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3 with other catalysts in synthetic metabolic pathways to access a variety of challenging anti-Markovn
5 food production, is an important mitigation pathway to achieve the less than 2 degrees C global targ
7 ed for precise control of complex signalling pathways to achieve proper patterning, the limb is also
8 nding how cells integrate multiple signaling pathways to achieve specific cell differentiation is a c
9 es mainly upon its own arginase-AdoMetDC/ODC pathway to acquire the polyamines it needs to develop.
10 es target the beta-adrenergic (beta-AR)/cAMP pathway to activate cytosolic lipases and induce their r
11 ugh the mycothiol/mycothione reductase/NADPH pathway to activate TP053, preferentially via a dithiol-
12 picomplexan parasites, uses Ca(2+) signaling pathways to activate gliding motility to power tissue di
15 s, however, animals use alternative neuronal pathways to adapt to the metabolic challenges of altered
16 a full G-protein-coupled receptor signalling pathway to adaptively transduce photons into quantum bum
17 urrent injection efficiency model provides a pathway to address the limiting factors in electrically-
18 hilic inflammation and diabetic complication pathways to address the greater morbidity and mortality
21 on has modified starch and ketone metabolism pathways to allow for human consumption, the concomitant
22 hese diseases have often targeted downstream pathways to ameliorate consequences of protein dysfuncti
23 otein (RP)-murine double minute 2 (MDM2)-p53 pathway to APC loss-induced tumorigenesis, we crossed mi
27 versally conserved TOR (Target of Rapamycin) pathway to balance growth and development with the avail
28 wedge)2 allows the semiconducting conduction pathway to be modulated solely by surface functional gro
29 ajor challenge in the field by positing this pathway to be targeted for modulation of NETs while pres
30 ional analysis identified interferon-related pathway to be the most responsive genes and further conf
31 es could be a key strategy to enable foreign pathways to be efficiently controlled within eukaryotic
32 els imitating drug perturbation allows these pathways to be realistically rendered in comparison to t
34 anslation and respiratory electron transport pathways to be significantly downregulated after RK-33 o
36 for therapeutically enhancing VISTA-mediated pathways to benefit the treatment of autoimmune and infl
41 Extensive subnational differences in patient pathways to care call for differentiated approaches to p
42 ificance of an ER-mitochondrial PC synthesis pathway to cellular phospholipid homeostasis, and establ
46 erential attunement of the magnocellular (M) pathway to clear threat, and of the parvocellular (P) pa
50 We conclude that Aquarius allows small RNA pathways to compete for access to nascent transcripts un
51 both E6 and E7 reduce the ability of the HR pathway to complete double-strand break (DSB) repair by
54 erial protein drives a multistep biochemical pathway to control ubiquitination and tubular ER functio
56 with serotonergic and neuropeptide signaling pathways to control food-regulated behavioral state swit
57 -factors and integrate signals from multiple pathways to control metabolism, oxidative stress respons
58 as been a considerable amount of research on pathways to control the direction of magnetization with
59 regulators of the TORC1 and TORC2 signaling pathways to coordinate cellular stress responses with st
60 st Saccharomyces cerevisiae employs multiple pathways to coordinate sugar availability and metabolism
61 s measured by the ability of one morphogenic pathway to cross-activate core transcription factors and
63 nderline the ILC2/IL-13 axis as a targetable pathway to curtail the M-MDSC compartment and improve bl
64 ariable stress, and capitalize on converging pathways to define molecular and physiological mechanism
65 may use the same internalization-degradation pathway to deliver active payloads, strategies aimed at
68 d individual steps in the multistep reaction pathway to determine which processes limit steady-state
70 omeobox genes function in parallel intrinsic pathways to determine RGC fate and therefore generated D
71 li1, Ptch1, SMO), and mTOR (pS6K1) signaling pathways to determine the mechanism of action of itracon
72 's response to nanoparticles and opens a new pathway to develop nanomedicines for many diseases assoc
73 , a critical need persists for new, feasible pathways to develop antibacterial agents to treat people
74 g or mobile genetic elements, via an unknown pathway, to direct guide-dependent cleavage of foreign D
77 is therefore a key link connecting metabolic pathways to DKD pathogenesis, and measuring urinary fuma
81 beta) signals through both SMAD and non-SMAD pathways to elicit a wide array of biological effects.
