ライフサイエンスコーパス: pathway of

1 We identified the biosynthetic pathway of 1 and completely mapped the enzymatic sequenc

2 An evolutionary pathway of 1 nt intron shift, involving an alternatively

3 between aerobic and anaerobic biodegradation pathways of 1,2-DCA in the field and suggests that this

4 affects the thermodynamic of the permeation pathway of 2-APB, leading to different entropic contribu

5 eir interconversion rates along the reaction pathway of a bacterial homodimeric enzyme, fluoroacetate

6 spersion was predictive of the autodegration pathway of a ubiquitin ligase (AUC = 0.69, p<10(-4)).

7 ial PM 2.5 contributors and PM 2.5 transport pathways of a network of 189 cities in China.

8 and metabolic diseases, that share the same pathways of accelerated aging.

9 n of histone H3K27 trimethylation as a novel pathway of acquired resistance to tyrosine kinase inhibi

10 mechanisms underlying G protein-independent pathways of activating GIRK channels provides a unique s

11 One pathway of activation is initiated by N-cadherin ligatio

12 Studying the pathways of activation and regulation of ILC2s are curre

13 This shows that two different pathways of activation, immunogenic and tolerogenic, ind

14 phosphorylated ARH1, the possible unbinding pathways of ADP-ribose from non-phosphorylated and phosp

15 n terms of the general metabolic background, pathways of AGE formation, and the status of plant anti-

16 ing the evolution of the direct and indirect pathways of allorecognition following tissue transplanta

17 spase-6 is critical to the neurodegenerative pathways of Alzheimer's, Huntington's, and Parkinson's d

18 e discovered a novel, on-surface aggregation pathway of amyloidogenic polypeptide that eliminates thi

19 previously undescribed virulence regulatory pathway of an important human pathogen and suggest new t

20 viously been identified as metabolite in the pathway of anaerobic degradation of naphthalene by sulfa

21 onset of anoxia, consistent with documented pathways of anoxic dark fermentation in microalgae.

22 The results indicate that the intrinsic pathway of apoptosis contributes significantly to the tu

23 are crucial regulators of the mitochondrial pathway of apoptosis in normal physiology and disease.

24 Within the mitochondrial pathway of apoptosis, VDAC2 controls both the localizati

25 and Bak, two critical genes in the intrinsic pathway of apoptosis, were deleted specifically from kid

26 h)-dependent triggering of the mitochondrial pathway of apoptosis.

27 n beta cells via regulation of the intrinsic pathway of apoptosis.

28 Of the two best understood pathways of apoptosis, the extrinsic and intrinsic (mito

29 Notably, we find that axons within the WM pathways of AS model mice are abnormally small in calibe

30 We explored the extent and pathways of ascorbate loss in variously washed and store

31 xidative phosphorylation are the fundamental pathways of ATP generation in eukaryotes.

32 The cellular degradative pathway of autophagy has a fundamental role in immunity.

33 Overall, our findings establish a pathway of autophagy specific to the DNA damage response

34 iates a previously undescribed and selective pathway of autophagy that we term genotoxin-induced targ

35 The reaction involves a tandem pathway of aza-Michael addition, SN2, and a unique redox

36 Collectively, strategies that manipulate pathways of B cell activation may facilitate the develop

37 BAFF is an ideal molecule to improve early pathways of B cell activation, as it links innate and ad

38 The glyoxylate shunt is a metabolic pathway of bacteria, fungi, and plants used to assimilat

39 However, the evolutionary pathways of bat CoVs remain elusive.

40 f GLP-1 gene through enterohepatic recycling pathways of bile acids.

41 ers contributes to the different aggregation pathways of both alloforms and also to the increased cyt

42 s a flowering repressor in the vernalization pathway of Brachypodium and likely other temperate grass

43 neurodevelopmental processes and the complex pathways of brain disorders.

44 med to elucidate the origin and hydrological pathways of BTs in Toronto, Canada, by quantifying three

45 e to assess the effects of fire and recovery pathways of burned TMCFs, with a detailed analysis of ca

46 t-activating IgG autoantibodies that drive a pathway of C5a generation and C5aR1 activation that fuel

47 rk within the well-studied sex determination pathway of Caenorhabditis elegans Repression of nhl-2 by

48 d nondestructive approach to probe metabolic pathways of carbon substrates at the single-cell level.

