ライフサイエンスコーパス: pathologic

1 tastases with a > 1.0 cm diameter all showed pathologic (18)F-FET uptake, which did not correlate wit

2 drenergic agonists confer protection against pathologic airway changes is warranted.

3 G, (18)F-PBR111, and (18)F-AV45 all detected pathologic alterations between TG and WT mice, only (18)

4 rlaps between the principal clusters of both pathologic alterations in the heteromodal association re

5 of the cortical distribution of early-stage pathologic alterations is critical in understanding the

6 g Brain Study, determine spatial patterns of pathologic alterations, and provide means for improved i

7 the expression of host prion protein or its pathologic amyloid form.

8 Molecular marker studies and pathologic analyses from surgical excision were reviewed

9 data, incidence of complications, and nodule pathologic analyses were assessed through electronic med

10 Radiographs of the specimen and pathologic analysis helped verify target and reflector r

11 Gross pathologic analysis showed gradual device resorption unt

12 Pathologic analysis was reviewed.

13 to be in complete remission by conventional pathologic analysis.

14 mined progression, definitive treatment, and pathologic and biochemical outcomes after delayed radica

15 Our findings suggest that some of the pathologic and clinical alterations of T2D might be tran

16 ods We genotyped 102 ACCs that had available pathologic and clinical data.

17 l networks are mechanistically linked to the pathologic and clinical features of Alzheimer's disease

18 Reference standard was pathologic and imaging follow-up.

19 splayed a striking acquisition of CC-related pathologic and molecular features, which was absent in t

20 endent network, will unveil novel intestinal pathologic and therapeutic targets for diabetes and obes

21 rectomy, and in CS-exposed mice, we assessed pathologic and ultrastructural renal lesions, and measur

22 ations between GRPR expression and clinical, pathologic, and biologic parameters.

23 bgroups characterized by distinct molecular, pathologic, and clinical features, with clear relevance

24 Together, extension of these clinical, pathologic, and genetic associations from tissue to the

25 Clinical, pathologic, and molecular risk stratification should be

26 e cohort study to characterize the clinical, pathologic, and survival implications of (non-V600) BRAF

27 caffeine attenuated not only hypoxia-induced pathologic angiogenesis, but also hyperoxia-induced vaso

28 Results Surgical-pathologic assessment demonstrated DCIS components in 13

29 the absence of inflammation, a biofilm with pathologic bacteria can cover implant surfaces exposed t

30 tiple anatomical targets to study normal and pathologic brain function.

31 the role of neurotransmitters in normal and pathologic brain function.

32 d initial (18)F-FDG PET/CT within 3 mo after pathologic breast cancer diagnosis and before initial tr

33 form a genome-wide association study for NFT pathologic burden and report the association of the PTPR

34 Delirium (never vs ever) and pathologic burden of neurofibrillary tangles, amyloid pl

35 ession and interactions between delirium and pathologic burden were assessed.

36 in energy production, such as physiologic or pathologic cardiac growth, remain elusive.

37 Neuronal inflammation is the characteristic pathologic change of acute neurologic impairment and chr

38 9-mediated Cdk5 inhibitory peptide reverses pathologic changes and behavioral deficits in the Alzhei

39 ion of Cdk5 inhibitory peptide (CIP) reduces pathologic changes and prevents brain atrophy and memory

40 These pathologic changes decrease cognitive performance and in

41 ns among DHA, APOE genotype, and stage of AD pathologic changes may explain the mixed results of DHA

42 I discuss pathologic changes regulating interstitial myofibroblast

43 ion analysis, but staging of alpha-synuclein pathologic changes was unrelated.

44 SIgA intact or SIgA deficient, we found that pathologic changes were localized almost exclusively to

45 months of treatment of AAV9-GFP-CIP reduced pathologic changes, including tau hyperphosphorylation,

46 d whether curcumin leads to intracellular AD pathologic changes.

47 Pathologic characteristics achieving P<0.1 were added in

48 All patients had normal brain pathologic characteristics at autopsy.

49 Demographic data, pathologic characteristics of tumors, postoperative foll

50 FP-producing tumors that have more favorable pathologic characteristics, lower posttransplant recurre

51 by studying adult patients with normal brain pathologic characteristics.

