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1 LRRK2 G2019S carriers may reflect a distinct pathogenic mechanism.
2 lso impairs translation, suggesting a common pathogenic mechanism.
3 and provides further understanding of their pathogenic mechanism.
4 ogenic malignant state through a TF-mediated pathogenic mechanism.
5 were detected, suggesting an immune-mediated pathogenic mechanism.
6 in the same individuals, suggesting similar pathogenic mechanisms.
7 ia is a heritable brain illness with unknown pathogenic mechanisms.
8 suggesting that the 2 syndromes share common pathogenic mechanisms.
9 model for investigating plasmid-independent pathogenic mechanisms.
10 r concomitant symptoms, suggesting different pathogenic mechanisms.
11 hese disorders and little is known about the pathogenic mechanisms.
12 disease, yet we know very little about their pathogenic mechanisms.
13 ty of the infection and provide insight into pathogenic mechanisms.
14 choring proteins could provide insights into pathogenic mechanisms.
15 of sulfur metabolism with poorly understood pathogenic mechanisms.
16 Typical therapies try to reverse pathogenic mechanisms.
17 verse etiologies are likely due to different pathogenic mechanisms.
18 ndation for further revealing the chlamydial pathogenic mechanisms.
19 se that might shed light on their respective pathogenic mechanisms.
20 sis of lupus nephritis involves a variety of pathogenic mechanisms.
21 gments, suggesting a chirality of underlying pathogenic mechanisms.
22 ses with distinct clinical presentations and pathogenic mechanisms.
23 n and human disease, and delineate potential pathogenic mechanisms.
24 taneous NVP HSR and advance insight into its pathogenic mechanisms.
25 milar in Ig-MPGN and C3G, suggesting similar pathogenic mechanisms.
28 argets and viral proteins, suggesting common pathogenic mechanisms among obligate intracellular micro
30 ansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approac
31 sease, reflecting possible variations in the pathogenic mechanism and in host and exposure risk facto
32 2A rRNA hypermethylation is unlikely to be a pathogenic mechanism and may be an artefact of previous
38 dynamic events is critical for understanding pathogenic mechanisms and development of effective treat
39 ad nature of this damage makes understanding pathogenic mechanisms and devising new treatments diffic
41 -mutant can be used for studying the disease pathogenic mechanisms and for testing novel therapies fo
42 sensitive asthma and to use them to identify pathogenic mechanisms and investigate new treatment appr
44 early multiple sclerosis lesion and identify pathogenic mechanisms and opportunities for therapy.
45 iatric diseases, little is known about their pathogenic mechanisms and potential therapeutic interven
46 cribe the animal models available to uncover pathogenic mechanisms and related host immune responses.
47 elop suitable experimental models to explore pathogenic mechanisms and therapeutic opportunities.
49 remains unclear whether these factors share pathogenic mechanisms and whether links exist with islet
52 orroborating clinical assessments, informing pathogenic mechanisms, and revealing new therapeutic tar
58 DL2 have similar clinical profiles, distinct pathogenic mechanisms are likely to drive toxicity in Dr
61 n amyloid-beta (Abeta) production is a major pathogenic mechanism associated with Alzheimer's disease
62 oach to AD therapeutics by stabilizing early pathogenic mechanisms associated with synaptic abnormali
65 ow PSEN1 mutations cause FAD is unclear, and pathogenic mechanisms based on gain or loss of function
66 how that high c-Jun elevation is a potential pathogenic mechanism because it inhibits myelination.