49 In this issue, Ando et al. delineate two pathways of caspase-2 activation and show that, in respo

50 ment with CBZ-10,11-epoxide a transformation pathway of CBZ in intact tomato plants is proposed that

51 of CCC DNA, which should help elucidate the pathways of CCC DNA formation and the factors involved.I

52 C DNA, thus providing important clues to the pathways of CCC DNA formation.

53 also provide new evidence that the signaling pathway of cellular MKK2 phosphorylation plays an import

54 transcripts encoding multiple cytokines and pathways of cellular activation.

55 encoding an enzyme in the de novo synthesis pathway of ceramides.

56 iched products and to study the racemization pathway of chiral 1,2-disubstituted adamantane derivativ

57 ere, but little is known about the formation pathway of chloroform in soil.

58 H (CFH), thereby inhibiting the alternative pathway of complement activation.

59 tor H, the main regulator of the alternative pathway of complement activation.

60 Eculizumab inhibits the terminal, lytic pathway of complement by blocking the activation of the

61 l experiments, activation of the alternative pathway of complement in the carriers of rs800292 minor

62 The classical pathway of complement is activated upon binding of the 7

63 In C3 glomerulopathy (C3G), the alternative pathway of complement is frequently overactivated by aut

64 used by inherited defects of the alternative pathway of complement, or the proteins that regulate thi

65 t for the classical, alternative, and lectin pathways of complement activation, and its cleavage prod

66 egatively regulates the classical and lectin pathways of complement to protect human tissue from aber

67 All 3 activation pathways of complement-the classic pathway (CP), the alt

68 computational approach to study the multiple pathways of complex reactions and large-scale conformati

69 ndamental understanding of the structure and pathways of complexation-driven assemblies, and raise in

70 t not only functional conformations but also pathways of conformational change, protein folding, and

71 Sulfidation may also favor desirable pathways of contaminant removal, such as (i) dechlorinat

72 experiments, we have discovered a major sub-pathway of conventional long-patch BER that involves for

73 er highlighting the complexity of lipoglycan pathways of Corynebacterineae.

74 l reductants of Cr(VI), but the kinetics and pathways of Cr(VI) reduction by such clay minerals are p

75 standing the potential reaction kinetics and pathways of Cr(VI) remediation products in the presence

76 The altered carbon assimilation pathway of crassulacean acid metabolism (CAM) photosynth

77 Understanding the environmental pathways of Cryptosporidium is essential for effective m

78 owed that DMSO could modify the dissociation pathway of CYP142A1, while CIU revealed the protective e

79 nsecutive reactions of the two-step indirect pathway of Cys-tRNA(Cys) synthesis (tRNA-dependent cyste

80 human monocyte subsets trigger a regulatory pathway of cytokine-mediated signaling at the EC interfa

81 es associated with groups of drugs uncovered pathways of cytotoxic response shared by each group.

82 The metabolic pathway of de novo lipogenesis is frequently upregulated

83 Moreover, the intermediary metabolic pathway of de novo lipogenesis, which synthesizes lipids

84 her, we uncover an immune-regulated cellular pathway of defense that promotes maintenance of Mtb with

85 Two pathways of degradation of anthocyanins were identified:

86 The novel pathway of Delayed reaction constituted a major route fo

87 crucial enzyme in the lysosomal degradation pathway of dermatan sulfate and heparan sulfate.

88 hanism of protection was found to be a novel pathway of direct TGF-beta-dependent Treg-cell suppressi

89 ith the aim of identifying putative cellular pathways of disease pathogenesis.

90 erse primary and secondary causes and shared pathways of disease progression, correlating with substa

91 showed that direct RB loss was the preferred pathway of disruption in human disease.

92 the dysregulation of the canonical signaling pathway of Dock7 as a possible cause of the aberrant for

93 important interaction between donor age, the pathway of donor death, and total ischemic time on graft

94 interaction with donor characteristics, the pathways of donor death, and graft outcomes may have imp

95 The non homologous end-joining (NHEJ) pathway of double-strand break (DSB) repair often requir

96 synthesis in the non-homologous end-joining pathway of double-strand break repair.

97 , the contribution of the direct and delayed pathways of double ionization is investigated for the ab

98 affects the stability and folding/unfolding pathway of DraE.

