ライフサイエンスコーパス: pathogenicity

1 rovided functional evidence to support their pathogenicity.

2 he determinants of host-specific Ebola virus pathogenicity.

3 strating that the plasmid does not influence pathogenicity.

4 o escape and modulate autophagy for enhanced pathogenicity.

5 ction may contribute to differences in viral pathogenicity.

6 RNA and on host proteins for replication and pathogenicity.

7 responsive signalling are crucial for fungal pathogenicity.

8 tic activity was required to maintain cancer pathogenicity.

9 tructures, consequently resulting in loss of pathogenicity.

10 ependent replication before making claims of pathogenicity.

11 T, are unlikely to represent markers of CPVT pathogenicity.

12 th certain mechanisms of immune function and pathogenicity.

13 to Indiana turkeys, in which it evolved high pathogenicity.

14 gastrointestinal chlamydiae in genital tract pathogenicity.

15 tent with the key role of biofilms in fungal pathogenicity.

16 ced by Avrb6, a TAL effector determining Xcm pathogenicity.

17 on raise the prospect of facile reversion to pathogenicity.

18 e L3 region may therefore play a key role in pathogenicity.

19 ynthesis and are implicated in virulence and pathogenicity.

20 ibility and not to modifications of parasite pathogenicity.

21 Metabolism is integral to pathogenicity.

22 factorial process leading to strain-specific pathogenicity.

23 ty, proinflammatory cytokine production, and pathogenicity.

24 -quinolone molecules which are important for pathogenicity.

25 to Indiana turkeys, in which it evolved high pathogenicity.

26 ecies production abrogates influenza A virus pathogenicity.

27 icient NDV infection and their role in avian pathogenicity.

28 n be predicted and directly tested to assess pathogenicity.

29 s information may be useful in prediction of pathogenicity.

30 iator of bacterial physiology, motility, and pathogenicity.

31 this large deletion in virus propagation and pathogenicity.

32 in relation to overall fungal physiology and pathogenicity.

33 defining characteristic of alphaherpesvirus pathogenicity.

34 e (PCS) that can affect virus activation and pathogenicity.

35 which represent key components of bacterial pathogenicity.

36 important roles in growth, conidiation, and pathogenicity.

37 as being important in cellular transport and pathogenicity.

38 ementary DNA sequencing were used to confirm pathogenicity.

39 Here we provide a first rationale for N184K pathogenicity.

40 ands, is a host determinant of K. pneumoniae pathogenicity.

41 associated with antimicrobial resistance and pathogenicity.

42 data were known and used to evaluate strain pathogenicity.

43 GEnCs, confirming their potential glomerular pathogenicity.

44 rice were used to test RBSDV infectivity and pathogenicity.

45 is an important factor contributing to ZIKV pathogenicity.

46 ave reduced fucosylation that enhances their pathogenicity.

47 tically important aspects of M. tuberculosis pathogenicity.

48 mplete understanding of PEDV replication and pathogenicity.

49 erosol transmission, affecting virulence and pathogenicity.

50 es after adoptive transfer, indicating their pathogenicity.

51 an endosomal NOX2 inhibitor decreases viral pathogenicity.

52 nd sequestration plays a significant role in pathogenicity.

53 olavirus genus which greatly differ in their pathogenicity.

54 n failed appressorium function and decreased pathogenicity.

55 red a promising strategy to combat bacterial pathogenicity.

56 ce for which there is inadequate evidence of pathogenicity.

57 mechanical stability and also play roles in pathogenicity.

58 t of the host intestine to enhance bacterial pathogenicity.

59 nd represents an important step in microbial pathogenicity.

60 lets with TC-PC177 or PC21A to compare their pathogenicities.

61 We selected the low-pathogenicity A/duck/Hokkaido/69/2000 (H5N3) (dk/Hok/00)

62 onsible for enhanced viral dissemination and pathogenicity, although these effects were augmented by

63 were filtered, validated, and prioritized by pathogenicity analysis.

64 Phages play key roles in the pathogenicity and adaptation of the human pathogen Staph

65 tion will provide greater insight into viral pathogenicity and antiviral responses.

