic implications of serologic abnormalities in

74 cted to HLA-B27 positive cases, has profound pathogenetic implications.

75 be detected using MC but may have important pathogenetic implications.

76 and primary myelofibrosis has diagnostic and pathogenetic implications.

77 rophilic inflammation is understood to be of pathogenetic importance in chronic obstructive pulmonary

78 as to examine the clinical, therapeutic, and pathogenetic importance of c-Abl in this disease.

79 To identify the pathogenetic importance of telomerase in lung fibrosis,

80 anges in gene expression in PBMCs, providing pathogenetic insights and a core subset of genes that, i

81 Our results provide new pathogenetic insights and identify possible therapeutic

82 Third, the pathogenetic insights have delivered new treatment optio

83 esent in GBA (mut/wt) carriers may offer new pathogenetic insights to and potential therapeutic targe

84 in IgG-deficient mice implicated IgG as the pathogenetic ligand for endothelial FcgammaRIIB in obesi

85 guidelines, six variants were classified as "pathogenetic/likely pathogenetic" and two as "of uncerta

86 A common pathogenetic link between LGL leukemia and RA is propose

87 Hashimoto's thyroiditis strongly suggests a pathogenetic link between this autoimmune disorder and m

88 netic basis of PH and cellular and molecular pathogenetic links should further expand our understandi

89 Pathogenetic markers of diabetic kidney disease (DKD) pr

90 ints to cell-mediated immunity as a relevant pathogenetic mechanism and potential therapeutic target

91 ed gene cluster and malignancy, reveal a new pathogenetic mechanism associated with acquired regions

92 me that AVS, COA and HLHS can share a common pathogenetic mechanism at the molecular level, explainin

93 The pathogenetic mechanism by which a poly-A tract results i

94 The findings suggest a common pathogenetic mechanism connecting certain iDCMs and othe

95 s persist, however, regarding this potential pathogenetic mechanism for ARMS tumor initiation.

96 voltage-dependent gating represent a common pathogenetic mechanism for genetically inherited channel

97 an lead to cell damage, representing a novel pathogenetic mechanism for glucocorticoid-induced myopat

98 utations in caveolin-3 may represent a novel pathogenetic mechanism for LQTS.

99 ostatic control by PRDM1 may be an important pathogenetic mechanism for NKCL.

100 tic variation is now being investigated as a pathogenetic mechanism for other diseases.

101 possibly leading to central apnea, may be a pathogenetic mechanism for SUDEP.

102 oblastic bone formation is impaired, a clear pathogenetic mechanism has not been depicted yet.

103 blish chronic active BCR signalling as a new pathogenetic mechanism in ABC DLBCL, suggesting several

104 cogenic transcripts may represent a critical pathogenetic mechanism in MLL-rearranged B-ALL and suppo

105 lammatory cell responsiveness to PGE(2) as a pathogenetic mechanism in patients with aspirin-sensitiv

106 nitric oxide (NO) is considered an important pathogenetic mechanism in pulmonary arterial hypertensio

107 sociated cellular stressors may be a seminal pathogenetic mechanism in the development of involutiona

108 and Creutzfeldt-Jakob disease share a common pathogenetic mechanism involving aggregation and deposit

109 uption of the barrier element as a potential pathogenetic mechanism of human disease.

110 rt a role for impaired ubiquitination in the pathogenetic mechanism of RCBTB1 mutations.

111 lutamatergic terminals can constitute a main pathogenetic mechanism of RLS symptoms.

112 ic organismal aging in mice may be a pivotal pathogenetic mechanism of the age-related bone loss and

113 In conclusion, we report new insight in the pathogenetic mechanism of viitligo and indicate that the

114 re considered in the context of the presumed pathogenetic mechanism related to the neurotropic proper

115 in human autoimmune diseases, but a unifying pathogenetic mechanism remains elusive.