52 and OS were highest in patients who achieved pathologic complete response (pCR) (P < 0.0001 and P < 0

53 lysis of breast cancers were associated with pathologic complete response (pCR) after neoadjuvant che

54 a model of pathologic response, considering pathologic complete response (pCR) as the complete absen

55 Purpose To determine the pathologic complete response (pCR) rate in estrogen rece

56 ith dual HER2 blockade resulted in increased pathologic complete response (pCR) rates compared with e

57 Prediction in Early Breast Cancer) compares pathologic complete response (pCR) rates of T-DM1 versus

58 A pathologic complete response (pCR; no invasive or in sit

59 ed (DW) magnetic resonance (MR) imaging with pathologic complete response after preoperative combined

60 The current best clinical method to predict pathologic complete response is SUVmax in (18)F-FDG PET/

61 associated with a major pathologic response (pathologic complete response or <5% residual cancer cell

62 cting overall or disease-free survival and a pathologic complete response to preoperative anthracycli

63 Non-resolving inflammation is a central pathologic component of obesity, insulin resistance, typ

64 ation between rs1801198 and OCM markers or a pathologic condition.Thirty-four studies met the inclusi

65 irradiation, chemotherapy, and primary brain pathologic conditions affect magnetic resonance (MR) ima

66 gen content, extraction and metabolism under pathologic conditions and thus advance knowledge of reti

67 mechanism that amplifies bone resorption in pathologic conditions of accelerated bone turnover.

68 Several pathologic conditions of the heart lead to cardiac struc

69 ave been found to influence a broad array of pathologic conditions ranging from heart disease to diab

70 KChIP2 expression or inhibiting miR-34 under pathologic conditions restored channel function and more

71 mpact its function in normal development and pathologic conditions such as NB tumorigenesis.

72 signaling protects podocyte integrity under pathologic conditions, most likely by suppression of TRP

73 lated by an IRF8-independent mechanism under pathologic conditions.

74 ssion in MDSCs when they are generated under pathologic conditions.

75 arrier injury or aggravate such injury under pathologic conditions.

76 ular eosinophilic traps (EETs) under similar pathologic conditions.

77 from the TwinsUK study cohort without ocular pathologic conditions.

78 especially retinal and neuro-ophthalmologic pathologic conditions.

79 bolism (OCM) markers or its association with pathologic conditions.We assessed the association of rs1

80 ents, have short follow-up periods, and lack pathologic confirmation of the diagnosis.

81 Drp1 showed defective efferocytosis and its pathologic consequences in the thymus after dexamethason

82 hages to clear multiple ACs and to avoid the pathologic consequences of defective efferocytosis in vi

83 alpha-synuclein (alpha-SYN) is a major pathologic contributor to Parkinson's disease (PD).

84 To identify pathologic correlates of disease duration in participant

85 tly induced by capillary flow but reduced by pathologic cyclic stretch and inflammatory stimuli.

86 ctious process was based on microbiologic or pathologic data as well as on clinical and radiologic fo

87 LVAD support causes pathologic degradation of von Willebrand factor (vWF) an

88 fferentiation of myofibroblasts culminate in pathologic deposition of collagen.

89 l relationships between areas of distinctive pathologic deposits were then studied.

90 Although beta-amyloid is necessary for the pathologic diagnosis of AD, it is not sufficient to make

91 osis of AD, it is not sufficient to make the pathologic diagnosis or cause dementia.

92 tissue (RDT) has been postulated to restrict pathologic disc displacement.

93 uli suggest that the RDT is not resistive to pathologic disc displacement.

94 ximately 25% of all patients with aggressive pathologic disease in our cohort) who benefit from this

95 anced esophageal cancer, and to evaluate how pathologic disease response to neoadjuvant treatment imp

96 AAV1-mIL-6 showed significantly less plaque pathologic disorder than dox or AAV1-mIL-6 only groups.

97 logic outcomes in mice with moderate amyloid pathologic disorder.

98 ystem activation during various IL-33 driven pathologic disorders.

