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1 GRP2 variants that were biallelic and likely pathogenic.
2 amino acid change (LAMB2-S83R) alone is not pathogenic.
3 ters the oral microbiota and renders it more pathogenic.
4 e a 50% reduction of TBK1 protein levels are pathogenic.
5 the oral microbiota of diabetic mice is more pathogenic.
7 in M2 in minimal medium and demonstrate that pathogenic Acinetobacter species produce both a function
11 (TCGA) data set and observe that bi-allelic pathogenic alterations in homologous recombination (HR)
14 vel strategies to effectively address highly pathogenic and lethal infections stemming from bacterial
16 ications for the stability of cooperation in pathogenic and non-pathogenic environments, in biotechno
18 HFrEF; EF <40%) is well established, but its pathogenic and prognostic significance in HF with midran
19 isms, they also have the potential to become pathogenic and promote autoimmune and inflammatory disea
21 atics tools classified 11 variants as likely pathogenic and showed no association with diabetes risk
22 thod, MutPred-LOF, for the discrimination of pathogenic and tolerated variants that can also generate
23 erplay between host non-self RNA sensors and pathogenic arenaviruses, which also provides insights in
26 from disrupting the autoprotective role that pathogenic ataxin-3 has against itself, which depends on
29 rnative clade 2.3.4.4 CVVs.IMPORTANCE Highly pathogenic avian influenza (HPAI) A(H5) viruses have cir
31 morbidity and mortality annually, and highly pathogenic avian influenza (HPAI) viruses along with oth
32 birds have the potential to mutate to highly pathogenic avian influenza (HPAI) viruses, but such viru
34 mic H1N1 influenza A (H1N1) virus and highly pathogenic avian influenza A (H5N1) virus induce express
35 le-genome sequences of representative highly pathogenic avian influenza A(H5) viruses from Vietnam we
36 ry team investigated 2 human cases of highly pathogenic avian influenza A(H5N1) virus infection, dete
39 proteins and nucleic acids from a variety of pathogenic bacteria and operates in a continuous and ult
40 of the heme-sensing and transport systems of pathogenic bacteria and the potential of these systems a
44 that can evaluate antibiotic resistance for pathogenic bacteria in order to deliver targeted antibio
45 e conserved in other bacteria, including the pathogenic bacteria lacking the assembly factor CcoH as
48 -inositol phosphatases (PTPLPs) from the non-pathogenic bacteria Selenomonas ruminantium (PhyAsr) and
49 have served as powerful therapeutics against pathogenic bacteria since the golden age of antibiotics
52 ectins play important roles in infections by pathogenic bacteria, for example, in host colonization,
53 trains of Zika and Dengue virus, distinguish pathogenic bacteria, genotype human DNA, and identify mu
54 ellular processes, inhibiting growth of many pathogenic bacteria, including the major respiratory pat
55 per and zinc, altered gut microbiota to more pathogenic bacteria, increased inflammatory markers, and
62 experiments to address this question in the pathogenic bacterium, Pseudomonas aeruginosa Although pu
64 not only a mechanism by which T cells become pathogenic before entering the CNS, but also the potenti
68 This review captures recent knowledge on pathogenic CD4(+) T cells in asthmatic patients by drawi
71 st in metabolic pathways between healthy and pathogenic cells, there is opportunity for selective reg
73 ost of studies have focused on molecular and pathogenic characterization of PEDV, whereas there were
77 hensive genome sequencing did not reveal any pathogenic coding or canonical splicing mutations within
81 in identifying the risk factors for and the pathogenic contributors to the syndrome and in character
82 eurodevelopmental disorders, we suggest that pathogenic de novo variants in GRIA4 lead to intellectua
85 African swine fever virus (ASFV) is a highly pathogenic, double-stranded DNA virus with a marked trop
86 lication rate almost completely retained the pathogenic E. coli in the subsurface, suggesting that ut
88 inflammation was mediated by IL-5-expressing pathogenic effector Th2 cells and was independent of TCR
89 dges the gap between genetic association and pathogenic effects and yields novel insights into the un
92 ay promote or impede such signalling and the pathogenic effects of ganglioside antibodies.awx012media
93 ectious diseases, and may have protective or pathogenic effects, depending on the tissue and disease
96 lected for the precise traits that now allow pathogenic enterococci to survive desiccation, starvatio
97 and acid-adapted bacterial species promote a pathogenic environment, leading to demineralization.