82 The work demonstrates a general and scalable pathway to enable the high-temperature capacitive energy
85 clonal antibodies to block immune regulatory pathways to enhance tumor-specific immune responses for
90 (2017) and Shin Yim et al. (2017) identify a pathway to explain how these aspects of our physiology a
93 ization of diverse H2 and formate generating pathways to facilitate interactions with partner methano
96 concentrations at each step of the NF-kappaB pathway, to find that input discernibility decreases as
97 eport a long-term chronosequence of recovery pathways to fire suggesting faster recovery rates than p
100 f the ligand-receptor interaction biases the pathway to form precipitous aggregates containing short
101 king SFAs into the glycerolipid biosynthetic pathway to form saturated phospholipids, which ultimatel
104 t ingestion appears to be the major exposure pathway to FRs (median total exposure 230 pg/kg bw/d, ac
106 that methylation could either be on a causal pathway to future disease or could be a noncausal biomar
107 , and plants can be combined to encode a new pathway to generate a novel chlorinated coumarin "non-na
108 ates phytohormone biosynthesis and signaling pathways to generate daily rhythms in hormone activity t
109 glycosylase (UNG) and mismatch repair (MMR) pathways to generate mutations at G-C and A-T base pairs
110 r simulations of desflurane reveal a binding pathway to GLIC via a membrane-embedded tunnel using an
112 C-6/netrin-mediated, RAC-dependent signaling pathway to guide left/right patterning within this circu
113 diation of medical imaging has no documented pathway to harm, whereas the LNTH and ALARA most assured
115 real-world chemical exposures with molecular pathways to help scientists generate testable hypotheses
117 e study demonstrates a low-cost and scalable pathway to high-performance flexible thin film thermoele
119 a-occupational, and residential use exposure pathways to house dust pesticide concentrations: meta-re
120 ysis were linked to discrete adverse outcome pathways to identify potential adverse outcomes and biom
121 x and gender science, and identify strategic pathways to improve the cardiovascular health of women.
122 angiotensin II-dependent NFkappaB signaling pathways to improve the treatment of this breast cancer
124 at enables simultaneous testing of different pathways to incident adolescent-onset MDD composed of co
125 f back-mutation to F427 offers an accessible pathway to increase fitness in rCan, reversion in K33S-G
126 esponse, triggering an adaptive mitohormetic pathway to increase hepatic beta-oxidation and mitochond
127 ce of both reward surfeit and reward deficit pathways to increased body weight are evaluated, and we
128 the extrinsic Fas-mediated membrane receptor pathway to induce apoptosis, which is regulated by p53.
129 conclude that Leishmania uses an alternative pathway to induce host autophagy while simultaneously in
131 -radiative energy dissipation is a potential pathway to induce structural-phase transitions in two-di
132 urther emphasizing the need to regulate both pathways to induce indefinite survival of the graft.
133 eeds to potentiate only particular GABAergic pathways to induce sleep without reducing EEG power.
134 in-dependent (but IFN-independent) signaling pathways to induce STAT1 activation, which may allow the
136 oitation of the evolutionarily conserved Wnt pathway to inhibit autolysosome generation, thereby lead
137 suggesting that the DCs use this particular pathway to inhibit CD8 T-cell-mediated tumor immunity.
138 ophosphate (cAMP)-dependent protein kinase A pathway to inhibit HIV-1 activation and replication in r
143 e lymphocytes exploit a common DDR signaling pathway to limit DSBs at multiple genomic locations with
144 fungal apoptosis-like programmed cell death pathway to maintain sterilizing immunity in the lung.
146 the Coulomb interaction, which opens up new pathways to manipulate and control the behavior of these
148 vivo transport of ultrasmall AuNPs open up a pathway to maximize their biomedical potentials and mini
149 Cav) channels couple intracellular signaling pathways to membrane potential by providing Ca(2+) ions
151 This has been proposed as one potential pathway to mitigate the effects of greenhouse gas releas
152 pses at the very first stage of the auditory pathway to modify their properties, by decreasing in siz
153 context of cancer, EBV hijacks the exosomal pathway to modulate cell-to-cell signaling by secreting
154 or the use of biologic agents targeting such pathways to modulate autoimmune and neoplastic disease.