99 ndings are consistent with the hypothesis of pathologic disruption of a striatopallidal-thalamo-corti

100 The pathologic disulfide HMGB1 isoform progressively increas

101 tein (APP) processing and clearance, and the pathologic effect of certain APP metabolites on ELN func

102 mice resulting in high viral titers without pathologic effects.

103 Hydatidiform moles are intriguing pathologic entities representing abnormal placental vill

104 vasive adenocarcinoma on results of surgical pathologic evaluation.

105 nitored by both sophisticated radiologic and pathologic evaluations.

106 Microglia are activated by any type of pathologic event or change in brain homeostasis.

107 Our study directly demonstrates the pathologic evolution of HCC during advanced tumor develo

108 On pathologic examination of the biopsy samples, all were p

109 even of 215 enrolled patients had PET/CT and pathologic examination results for the abdomen and pelvi

110 Pathologic examination revealed 19 (19.6%) complete and

111 in tumor characteristics, including size at pathologic examination, grade, hormone receptor status,

112 d the explanted liver underwent quantitative pathologic examination.

113 erventions, it is shown successfully to damp pathologic eye oscillations while allowing normal saccad

114 ilan criteria [10.0; 3.7-33.3; P < .001) and pathologic factors (>2 tumors [4.39; 1.32-14.6; P = .02]

115 e analysis controlling for pretransplant and pathologic factors (HR 1.32, P = 0.044).

116 Pathologic factors within the microenvironment that impa

117 ors is predicted by important radiologic and pathologic factors, and is negligible for patients withi

118 Guidelines for SLNB have focused on pathologic factors, but patient factors, such as age, ar

119 in thin melanoma independent of traditional pathologic factors.

120 Hypoxia is a commonly found pathologic feature of HGGs.

121 B lymphocytes are a key pathologic feature of multiple sclerosis (MS) and are be

122 nition by innate T cells may be an important pathologic feature of neuroinflammatory disease and that

123 human cancers, sharing similar clinical and pathologic features as well as oncogenic events, includi

124 For each patient, clinical and pathologic features as well as scan results, including s

125 ionships between SUV and clinical as well as pathologic features in patients with positive findings w

126 Clinical and pathologic features in the livers, including AST, ALT, a

127 An anti-TSLP antibody abrogates all pathologic features of asthma in this model.

128 facial weakness and additional clinical and pathologic features that distinguish it from other conge

129 sted between plasma NFL and diagnosis, Abeta pathologic features, CSF biomarkers of neuronal injury,

130 ion on tumor cells with adverse clinical and pathologic features, including tumor aggressiveness.

131 MCI and patients with AD dementia with Abeta pathologic features.

132 ctor of nodal metastasis, grade, and adverse pathologic features.

133 role for ET receptor-Gbetagamma signaling in pathologic fibroblast activation.

134 of the AP1 transcription factor c-JUN in the pathologic fibroblasts.

135 N and in whom IPMN was confirmed by surgical pathologic findings at a single institution from July 1,

136 th AD progression, and is associated with AD pathologic findings at autopsy.

137 Pathologic findings included diffuse alveolar damage wit

138 hundred seven of 118 patients (90.7%) showed pathologic findings indicative for tumor recurrence in (

139 iated with invasive carcinoma based on final pathologic findings may need to be considered.

140 tion and severity of hyperphosphorylated tau pathologic findings measured by fluorine 18-labeled AV-1

141 ic duct diameter, intraoperative blood loss, pathologic findings of disease, and intraoperative drain

142 is of invasive carcinoma from final surgical pathologic findings were compared by tumor, host, and sy

143 The differential diagnosis, pathologic findings, and diagnosis are discussed.

144 a, clinical information, treatment regimens, pathologic findings, and outcome were analyzed.

145 The differential diagnosis, pathologic findings, genetic testing results, and diagno

146 or lesions were measured in 69 patients with pathologic findings.

147 22.2%) had invasive carcinoma based on final pathologic findings.

148 Forty-three patients showed no pathologic findings.

149 agnosis of invasive carcinoma based on final pathologic findings.

150 d death in Tennessee with novel clinical and pathologic findings.