66 s are relevant for understanding V. cholerae pathogenicity and are mediated through the periplasmic b

67 How TH cells acquire pathogenicity and communicate with myeloid cells and cel

68 Because the pathogenicity and demyelinating properties of anti-MAG a

69 on of the molecular mechanisms of chlamydial pathogenicity and development of medical utility of the

70 Because of its high pathogenicity and lack of licensed antivirals and vaccin

71 Because of the pathogenicity and low incidence of avian influenza virus

72 their unique aspects that contribute to the pathogenicity and persistence of these emerging pathogen

73 hlight RNA-binding proteins as regulators of pathogenicity and potential targets of antimicrobial the

74 ers serve diverse functions including aiding pathogenicity and protecting against predators.

75 ghts into host determinants of K. pneumoniae pathogenicity and raises the possibility that functional

76 eceptor preference have led to the increased pathogenicity and rapid spread of CV-A24v.

77 of low-temperature of cold tolerance, fungal pathogenicity and specialized host infection.

78 fection, which we subsequently used to study pathogenicity and to examine antiviral efficacy of the n

79 We determined the pathogenicity and transmissibility of influenza A/Italy/

80 r in vitro genetic compatibility and in vivo pathogenicity and transmissibility.

81 l properties of this subtype, especially the pathogenicity and transmission in mammals, are not known

82 the relevance of the colony biofilm model to pathogenicity and underscore the potential of cbb3-type

83 idial mass production as well as improve the pathogenicity and virulence of entomopathogenic fungi in

84 source, allowing for varying survivability, pathogenicity and virulence of pathogen strains, and var

85 ation, appressorial formation as well as its pathogenicity and virulence.

86 play critical roles in bacterial physiology, pathogenicity, and antibiotic resistance.

87 tors of bacterial growth, stress adaptation, pathogenicity, and antibiotic tolerance.

88 cterize determinants of host/tissue tropism, pathogenicity, and antigenicity for the development of a

89 nctionally important in host/tissue tropism, pathogenicity, and antigenicity in other parvoviruses an

90 E, with myelin antigen processing and T cell pathogenicity, and identify ATG-dependent phagocytosis i

91 nt MAPPIN (Method for Annotating, Predicting Pathogenicity, and mode of Inheritance for Nonsynonymous

92 te fundamental molecular mechanisms of viral pathogenicity, and the specific targeting of this pathog

93 and the role of potential antibody-mediated pathogenicity as part of the pathophysiology cascade in

94 thmatic patients, and the features of T-cell pathogenicity at the single-cell level.

95 ecular and antigenic features related to low pathogenicity avian influenza A(H3N2) viruses and were d

96 9 ca The second approach was to select a low-pathogenicity avian influenza H5 virus that elicited ant

97 e SDPs will explain the differences in human pathogenicity between Reston and the other four ebolavir

98 e changes were functionally tested for their pathogenicity by assaying the impact on complex formatio

99 cies production paradoxically promotes virus pathogenicity by mechanisms not yet defined.

100 in RESTV-infected MDMs contributes to lower pathogenicity by preventing the cytokine storm observed

101 al tissues, contributes to Y. enterocolitica pathogenicity by undermining protective antibacterial re

102 The virus appears to have gained significant pathogenicity, causing serious human diseases, including

103 definition of cosegregation as criteria for pathogenicity classification.

104 We developed M-CAP, a clinical pathogenicity classifier that outperforms existing metho

105 d organs donor cells undergo "licensing" for pathogenicity, consisting of vigorous increase in number

106 This increase in pathogenicity correlated to an increase in RABV mRNA and

107 , and provide a foundation for understanding pathogenicity determinants in economically important Par

108 Unlike commonly-used predictors of pathogenicity, DOMINO takes into consideration features

109 f genetics requires that we accurately infer pathogenicity even for rare or private variation.

110 Therefore, SBV mutants can retain pathogenicity even when they are unable to fully control

111 riptome analyses, phylogenetic analyses, and pathogenicity experiments were performed.