99 ntly been identified within the biosynthetic pathway of each exopolysaccharide.

100 This study demonstrates a likely pathway of effects of OSAS on neurocognitive function in

101 , revealing the kernel-to-surface relaxation pathway of electron dynamics.

102 The chlorination pathway of electrophilic substitution of Cl at the ortho

103 der both warming levels highly depend on the pathways of emissions scenarios, with different greenhou

104 s suggest that nitrite oxidation is the main pathway of energy production in Nitrospinae.

105 talysts for membrane fusion in the secretory pathway of eukaryotic cells.

106 ng and research efforts to elucidate current pathways of exposure.

107 These findings chart the pathway of FABP4 secretion and provide a potential thera

108 nidazole inhibits the ferredoxin/hydrogenase pathway of fermentative eukaryotic H2 production, sugges

109 ecular basis of the unconventional secretory pathway of FGF2.

110 A two-branched differentiation pathway of five fibroblastic subtypes was predicted usin

111 and regulating two independent biosynthetic pathways of floral volatile compounds.

112 ough mouse models have offered insights into pathways of food sensitization, differences between rode

113 We sought to identify the MB signaling pathway of formoterol and the differences in signaling b

114 The lowest action folding pathway of FSD-1 is consistent with recent experiments.

115 ngation, thus deciphering a novel regulatory pathway of gene expression.

116 yte maturation and might act within the same pathways of genes already associated with central hypomy

117 alysis was used to explore shared functional pathways of genes with differential DNA methylation.

118 use T cell blasts by starving the hexosamine pathway of glucose and glutamine.

119 ctures of isolated glycans, and to elucidate pathways of glycan biosynthesis.

120 alyzes stereospecific invertive substitution pathways of glycosyl chlorides.

121 ochemical studies support a uniquely nuanced pathway of Gram-negative CAMPs resistance and provide a

122 ties remain in the flux rates and production pathways of greenhouse gases in these dynamic systems.

123 st which subsequently follows a monometallic pathway of H2 generation from the Co(III)-hydride and/or

124 The formation pathway of haloforms through trihaloacetyl compounds can

125 The pathway of HCV morphogenesis and secretion has not been

126 strate that the unique endocytic trafficking pathway of Hendra virus F protein is required for proper

127 spectroscopy to directly probe the reaction pathways of highly excited states of energetic molecules

128 powerful technology that reveals the escape pathways of HIV-1 and may enable its capture.

129 Here we describe the pathways of host-parasite interaction at the parasitopho

130 To characterize the development pathway of human IgE(+) PCs and to determine the ontogen

131 lial Growth Factor (VEGF) secretion for this pathway of hypoxia-mediated self-renewal.

132 be especially valuable in elucidating these pathways of IDP folding.

133 Underlying signaling pathways of IL-12 were determined by using specific inhi

134 It blocks the signaling pathways of IL-4 and IL-13, key cytokines that drive typ

135 rterial inflammation do not share underlying pathways of immune activation and also that therapeutic

136 nction that is able to exploit an endogenous pathway of immunoregulation in the host.

137 Our results illustrate how extrinsic pathways of immunosuppression elaborated by melanoma cel

138 A novel pathway of increasing the surface density of catalytical

139 Coevolutionary pathways of indirect effects favour ongoing trait evolut

140 These findings describe a unique pathway of inflammasome regulation with the identificati

141 serving to simultaneously shut down multiple pathways of inflammation.

142 ide in APCs may contribute to the endogenous pathway of iNKT cell activation.

143 on, emphasizing how they may impact multiple pathways of innate immunity.

144 Here the quantified physical pathway of interfacial area change due to material excha

145 Both responses are mediated by a single pathway of interneurons.

146 ymes of the methylerythritol phosphate (MEP) pathway of isoprenoid biosynthesis, including the clinic

147 e, the 10 identified novel genes are part of pathways of kidney development, carbohydrate metabolism,

148 udies identified the LLO-dependent endocytic pathway of L. monocytogenes and support a novel model fo

149 features of speech sounds along the ventral pathway of language processing in the brain toward infer

150 s to capitalize on the highly active salvage pathways of Leishmania, which are purine auxotrophs.