151 The standard of reference was surgical-pathologic findings.

152 a diagnosis of DCIS based on final surgical pathologic findings.

153 rpose Skeletal-related events (SREs) such as pathologic fracture, spinal cord compression, or the nec

154 However, regulation of the pathologic functions of these cells in vivo is poorly un

155 s been made using genomics to identify novel pathologic genomic rearrangements, as well as therapeuti

156 ha-globin expression and a correction of the pathologic globin chain imbalance in cells from patients

157 (Abeta) accumulation in the brain is 1 of 2 pathologic hallmarks of Alzheimer disease (AD), and the

158 ta (Abeta) proteins in the human brain are 2 pathologic hallmarks of Alzheimer disease (AD).

159 Whether this pathologic heterogeneity is due to a cell of origin of b

160 advances have provided new insights into the pathologic, histologic, and genomic characterization of

161 The exovesicles (EVs) are involved in pathologic host-parasite immune associations and have be

162 arching for potential therapies for treating pathologic hyperbilirubinemia.

163 Chronic cardiac stress induces pathologic hypertrophy and fibrosis of the myocardium.

164 Here, we show that miR-29 promotes pathologic hypertrophy of cardiac myocytes and overall c

165 .e., postnatal development and exercise) and pathologic (i.e., pressure overload) myocardial hypertro

166 Ectopic cAMP signaling is pathologic in polycystic kidney disease; however, its sp

167 ficiency and increased erythropoiesis but is pathologic in thalassemia and hemochromatosis.

168 ntribute to mucosal homeostasis and initiate pathologic inflammation in allergic asthma.

169 gram registries, state tumor registries, and pathologic information databases that identified breast

170 of immune cells to survey tissues and sense pathologic insults and deviations makes them a unique pl

171 re is no experimental functional evidence of pathologic involvement for these cells.

172 the cellular prion protein (PrP(C)) into the pathologic isoform PrP(Sc) is a key feature in prion pat

173 14 clinical and radiologic items and 1 of 5 pathologic items for myositic IOI.

174 14 clinical and radiologic items and 5 of 7 pathologic items related to diagnosis of nonmyositic IOI

175 of infants with exaggerated physiologic and pathologic jaundice but adapts it to the microfluidic le

176 tients, (68)Ga-NeoBOMB1 rapidly localized in pathologic lesions, achieving high-contrast imaging.

177 Pathologic lung fibroblasts from SSc patients modify ECM

178 nd variable case definitions, poor access to pathologic lung tissue and to specimens from fatal cases

179 a disease, positive surgical margins, and/or pathologic lymph node invasion.

180 Stratification factors were pathologic lymph node status, lymph node staging procedu

181 oplastic disorders marked by infiltration of pathologic macrophage-, dendritic cell-, or monocyte-der

182 results reveal astrocytic CN/NFAT4 as a key pathologic mechanism for driving glutamate dysregulation

183 There are still many aspects of the pathologic mechanisms of CSU that need to be resolved, b

184 most cases, details of their physiologic and pathologic mechanisms remain at least partially obscure.

185 h is more closely associated with AD-related pathologic mechanisms.

186 lammation is increasingly considered to be a pathologic mediator of these commonly co-occurring disea

187 a modified version of the Meta-Analysis for Pathologic Myopia.

188 protein interactions that are essential for pathologic neovascularization in the eye.

189 Identification and reversal of these pathologic neuroadaptations are therefore critical for t

190 umor necrosis factor (TNF)-alpha and IL-17A, pathologic neutrophil recruitment, and microvascular rem

191 al ultrasonographic findings, and documented pathologic nodal status.

192 Microglia can strongly influence the pathologic outcome or response to a stressor due to the

193 rectal cancer in adult patients and reported pathologic outcomes (eg, positive circumferential resect

194 d enhance plaque clearance and could improve pathologic outcomes in mice with moderate amyloid pathol

195 lar sprouts and vessels, which suggests that pathologic outcomes of centrosome overduplication depend

196 view and analyze the evidence concerning the pathologic outcomes of laparoscopic (LRR) vs open (ORR)

197 Therefore, pathologic palmitate concentrations promote the acquisit

198 ject to bidirectional modulation by relevant pathologic perturbations.