112 Because of its extreme pathogenicity, F. tularensis is classified as a category

113 shmaniavirus (LRV1) has been implicated as a pathogenicity factor for leishmaniasis in rodent models

114 olog TrkAH have been implicated as bacterial pathogenicity factors, the discovery of this functionall

115 A typical pathogenicity filter identified causal variants for NS i

116 complement activation, and reduced antibody pathogenicity following treatment with immunoglobulin pr

117 ells sensitized against autoantigens acquire pathogenicity following two sequential events, namely ac

118 MAPPIN also correctly predicts pathogenicity for 87.3% of mutations from the Decipherin

119 ase-causing mutations and accurately predict pathogenicity for all mutations.

120 umed to be the primary site of infection and pathogenicity for astroviruses.

121 tion capacity of these viruses and potential pathogenicity has been difficult to ascertain.

122 hrough the secretion system, but its role in pathogenicity has remained unknown.

123 ly influenced by multiple factors, including pathogenicity, host factors, vaginal microbiome, false-n

124 To investigate differences in viral pathogenicity, humanized mice (hu-NSG-SGM3) were inocula

125 d thus providing a unique model for studying pathogenicity, immunity, vaccines, and antiviral drugs.

126 ibodies during infection, and contributes to pathogenicity in a mouse aerosol challenge model.

127 tion reduces virulence factor expression and pathogenicity in a murine model of pneumonia.

128 t DeltalasR mutant also enhances C. albicans pathogenicity in coinfection and induces extrusion of th

129 HgGLAND18 is necessary for pathogenicity in compatible interactions with soybean.

130 Results suggest high MRSA pathogenicity in dental wards highlighting the need for

131 cally ambiguous taxa with various degrees of pathogenicity in different hosts.

132 herefore influences the viral host range and pathogenicity in different species.

133 KP isolates, two had no evidence of enhanced pathogenicity in either mouse model, demonstrating that

134 flaviviral RNAs (sfRNAs) that are linked to pathogenicity in fetal mice.

135 nsidered biologically inert potentiate viral pathogenicity in honey bee larvae, and guidelines for OS

136 not been sufficient evidence to prove their pathogenicity in humans, and no variants in PALB2 that d

137 s species are associated with widely varying pathogenicity in humans, ranging from asymptomatic infec

138 vity, replication kinetics, plaque size, and pathogenicity in inbred mice.

139 on causes defects in growth, development and pathogenicity in M. oryzae.

140 decreased interferon signaling and increased pathogenicity in mice.

141 uble mutant showed a significantly increased pathogenicity in mice.

142 ected, and they also resulted in reduced IAV pathogenicity in mice.

143 binding (Zalpha) domain that is critical for pathogenicity in mice.

144 influences cholangiocyte tropism and reduces pathogenicity in mice.IMPORTANCE Rotavirus is the leadin

145 ritis in genome-wide association studies and pathogenicity in murine inflammatory disease models.

146 e important biological roles with respect to pathogenicity in some fungi but not in others.

147 of particular interest given their potential pathogenicity in the corresponding phenotypes and least

148 f the gastrointestinal tract with chlamydial pathogenicity in the upper genital tract suggests a pote

149 gastrointestinal tract may contribute to its pathogenicity in the upper genital tract.

150 tract, which correlated with its attenuated pathogenicity in the upper genital tract.

151 eading to the gastrointestinal tract and its pathogenicity in the upper genital tract.

152 ointestinal tract positively correlated with pathogenicity in the upper genital tract.

153 to block host gene expression showed reduced pathogenicity in vivo However, a virus where the ability

154 XP3 expression and IL-10 secretion, and lost pathogenicity in vivo.

155 0 expression by Th1 cultures, reducing their pathogenicity in vivo.

156 porating two of the stalk mutations retained pathogenicity in vivo.

157 orm of flagella-based motility necessary for pathogenicity; indeed, spirochaete flagella (periplasmic

158 nt and susceptible to infection with the low pathogenicity influenza virus A/Turkey/England/647/77 as

159 t innate immune responses and modulate virus pathogenicity involves the ability of the PA-X and NS1 p

160 of close saprophytic relatives reveals that pathogenicity is associated with remarkable expansions o

161 al factors that underlie V. parahaemolyticus pathogenicity is limited.

