ライフサイエンスコーパス: pathway

1 a critical part of the low zinc homeostasis pathway.

2 40 of 41 genes comprising the NOD signaling pathway.

3 ) and activation of the classical complement pathway.

4 gy, an autophagy-based alternative secretion pathway.

5 of PDGFRalpha+ cells via PI3K/Akt signaling pathway.

6 by promotes activation of the mTOR-HIF1alpha pathway.

7 the information transduction capacity of the pathway.

8 he activation of the mitochondrial apoptosis pathway.

9 or and the downstream JAK2-STAT5a signalling pathway.

10 vate the apoptotic or necroptotic cell death pathway.

11 e phosphorylation, angiogenesis, and the p53 pathway.

12 upregulation of "Axonal Guidance Signaling" pathway.

13 microbials that target this novel, essential pathway.

14 novel CO2-dependent changes in the NF-kappaB pathway.

15 murine lung via a TLR2/TLR4/MyD88-signaling pathway.

16 pendency from the BCL-2 to the ERK signaling pathway.

17 enzyme in its tricarboxylic acid cycle (TCA) pathway.

18 on was regulated by the Sonic Hedgehog (Shh) pathway.

19 enous cerebral cholinergic anti-inflammatory pathway.

20 have therapeutic potential in targeting this pathway.

21 involves inhibition of the p70S6K signaling pathway.

22 in the CA1-subiculum, but not in the CA3-CA1 pathway.

23 ing the mammalian target of rapamycin (mTOR) pathway.

24 lignin-derived biphenyl via a meta-cleavage pathway.

25 r progression by deactivating the JAK1/STAT3 pathway.

26 berrant activation of the Hedgehog signaling pathway.

27 itated through the induction of the NFkappaB pathway.

28 lective modulation of dysfunctional neuronal pathways.

29 h, in turn, may reveal further Wnt signaling pathways.

30 due to interacting or overlapping signaling pathways.

31 ated to restoration of ERK and AKT signaling pathways.

32 ng the nociceptive and pruritic transmission pathways.

33 ffold proteins and 1118 associated signaling pathways.

34 ecific lipids and their associated metabolic pathways.

35 with progressive spreading along anatomical pathways.

36 are mediated by shared or distinct signaling pathways.

37 the involvement of TH1 and type 2 interferon pathways.

38 o respond to regulatory signals in signaling pathways.

39 Lsh-/- NSPCs and suggests multiple aberrant pathways.

40 tracheas were assayed in vitro for signaling pathways.

41 nigrostriatal, mesolimbic, and mesocortical pathways.

42 i and in schizophrenia-associated biological pathways.

43 re associated with IL6, AMPK and PPAR signal pathways.

44 ne mutations induce DCM via diverse cellular pathways.

45 ignificant suppression of TEs and interferon pathways.

46 IKs are also involved in salinity signalling pathways.

47 ely a general tool for specific biosynthetic pathways.

48 mpound eyes participates in both entrainment pathways.

49 nds that can be used to infer NDMA formation pathways.

50 ria, suggesting cross-talk between these two pathways.

51 o a mechanism involving endogenous signaling pathways.

52 including important signaling and regulatory pathways.

53 o not inhibit several other lytic activation pathways.

54 ne signatures and substantiate several genes/pathways.

55 function in cell adhesion and communication pathways.

56 tract that are driven by perturbed cytokine pathways.

57 l asthma model was used to identify involved pathways.

58 thways as well as activation of inflammatory pathways.

59 spatial encoding throughout the human visual pathways.

60 PI3K/Akt and NF-kappaB pathways account for the anti-inflammatory role of MCL a

61 Samples with NOTCH pathway activation were also clinically distinct and wer

62 RASopathies are caused by altered levels of pathway activation, the signaling changes in developing

63 sion in ACC cells inhibited Wnt/beta-catenin pathway activity by promoting beta-catenin phosphorylati

64 ne kinase 1 (Sphk1) in the highest number of pathways affected by AngII.