67 The need for individualized definitions of pathogenic mechanisms before initiating therapy extends
68 al, and genetic evidence suggest overlapping pathogenic mechanisms between autism spectrum disorder (
73 and the biological function of PDZD7 and the pathogenic mechanism caused by PDZD7 mutations, we gener
74 rmore, in R6/2 mice, LNA-CTG blocked several pathogenic mechanisms caused by expanded CAG RNA, includ
75 rs underlying the formation of CPB and their pathogenic mechanism closely resemble those responsible
76 hese findings provide the first evidence for pathogenic mechanisms common to human cerebral malaria a
77 transgenic Xenopus laevis to investigate the pathogenic mechanism connecting light exposure and RD in
79 -mediated SHF deployment may be an important pathogenic mechanism contributing to OFT malformations i
84 in common with other neurodegenerations, the pathogenic mechanisms culminating in ALS phenotypes begi
85 studies establish for the first time that a pathogenic mechanism described previously in pulmonary f
86 occur in the AD circulation and suggest new pathogenic mechanisms, diagnostic tests, and therapies f
87 ective treatment for HD, in part because the pathogenic mechanism driving the disease is not fully un
88 causes a spectrum of liver diseases, but the pathogenic mechanisms driving the onset and progression
89 of which may lead to the development of key pathogenic mechanisms during acute and chronic diseases.
90 , facilitating research toward understanding pathogenic mechanisms, evaluation of therapeutic outcome
91 t perturbation of ALP function is a relevant pathogenic mechanism for AD-ANCL and supports the use of
94 neuropathy type 1E (HSAN1E) and a potential pathogenic mechanism for DNA methyltransferase (DNMT1) m
95 , our data thus unveil a clinically relevant pathogenic mechanism for HSCR that involves cell-autonom
97 umulatively, our results highlight a complex pathogenic mechanism for PD where short- and long-term o
98 These findings identify an in vivo molecular pathogenic mechanism for R91W mutation and provide a fea
100 ferentiation to myofibroblast might be a key pathogenic mechanism for the accumulation of myofibrobla
101 sing cells during development is a plausible pathogenic mechanism for the heterozygous mutations.
102 ngiotensin system (RAS) has emerged as a key pathogenic mechanism for these disorders; angiotensin (A
103 berrant target recognition as the underlying pathogenic mechanism for this novel KS-associated varian
106 activated epithelial cells, pointing to new pathogenic mechanisms for future clinical intervention.
108 , and leads to a better understanding of the pathogenic mechanisms for these diseases of complement d
110 marrow transplantation to target the primary pathogenic mechanism (GALC deficiency) and two secondary
111 ease heterogeneity and poor understanding of pathogenic mechanisms hampers the identification of ther
115 nantly muscle-specific phenotype a number of pathogenic mechanisms have been proposed, including a di
118 to abnormalities of translational control, a pathogenic mechanism implicated in an increasing number
119 al tubular epithelial cells is a fundamental pathogenic mechanism implicated in both acute kidney inj
123 creasing oxidative stress, revealing another pathogenic mechanism in C9ORF72-related ALS and FTD.
125 rus but provides a testable hypothesis for a pathogenic mechanism in culture-negative endophthalmitis
126 mpromises adhesion, and that this is a major pathogenic mechanism in DSG2-related and probably other
127 aberrant neovascularization is an essential pathogenic mechanism in many human diseases, including d
128 AR-gamma and GLUT-1 by E. coli K1 is a novel pathogenic mechanism in meningitis, and pharmacological
134 rization and oxidant generation as potential pathogenic mechanism in SCD as well as a modulator of he
138 und to have critical roles in regulating key pathogenic mechanisms in allergic inflammation, includin
141 ns for identifying preventive strategies and pathogenic mechanisms in autism and other neurodevelopme
142 s direct interaction might contribute to the pathogenic mechanisms in complement-mediated, inflammato
145 ion of many potential therapeutics targeting pathogenic mechanisms in in vitro models, there has been
146 ajor recent developments in understanding of pathogenic mechanisms in inflammatory and paraproteinaem
148 r patients will be required to elucidate the pathogenic mechanisms in patients with PV who have nonpa
150 ns for identifying preventive strategies and pathogenic mechanisms in schizophrenia and other neurode
151 gyric cortical dysplasias, suggesting shared pathogenic mechanisms in terms of microtubular function
153 tual disability, prompts us to hypothesize a pathogenic mechanism, in which APP acts as a modulator o
154 nflammatory cells that are implicated in the pathogenic mechanism, including mast cells, basophils, a
156 unction in Krabbe disease is compounded by a pathogenic mechanism involving at least the failure of N
157 ith Alzheimer's disease, suggesting a common pathogenic mechanism involving macrophage phagocytosis a
158 This association could be due to shared pathogenic mechanisms involving elevated matrix metallop
162 myloid beta protein (Abeta) is a fundamental pathogenic mechanism leading to the neuronal damage pres
163 nimals have shed light on previously unknown pathogenic mechanisms leading to the identification of p
165 provide an attractive model to discover the pathogenic mechanisms linking aberrant pre-messenger RNA
168 coli (EIEC) is a unique pathovar that has a pathogenic mechanism nearly indistinguishable from that
169 ion in larger prospective studies, and their pathogenic mechanisms need to be better understood.