162 Our study demonstrates that Kit(mut)'s pathogenicity is related to its mis-localization, and ma

163 igger inflammation in host cells via its cag pathogenicity island (cag PAI) type IV secretion system

164 ing directly to promoters on the Francisella Pathogenicity Island (FPI) and positively regulating the

165 stems from genes encoded on the Francisella pathogenicity island (FPI).

166 The Yersinia high-pathogenicity island (HPI) is common to multiple virulen

167 rinary E. coli isolates is the Yersinia high pathogenicity island (HPI), which directs the biosynthes

168 ls infected with either cagA-negative or cag pathogenicity island (PAI) mutant.

169 rry the Locus of Enterocyte Effacement (LEE) pathogenicity island (PAI), which encodes genes that med

170 enhanced bacterial expression of Salmonella pathogenicity island 1 (SPI-1) genes and increased intra

171 biquitination is triggered by the Salmonella pathogenicity island 1 (SPI-1) T3SS effectors SopB and S

172 terica subsp. salamae encodes the Salmonella pathogenicity island 1 (SPI-1), SPI-2, and the locus of

173 Here, starting with the 35 kb Salmonella pathogenicity island 1 (SPI-1), we eliminated internal r

174 ransferase Pat regulates genes on Salmonella Pathogenicity Island 1 (SPI1) that are required for the

175 ical Salmonella enterica serovar Typhimurium pathogenicity island 1 basal body, determined using sing

176 nuclear leukocytes, SipA or other Salmonella pathogenicity island 1 effectors had no effect on induct

177 effect was dependent on an intact Salmonella pathogenicity island 2 (SPI-2) type 3 secretion system.

178 Salmonella virulence depends in part on its pathogenicity island 2 type III secretion system (SPI-2

179 ses of H. pylori status, carriage of the cag pathogenicity island and assignment of H. pylori to phyl

180 A loss of cag pathogenicity island function was observed in 3 reisolat

181 interleukin 8 from AGS cells (to detect cag pathogenicity island function), neutral red uptake (to d

182 A (SspA) complex and the DNA-binding protein pathogenicity island gene regulator (PigR)-activates FPI

183 amidinotransferase enzyme located in the Hrp pathogenicity island, is required for systemic infection

184 thesis operon, the betA-betB operon, and the pathogenicity island, SaPI5, while virulence genes were

185 ments cancer risk is the strain-specific cag pathogenicity island, which encodes a type IV secretion

186 icobacter pylori strains that harbor the cag pathogenicity island, which encodes a type IV secretion

187 that induce the cycle of some Staphylococcal pathogenicity islands (SaPIs) by binding to the SaPI-enc

188 e clinically important Staphylococcus aureus pathogenicity islands (SaPIs) use this tactic to spread

189 Staphylococcus aureus pathogenicity islands (SaPIs), such as SaPI1, exploit sp

190 cells through the mobilization of S. aureus pathogenicity islands (SaPIs).

191 Here we show that their multiple pathogenicity islands form together a coherently organiz

192 induction of bacteriophages, the movement of pathogenicity islands, and the expression of virulence f

193 out 287 conidiation, colony sectorization or pathogenicity loci, many of which have not been reported

194 bal food security, little is known about the pathogenicity mechanisms employed by R. solani.

195 Despite their significant impact, the pathogenicity mechanisms of these bacteria are not yet c

196 anisms through culture will allow us to test pathogenicity models with viable microorganisms.

197 ied for diagnostic purposes and have unknown pathogenicity, need to be assessed with regards to their

198 o investigate this within the A2 domain, the pathogenicity of a diverse panel of antihuman fVIII A2 d

199 Pathogenicity of all previously unreported missense vari

200 biotic piglet model to study determinants of pathogenicity of C. jejuni.