151 step in characterizing distinct trafficking pathways of lignocellulolytic enzymes in filamentous fun

152 findings suggest that the general unfolding pathway of low charge state albumin ions is largely unaf

153 deficiency in cells, suggesting a conserved pathway of low zinc homeostasis.

154 k) is a central player in multiple signaling pathways of lymphoid and myeloid cells.

155 asingly being recognized in the biosynthetic pathways of many structurally complex natural products.

156 Although the biosynthetic pathway of MAs is well studied, the mechanism(s) by whic

157 t of atherosclerosis and possible regulatory pathways of MC1-R beyond anti-inflammation.

158 ly, Mot2 is not involved in the constitutive pathway of Mei2 turnover, but rather plays a regulatory

159 aper aims to elucidate whether the synthetic pathway of Melatonin in Saccharomyces and non-Saccharomy

160 provide further insight into the biochemical pathways of methanotrophy during the DWH blowout.

161 DCs), led us to propose a third, semidirect, pathway of MHC allorecognition.

162 -2) family of proteins governs the intrinsic pathway of mitochondrial apoptosis.

163 inner membrane Ca(2+) transporter and major pathway of mitochondrial Ca(2+) entry.

164 n kinase regulates the PINK1/Parkin and DJ-1 pathways of mitophagy during sepsis.

165 ulation in PTSD and demonstrate inflammatory pathways of molecular convergence and specificity, which

166 quantum mechanical calculations of reaction pathways of molecules under pressure, is introduced.

167 In contrast to degradation pathways of monocyclic aromatic compounds where ring-cle

168 Herein, reductive pathways of MoO(S2)2bpy (Mo-bpy) (bpy = 2,2'-bipyridine)

169 rization of multiple activation/deactivation pathways of MOR, and e) Suggestion from calculated trans

170 However, pathways of MT1-MMP up-regulation are not clearly unders

171 we aim to establish autophagy, a downstream pathway of mTOR, as a new therapeutic target for PKD.

172 tectable, which activated in vitro the STAT5 pathway of murine macrophages.

173 However, where IRF8 acts in the pathway of myeloid differentiation to influence PMN-MDSC

174 er-induced denitrification were the dominant pathways of N2 O production, and application of the nitr

175 tion from HIV exposures and better delineate pathways of NAb development.

176 gnificant role in unveiling the biosynthetic pathways of natural products, here we demonstrate that c

177 our knowledge of how cells die by regulated pathways of necrosis has increased tremendously.

178 g diverse canonical modes-of-action to infer pathways of neuronal cell protection connected to drug m

179 These data identify a pathway of neutrophil recruitment within glomerular capi

180 ted in mutations in the different activation pathways of NF-kappaB, which result in aberrations in pr

181 toxicity, as CPS1 enables an unconventional pathway of nitrogen flow from ammonia into pyrimidines.

182 (TCR) is an important and well-conserved sub-pathway of nucleotide excision repair that preferentiall

183 such resources are potentially an important pathway of nutrient acquisition for some volant and scan

184 bution (i.e., arboreal) may reveal important pathways of nutrient acquisition by invertebrate and ver

185 Cs) and tufted cells (TCs) comprise parallel pathways of olfactory bulb output that are thought to pl

186 odulation of the D1/GABAA receptor signaling pathway of ON-cBC dendrites by the ambient light level f

187 conditions have overlapping risk factors and pathways of oncogenesis.

188 e time of retirement, but there may be other pathways of onset of MSDs in old age.

189 tes), is essential in defining the oxidation pathways of organic compounds in the atmosphere but is h

190 Many positive signalling pathways of osteoclastogenesis have been characterized,

191 for future characterisation of biosynthetic pathways of other basidiomycete natural products in asco

192 studying microtubule nucleation and assembly pathways of other polymers.

193 blocks the bottleneck step of the converging pathways of oxidative burst triggering.

194 by the obesity, with signaling and metabolic pathways of pathological significance.

195 serum pNfH concentrations in the diagnostic pathway of patients suspected to have ALS.

196 To elucidate the pathways of perforin pore assembly, we carried out real-

197 namic acid, the committed step for the major pathway of Phe metabolism.