199 ntal and fetal oxygenation during normal and pathologic pregnancies in mice.

200 tects minute amounts of the disease-specific pathologic prion protein in cerebrospinal fluid (CSF) or

201 Oncogenesis is a pathologic process driven by genomic aberrations, includ

202 ine beyond that expected for delirium or the pathologic process itself.

203 The exact mechanism of this pathologic process remains elusive.

204 In these disorders, a pathologic process seems to have caused cognitive functi

205 l elastic response rather than a progressive pathologic process.

206 e with influenza A/PR/8/34 and examined lung pathologic processes and inflammation, as well as transc

207 Because pathologic processes begin decades before the onset of t

208 cells 5 (NFAT5) critically regulates diverse pathologic processes in synovial macrophages including t

209 rrogate measures of heterogeneous underlying pathologic processes leading to cognitive impairment.

210 ng independently and multiplicatively to the pathologic processes of classic dementia.

211 bserved after delirium is independent of the pathologic processes of classic dementia.

212 esulted in individuals with delirium and the pathologic processes of dementia declining 0.72 MMSE poi

213 Delirium in the presence of the pathologic processes of dementia is associated with acce

214 However, the combination of delirium and the pathologic processes of dementia resulted in the greates

215 Decline attributable to the pathologic processes of dementia was -0.39 MMSE points p

216 ditional biomarkers might reflect downstream pathologic processes or appear because of ongoing inflam

217 the effects of curcumin on intracellular AD pathologic processes remain largely unknown.

218 findings suggest that additional unmeasured pathologic processes specifically relate to delirium.

219 overlap in the diagnostic features of common pathologic processes such as infection, sterile inflamma

220 ported to play diverse roles in biologic and pathologic processes, including myogenesis.

221 ccumulation and oligomerization are early AD pathologic processes, which may lead to changes in infla

222 Angiogenesis is central to both normal and pathologic processes.

223 crucial role in a variety of physiologic and pathologic processes.

224 T, a common end point for multiple different pathologic processes.

225 o These data indicate that Gab2 mediates the pathologic progression of HCC by integrating multiple si

226 ents with 141 SSNs confirmed with surgically pathologic proof were retrospectively reviewed.

227 h functional proteins and the end product of pathologic protein misfolding.

228 leviates CHF in this model, attenuated these pathologic renal changes.

229 model, as were text features from the biopsy pathologic report.

230 Imaging and pathologic reports for consecutive post-LT patients foll

231 An important text feature from the pathologic reports was "severely atypical." Instead of s

232 Treated patients achieving complete pathologic response (cPR) had superior 5-year RFS (72%)

233 Clinical variables associated with a major pathologic response (pathologic complete response or <5%

234 Predictors of pathologic response and survival were determined.

235 ntify clinical factors associated with major pathologic response in a large cohort of patients who un

236 Although a major pathologic response occurs infrequently following preope

237 We previously demonstrated that a major pathologic response to preoperative therapy, defined his

238 Pathologic response was defined as complete versus incom

239 A major pathologic response was seen in 77 patients (13.2%) incl

240 Independent predictors of major pathologic response were bevacizumab use (odds ratio [OR

241 enhancement had the highest association with pathologic response, achieving an AUC of 0.92 (95% confi

242 with breast cancer and to outline a model of pathologic response, considering pathologic complete res

243 3.2%) including 23 (3.9%) who had a complete pathologic response.

244 radiosensitizer were associated with a major pathologic response.

245 preparation was assessed for physiologic and pathologic responses to the cholinergic agonist carbacho

246 These pathologic responses were abrogated in cyclophilin D-kno

247 ing RCTs are awaited to assess whether these pathologic results have an effect on disease-free and ov

248 s, clinical Alvarado scoring, CT images, and pathologic results of the patients were evaluated.

249 xternal iliac and obturator) LN regions with pathologic results, respecting laterality.

250 roemulsion affected the hallmark features of pathologic retinal angiogenesis, reducing neovascular tu

251 xillin is an effective strategy for treating pathologic retinal neovascularization.