201 opulations coupled with the putative reduced pathogenicity of C. perfringens by BEOs contributed to t

202 rveillance to assess mutations affecting the pathogenicity of circulating viruses.IMPORTANCE Influenz

203 Pathogenicity of CNVs was assessed based on the American

204 ghlights the importance of investigating the pathogenicity of de novo variants because they are not a

205 Therefore, this study sought to evaluate the pathogenicity of de novo variants previously associated

206 The underlying mechanisms determining the pathogenicity of different ebolavirus species are not ye

207 nclusion, coinfections are frequent, and the pathogenicity of each organism appears to be enhanced by

208 ociation and the parameters representing the pathogenicity of each variant and the mode of inheritanc

209 However, its role in the development and pathogenicity of filamentous fungi such as the rice blas

210 daptation, fungal evolution, host range, and pathogenicity of fungal plant pathogens in the context o

211 esponse, and thereby contributed to the high pathogenicity of H5N1 virus in mice.

212 her our understanding of the determinants of pathogenicity of H5N1 viruses in mammals.IMPORTANCE High

213 s strong support for role of CNGA2 gene with pathogenicity of ICA in humans.

214 Importantly, pathogenicity of IL-1R1-deficient T cells was fully rest

215 plicated in processes that contribute to the pathogenicity of infection.

216 ships of AIPL1 and reliably establishing the pathogenicity of its variants.

217 Our study confirms the pathogenicity of Kir2.1-52V in 1 patient with long-QT sy

218 BRCA mutations and HR defects, cementing the pathogenicity of L35P.

219 Collectively, these data show the pathogenicity of LAMB2-S80R and provide the first eviden

220 modulator, dictates growth, conidiation and pathogenicity of M. oryzae.

221 of giant viruses, we demonstrated the human pathogenicity of Mimivirus in pneumonia and Marseillevir

222 rner), an ensemble method for predicting the pathogenicity of missense variants on the basis of indiv

223 lasts from affected subjects, confirming the pathogenicity of MRPS34 mutations.

224 In this review we analyze the pathogenicity of nonsynonymous variants in the newly dis

225 Existing algorithms predict pathogenicity of nsSNVs; however, they are unable to dif

226 st cells could play an important role in the pathogenicity of P. aeruginosa infections.

227 osa virulence factor that contributes to the pathogenicity of P. aeruginosa We were able to detect PQ

228 We demonstrate that the pathogenicity of Pseudomonas aeruginosa strains derived

229 Rs-cps is essential for the reproduction and pathogenicity of R. similis.

230 that genetic interactions contribute to the pathogenicity of rare, multigenic copy-number variants (

231 LY expression and activity, which may affect pathogenicity of S. intermedius.

232 i-AMP signalling networks in the biology and pathogenicity of S. mutans.

233 the main causative agent responsible for the pathogenicity of S. scabies and cello-oligosaccharides a

234 Lynch syndrome, associated cancer risks and pathogenicity of several variants in the Icelandic popul

235 linicians undertaking the task to assess the pathogenicity of specific mtDNA mutations.

236 Exposure to hypoxia attenuated the pathogenicity of strains from acute (but not chronic) in

237 uses sequence context alterations to predict pathogenicity of synonymous and non-coding genetic varia

238 a pro-inflammatory cytokine required for the pathogenicity of T helper 17 (Th17) cells but the molecu

239 adigms and warrant further assessment of the pathogenicity of TH1 cells in patients with severe asthm

240 tin ligase Itch, restricts the frequency and pathogenicity of Th17 cells.

241 iR-183, miR-96, and miR-182, can enhance the pathogenicity of Th17 cells.

242 w mutations in the NS1 protein affecting the pathogenicity of the circulating viruses is highly impor

243 immune responses and, as a consequence, the pathogenicity of the circulating viruses is highly relev

244 The pathogenicity of the clinically important yeast, Candida

245 results provide convincing evidence for the pathogenicity of the identified mutations and suggest th

246 ng and complementation studies validated the pathogenicity of the MECR mutations.

247 treatment with IL-17 antibody decreases the pathogenicity of the oral microbiota in diabetic mice; w

248 n E. histolytica and thus contributes to the pathogenicity of the parasite.

249 e response-related pathway in modulating the pathogenicity of the repeat tracts in HD, and possibly,

250 l membrane trafficking in the physiology and pathogenicity of the rice blast fungus.

251 lso identified, which may be involved in the pathogenicity of the sunflower rust pathogen.

252 Together, these studies confirm the pathogenicity of the TBK1 gene duplication in human glau

253 mics simulations and appears to underlie the pathogenicity of the V71F mutant.