65 Among three pathways, AhR was the most sensitive one activated by ex

66 Focused bioinformatics pathway analysis demonstrated that IgE activation aligne

67 Gene set enrichment and pathway analysis of the microarray dataset showed enrich

68 d the upregulation of the TGF-beta signaling pathway and alpha1-antitrypsin protein (a serine proteas

69 suppression of type I interferon-signalling pathway and an aberrant expression of host genes associa

70 BB is disrupted by downregulation of the Shh pathway and breakdown of TJPs, secondary to increased MM

71 vities and rates for the desired epoxidation pathway and present smaller enthalpic barriers for both

72 hat Hop is a critical component of the piRNA pathway and that it maintains genome integrity by silenc

73 n with existing models that emphasize stress pathways and accelerated limbic system development.

74 tudy between cell-specific dynamic signaling pathways and drug sensitivity.

75 Both in G protein-mediated pathways and in beta-arrestin 2 recruitment, no ligand-i

76 rtrophy and hyperplasia for health, critical pathways and mechanisms in (involuntary) adipose tissue

77 the endothelium and uncovered core metabolic pathways and mechanisms of regulation that drive the ang

78 n, stronger regulation of genes in metabolic pathways and more dramatic glycolytic responses to hormo

79 ion of HCC by integrating multiple signaling pathways and suggest that Gab2 might be a powerful thera

80 e systems, by influencing cellular signaling pathways and sulfhydration of target proteins.

81 ing multiple labeling approaches to identify pathways and their postsynaptic sites in the amygdala in

82 oxin oxidoreductase reaction and anaplerotic pathways) and Re-citrate synthase (Ccar_06155) was a key

83 se in the overall flux through the shikimate pathway, and a redirection of carbon flux toward the shi

84 eatures as they propagate along the auditory pathway, and form an empirical framework to study the re

85 C, likely arises from different pathogenetic pathways, and benign breast disease (BBD) predicts futur

86 with associations between mutated genes and pathways, and stage or subtype of T-ALL.

87 c signaling, cross-talk with other signaling pathways, and the effects of betaAR-directed drugs.

88 lation of neuronal processes by the NRG/ErbB pathway are discussed.SIGNIFICANCE STATEMENT Numerous Ne

89 Surprisingly, what signaling pathways are active in the basal state and the functiona

90 ing the G1 phase of the cell cycle, but both pathways are active in the S and G2 phases.

91 In addition to TCR signaling, costimulatory pathways are involved in T cell activation.

92 ons, and that anabolic rather than catabolic pathways are more stringently required, likely due to fu

93 The huntingtin aggregation pathways are of therapeutic and diagnostic interest, but

94 sed MMP-9 activity which suggests that these pathways are potential novel targets for host directed t

95 n of epithelial NF-kappaB and PI3K signaling pathways are restricted by the M-ILK deficiency.

96 ins lysosomal homeostasis, and implicate the pathway as a modulator of degenerative diseases.

97 hese results unveil a CDK4-PIN1-p53-RS-c-Myc pathway as a novel mechanism for the GOF of p53-RS in HC

98 2+)]c to trigger the PYK2/MEK/ERK signalling pathway as a positive feedback mechanism that amplifies

99 n guidance and actin cytoskeleton signalling pathways as well as activation of inflammatory pathways.

100 This combined functional and mutational pathway assessment of a single cell could be of signific

101 The results of GO and KEGG pathways associated proteomics analysis indicated that e

102 s, STAT3 occurred in four of seven activated pathways associated with pro-oncogenic genes at network

103 hus promoting cell internalization by active pathways, attachment of cargo molecules to CPPs invariab

104 ss-talk between Akt and the noncanonical Wnt pathway but also reveals the impact of such cross-talk o

105 polymers share a common precursor synthesis pathway, but differ in the final transfer of the TA chai

106 regulates the paracellular Ca(2+) transport pathway by modulating Cldn14 expression in the TAL.

107 a bewildering array of potential signalling pathways by which a fall in oxygen levels might initiate

108 initiate infection in a cell.IMPORTANCE The pathways by which a virus enters a cell transform its pa

109 Here, we have examined the host pathways by which vMIA traffics from the ER to mitochond

110 The TRAIL pathway can mediate apoptosis of hepatic stellate cells

111 Thus, feedback interactions within the ERK pathway can regulate cell proliferation and transformati

112 ost-dispensable genes and suggest that these pathways can be studied for therapeutic intervention.

