ライフサイエンスコーパス: pathological

1 Here, we tested the claim that pathological accumulation of alpha-synuclein, and subseq

2 of human CLPX, p.Gly298Asp, that results in pathological accumulation of the heme biosynthesis inter

3 A pathological ACH test was observed at lower ACH doses in

4 There were 813 patients (59%) with a pathological ACH test, 33% for CMD and 26% for epicardia

5 rly with cortical amyloid-beta accumulation (pathological ageing, n = 15).

6 ng amyloid [Formula: see text] that may form pathological aggregates if not effectively cleared.

7 These data raise the possibility that pathological aggregation could compromise the function o

8 r understanding the mechanisms promoting the pathological aggregation of this protein.

9 sically unfolded C-terminal domains to drive pathological aggregation.

10 cause cognitive dysfunction in normative and pathological aging has been linked to hyperexcitability

11 able and highly sensitive to both normal and pathological aging processes across adulthood.

12 Pathological alpha-syn assembly mainly occurred through

13 urther, inhibition of MARKs led to increased pathological alpha-synuclein burden.

14 oplasmic reticulum (ER) is becoming a common pathological alteration in ALS, representing one of the

15 of the paracellular seal to physiological or pathological alterations in cell shape or movement.

16 Our data provide insight into the pathological alterations occurring centrally and periphe

17 The results well matched the pathological analysis, indicating that PCA-tdTHz is a qu

18 patients with advanced cancer and available pathological and clinical annotations.

19 neovascularization and their contribution to pathological and clinical stages leading to vision loss

20 This allows direct access to pathological and control human brain tissue based on an

21 by loss of motor neurons and shows clinical, pathological, and genetic overlap with frontotemporal de

22 ein, we review the contribution of clinical, pathological, and genetic risk factors to transformation

23 tly promotes endothelial cell activation and pathological angiogenesis in our previous study, but the

24 helial cell glycolysis, which is crucial for pathological angiogenesis in proliferative retinopathies

25 hors show that adenosine receptor A2A drives pathological angiogenesis in the oxygen-induced retinopa

26 In pathological angiogenesis of human ovarian carcinomas, r

27 Inhibiting pathological angiogenesis therefore represents a promisi

28 ication signals in driving physiological and pathological angiogenesis.

29 this question, unmedicated individuals with pathological anxiety (n = 25) and matched healthy contro

30 e hypervigilance that is a common symptom of pathological anxiety.

31 ode metastases detected by means of standard pathological assessment or a multimarker molecular assay

32 red most of the major PH subtypes with known pathological basis defined by the World Health Organizat

33 which can be used to model physiological and pathological behavior.

34 as increased in photoreceptors in a model of pathological blood vessels invading photoreceptors: the

35 d osteoclastogenesis, and protects mice from pathological bone loss in disease models.

36 steoclast-expressed MYC in physiological and pathological bone loss is not known.

37 through Ca(2+)-dependent mechanisms causing pathological bone loss.

38 Focal seizures are episodes of pathological brain activity that appear to arise from a

39 The pathological brain activity was recorded intra-operative

40 s with hemoptysis, TAE of the BAA and of the pathological bronchial circulation, in association with

41 ial embolization (TAE) of the BAA and of the pathological bronchial circulation.

42 specifically inhibits the nuclear export of pathological C9ORF72 transcripts, the production of dipe

43 cellular adrenergic signalling in normal and pathological cardiac function.

44 Pathological cardiac hypertrophy induced by stresses suc

45 Pathological cardiac hypertrophy, a dynamic remodeling p

46 Herpud1 is a novel negative regulator of pathological cardiac hypertrophy.

47 r accelerating autophagic flux can result in pathological cardiac remodeling, the physiological signa

48 ministration into the MI border zone reduces pathological cardiac structural and functional remodelin

49 r therapeutic interventions in the course of pathological cartilage injury.

50 lloproteinases (MMPs) is a common feature of pathological cascades observed in diverse disorders, suc

51 , we apply the same analytic approaches to a pathological case-control series and show a predictive A

52 cterized by granulomatous lesions containing pathological CD207(+) dendritic cells (DCs) with constit

53 Ferroptosis has been implicated in the pathological cell death associated with degenerative dis

54 te coronary syndromes (ACS) at the clinical, pathological, cellular, and molecular levels.

55 Similar pathological changes also occur at every level of the sp

56 imited resolving power for discerning subtle pathological changes associated with early diseases.