116 s identify CREBBP/EP300 mutations as a major pathogenetic mechanism shared by common forms of B-cell

117 ly important rSNPs, and it also identifies a pathogenetic mechanism that could potentially underlie o

118 These molecular changes define a pathogenetic mechanism that leads to preaxial polydactyl

119 an congenital abnormalities and identifies a pathogenetic mechanism that may underlie other congenita

120 We describe a pathogenetic mechanism underlying a variant form of the

121 s suggest that downregulation of mGluR5 is a pathogenetic mechanism underlying nicotine dependence an

122 ritical for dermatitis, revealing a separate pathogenetic mechanism.

123 with normal skeletal muscle through a novel pathogenetic mechanism.

124 of different inflammatory diseases, yet the pathogenetic mechanisms and cell types involved vary sig

125 tools for the elucidation of the underlying pathogenetic mechanisms and for preclinical studies.

126 Growing understanding of ebolavirus pathogenetic mechanisms and important new clinical obser

127 a basis for further studies to elucidate the pathogenetic mechanisms and phenotypic spectrum of assoc

128 genes will facilitate better elucidation of pathogenetic mechanisms and possible corrective therapie

129 nd pathways provide insights into underlying pathogenetic mechanisms and possible triggers of GV, est

130 tely, liver cancer, despite the fact that no pathogenetic mechanisms are known which are shared by th

131 rder to understand their contribution to the pathogenetic mechanisms associated with cortical patholo

132 There appear to be common pathogenetic mechanisms between poor oral health and car

133 These pathogenetic mechanisms can include functional alteratio

134 r this disease course results from different pathogenetic mechanisms compared with secondary progress

135 recent years, a general understanding of the pathogenetic mechanisms driving HUS has increased.

136 We will take a journey from basic pathogenetic mechanisms elicited by viral infections tha

137 dings support the hypothesis of two separate pathogenetic mechanisms for M. pneumoniae-associated neu

138 The pathogenetic mechanisms for these changes had not been i

139 hypomyelinating leukodystrophies (HLD7) with pathogenetic mechanisms hypothesised to involve impaired

140 to greatly enhance our understanding of the pathogenetic mechanisms in lymphoma.

141 The cascade of inflammatory pathogenetic mechanisms in multiple sclerosis (MS) has n

142 Pathogenetic mechanisms in PV, ET, and PMF include stem

143 We attempted to elucidate possible pathogenetic mechanisms in scleroderma by analysis of ge

144 JSN in the contralateral knee suggests that pathogenetic mechanisms in that joint were different fro

145 f Notch has provided important insights into pathogenetic mechanisms in the CNS and many other tissue

146 Our findings demonstrate the different pathogenetic mechanisms in wild-type and humanized mice

147 Because of the inherent complexity of the pathogenetic mechanisms involved in CF, which include im

148 Insights into the pathogenetic mechanisms involved in lymphoma impact the

149 hemostatic complications, the already known pathogenetic mechanisms involved, and the effect of vary

150 These results suggest that common pathogenetic mechanisms involving apoptosis of both thym

151 ggesting that exploration of other causes or pathogenetic mechanisms is warranted.

152 ntified in which mutations can cause NM, the pathogenetic mechanisms leading to the phenotypes are po

153 Different pathogenetic mechanisms might cause similar asthma sympt

154 The pathogenetic mechanisms of CR need to be better understo

155 kappaB functions that underlie the molecular pathogenetic mechanisms of E. coli O157:H7.

156 d provide new insight into the pathology and pathogenetic mechanisms of HACD1 CNM.

157 Pathogenetic mechanisms of HE deduced from cell culture

158 eve our data provide novel insights into the pathogenetic mechanisms of HHT and potential therapeutic

159 , we discuss recent literature investigating pathogenetic mechanisms of lupus glomerulonephritis.

160 Pathogenetic mechanisms of narcolepsy have so far mainly

161 formation is available on manifestations and pathogenetic mechanisms of PDN in type 2 diabetic models

162 hogenesis of AILD, definition of the precise pathogenetic mechanisms of recurrent AILD, and developme

163 finition, and in identifying possible immuno-pathogenetic mechanisms of severe infection.