113 erdependent targeting of different silencing pathways can potentiate the establishment of off-target

114 first enzyme of the general phenylpropanoid pathway catalyzing the nonoxidative elimination of ammon

115 Mutations of the beta-catenin pathway change the phenotype of a common nevus with BRAF

116 ylation status of NBS1 determines the repair pathway choice of dysfunctional telomeres.

117 e Bone Morphogenetic Protein (BMP) signaling pathway, Decapentaplegic (Dpp), specifically in the Clas

118 R-664-3p and miR-708-5p may be implicated in pathways determining lifespan in mammals.

119 Subsequently, the two pathways diverge to produce distinct thermodynamically s

120 al response through activating the ER stress pathway during viral infection.

121 cked by drugs acting on serotonin signalling pathways e.g. trazodone and lorcaserin.

122 oglycan 1 (Dag1) directly binds to the Hippo pathway effector Yap to inhibit cardiomyocyte proliferat

123 HRI coordinates 2 key translation-regulation pathways, eIF2alphaP and mTORC1, to circumvent ineffecti

124 ite tryptophan, Trp-321, participates in off-pathway electron transfer.

125 campal areas, as well as in cortico-striatal pathways, emerges primarily via monosynaptic structural

126 Compared to the reference mitigation pathway, eradicating extreme poverty increases the effor

127 However, the pathways essential for conferring the tolerizing DC phen

128 rtments might yield significant benefits for pathway flux, as well as for toxicity mitigation.

129 In summary, we identified a novel pathway for regulation of beta-catenin levels and define

130 The objective is to find a new pathway for significant reduction in CO2 capture energy

131 Thirty-five years ago, a third pathway for the metabolism of arachidonic acid by cytoch

132 r results suggest that in marine ecosystems, pathways for bottom-up and top-down forces are not neces

133 m and mammalian phagocytes share mechanistic pathways for chemotaxis and phagocytosis; Dictyostelium

134 translational Sec and post-translational Tat pathways for integration.

135 The individual importance of these pathways for the generation of essential sphingolipids i

136 ignaling is a ubiquitous signal transduction pathway found in most if not all metazoan cell types cha

137 Dysregulation of the pathway from the prelimbic (PrL) cortex to the nucleus a

138 These studies identify taste pathways from sensory detection to higher brain that inf

139 on, COL4 accumulation in ECM, and complement pathway gene alteration, it impacted the composition of

140 thermore, sgRNA targeting GPI anchor protein pathway genes induced loss of function mutations in huma

141 regarding the mechanisms that link 1-carbon pathway genetics and the condition that we suggest calli

142 In plant-beneficial bacteria, this pathway has been shown to suppress the growth of bacteri

143 Although many pathways have been implicated in stretch-induced remodel

144 Both signaling pathways have been predicted previously using the pertur

145 ystem that facilitate navigation through the pathway hierarchy and enable efficient reuse of Reactome

146 onal significance of mutations in the CTLA-4 pathway identified by gene-sequencing approaches.

147 K-Akt signaling pathway, metabolic pathways (pathway IDs: 5200, 4151, 1100) were significantly enrich

148 Among several pathways implicated in E-T coupling, activation of volta

149 scam is expressed along the developing optic pathway in a pattern consistent with a role in regulatin

150 t studies identified a crucial role for this pathway in activity-dependent long-term depression (LTD)

151 unctional specialization of the left dHb-IPN pathway in attenuating the response to fear.

152 expression of key enzymes of the kynurenine pathway in brains of newborn and adult infected rats and

153 ence of involvement of the mTORC1-HIF-1alpha pathway in burn-induced metabolic derangements.

154 d cancer prevention and Orai1-SOCE signaling pathway in cancer cells.

155 r studies uncover a new metastasis-promoting pathway in Ewing Sarcoma, with therapeutically targetabl

156 linked to a paracrine activation of the mTOR pathway in lymphatic endothelial cells.

157 igate the role of neutrophils and the IL-17A pathway in mediating pediatric severe therapy-resistant

158 e data identify activation of the MAP kinase pathway in microglia as a cause of neurodegeneration and

159 sponsible for the resolving and nonresolving pathway in myocardial healing.

160 to test effects of agents that target the NO pathway in reducing arterial stiffness in HFpEF.

161 ociated with augmented activation of the ERK pathway in vitro and in hearts in vivo.