57 roviding direct evidence of undefined unique pathological changes at different bone hierarchical leve

58 Pathological changes in diabetes include mesangial expan

59 Together, these findings suggest that pathological changes in renal iron homeostasis occurs in

60 anding of the regulatory networks that drive pathological changes in the heart, this approach has bee

61 A major cause of inaccurate examinations of pathological changes in the paranasal sinuses may be due

62 Pathological changes in vascular permeability are driven

63 Clinical and pathological characteristics, time to development of neu

64 analysed in the per-protocol population, was pathological complete response, assessed via specimens o

65 However, the distinction between the pathological condition and the benign one is very challe

66 sses, and have also been implicated in human pathological conditions (including cancer).

67 ervous system (CNS) that become activated in pathological conditions and determine the fate of other

68 perties of a cell reflect its biological and pathological conditions and there have been active resea

69 helial Wnt signaling and BBB integrity under pathological conditions in adult mice.

70 hanism of how mTORC1 activation occurs under pathological conditions is not completely known.

71 corneal tissue structure in homeostatic and pathological conditions is unknown.

72 ation of tissues, cell divisions, aging, and pathological conditions observed in many cancers.

73 Under pathological conditions of dysregulated Ca(2+) cycling,

74 ength of these currents becomes larger under pathological conditions or drug administrations.

75 levels, such as attention and arousal and in pathological conditions such as Alzheimer's disease.

76 r processes such as cell differentiation and pathological conditions such as tumor cell migration.

77 ied mitochondrial fragmentation during acute pathological conditions that mimic severe, moderate, and

78 TGF-beta1 is involved in many pathological conditions, including autoimmune disorders,

79 namics play an important role within several pathological conditions, including cancer and neurologic

80 tion of protein under many physiological and pathological conditions, including cancer.

81 ntal inflammation is associated with several pathological conditions, including stillbirth and fetal

82 articipate in a variety of physiological and pathological conditions, including tumor suppression [2]

83 let hyperreactivity, which is common in many pathological conditions, is associated with increased at

84 ytosolic accumulation of self-DNA results in pathological conditions, such as autoimmunity.

85 Under pathological conditions, Tau dissociates from axonal mic

86 anges in cardiomyocytes in physiological and pathological conditions, thereby providing novel therape

87 olved in a variety of cellular processes and pathological conditions, which makes it a promising phar

88 may be inadequate and misleading under many pathological conditions.

89 y thus be a useful tool to study healthy and pathological conditions.

90 during a broad spectrum of physiological and pathological conditions.

91 ular metabolism under both physiological and pathological conditions.

92 programs of CNS myelination under normal and pathological conditions.

93 ns are substantially reorganized during many pathological conditions.

94 ainst pathogens and whose imbalance leads to pathological conditions.

95 neurodegenerative diseases as well as other pathological conditions.

96 the therapeutic spectrum of HU to additional pathological conditions.

97 hondria and released into bloodstream during pathological conditions.

98 hese RNAs must remain unrecognized under non-pathological conditions.

99 e mTORC2 kinase under both physiological and pathological conditions.

100 n be targeted to ameliorate dendrite loss in pathological conditions.

101 ggable target to modulate angiogenesis under pathological conditions.

102 s, cell competition may occur in a number of pathological conditions.Cell competition causes the remo

103 The causes of pathological connections between renal arteries may be c

104 eatic islets of Langherans, and for multiple pathological consequences encountered by patients suffer

105 d to functional differences with significant pathological consequences.

106 e roles of class II PI3 kinases in different pathological contexts is leading to an increased interes

107 of FA homeostasis and its physiological and pathological contributions.

108 We observed pathological cross-seeding between DISC1 and mutant HTT

109 exert significant impact on both normal and pathological DAergic homeostasis.

110 kdown effectively ameliorates SMA-associated pathological defects across species, including worm, zeb

111 articulations to closure, both in normal and pathological development, also affecting the long-term e

112 lassification into one of the 10 most common pathological diagnoses was most accurate (up to 60.2%) w

113 To characterize in vivo signatures of pathological diagnosis in a large cohort of patients wit

114 A patient with clinical PSP and pathological diagnosis of corticobasal degeneration had

115 on were assessed and tested as predictors of pathological diagnosis using support vector machine (SVM

116 cine valve interstitial cells, CNP inhibited pathological differentiation via the guanylate cyclase N

117 rains caused a nearly identical clinical and pathological disease phenotype, yet maintained their str

118 tivation has been implicated in a variety of pathological disorders including ischemia/reperfusion in

119 Because RAGE plays a role in many pathological disorders, it has become an attractive targ

120 can protect mice against DENV infection and pathological effects, suggesting that NS1-specific mAb m

121 ccur simultaneously and may have synergistic pathological effects.