164 esearch is needed to better characterize the pathogenetic mechanisms of SLE, identify additional ther

165 The pathogenetic mechanisms of these diseases and the causes

166 as a minor cause of Noonan syndrome and the pathogenetic mechanisms of those mutants is discussed.

167 we summarize current knowledge regarding the pathogenetic mechanisms of viral HCC.

168 We here focused on the pathogenetic mechanisms potentially linking immune cell

169 4, -19q13.32, +16p11.2), suggesting distinct pathogenetic mechanisms relative to age.

170 upregulated at the growth plate, the precise pathogenetic mechanisms remain to be elucidated.

171 ls; however, the common underlying molecular pathogenetic mechanisms remain unclear.

172 ted with Filamin-A (FLN-A) mutations but the pathogenetic mechanisms remain unclear.

173 and exogenous glucocorticoid excess, yet its pathogenetic mechanisms remain unclear.

174 no effective therapies for this illness, and pathogenetic mechanisms remain undefined.

175 In contrast, the pathogenetic mechanisms responsible for type 1 VWD remai

176 of SSc-ILD have not been validated, and the pathogenetic mechanisms that engender this pulmonary res

177 ncoprotein PAX-FOXO1, but the underlying RMS pathogenetic mechanisms that impede differentiation and

178 RASopathies can be caused by several pathogenetic mechanisms that ultimately impact or alter

179 important in leukemogenesis, the underlying pathogenetic mechanisms they trigger remain largely unkn

180 These findings suggest that complex pathogenetic mechanisms underlie human deafness DFNB59.

181 These results indicate that different pathogenetic mechanisms underlie transformation to JAK2

182 55), further implicating HF1 function in the pathogenetic mechanisms underlying AMD.

183 Major gaps remain regarding pathogenetic mechanisms underlying clinical heterogeneit

184 F-beta signaling contributes to knowledge of pathogenetic mechanisms underlying common craniofacial b

185 mbryo as a novel model system to dissect the pathogenetic mechanisms underlying HSP.

186 orders alludes to the possibility of diverse pathogenetic mechanisms underlying inflammatory bowel di

187 of normal and variant NOD2 proteins and the pathogenetic mechanisms underlying NOD2-associated infla

188 This review examines the fundamental pathogenetic mechanisms underlying this disorder, which

189 Further insight into GCH1-associated pathogenetic mechanisms will shed light on the role of d

190 ether these DLBCL subtypes arise by distinct pathogenetic mechanisms, we analyzed 203 DLBCL biopsy sa

191 f B-cell differentiation stage and potential pathogenetic mechanisms.

192 s a deeper understanding of the underpinning pathogenetic mechanisms.

193 iac transplants, likely indicating divergent pathogenetic mechanisms.

194 cation of the different forms and insight on pathogenetic mechanisms.

195 nct genetic pathways linked to DCM and their pathogenetic mechanisms.

196 aises the possibility that they share common pathogenetic mechanisms.

197 ts are being developed that may target these pathogenetic mechanisms.

198 on of the cREL locus, suggesting alternative pathogenetic mechanisms.

199 ink between a modifiable risk factor and the pathogenetic mechanisms.

200 ly unexplored level of complexity in disease pathogenetic mechanisms.

201 tis and be of help to better understand some pathogenetic mechanisms.

202 This mechanism provides a novel pathogenetic model for the association of 13q deletions

203 Recently, a new pathogenetic model involving miRNAs and protein coding g

204 e rodent with brain iron deficiency (BID), a pathogenetic model of restless legs syndrome (RLS).

205 Key findings support a causal or pathogenetic model of superficial placentation driven by

206 Current pathogenetic models suggest that postprandial hyperlipid

207 ardiographic septal shape and the underlying pathogenetic mutation, time has come to subdivide the on

208 alysis is now uncovering a remarkable set of pathogenetic mutations that alter the Hh pathway, thus c

209 tients with systemic mastocytosis, but their pathogenetic or treatment relevance is unknown.