162 tin significantly inhibited Wnt/beta-catenin pathway in vitro and in vivo.

163 The identification of the role of the JNK pathway in VZV infection of neurons reveals potential av

164 ctor 21 (FGF21), and activation of signaling pathways in adipose tissue.

165 An improved understanding of pathogenic pathways in AKI may identify novel therapeutic approache

166 IL-6- and IL-21-induced Th17 differentiation pathways in autoreactive CD4 T cells, highlighting its p

167 ggest that the encapsulation of heterologous pathways in bacterial microcompartments might yield sign

168 sion (GO IDs: 0030198, 0044281, 0007155) and pathways in cancer, PI3K-Akt signaling pathway, metaboli

169 Visualization of metabolites, reactions and pathways in genome-scale metabolic networks (GEMs) can a

170 batch effects and able to identify perturbed pathways in individual samples.

171 e role of CNS-resident and peripheral immune pathways in microbiota-gut-brain communication during he

172 asome activation might represent interacting pathways in patients with SA.

173 ted by cAMP) directly activated by cAMP Epac pathways in the effects of ANP on beta-cell function; th

174 the skin handles the activation of oncogenic pathways in the stem cell compartment and how wild-type

175 ly attenuated TGF-beta1-mediated profibrotic pathways in vitro and in vivo, while esculetin significa

176 play important roles in multiple signalling pathways in vivo.

177 ted infants remain undefined, but postulated pathways include loss of neuronal progenitor cells, dama

178 Gene Set Enrichment Analysis revealed pathways including apoptosis, DNA repair and early estro

179 ticipate in the effector portion of the RdDM pathway, including RNA POLYMERASE V (POL V), DOMAINS REA

180 tial expression of 412 genes and of multiple pathways, including CADM1, SPHK1, and YAP/TAZ, whose exp

181 nked SMYD2 to other PKD-associated signaling pathways, including ERK, mTOR, and Akt signaling, via PT

182 is of these probes revealed a convergence of pathways indicating activation of PKA.

183 hibit important kinases in the BCR signaling pathway inhibit activation of lytic viral expression but

184 Vismodegib, a first-in-class Hedgehog-pathway inhibitor, is approved for use in adults with ad

185 applicable to resolving many other receptor-pathway interactions.

186 Diverse protein import pathways into mitochondria use translocons on the outer

187 enchymal transition and the ERK1/2 signaling pathway inversely affected by miR-519d or EphA4 expressi

188 mics approach in understanding the metabolic pathways involved in IBD.

189 ospinal tract is one of the descending motor pathways involved in recovery of hand function after inj

190 he rat, thus, elucidating potential neuronal pathways involved in the regulation of the HPA axis in m

191 ction models, we show that the SIP signaling pathway is active during infection and contributes signi

192 A competitive alternative pathway is also found where the decarboxylation happens

193 duced RVFV replication, indicating that this pathway is important for viral replication.

194 e presence of WNV through the MAVS signaling pathway is not required for generation of effective immu

195 rophages, PGE2 via the cAMP/protein kinase A pathway is potently inducing IL-1beta transcription, as

196 A similar pathway is proposed for decarboxylation of propionate 4,

197 nduction of DLL4 transcription and that this pathway is required for DLL4 expression.

198 study information transmission in signaling pathways, it does not capture the overlap between TNF-in

199 much is known about the underlying signaling pathways, it remains unclear how macroscopic features of

200 not appear to act in any of the three major pathways known to mend DNA DSBs, namely homologous recom

201 , the identity and hierarchy of the HDR (sub)pathways leading to the formation of PGE products remain

202 to be interference with the lipid signaling pathway, leading to reduced expression of MDR transporte

203 somal degradation, one of the most important pathways linked to ageing.

204 t years in understanding the SnRK1 signaling pathway, many of its components remain unidentified.

205 inhibitors with agents that target apoptotic pathways may be a promising therapeutic approach.