156 yl group of caffeoyl-coenzyme A (CoA) on the pathway to monolignols, with their ring methoxylation st
158 indicate that Leishmania uses an alternative pathway to mTOR to induce autophagy in host macrophages.
159 practising PLA improve key behaviours on the pathway to neonatal mortality, with the strongest eviden
162 interactions in kidneys but also offer a new pathway to noninvasively image kidney dysfunction and lo
163 edly, all mono- and polysynaptic ST afferent pathways to NTS-CeA neurons were organized exclusively a
165 ture of organic chromophores that provides a pathway to overcoming the aforementioned disadvantages.
166 ery unexpectedly, we identify a new response pathway to OXPHOS dysfunction in which the intra-mitocho
170 nce experience and physiology via descending pathways to physiological effector systems, including th
173 olecular control might have made the initial pathways to prebiotic systems evolution more intricate,
174 sion genes involved in the phototransduction pathway to predict the diel activity patterns of ancestr
175 mathematical model that uses DRC in multiple pathways to predict cellular resistance to killing by DN
176 its functional features of the drug-specific pathways to predict new indications as well as adverse r
177 his "cage-walking" process provides a unique pathway to preferentially introduce functional groups at
178 uses both class I and II antigen-processing pathways to present peptides derived from intracellular
181 ble to grow by subverting immune suppressive pathways, to prevent the malignant cells as being recogn
182 dy-positive relatives of T1D patients in the Pathway to Prevention (PTP) Study of the Type 1 Diabetes
184 ing their retention of an oxygen-independent pathway to produce pseudocobalamin, which is used as a c
185 up is primarily metabolized by the arginase pathway to produce the polyamines required for Plasmodiu
187 c clusters may have enabled the evolution of pathways to produce specialized amino acids, thereby inc
188 ukaryotes have different anaerobic metabolic pathways to prokaryotes such as bacteria and archaea.
190 (MAPK)-MAPK-activated protein kinase 2 (MK2) pathway to promote actin polymerization and endothelial
191 cert with the fibroblast growth factor (FGF) pathway to promote branch morphogenesis, while correct p
192 functions in concert with the DAF-7/TGF-beta pathway to promote germline proliferation and is not req
193 DAF-2/insulin IGF-1 receptor (IIR) signaling pathway to promote germline stem cell proliferation.
195 which would otherwise stimulate the MAPK/ERK pathway to promote NE differentiation of prostate cancer
196 rs, we found activation of the Wnt signaling pathway to promote neurogenesis of the ENS in vitro.
197 ding direct evidence for the ability of this pathway to promote the myelination of human sensory axon
198 converge on activation of the Wnt signaling pathway to promote tooth morphogenesis through the bud-t
201 t may in fact engage with integrin signaling pathways to promote T-lymphocyte antitumor functions, wi
203 ast to normal cells, cancer cells coopt this pathway to propagate structural and numerical chromosoma
204 sensitivity to immunosuppressive checkpoint pathways to provide greater proliferative capabilities a
205 e PGCs of this sea urchin institute parallel pathways to quiesce translation thoroughly but transient
208 ntry Units (CEUs), structures that provide a pathway to rapidly recover Ca(2+) ions from the extracel
210 uctures, coupling autocatalytic and assembly pathways to realize a reproducing supramolecular system.