170 ling in 22q11DS mice, and it may mediate the pathogenic mechanism of 22q11DS-related psychosis and co
173 itochondrial calcium deregulation is a novel pathogenic mechanism of cognitive deficiencies in schizo
177 viruses and thus shed important light on the pathogenic mechanism of human arenavirus pathogens.
178 ion, our study provides new insight into the pathogenic mechanism of intracellular bacteria to modula
180 ase, with implications for understanding the pathogenic mechanism of Parkinson's disease and for deve
181 provides novel structural insights into the pathogenic mechanism of S427L in mediating proximal rena
182 pport decreased glutamatergic signaling as a pathogenic mechanism of schizophrenia, yet the molecular
183 hese PDI modifications may contribute to the pathogenic mechanism of several diseases associated with
184 ole for LRRK2 in PKA signaling and suggest a pathogenic mechanism of SPN dysfunction in Parkinson's d
185 to be hallmarks of H5N1 virus infection, the pathogenic mechanism of the A(H7N9) virus in humans is l
187 a valuable genetic model for elucidating the pathogenic mechanism of the WDR81 mutation in CAMRQ2.
188 of deafness more than twenty years ago, the pathogenic mechanism of this mutation of ribosomal RNA r
189 production of this cytokine is implicated in pathogenic mechanisms of a number of inflammatory diseas
190 for B. mallei are not well known, and their pathogenic mechanisms of action and host factors are lar
191 database also includes information about 13 pathogenic mechanisms of action for B. mallei and B. pse
192 database also includes information about 10 pathogenic mechanisms of action for B. mallei secretion
193 ins for B. mallei and B. pseudomallei, their pathogenic mechanisms of action, and host factors are no
195 is study may deepen our understanding of the pathogenic mechanisms of ALS and other devastating disea
196 provides novel mechanistic insights into the pathogenic mechanisms of apoE4 and insulin resistance in
203 tegy for UFCRC, and provide insight into the pathogenic mechanisms of colorectal carcinogenesis.
205 es across all networks reflected established pathogenic mechanisms of diabetes complications, such as
207 SCN should be further evaluated to elucidate pathogenic mechanisms of diseases involving blood pressu
208 y A potential agent of bioterrorism, but the pathogenic mechanisms of F. tularensis are largely unkno
209 ome and NAFLD in rodents and humans, but the pathogenic mechanisms of fructose-induced metabolic synd
210 citing advances reveal the complexity of the pathogenic mechanisms of FTD and ALS and suggest promisi
212 r findings may help understand the potential pathogenic mechanisms of HAART-associated NeuroAIDS and
217 ssing a human mutant VCP in neurons to study pathogenic mechanisms of mutant VCP-mediated neurodegene
221 Delineation of shared and disease-specific pathogenic mechanisms of remodelling between the sinonas
225 dopamine hypothesis attempts to explain the pathogenic mechanisms of the disorder, and the neurodeve
228 adenovirus 1 (MAV-1) infection to study the pathogenic mechanisms of this important cause of pediatr
229 RRT2 at the synapse and the understanding of pathogenic mechanisms on the basis of PRRT2-related neur
230 ations are necessary to better elucidate the pathogenic mechanisms, our report includes a treatment p
231 types, clinical presentations, risk factors, pathogenic mechanisms, outcome assessment, therapeutic r
232 ortality benefit; this may reflect competing pathogenic mechanisms, patient heterogeneity, or true in
233 ivitis (VKC) is a severe ocular allergy with pathogenic mechanism poorly understood and no efficaciou
236 ad to neurodegeneration and are amplified by pathogenic mechanisms related to brain ageing and accumu
237 in Eda and Edar mutant mice and explore the pathogenic mechanisms related to glandular function, mic
238 research focused on establishing convergent pathogenic mechanisms relevant to the potential treatmen
240 osis (IPF) is a devastating disease, and its pathogenic mechanisms remain incompletely understood.