206 esult of activation of alternative signaling pathways mediated by factors secreted by BM stromal cell

207 The PI3K/Akt/mTOR pathway mediates signals from multiple receptors includi

208 ) and pathways in cancer, PI3K-Akt signaling pathway, metabolic pathways (pathway IDs: 5200, 4151, 11

209 lls, we find that activation of the MAPK/ERK pathway mirrors the rapid and dynamic induction of DLL4

210 g density model, and to a higher degree, the pathway model of biological ET partly capture the predic

211 The opposed defined-pathway model stems from experimental results that show

212 d after the addition of NADP (NADPH) oxidase pathway modulators and inhibitors of Toll-like receptors

213 erleukin 23 (IL23) and T-helper (Th) 17 cell pathway molecules are increased in inflamed intestinal t

214 ially regulated through two myosin-signaling pathways, myosin light chain kinase and Rho-associated k

215 A transition in the dominant dissipation pathways occurs at T 110 K with relatively larger cont

216 owed that DMSO could modify the dissociation pathway of CYP142A1, while CIU revealed the protective e

217 crucial enzyme in the lysosomal degradation pathway of dermatan sulfate and heparan sulfate.

218 lial Growth Factor (VEGF) secretion for this pathway of hypoxia-mediated self-renewal.

219 upled electron transfer (PCET) steps along a pathway of redox active amino acids (Y122beta <--> [W48b

220 ucture of chicken Slo2.2, the ion permeation pathway of the channel is closed by a constriction of th

221 This shows that two different pathways of activation, immunogenic and tolerogenic, ind

222 Notably, we find that axons within the WM pathways of AS model mice are abnormally small in calibe

223 med to elucidate the origin and hydrological pathways of BTs in Toronto, Canada, by quantifying three

224 chemistries and processes.Probing the growth pathways of quasicrystalline materials, where tiling uni

225 our laboratory and others have shown several pathways of regulation of ILC2s by co-stimulatory molecu

226 This unconventional signaling pathway offers an innovative therapeutic target for trea

227 a number of proteins fold in a reproducible pathway one foldon unit at a time.

228 n nanomedicine to down-regulate inflammatory pathways or to be employed as diagnostic tools with colo

229 l feedback between AR and PI3K/AKT signaling pathways, pAKT levels were increased in androgen-deprive

230 ancer, PI3K-Akt signaling pathway, metabolic pathways (pathway IDs: 5200, 4151, 1100) were significan

231 synaptic stimulation of the bacterial repair pathway perhaps by contributing to the RecA homology sea

232 d an important role for the PLCbeta-PKCalpha pathway, possibly regulating activation of SFKs, which a

233 HSP70, ubiquitin and the autophagy-lysosome pathway proteins Lamp2 and p62 relocalized to the area o

234 ce perinuclear relocalization of several RAS pathway proteins, including the kinases CK2 and p-ERK1/2

235 on of different elements in the sensorimotor pathway, providing a unique tool for studying neuroprost

236 ofactors that are intermediates of metabolic pathways, providing potential cross talk between metabol

237 tiple carbon fixation routes (Wood-Ljungdahl pathway, pyruvate:ferredoxin oxidoreductase reaction and

238 This pathway recruits negatively reinforcing dopaminergic neu

239 ors and that members of the Notch signalling pathway regulate further differentiation of the progenit

240 an attempt to identify novel actin signaling pathways regulated by NPM-ALK, a comprehensive phosphopr

241 The latter reaction pathway requires a C13=C14, C15=N double-isomerization o

242 Stimulation of the MAPK pathway results in mitogen- and stress-activated protein

243 xygenase-2, the initiating enzyme in the RvT pathway, reversed the protective actions of these statin

244 in NT and CT systems via two major transport pathways: runoff and leaching.

245 Multiple inflammatory pathways showed stronger enrichment in AD than psoriasis

246 mportant regulators of the DLK/JNK signaling pathway.SIGNIFICANCE STATEMENT Neuronal degeneration occ

247 to drive immune escape via a C3/C5-dependent pathway.Significance: This provocative study suggests th

248 rt and that inhibiting the caveolae-mediated pathway significantly reduced cellular uptake of MOFs.