254 if this single amino acid (R) influences the pathogenicity of the virus, we generated a recombinant v

255 Potential pathogenicity of these alleles was supported by co-segre

256 To validate and model the pathogenicity of these CDK10 germline mutations, we gene

257 tially affected the systemic replication and pathogenicity of these H5N1 influenza viruses in mice.

258 in isolation is insufficient to explain the pathogenicity of these mutations.

259 We have characterized the pathogenicity of these strains in a mouse ocular model o

260 confusion exists as to how to interpret the pathogenicity of these variants, hindering our ability t

261 bscess, and M. oralis may participate in the pathogenicity of this deadly infection.

262 ous region in zebrafish in order to test the pathogenicity of this structural variant.

263 Studies of the pathogenicity of VA1 are currently impossible because th

264 We demonstrated the pathogenicity of variant p.Gly131Glu by assessing the in

265 rated mouse models in the study of potential pathogenicity of variants of potential clinical interest

266 if and glycosylation of the E protein in the pathogenicity of ZIKV.

267 and evolutionary information to evaluate the pathogenicity or regulatory functions of non-coding vari

268 racteristics that confer a growth advantage, pathogenicity, or cell adaptability in order to better u

269 functionally impair Pol gamma, with greater pathogenicity predicted for the single P587L variant.

270 To our knowledge, MAPPIN is the first nsSNV pathogenicity prediction algorithm that provides mode of

271 83 median score) consistently achieve higher pathogenicity prediction probabilities than control vari

272 a plethora of tools are available for making pathogenicity predictions over a genome-wide scale, prev

273 e development of "lookup tables" of accurate pathogenicity predictions.

274 profiles, protein spectra, antibiogram, and pathogenicity) properties, we classify Brachyspira hamps

275 tional significance of glycosylation in ZIKV pathogenicity, recombinant ZIKVs from infectious clones

276 Pathogenicity-related factor prediction, orthology and m

277 considerable number of (small) secreted and pathogenicity-related proteins were only found in these

278 ents to spatially organize the metabolism of pathogenicity-relevant carbon sources, such as 1,2-propa

279 L. pneumophila pathogenicity relies on secretion of more than 300 effec

280 has been linked to intestinal disorders, its pathogenicity remains controversial because most carrier

281 signatures contribute to the differences in pathogenicity reported for ebolavirus species and sugges

282 er-base single nucleotide polymorphism (SNP) pathogenicity scores across relevant genomic intervals f

283 extremely rare in human populations and have pathogenicity scores highly suggestive of a functional e

284 PA-X and NS1 (PAMUT(-)/NS1MUT(+)) presented pathogenicity similar to that of a virus containing both

285 (56.7%) caused 100% mortality and 24 were of pathogenicity similar to that of A/Anhui/1/2013 (H7N9),

286 the lung is the organ where "licensing" for pathogenicity takes place is based on biased data collec

287 pacity for earlier dissemination and greater pathogenicity than the parental virus.

288 several dynamic factors, including bacterial pathogenicity, the fitness costs of resistance in the hu

289 iral determinants of CHIKV dissemination and pathogenicity, their further study should help to elucid

290 matode Heterorhabditis bacteriophora and its pathogenicity toward insect larvae.

291 Here we present the Transcript-inferred Pathogenicity (TraP) score, which uses sequence context

292 Decreased pathogenicity was correlated with diminished virus repli

293 tegrity, resistance to external stresses and pathogenicity was evaluated.

294 VACV-E3LDelta83N is attenuated in vivo, and pathogenicity was restored in either RIPK3- or DAI-defic

295 berrant kidney cell proliferation leading to pathogenicity, we generated mouse models expressing thes

296 netic basis of highland adaptation of fungal pathogenicity, we present here the 116 Mb de novo assem

297 These pathogenicities were significantly reduced by MLA, sugge

298 h, conidiation, appressorium penetration and pathogenicity, which is similar to the phenotype of the

299 ous viral infections could likewise increase pathogenicity, which was tested by coinfecting mice with

300 was more consistent than that of chlamydial pathogenicity with ascending infection in the genital tr