98 ability of cooperation in pathogenic and non-pathogenic environments, in biotechnological application
99 rous studies have examined the prevalence of pathogenic Escherichia coli in poultry and poultry produ
100 d model might be useful to investigate early pathogenic events and prove molecular concepts in patien
102 The amyloid-beta peptide (Abeta), a key pathogenic factor in Alzheimer disease, induces profound
103 monstrates that RNA misprocessing is a major pathogenic factor in CDM and provides novel mouse models
106 Our findings suggest that AT and ClfA are pathogenic factors that could be therapeutically targete
109 elial cells much more efficiently than other pathogenic flaviviruses because it binds Gas6 more avidl
111 to the role of bacteriophages as potentially pathogenic for mammals and their possible implication in
113 , and considers changes in the wall of plant-pathogenic fungi during on and in planta growth, followi
115 ion, the recombinant strains were similar to pathogenic G1 strains, but in the non-structural region
116 d genomic sequencing to identify potentially pathogenic gene variants in families in which a person h
117 The primary outcome was identification of a pathogenic germline mutation associated with cancer pred
121 family Tectiviridae can infect commensal and pathogenic Gram-positive and Gram-negative bacteria.
127 nger sequencing and discovered a potentially pathogenic, homozygous variant, c.240C > G (p.Phe80Leu).
128 sophila HD model, we find that nonaggregated pathogenic Htt acts locally at synaptic terminals to dis
132 e susceptibility to IAV in males and augment pathogenic immune responses in the lung, including activ
133 vulnerability to schizophrenia (SZ), but the pathogenic impact of SZ-risk mutations on corticogenesis
134 The DGCR2 missense SZ-risk mutation had a pathogenic impact on projection neuron laminar allocatio
138 y cytokines that can be elevated in RA evoke pathogenic increases in sympathetic activity and reducti
139 stood how innate cells integrate qualitative pathogenic information to generate tailored protective a
141 immune activation markers, suggesting their pathogenic involvement in AIDS- or non-AIDS-related comp
142 onstrating that these APOL1 risk alleles are pathogenic is still lacking because the APOL1 gene is pr
145 sis mainly by regulating the accumulation of pathogenic leukocyte subtypes, which drive the fibrotic
146 ations were classified as pathogenic, likely pathogenic, likely benign and benign per the chance of c
148 ic testing identified variants classified as pathogenic, likely pathogenic, or uncertain significance
151 tu during AH, providing a previously unknown pathogenic mechanism and new avenues for treatment.
153 ling in 22q11DS mice, and it may mediate the pathogenic mechanism of 22q11DS-related psychosis and co
154 itochondrial calcium deregulation is a novel pathogenic mechanism of cognitive deficiencies in schizo
156 The need for individualized definitions of pathogenic mechanisms before initiating therapy extends
157 ease heterogeneity and poor understanding of pathogenic mechanisms hampers the identification of ther
162 the course of MS is driven by the very same pathogenic mechanisms responsible for the disease, the a
163 humans, and used this system to explore the pathogenic mechanisms resulting from the sporadic Alzhei
164 nced considerably in recent years, revealing pathogenic mechanisms that potentially underlie ciliopat
166 ovide a cellular phenotype for investigating pathogenic mechanisms underlying AS and identifying nove
170 Skin provides the first defense against pathogenic micro-organisms and is also colonized by a di
172 rtant roles in the innate immune response to pathogenic microbes, but mounting data suggest these pat
173 th activity against human opportunistic food pathogenic microbes, have been isolated from the ethyl a
177 en normal skin microbial interactions versus pathogenic microbial interactions in wound repair is imp
178 hoglycerate isomers is catalysed in numerous pathogenic microorganisms by a cofactor-independent muta
181 Our findings establish L35P as the first pathogenic missense mutation in PALB2 and directly demon
185 Reminiscent of our earlier studies on a pathogenic mutation that generates full-length M1 and M8
187 A comparison of the distribution of the pathogenic mutations along the length of DYRK1A with tha
190 single, in vivo model for studying multiple pathogenic mutations in ATP7 proteins using Drosophila m
191 effective index to investigate the effect of pathogenic mutations in RBP binding sites, especially th
192 understand the mechanistic changes caused by pathogenic mutations in the TNT1 region, six hypertrophi
193 e DNAm signatures were able to differentiate pathogenic mutations in these two genes from controls an
194 al insight into multiple mechanisms by which pathogenic mutations interfere with enzyme function, and
195 lysis of the gATP7-GFP transgenes containing pathogenic mutations showed that the function of ATP7 wa
196 validated on 99 newly-discovered genes with pathogenic mutations, the algorithm displays an excellen
199 s a system to dissect host interactions with pathogenic ncRNAs, using comprehensive transcriptome ana
200 Olfactomedin-4 might serve as a marker of a pathogenic neutrophil subset in patients with septic sho
201 quantifies the transport of Escherichia coli pathogenic O157:H7 and nonpathogenic K12 strains in wate
202 years; 11 male and 16 female) presented with pathogenic or likely pathogenic CNVs (0.08-18.9 Mb).