212 of DNA lesions, which are sensed by distinct pathways to recruit repair factors specific to the damag
213 eaving enzyme (BACE1) from the endolysosomal pathway to recycling endosomes represents an important t
214 is that inhibiting enzymes in the mevalonate pathway to reduce cellular cholesterol increases the res
216 naling interplays with the CRE1-dependent CK pathway to regulate early nodulation in response to both
218 cific miRNAs are generated by an alternative pathway to regulate genes involved in cellular growth ar
219 we focus on the role of the Notch signalling pathway to regulate GI stem cell function in adult small
220 PS33B interacted with the GDI2/RAB11A/RAB27A pathway to regulate the trafficking of secretory protein
222 ively modulate the KEAP1-NRF2 cytoprotective pathway to regulate tumor progression and radiochemoresi
224 ta cytokines signal via a complex network of pathways to regulate proliferation, differentiation, adh
227 ulatory module, or exist largely as distinct pathways to repress self-reactive T cells remains incomp
228 eta and also IL-6, IL-8, and CXCR1 signaling pathways to reverse the proapoptotic effect of the IL-32
229 in the development of high-spin species as a pathway to scalable QC systems within magnetic molecules
230 at need for a reliable method to control the pathway to seizure onset, which would allow investigatio
231 tion that preserves the geniculohypothalamic pathway to show that GABAergic thalamic neurons inhibit
232 act together with the piRNA and nuclear RNAi pathways to silence repetitive elements and prevent geno
233 sts readily decompose, via little-understood pathways, to species that promote double-bond migration
236 embling nanosystems and conceptualizes a new pathway to spontaneous compartmentalization for a wide r
240 LGR5 primarily functions via the IQGAP1-Rac1 pathway to strengthen cell-cell adhesion in normal adult
241 r characterized by involvement in biological pathways to study their functional implications in aging
243 35 member B2 (SLC35B2) function in a common pathway to sulfate CCR5 on extracellular tyrosine residu
244 remodeling factor to engage a core survival pathway to support its cancerous phenotypes, and reveal
245 w-value signals are sent by the CDt-indirect pathway to suppress saccades to valueless objects, where
247 onal components in the programmed cell death pathway to test the hypothesis that neutrophils fed CA-M
248 genetic risk variants, genes, or biological pathways; to test for pleiotropic associations with othe
250 OFC also sends a uniquely one-way excitatory pathway to the amygdalar inhibitory intercalated masses
254 hydroxymethylphosphonate on the biosynthetic pathway to the commercial herbicide phosphinothricin, un
258 ow here that ATP binding opens the transport pathway to the extracellular space and reconfigures the
260 suggest that the contribution of the C-NHEJ pathway to the formation of a 0.4-Mbp deletion rearrange
264 t favored energetically, while the potential pathway to the minor isomer leads instead to decompositi
266 Redirection of Gpd1 from the PTS2 import pathway to the PTS1 import pathway supports Gpd1 monomer
269 nergic neurons project via the nigrostriatal pathway to the striatum to regulate voluntary movement.
271 Our study links the inositol pyrophosphate pathway to the synthesis of polyphosphate in acidocalcis
272 sly uncovers the existence of an alternative pathway to the well-described POMT (protein O-mannosyltr
273 a pathway from pOFC to IM exceeded all other pathways to the amygdala by density and size and proport
274 ynaptic characteristics of visceral afferent pathways to the central nucleus of the amygdala (CeA) in
276 nderstanding of the contribution of FcgammaR pathways to the induction and regulation of antibody and
277 uced selectively in the CS-specific auditory pathways to the LA in a mouse model of auditory discrimi
278 d depotentiation of the CS-specific auditory pathways to the LA suppressed conditioned fear responses
279 is could be significant in terms of creating pathways to the long-range room temperature magnetic ord
280 cal evidence has linked alterations in these pathways to the pathogenesis of several neurodegenerativ
281 we ask whether the excitability of the motor pathways to the real (disembodied) hand are affected by
285 t and the Tmcs interact within the secretory pathway to traffic Tmc proteins to the hair bundle.
287 Topics discussion, we review the historical pathways to training; discuss the training needs for the
289 HIV-1 requires a specialized nuclear export pathway to transport unspliced and partially spliced vir
291 cadian clock interacts with other regulatory pathways to tune physiology to predictable daily changes
292 was examined in the key genes of the folate pathway to understand its linkage with folate levels.
293 rtance of studying the dynamics of signaling pathways to understand their physiological response.
294 can computationally represent drug-signaling pathways to understand unintended drug actions and to fa
295 uch a sensing platform may offer a different pathway to utilize manganese nanoparticles based CNTs co
296 hatase 1B (PTP1B), and the relevance of this pathway to VEGF-induced angiogenesis, especially in diab
298 heroprotective reverse cholesterol transport pathway, to which biliary and transintestinal cholestero
299 alkoxysilanes via both 2,1 and 1,2 insertion pathways to yield 4- and 5-membered chelates, respective
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