252 born dentate granule cells contribute to the pathologic retrograde sprouting of mossy fiber axons, bo

253 positive findings for nodal disease on final pathologic review was calculated for patients with and w

254 resection, and who had previously undergone pathologic review, were included.

255 d between 1995 and 2015 confirmed by central pathologic review.

256 nalysis of clinical HCC specimens supports a pathologic role for IRF5 in HCV-induced HCC, as IRF5 exp

257 nd to describe the distinctive features from pathologic RPE detachments and choroidal neovascularizat

258 membrane were the features distinctive from pathologic RPE detachments and CNVs.

259 reatments, they should be distinguished from pathologic RPE detachments and CNVs.

260 an alternative explanation for some forms of pathologic scarring that are now attributed to truncated

261 nically relevant model to investigate causal pathologic sequences and potential therapeutic intervent

262 rcholesterolemia increases the incidence and pathologic severity of colorectal neoplasia in two indep

263 this study, FEN1 expression and its clinical-pathologic significance in non-small-cell lung cancer (N

264 Pathologic specimens were obtained from patients cared f

265 mmittee on Cancer clinical stage (CS), final pathologic stage (PS), estrogen receptor status (E), and

266 to age, gender, Charlson comorbidity index, pathologic stage (pT3/T4N0, pT3/T4Nx and pTanyN+), and s

267 diagnosis period 2008-2012 and more accurate pathologic stage at diagnosis.

268 86% to 97% by clinical stage, 86% to 97% by pathologic stage, and 71% to 99% by CPS+EG score.

269 rapy than presenting clinical stage or final pathologic stage.

270 ntial therapeutic target to be considered in pathologic states characterized by overproduction of IL-

271 decided to evaluate their alterations in the pathologic states ending in cSCC.

272 -IFN-based therapies and expand the class of pathologic states that are viewed as protein-misfolding

273 controls gene expression in physiologic and pathologic states.

274 n of interleukins IL-6 and IL-8 triggered by pathologic stimuli relevant to AMD, such as cholesterol

275 iomyocytes to adapt to either physiologic or pathologic stresses.

276 Additional imaging and pathologic studies are needed to confirm these findings.

277 were 1096 deceased persons from two clinical-pathologic studies.

278 physiologic profile, without any evidence of pathologic sub-RPE material.

279 ging studies have illustrated a more complex pathologic substrate involving cortical demyelination, g

280 The pathologic substrates of this association are not yet kn

281 New and unique physiologic and pathologic systemic and neuro-ocular responses have been

282 Patients in the UR group had higher pathologic T stage (pT3 and T4: 86% v 73%; P < .01), hig

283 Pathologic T3b/T4 stage, Gleason score 8-10, lymph node

284 , but the molecular mechanism leading to the pathologic tau formation in Alzheimer's disease (AD) bra

285 sts that direct inhibition of FXIa can block pathologic thrombus formation while preserving normal he

286 licated in the regulation of necroptosis and pathologic tissue injury, in directing IFN-beta producti

287 lp quantitatively differentiate healthy from pathologic tissue.

288 ist in the early detection and management of pathologic tooth wear.

289 generally without a clear cutoff signifying pathologic transition.

290 inority of esophageal cancers demonstrates a pathologic tumor response (pTR) to neoadjuvant chemother

291 and tumor characteristics were assessed, and pathologic tumor stages were provided as T, N, and M cat

292 e heterogeneity or the inclusion of only one pathologic type.

293 anding body of literature on physiologic and pathologic uptake patterns and pitfalls.

294 plaques, and LBD stage to determine whether pathologic variables are associated with disease duratio

295 More importantly, we identified likely pathologic variants in several novel candidate genes suc

296 ant AAV serotype 1 (rAAV1) transduces ECs of pathologic vessels, and that editing of genomic VEGFR2 l

297 Pathologic vWF metabolism may be a mechanistic link betw

298 ce MPhi polarization in both physiologic and pathologic wound healing, with particular attention to d

299 ur in a timely, progressive fashion promotes pathologic wound healing.

300 ion of inflammation is critical for treating pathologic wound healing.