198 i is due to the dilution effect of different pathways of phenylalanine biosynthesis in Pseudomonas sp

199 he key enzyme required for the mitochondrial pathway of phosphatidylethanolamine production, is close

200 his review will focus on the chaperone-usher pathway of pilus biogenesis, a widespread assembly line

201 Recently, a non-canonical pathway of PKGIalpha activation has been proposed, in wh

202 Second, transport pathways of PM 2.5 are revealed by another motif, which

203 indicated both resistance and vulnerability pathways of population responses to climate: in less sui

204 ting that one factor may use two independent pathways of post-transcriptional gene regulation.

205 family of natural products.The biosynthetic pathway of preakuammicine, a monoterpene precursor of th

206 Understanding and blocking the self-renewal pathway of preleukemia stem cells could prevent acute my

207 and biological importance, the biosynthetic pathways of prenylated stilbenoids remain to be elucidat

208 the initial sites of prion accumulation and pathways of prion spread during early CWD infection rema

209 Exogenous TGFbeta promotes EMT in a unique pathway of PRMT5-MEP50 catalyzed histone mono- and dimet

210 Renal fibrosis is the common pathway of progression for patients with CKD and chronic

211 oaches to dissect the complicated misfolding pathways of protein aggregation.

212 ow the presence of links affects the folding pathways of proteins.

213 ted to a dependence on a cross-compartmental pathway of pyrimidine metabolism in an aggressive subset

214 with a special emphasis on lytic cell death pathways of pyroptosis and necroptosis and their implica

215 chemistries and processes.Probing the growth pathways of quasicrystalline materials, where tiling uni

216 erstanding of the solidification and melting pathways of quasicrystals, we performed synchrotron-base

217 modulating RT kinetics by targeting the PCET pathway of radical transport.

218 g stalk domains, providing insights into the pathway of receptor-activated virus entry.Nipah virus ca

219 upled electron transfer (PCET) steps along a pathway of redox active amino acids (Y122beta <--> [W48b

220 Diverse pathways of regulated necrosis have been reported to con

221 We have thus uncovered a pathway of regulation whereby APC/C(Fzr/Cdh1) negatively

222 our laboratory and others have shown several pathways of regulation of ILC2s by co-stimulatory molecu

223 of the N-terminus of hDAT in controlling the pathways of release.

224 ript levels of genes involved in alternative pathways of respiration and amino acid catabolism were u

225 ized interventions targeting neurobiological pathways of risk associated with inflammation.

226 d repressor, Mig1, from a paradigm signaling pathway of Saccharomyces cerevisiae.

227 species obtained during the chemiexcitation pathway of Schaap's adamantylidene-dioxetane probe.

228 nd antagonizes fibrillation and cytotoxicity pathways of secondary nucleation induced by seeding.

229 inding to the P450 active site and different pathways of signal transduction from the allosteric site

230 s offer the potential to specifically target pathways of significance.

231 The photoinduced rearrangement pathways of simple 2,5-dienones and the natural product

232 eriment and theory, we explain the shuttling pathways of single dopants into and out of the nanoparti

233 modeling, we found that the main dissipation pathways of SM at the plot scale were degradation (71%),

234 mutations of pathways and finds all possible pathways of small systems without initial guesses on pat

235 tanding of the production and transformation pathways of soil organic N metabolites, including the un

236 Although the speed and pathways of spread varied across seasons, seven of eight

237 -dependent, TLR4- and type I IFN-independent pathway of sterile liver injury in which hepatocytes are

238 he aminoquinone skeleton in the biosynthesis pathway of Streptomyces species.

239 The thermodynamics and reaction pathway of sulfur cathode in MgTFSI2 -DME electrolyte, a

240 By a pathway of targeted delivery involving microtubule highw

241 The N-end rule pathway of targeted protein degradation is an important

242 ity and further suggest that RBPs direct the pathway of tau aggregation and the resulting neurodegene

243 confirm parallel but symbiotic developmental pathways of Th22 and Th17 differentiation.

244 A model for the assembly pathway of the catalytic core is proposed.

245 ucture of chicken Slo2.2, the ion permeation pathway of the channel is closed by a constriction of th

246 dvance our understanding of the biosynthesis pathway of the chlorophylls and the formation of the for

247 play a critical role in the P2X7R signaling pathway of the CNS.

248 r results, the activation of the alternative pathway of the complement system strongly contributes to

249 itor fat synthesis in vivo, but the chemical pathway of the deuterons into fat remains unclear.