122 Thus, pathological elevation of Ephexin5 expression critically

123 of their quantity in human serum to mark the pathological elicitation of these cells in vivo and thei

124 l cycle arrest, yet remains critical for the pathological, EMT-inducing arm of TGFbeta signaling.

125 al depolarization, disordered autophagy, and pathological endoplasmic reticulum stress.

126 I is typically considered and treated as one pathological entity, although in fact it is a syndrome c

127 we suggest that the application of molecular pathological epidemiology to S. aureus infection can ush

128 ination and may inform mechanisms underlying pathological epithelial cell detachment.

129 isplay of the PAD in tau represents a common pathological event in many tauopathies.

130 Reference standard was a combination of pathological evidence and tumor growth at follow-up CT/M

131 Pathological examination shows that ChHV5 is shed in ski

132 On the pathological examination, all left testes in the torsion

133 ex differences that contribute to normal and pathological fear behaviors in humans and animal models.

134 The hallmark pathological feature in most cases of ALS is nuclear dep

135 Intestinal inflammation is the central pathological feature of colitis and the inflammatory bow

136 on-hematological conditions and is a central pathological feature of myelofibrosis.

137 Shared pathological features among muscular dystrophies include

138 We revealed the same pathological features in a mouse model of human Adrenomy

139 characterise the clinical, physiological and pathological features of copper-deficient peripheral neu

140 However, the characteristic pathological features of INCL were almost completely abs

141 y mice faithfully recapitulated clinical and pathological features of meningeal infiltration seen in

142 ingly recognised, however, that clinical and pathological features of MSA are broader than previously

143 We evaluated clinical, radiological and pathological features of patients referred for suspected

144 of auditory stimuli was associated with core pathological features of schizophrenia, increasing confi

145 Notably, the pathological features of tau pathology in these diseases

146 geting antibody to rodents reduces or delays pathological features of TBI.

147 e present with uniform clinical, genetic and pathological features, we further propose the disorder b

148 ompasses not only a specific cerebrovascular pathological finding, but also different clinical syndro

149 The pathological findings suggest axonal degeneration and re

150 ng PGRN display reduced autophagic flux, and pathological forms of TDP-43 typically cleared by autoph

151 interest to understand its physiological and pathological functions.

152 n, and 17% higher in the ventral striatum in pathological gamblers compared with control subjects.

153 vely correlated with gambling distortions in pathological gamblers.

154 ional decision-making, such as addiction and pathological gambling.

155 bout the role of epigenetic modifications in pathological gene expression patterns in CCC patients' m

156 relations between SWI grade, rCBV ratio, and pathological grading were evaluated.

157 macrophages, which remained unchanged among pathological groups.

158 The pathological hallmark of Alzheimer's disease (AD) is acc

159 ant huntingtin protein (mHTT) aggregates-the pathological hallmark of Huntington disease (HD)-within

160 f the human alpha-synuclein protein is a key pathological hallmark of PD and is associated with the p

161 urodegenerative conditions, are defined by a pathological hallmark: neurofibrillary tangles (NFTs).

162 assessed by retrospective correlations with pathological hallmarks Here, we show for the first time

163 Pathological hallmarks of Alzheimer's disease (AD) inclu

164 beta (Abeta) and tau represent the two major pathological hallmarks of Alzheimer's disease (AD).

165 re central players in many physiological and pathological human processes.

166 ivation of EHMT1/2 was sufficient to promote pathological hypertrophy and fetal gene reexpression, wh

167 uppression of this pathway protected against pathological hypertrophy both in vitro and in mice.

168 Taken together, we demonstrate that pathological hypertrophy occurs in AC and is secondary t

169 cardiomyocytes respond to AC progression by pathological hypertrophy.

170 logical extracellular K(+) concentrations or pathological hypokalaemia, however, the underlying mecha

171 logical extracellular K(+) concentrations or pathological hypokalaemia, human cardiomyocytes show bot

172 atures are effective, on large-scale digital pathological images, the process of extracting these fea

173 Axon degeneration is an early event and pathological in neurodegenerative conditions and nerve i

174 o threatening environmental stimuli, becomes pathological in trauma- and stress-based psychiatric syn

175 Interestingly, other pathological inclusions lead to similar outcomes, but th

176 atory mechanisms that balance protective and pathological inflammation, but these mechanisms might al

177 olecules that promote both physiological and pathological inflammation.

178 ocytes and play key roles in both normal and pathological inflammation.

179 of common genes that play a central role in pathological inflammation.

180 at can also result in a potent and sometimes pathological inflammatory response.

181 njury in HTG mice while there was no obvious pathological injury in normal mice.