210 eries provides the clinical correlate to the pathogenetic parallels between CRDD and Crohn disease.

211 Here, we investigated whether this pathogenetic pathway could affect podocyte phenotype in

212 BCR signaling is a central pathogenetic pathway in chronic lymphocytic leukemia (CL

213 inhibition of terminal differentiation as a pathogenetic pathway in DLBCL, particularly for the acti

214 Further studies supported a pathogenetic pathway whereby the CD8+ T cell product, IF

215 of various protein fragments into a rational pathogenetic pathway(s).

216 novo lipogenesis [DNL]) may be a modifiable pathogenetic pathway.

217 uggesting that they are involved in a common pathogenetic pathway; however, the molecular mechanism t

218 Deeper insight into pathogenetic pathways and into the biological effects of

219 sis of DR through the modulation of multiple pathogenetic pathways and may be novel therapeutic targe

220 nterrupt neointimal hyperplasia and relevant pathogenetic pathways are essential.

221 The pathogenetic pathways include oxidative stress, advanced

222 of asthma is likely due in part to distinct pathogenetic pathways that depend on preceding/comorbid

223 with non-TNBC, likely arises from different pathogenetic pathways, and benign breast disease (BBD) p

224 al/retinal pathologies, suggesting different pathogenetic pathways.

225 ure treatments targeted directly at relevant pathogenetic pathways.

226 ciated with inherent susceptibility for TNBC pathogenetic pathways.

227 ined and possibly different location-related pathogenetic pathways.

228 hat relapse may reflect at least 3 differing pathogenetic pathways.

229 , indicating the existence of four different pathogenetic patterns.

230 hether these indicators represent a distinct pathogenetic phenotype of DKD will require a large study

231 Numerous cytokine activities with pathogenetic potential have now been demonstrated in rhe

232 pancreatic beta-cells is a well established pathogenetic process in type 2 diabetes.

233 The pathogenetic process involving hyperglycemia, BMDCs, and

234 s in schizophrenia, suggesting that a shared pathogenetic process might underlie diverse cortical pat

235 Lipotoxicity is a presumed pathogenetic process whereby elevated circulating and st

236 helial-mesenchymal transition (EMT) as a key pathogenetic process.

237 The key pathogenetic processes and causes of death are unknown,

238 These pathogenetic processes are interdependent and also indiv

239 A better understanding of pathological and pathogenetic processes in patients with a CIS will facil

240 To investigate pathogenetic processes relevant to cutaneous lupus as co

241 t ulcerative colitis, highlighting the close pathogenetic relationship between early- and adult-onset

242 Other recent observations of potential pathogenetic relevance in this disease include the descr

243 lood, Wang et al describe the occurrence and pathogenetic relevance of IDH2R172 mutations in angioimm

244 Thus, these data highlight the pathogenetic relevance of the macrophage polarization st

245 Investing in primary prevention and pathogenetic research is essential to reduce this burden

246 Here we examine the pathogenetic role and immunomodulatory function of mycol

247 re, this child-rearing style may also play a pathogenetic role by transmitting trauma- and stressor-r

248 A pathogenetic role for autoantibodies is suspected, but t

249 nted genes L3MBTL1 and SGK2, indicative of a pathogenetic role for loss of the active paternally inhe

250 Our results demonstrate a pathogenetic role for VWF-platelet interaction in flow d

251 nt fusion protein NPM-ALK plays an important pathogenetic role in ALK+ anaplastic large-cell lymphoma

252 established as an oncogene with an important pathogenetic role in breast cancer and other human tumor

253 rosis factor-alpha and interleukin-6, play a pathogenetic role in chronic heart failure, and anti-inf

254 overexpression of c-Abl is likely to play a pathogenetic role in CLL and that STI-571 may be of pote

255 tioxidant defenses have been shown to play a pathogenetic role in human and animal models of inflamma

256 th, survival, and motility and plays a major pathogenetic role in human prostate cancer (PCa).