241 in various human diseases, but miRNA-related pathogenic mechanisms remain incompletely understood.
247 These communications enable the critical pathogenic mechanism responsible for the maculopathy, na
249 of gastroenteritis across the globe, but the pathogenic mechanisms responsible for disease are not we
250 the course of MS is driven by the very same pathogenic mechanisms responsible for the disease, the a
252 associated neuroinflammation is a potential pathogenic mechanism resulting in neuronal damage and de
253 humans, and used this system to explore the pathogenic mechanisms resulting from the sporadic Alzhei
254 ddress the symptoms but also the underlining pathogenic mechanism(s) and prevent airway remodelling.
255 ic pathways in lupus nephritis, the emerging pathogenic mechanism(s) may be encountered with new indi
256 Recent studies have begun to reveal common pathogenic mechanisms shared by AD and metabolic disorde
257 m and that this may be linked to other known pathogenic mechanisms such as mitochondrial dysfunction.
258 , independent of age, suggesting that common pathogenic mechanisms, such as abnormal immune response
259 rearrangements and provides insight into new pathogenic mechanisms, such as altered regulation due to
260 nsistent with the notion of loss of CSE as a pathogenic mechanism, supplementation with cysteine reve
261 ation is a hallmark of many cancers, yet the pathogenic mechanisms that distinguish cancer-associated
263 nced considerably in recent years, revealing pathogenic mechanisms that potentially underlie ciliopat
264 for idiopathic pulmonary fibrosis (IPF), the pathogenic mechanisms that underlie the effects of advan
265 odegenerative proteinopathies share a common pathogenic mechanism: the abnormal accumulation of disea
266 s and polyglutamine diseases, share a common pathogenic mechanism: the abnormal accumulation of disea
267 diverse pathologies with distinct underlying pathogenic mechanisms; the final disease outcome is then
268 this cholesterol trafficking defect, but the pathogenic mechanisms through which NPC1 deficiency caus
271 means of testing the hypothesis that common pathogenic mechanisms underlie ADHD and these other neur
274 ovide a cellular phenotype for investigating pathogenic mechanisms underlying AS and identifying nove
278 gest fundamental differences in the dominant pathogenic mechanisms underlying MFS, SSS and the acrome
282 g protein (RBP) impedes the clarification of pathogenic mechanisms underlying TDP-43 proteinopathy.
283 stantial gaps remain in our understanding of pathogenic mechanisms underlying the development of type
284 al PD subtypes have been identified, but the pathogenic mechanisms underlying the observed clinicopat
287 ic stroke has long been recognized; yet, the pathogenic mechanisms underlying this relationship are i
288 a high relevance of these processes for the pathogenic mechanisms underlying this type of vasculitis
289 how red blood cells (RBCs) are produced, the pathogenic mechanisms underlying various forms of anemia
293 thus providing a unique opportunity to study pathogenic mechanisms unrelated to alpha-synuclein toxic
299 at onset in HD and SCAs, suggesting a common pathogenic mechanism, which could operate through the ob
300 nalling reconciles the existence of a shared pathogenic mechanism with the biological and clinical he
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