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1                                                             Patients were required to have 1) objective clinical evidence
2                                                             Patients were required to have a dedicated tumor biopsy for d
3                                                         All patients were required to have a histologic diagnosis of panc
4                                                In 4 trials, patients were required to have a history of migraine attacks
5                                                             Patients were required to have a malignant solid tumor for wh
6                                                             Patients were required to have a malignant solid tumor for wh
7 ipants had minimal levels of severity and endogenicity, all patients were required to have a score of at least 20 on the
8                                                    Eligible patients were required to have adequate hepatic and renal fun
9 articipants (from December 15, 2000, to September 1, 2001), patients were required to have advanced GIST that was not sur
10                                                             Patients were required to have an implantable cardioverter-de
11                                                             Patients were required to have an initial diagnosis of clinic
12                                                             Patients were required to have at least 1% PD-L1 expression d
13                                                             Patients were required to have chemosensitive or stable disea
14                                                             Patients were required to have chronic heart failure (NYHA II
15                                                             Patients were required to have early-stage disease and gadoli
16                                                             Patients were required to have Eastern Cooperative Oncology G
17                                                             Patients were required to have EGFr expression demonstrated o
18                                          At enrollment, all patients were required to have evidence of low bone mass, exc
19                                                             Patients were required to have good performance status, no pr
20                                                             Patients were required to have histologically proven adenocar
21                                                             Patients were required to have no clinically significant card
22                                                         All patients were required to have one or more indications for tr
23                                                             Patients were required to have received irinotecan, either al
24                                                             Patients were required to have received no more than three pr
25                                                             Patients were required to have relapsed/refractory disease, a

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