250 cells and is regulated by the antiviral RNAi pathway of the host.

251 to date reside in the polyamine biosynthesis pathway of the human parasite Trypanosoma brucei, an ear

252 The contact pathway of the plasma clotting cascade is dispensable fo

253 ion are critically involved in the apoptotic pathway of the pre-diabetic heart.

254 ield interesting aspects with respect to the pathway of the reaction and the directing group abilitie

255 iations is that they can compromise drainage pathway of the related sinus, which results in inflammat

256 The biosynthetic pathway of the sphingolipids affords many opportunities

257 estimates for the energetics, timescale, and pathway of the T4 injection process as well as the force

258 the striatum between the direct and indirect pathways of the basal ganglia (BG).

259 haviors analogous to the direct and indirect pathways of the basal ganglia.

260 plings in sampling and predicting activation pathways of the beta 2-adrenergic receptor (beta 2-AR),

261 represent the major biological processes and pathways of the cell.

262 he morphological features of the centers and pathways of the cerebrocerebellar circuits, paying parti

263 now show that in AAV-NT mice, the signaling pathways of the CR mediators, AMP-activated protein kina

264 lar investigations can identify transmission pathways of the HPAI virus.

265 to solve for the minimum free-energy gating pathways of the proton-activated bacterial GLIC channel.

266 he identified byproducts, the transformation pathways of the reactive UV filters were proposed for th

267 of two dopamine-receptor-expressing efferent pathways of the striatum.

268 ight is presented on the individual reaction pathways of the terpenes hydroxydammarenone and abietic

269 onstrate that differences in the aggregation pathways of the two Abeta alloforms occur as early as du

270 Understanding the developmental pathway of these antibodies has provided insights into t

271 e of Slo2.2 suggests that the ion permeation pathway of these channels is closed by a single constric

272 , thus avoiding the typical decarboxylation pathway of these substrates.

273 Additionally, functional connectivity pathways of these subunits and their correlation with ta

274 However, the reaction pathways of these two substrates are different.

275 n and provided no insight into the catalytic pathway of this enzyme.

276 However, the underlying molecular pathways of this disease remain undefined.

277 Understanding of the underlying pathways of this heterogeneous disease is needed for the

278 Our data identify a new pathway of thrombosis involving leukocyte Mac-1 and plat

279 oyl diacylglycerol (PODAG) stimulate the IMD pathway of ticks.

280 crucial role for endosomal PAR2 signaling in pathways of tissue repair and tumor biology.

281 These results suggested that the pathway of TNFalpha/TNFRI-mtO2(.-)-pCREB triggers pC/EBP

282 the second biochemical route, the shikimate pathway of Tobacco plant was engineered to accumulate pr

283 the initial radical generation for different pathways of toluene oxidation but they do not seem to fa

284 d behavior can influence the dominant energy pathways of top predators, with implications ranging fro

285 might be detected compared with the standard pathway of TRUS-biopsy for all.

286 ve metabolites generated from the kynurenine pathway of tryptophan degradation have been implicated i

287 t and rate-limiting enzyme in the kynurenine pathway of tryptophan metabolism.

288 The kynurenine pathway of tryptophan oxidation is associated with centr

289 pothesis that TG processing in the secretory pathway of TSHR-hyperstimulated thyrocytes alters the st

290 recently identified a new mechano-enzymatic pathway of TTR fibrillogenesis in vitro, catalysed by se

291 n have limited specificity due to endogenous pathways of TU incorporation.

292 acterizing the photodegradation kinetics and pathways of two largely employed antibiotics families: s

293 dren with evidence of activation of multiple pathways of type 2 inflammation in early life are at gre

294 is directly sensed by the Cys-Arg/N-end rule pathway of ubiquitin-mediated proteolysis, through oxyge

295 athematically that there is a unique minimal pathway of unlinking replication links by reconnection w

296 We conclude that the minimal pathway of unlinking replication links that was found un

297 ransform epithelial cells-a novel, potential pathway of VAT-enhanced tumorigenesis.

298 VEGFR2, in addition to the primary signaling pathway of VEGF/VEGFR2/calpain/PI3K/AMPK/Akt/eNOS.

299 This approach defines potential pathways of viral evolution, beyond those already observ

300 we summarize common and cancer type-specific pathways of VTE in cancer patients.