257 the bone marrow of MDS patients and played a pathogenetic role in the development of ineffective hema

258 oxygen/nitrogen species-PARP pathway plays a pathogenetic role in the development of liver inflammati

259 r, these results suggest that CLU may play a pathogenetic role in TTR and Ig light chain amyloidoses

260 ter studies in human primary GBM, validate a pathogenetic role of a common tumour suppressor mutation

261 vations provided novel information about the pathogenetic role of a TESC-NHE1-pHi axis in mediating s

262 th diseased Bruch membrane in PXE suggests a pathogenetic role of Bruch membrane alterations for the

263 oral neomycin and polymyxin B, indicating a pathogenetic role of gut-derived bacterial products.

264 In order to assess the pathogenetic role of lesions in the grey and white matte

265 y have clinical utility given the widespread pathogenetic role of MYC in cancer.

266 Our findings are consistent with a pathogenetic role of TGF-beta1/3, demonstrating the effi

267 of aPLA(2)R antibody titer and highlight the pathogenetic role of these antibodies, especially the Ig

268 To gain insight into and test the possible pathogenetic role of this pathway, we designed a conditi

269 It is unclear whether it has a pathogenetic role or simply reveals the presence of unde

270 se (IBD), and in various carcinomas, yet its pathogenetic role remains unknown.

271 ative vasculopathies in which EndoMT plays a pathogenetic role.

272 chemokine expression, we attempted to reveal pathogenetic roles for this pathway of MC activation.

273 vels of specific antibodies assigned salient pathogenetic roles in IgA nephropathy.

274 es of autoantibody, but their most important pathogenetic roles may be to present autoantigens to T c

275 The possible pathogenetic roles of disturbed glycogen metabolism and

276 volve through similar or different molecular pathogenetic routes.

277 These findings support the pathogenetic segregation of these entities and define no

278 is intimately linked with the unraveling of pathogenetic sequelae.

279 ically defined mouse models to elucidate the pathogenetic sequence that is initiated by fibrillin-1 d

280 ) than those with the CC genotype, which, if pathogenetic, should put them at increased risk of strok

281 erine 129 phosphorylation of alpha-Syn is of pathogenetic significance and that promoting PP2A activi

282 Ang-2 has recently been shown to have pathogenetic significance in sepsis and acute lung injur

283 and the insulin resistance syndrome, and the pathogenetic significance of these associations is under

284 st this bacterium in ReA patients, but their pathogenetic significance, autoimmune potential, and rel

285 ies to SERCA2a suggesting that they may have pathogenetic significance.

286 umerous chromosomal aberrations of uncertain pathogenetic significance.

287 These results provide insights into the pathogenetic similarities and differences between PsC an

288 ghput experimental model of epilepsy-related pathogenetic states.

289 Cortical spreading depression (CSD) is a key pathogenetic step in migraine with aura.

290 , inclusion of noncoding genomic elements in pathogenetic studies and their consideration as therapeu

291 ue to limited access to human neural tissue, pathogenetic studies have, so far, mostly focused on the

292 tform using BAGS-assigned subtypes may allow pathogenetic studies to improve disease management.

293 mission of HIV in multiple epidemiologic and pathogenetic studies.

294 mong at least 10 sarcomeric genes confer the pathogenetic substrate for this 'disease of the sarcomer

295 scattered among at least 14 genes confer the pathogenetic substrate for this 'disease of the sarcomer

296 Pathogenetic theories of dacryops that implicate a failu

297 and small sensory fiber PDN and responds to pathogenetic treatment.

298 ally improved clinical outcomes and informed pathogenetic understanding, but no cure as yet exists.

299 ders are at a crossroads of rapidly evolving pathogenetic understanding, leading to changes in diagno

300 the endoplasmic reticulum (ER) and elicits a pathogenetic unfolded protein response (UPR).