182 ovides interpretable features that could aid pathological inspections.

183 similarly increased in number after relevant pathological insults (infarcts), suggesting a similar ex

184 losis (TB) risk and adverse outcomes but the pathological interactions between DM and TB remain incom

185 g the normal prion protein (PrP(C)) into the pathological isoform.

186 otif that drives VE-cadherin endocytosis and pathological junction disassembly associated with the en

187 s relative to VA1994, displaying less-severe pathological lesions in, and reduced bacterial recovery

188 loid cells are responsible for the elevated, pathological levels of suPAR, as evidenced by BM chimera

189 Alcohol produced a pathological-like pattern of aggression in AHAs; these m

190 tributor to excitability in the brain, where pathological loss of function leads to such disorders as

191 In the normally avascular cornea, however, pathological lymphangiogenesis mediates diseases like co

192 therapeutic value in diseases accompanied by pathological lymphangiogenesis.

193 We aimed to identify genetic and pathological markers that have the strongest association

194 recursors of myofibroblasts, are a source of pathological matrix collagens and may be promising targe

195 It is also very likely that the pathological meanings of altered TSPO binding or express

196 ata, we propose oxidative stress as a common pathological mechanism leading to PVI impairment in schi

197 s of storing energy and explanations for the pathological metabolic state of obesity.

198 ificant effects on recipient cells, and that pathological muscle conditions such as denervation induc

199 ficult to achieve and structural analysis of pathological myocardial structure is often limited to tw

200 e for Gbetagamma-GRK2 inhibition in limiting pathological myofibroblast activation, interstitial fibr

201 er N-terminal antibody, was not sensitive to pathological N-terminal conformations.

202 pression of CCN1 and significantly decreases pathological neovascular growth in OIR.

203 decreases key glycolytic enzymes and reduces pathological neovascularization in the OIR mice.

204 Pathological neovessels growing into the normally avascu

205 t with the beta-sheet secondary structure of pathological oligomeric conformers, characteristic of ma

206 The precise cause of ET is unknown, however pathological oscillations of a network of a number of br

207 ectomy (LP), and robotic proctectomy (RP) in pathological outcomes and overall survival (OS).

208 resection margin positivity (CRM+) and other pathological outcomes, quality of life (36-Item Short Fo

209 ry responses implicated in protective versus pathological outcomes.

210 There is increasing evidence that the pathological overeating underlying some forms of obesity

211 N-methyl-D-aspartate receptors (NMDARs) and pathological pain are controlled by ephrin-B-induced ext

212 gical pain sensitivity, and is diminished in pathological pain states.

213 ischemic stroke, neuronal inflammation, and pathological pain.

214 main incompletely characterized in models of pathological pain.

215 Associations of RDW and NLR with clinic/pathological parameters were analyzed using non-parametr

216 ry to caveolae may specifically inhibit this pathological pathway, we conjugated SOD with antibodies

217 of MSA, is considered from both clinical and pathological perspectives.

218 y been demonstrated during artificial and/or pathological perturbations.

219 ntly challenged by physiological demands and pathological perturbations.

220 e patient mutation N1768D reproduces several pathological phenotypes, including spontaneous seizures

221 excitation/inhibition balance may relate to pathological phenotypes.

222 in toxicity have been observed in different pathological phenotypes.

223 Our results reveal a controlled, non-pathological, physiological role of protein aggregation

224 key role in the physiological hemostasis or pathological process of thrombosis.

225 ging, and is usually evident years after the pathological process.

226 iral infections have been proposed to elicit pathological processes leading to the initiation of T he

227 extrusion to developmental, homeostatic and pathological processes such as cancer metastasis, its un

228 important roles in several physiological and pathological processes, including cancers, infection, an

229 yet this damage initiates and potentiates in pathological processes.

230 to be essential in lots of physiological and pathological processes.

231 es to functions in various physiological and pathological processes.

232 plays an important role in physiological and pathological processes.

233 reduced gene expression in physiological and pathological processes.

234 h amyloid- dependent and amyloid-independent pathological profiles can be identified in the cognitive

235 to more fully characterise the heterogeneous pathological profiles in the population.

236 This study reanalyses pathological prognostic factors related to IBTR using lo

237 Pathological proliferation of retinal blood vessels comm

238 s control physiological assembly and prevent pathological protein aggregation, suggesting a potential

239 leen size in multiple SMA mouse models and a pathological reduction in red pulp and extramedullary he

240 ) was significantly greater in those with no pathological regression (P = 0.008).

241 brain, VRAC contributes to physiological and pathological release of a variety of small organic molec

242 ch may serve as a new therapeutic target for pathological remodeling and heart failure.