204 une system, MG also detect "danger" signals (pathogenic or traumatic insult), become activated, produ
206 17 cells can protect against colonization by pathogenic organisms, they also have the potential to be
208 es expressing human tau proteins harboring a pathogenic P301L MAPT mutation labeled with green fluore
209 S and SYNJ1 loss of function share a similar pathogenic pathway in deregulating DAergic neuron SV end
212 be the causal relationship between multiple pathogenic pathways in human neurons obtained from idiop
213 position effects and their association with pathogenic phenotypes in 17 subjects with apparently bal
215 stribution of the system among commensal and pathogenic phytobacteria suggests that the T6SS provides
216 , including one harboring the most prevalent pathogenic point mutation, and compared them with two ex
217 ed by host restriction genes Fv1 and Apobec3 Pathogenic potential maps to the env transmembrane subun
222 Even though GRG and OURT possess different pathogenic properties, there was significant overlap in
223 The factors that distinguish infectious and pathogenic protein aggregates from more innocuous ones a
226 better define the phenotype associated with pathogenic RASGRP2 variants, we compared high-throughput
227 signals is important for both symbiotic and pathogenic relationships, but is often poorly understood
228 syndrome coronavirus (SARS-CoV) is a highly pathogenic respiratory virus that causes morbidity and m
229 syndrome coronavirus (MERS-CoV) is a highly pathogenic respiratory virus that emerged from zoonotic
231 ated in lung disease induced by other highly pathogenic respiratory viruses.IMPORTANCE PF has many ca
232 eckel-Budimmir et al. (2017) reveal that the pathogenic response of mice to a Plasmodium berghei infe
238 proteinuria by anti-PD-L1 mAb supported the pathogenic role of these macrophages but not the PD-L1(-
239 et al. (2017) explore the protective versus pathogenic roles of DENV-immune antibodies in ZIKV infec
241 h which self is distinguished from non-self, pathogenic signals are recognized and eliminated, and ti
243 d apoptosis) is specifically associated with pathogenic SIV infection and absent during the course of
244 s) and expand in lymph nodes (LNs) following pathogenic SIV infection in a cohort of vaccinated macaq
245 iated B cell dysfunction associated with the pathogenic SIV infection is characterized by loss of nai
246 ed to preinfection levels during the chronic pathogenic SIV infection, restoration is mainly due to a
248 IMPORTANCE We previously demonstrated that a pathogenic SIVmac239 virus and a live-attenuated, deglyc
249 Sequencing and comparing the genomes of two pathogenic species of Batrachochytrium to those of close
250 antifungal agents to manage infections with pathogenic species such as Cryptococcus neoformans Becau
253 tional characterization of the PerR from the pathogenic spirochete Leptospira interrogans, a rare exa
255 iants would not have been elevated to likely pathogenic status without knowing their de novo status.
256 higher TNF-alpha, IL-6, and IL-1beta) toward pathogenic stimuli, a process also mediated by JNK activ
259 Cfh deletion protected the mice from the pathogenic subretinal accumulation of mononuclear phagoc
261 T cell-mediated disease primarily driven by pathogenic T cells that produce high levels of IL-17 in
265 nly a few members of the Parvoviridae family pathogenic to humans, especially young children and immu
267 ough the H5N8 virus has been only moderately pathogenic to mammalian hosts, virulence can still incre
268 s is a form of programmed cell death that is pathogenic to several acute and chronic diseases and exe
277 ly actionable genomic findings (for example, pathogenic variants in BRCA1) identified in the course o
278 g, and linkage analysis to identify putative pathogenic variants in candidate disease genes for tooth
279 inant Robinow syndrome, we also found likely pathogenic variants in candidate genes GPC4 and RAC3, bo
281 cedented power to detect three categories of pathogenic variants in particular: structural variants,
282 ures distinguished the cases associated with pathogenic variants in specific genes from each other or
285 entations because accurate interpretation of pathogenic variants is critical for delivering solid cli
286 u knock-out is lethal in mice, and recessive pathogenic variants of this gene have never been reporte
288 other eight families segregation of multiple pathogenic variants was observed, affecting 19 genes tha
295 ember of the Filoviridae family, is a highly pathogenic virus that causes severe hemorrhagic fever in
296 e population diversity of an important plant-pathogenic virus, we performed evolution experiments wit
300 The factors responsible for the emergence of pathogenic ZIKV are not understood at this time, althoug
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