249 l on net N2O production with both production pathways stimulated by low O2, independent of NO2(-) con

250 nce, as therapeutic targeting of a signaling pathway such as NG2/CSPG4 may have different effects on

251 e membrane, and degraded by the proteasome-a pathway termed endoplasmic reticulum-associated protein

252 regulator that senses amino acids through a pathway that converges on the Rag GTPases, an obligate h

253 autophagy, a critical catabolic homeostasis pathway that involves sequestration of selected cytoplas

254 Furthermore, one pathway that is involved in cell cycle regulation, REACT

255 R) is a DNA double-strand break (DSB) repair pathway that protects the genome from chromosomal instab

256 n DNA replication is inhibited by a 3' to 5' pathway that requires extensive uridylation of mRNA deca

257 Together, our data reveal an HSPG-dependent pathway that specifically allows dendrites of space-fill

258 ophan by immunoregulatory macrophages is one pathway that suppresses local T cell proliferation.

259 the plasma membrane can initiate a signaling pathway that ultimately increases nuclear CREB phosphory

260 nd TGF-beta are strongly connected signaling pathways that are important in advanced CRC.

261 NLRP3 inflammasome and additional downstream pathways that compromise the integrity and function of t

262 annels are thought to act on elements of the pathways that couple agonist binding to channel gating.

263 Charged residues on the LBD surface form pathways that facilitate glutamate binding by effectivel

264 explored modified Langmuir-Hinshelwood type pathways that have been proposed for oxidation reactions

265 Thus, manipulating pathways that induce oxidative, thiol and metal stress i

266 ct response to radiation and identify target pathways that may be exploited for neoadjuvant therapies

267 teome and reveal signaling and bioenergetics pathways that mediate lymphocyte exit from quiescence.

268 ex network of transcriptional regulators and pathways that orchestrate the cellular response to ssUVR

269 It also activates ER stress pathways that promote acinar cell death.

270 nreceptor tyrosine kinases acts in signaling pathways that regulate cell migration, cell adhesion, an

271 d multiple candidates in many cell signaling pathways that were able to mediate significant decreases

272 a(2+) binding rigidifies elements along this pathway, thereby blocking signal transmission.

273 ns discretely expressed in specific neuronal pathways; these accessory proteins provide a new dimensi

274 These results implicate biological pathways through which clozapine may act to cause this s

275 Our results define the molecular and neural pathways through which parallel biogenic amine signaling

276 versally conserved TOR (Target of Rapamycin) pathway to balance growth and development with the avail

277 to a neurochemical mimic of the light input pathway to the SCN.

278 hese diseases have often targeted downstream pathways to ameliorate consequences of protein dysfuncti

279 -factors and integrate signals from multiple pathways to control metabolism, oxidative stress respons

280 regulators of the TORC1 and TORC2 signaling pathways to coordinate cellular stress responses with st

281 glycosylase (UNG) and mismatch repair (MMR) pathways to generate mutations at G-C and A-T base pairs

282 ety of genes and identify multiple signaling pathways underlying taste cell differentiation and taste

283 st the existence of evolutionarily conserved pathways used by S100A4 to promote metastatic disseminat

284 w, we have tried to incorporate the reported pathways used so far for modification of 2-D graphene sh

285 Importantly, the TLR4 pathway was activated constitutively in KSHV-transformed

286 e may specifically inhibit this pathological pathway, we conjugated SOD with antibodies (Ab/SOD, size

287 tive bias for MOR-mediated signaling in each pathway, we demonstrate a strong correlation between the

288 tter understand the secoiridoid biosynthesis pathway, we generated transcriptome sequences from the r

289 The lysolipid and food and plant xenobiotic pathways were most strongly associated with diet quality

290 ase-1 (IDO-1) is an enzyme in the kynurenine pathway which augments tumor-induced immune tolerance.

291 Targeting signal transduction pathways which promote therapy resistance and metastatic

292 onist CD27 antibody that stimulates the CD27 pathway, which results in T-cell activation and antitumo

293 m patterns could vary in different signaling pathways, which could be related to conformational selec

294 d the activation of p53 and interferon (IFN) pathways, which enforced cell cycling in quiescent HSPCs

295 related to deregulation of central metabolic pathways, which may identify potential therapeutic targe

296 eration and identify ten recurrently altered pathways, with associations between mutated genes and pa

297 complement system and respective regulatory pathways, with concordant findings at the proteomic leve

298 ed by AFSC could target a specific signaling pathway within the glomerulus, thus representing a new p

299 s of olfactory health assess odor processing pathways within the brain and provide a limited understa

300 uring photodegradation of SDs, whereas a new pathway yielding oxidation of the benzene ring after the