243 MF represents pathological remodeling in the heart associated with car

244 Cardiac ischemic injury induces a pathological remodeling response, which can ultimately l

245 muscle repair and function and to slow this pathological remodeling.

246 that QUS imaging can non-invasively monitor pathological response and outcome of breast cancer patie

247 ain physiological functions and have similar pathological responses and organellar disorders with pan

248 These pathological responses promote regional vasoconstriction

249 nteractions with living cells, may result in pathological responses such as decompression sickness (D

250 This feedback loop contributes to pathological responses to infectious agents and is there

251 ed oncogenic serine/threonine kinases play a pathological role in diverse forms of malignancies, incl

252 our understanding of the relationship of the pathological role of Abeta and tau in synapse dysfunctio

253 hip OA subchondral bone, and to examine the pathological role of adipokines.

254 However, the pathological role of this receptor in GBM remains to be

255 d our understanding of the physiological and pathological roles of glutathione in living cells.

256 Pathological samples were ascertained following autopsy

257 o identify plausible mechanistic triggers of pathological scarring in skin wounds.

258 ncer in case of positive FS to achieve clear pathological section (PS).

259 ioactive neutrophil molecules and subsequent pathological sequelae.

260 To promote basal levels of the process in pathological settings, we previously screened a small mo

261 n, a hallmark of heart failure (HF), induces pathological signaling through G protein betagamma (Gbet

262 The hallmark of the TDP-43 pathological signature of sporadic ALS is restricted to

263 TIA1 mutations carriers showed a consistent pathological signature with numerous round, hyaline, TAR

264 ng the biological function of genes, and the pathological significance of genetic variants in human c

265 ellular aggregates of mutant huntingtin, the pathological significance of which has long been debated

266 tes are common but are small and of doubtful pathological significance.

267 ty, with signaling and metabolic pathways of pathological significance.

268 These data argue that TBI elicits pathological spine remodeling that contributes to behavi

269 of prion-like seeding as a mechanism for the pathological spread in tauopathy and other neurodegenera

270 ated this with grade (Gleason score; GS) and pathological staging (pT) of prostate cancer (PCa) follo

271 dy aimed to qualitatively evaluate whether a pathological state influenced flavanol plasma bioavailab

272 cting insulin deficiency as it occurs in the pathological state of type-1 diabetes as well as during

273 s represents a valid approach to investigate pathological states including Alzheimer's disease and HI

274 rix remodeling in other, related optic nerve pathological states, we found decreased expression of on

275 Glut release, which may be relevant in some pathological states.SIGNIFICANCE STATEMENT Astrocytes sp

276 In quiescent liver, PTEN causes pathological steatosis when lost, whereas its role in re

277 rtrophy is an adaptive response triggered by pathological stimuli.

278 In particular, accurate detection of pathological STR expansion is limited by the sequence re

279 Pathological studies reveal a variety of structural abno

280 l-based morphometry revealed that nearly all pathological subgroups and even individual patients shar

281 variant produces desmin aggregates, the main pathological symptom of myofibrillar myopathies.

282 activity that clears amyloid can also cause pathological synapse loss.

283 RP1 expression and increasing Gleason grade, pathological T score, positive lymph node status and pri

284 requirement may provide new ways to suppress pathological T-cell responses in transplantation or auto

285 Through injection of human AD-brain-derived pathological tau (AD-tau) into Abeta plaque-bearing mous

286 d seeding assays that allow the formation of pathological tau aggregates to be measured in situ withi

287 cerebrally injecting nontransgenic mice with pathological tau enriched from human tauopathy brains.

288 Pathological Tau mutants lacking the vesicle binding dom

289 These injections of pathological tau resulted in the propagation of tau path

290 ctures for polyQ lengths below and above the pathological threshold.

291 nticoagulant therapy-associated bleeding and pathological thrombosis pose serious risks to hospitaliz

292 rs as a potential target to treat or prevent pathological thrombosis, to inhibit contact activation i

293 ant developments in techniques of imaging of pathological tissues raised expectations among the clini

294 egory of NK cells in mucosal and non-mucosal pathological tissues.

295 ombination therapy is proposed to combat the pathological triad of extrasynaptic NMDA receptor signal

296 We find that acute and pathological tubular remodeling significantly affect TAT

297 We aimed to determine pretreatment pathological tumor extent in the resection specimen afte

298 pendent of the patient's age at surgery, the pathological tumor stage and presence of lymph node inva

299 Pathological tumor vessels were closed using particles f

300 y diverse neurophysiological disruptions and pathological underpinnings of the language network in ea