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1 were analyzed using a multivariate method of pattern recognition.
2 rape variety employing chemometric tools for pattern recognition.
3 eal-time signal processing applications like pattern recognition.
4                                       With a pattern recognition algorithm, we found that IMC-48 and
5                                Two real-time pattern recognition algorithms, using either (1) mechani
6  Purpose To investigate whether multivariate pattern recognition analysis of arterial spin labeling (
7 ic anonymization--for example for performing pattern recognition analysis on multicentre/multi-manufa
8 posed tool especially useful when performing pattern recognition analysis.
9                         We sought to compare pattern recognition and direct control in eight transhum
10 analysis showed principally up-regulation of pattern recognition and innate inflammatory pathways, wi
11      In this paper we demonstrate the use of pattern recognition and machine learning techniques to d
12 tures and memristors are being developed for pattern recognition and machine learning.
13 analysis (PCA) was applied in this study for pattern recognition and significant metabolites selectio
14       Herein, we applied a novel methylation pattern recognition and simulation approach, and we expl
15 e necessary for complex visual tasks such as pattern recognition and visual navigation.
16 or large-scale chemotype (consensus chemical pattern) recognition and drug target profiling.
17 developed to analyze the IR spectra by novel pattern-recognition and statistical tools, to determine
18 dditional inflammatory responses, as well as pattern recognition, and fibrogenesis.
19 a popular tool for dimensionality reduction, pattern recognition, and visualization of high dimension
20 n of a classic, well-defined data mining and pattern recognition approach termed the 'k-means' genera
21                                          The pattern recognition approach thus helps in identificatio
22 esults underline the utility of multivariate pattern recognition approaches for the identification of
23                                 Multivariate pattern recognition approaches have recently facilitated
24 iples of hexagonal TRIM5 assembly and capsid pattern recognition are conserved across primates, allow
25 n cognitive explanations of fly behaviour in pattern recognition assays.
26                                              Pattern recognition based on data drawn from large-scale
27 iting progression through mitosis or loss of pattern recognition by stimulator of interferon genes (S
28 ular pattern and damage-associated molecular pattern recognition by the innate immune system, and how
29                          Tools for automated pattern recognition can provide objective information to
30 Sensor arrays are further employed to enable pattern recognition capable of discriminating between si
31 evant applications such as search engines or pattern recognition circuits, and opens possibilities to
32                Seven of 8 subjects preferred pattern recognition control over direct control.
33 ormed a 6-8 week home trial using direct and pattern recognition control with a custom prostheses mad
34 files that goes beyond current computational pattern recognition, does not require knowledge of speci
35 he cellular and physiological responses upon pattern recognition, elucidating the molecular, biochemi
36      Key computational operations, including pattern recognition, event prediction, and plasticity, i
37 ural network (ANN) mediated multidimensional pattern recognition from experimental and calculated 2D
38                              Semi-supervised pattern recognition has been proposed to automate this t
39                     Results demonstrate that pattern recognition is a viable option and has functiona
40 fundamental design principles ranging from a pattern recognition method via deep-learning convolution
41                                        Using pattern recognition methods, the determined voltammetric
42          Pentraxin 3 (PTX3) is a fluid-phase pattern recognition molecule and a key component of the
43 We found that MAp44 competed with MASP-3 for pattern recognition molecule interaction, and knockdown
44 l accepted, whereas the role of properdin as pattern recognition molecule is controversial.
45             Toll-like receptor 4 (TLR4) is a pattern recognition molecule of the innate immune system
46        We focused on collectin-11 (CL-11), a pattern recognition molecule that can trigger complement
47 erefore challenge the view of properdin as a pattern recognition molecule, and argue that the experim
48 ement may be triggered directly by a soluble pattern-recognition molecule.
49  from cells, which may function as a soluble pattern-recognition molecule.
50                     We hypothesized that the pattern recognition molecules (PRMs) from the lectin pat
51 ructural homology shared by other complement pattern recognition molecules and has its major function
52 ective study was to assess the impact of the pattern recognition molecules of the lectin pathway on l
53  classical pentraxins in humans, are soluble pattern recognition molecules that regulate the innate i
54 D bound to CC and reduced deposition of Igs, pattern recognition molecules, and complement factors on
55 cation models in fried matrices based on the pattern recognition of images.
56                                          The pattern recognition of the 53,126 fluorescence responses
57 re curved or helically folded states enables patterned recognitions of amines and ammoniums.
58                                              Pattern recognition on rCBF maps indicated that IN-OT-in
59 ator testing, but it had no effect on fundus pattern recognition or diagnostic ability overall.
60 feature detection process is approached as a pattern recognition problem, and thus, ANN was utilized
61 nd understanding, rather than merely solving pattern recognition problems; (2) ground learning in int
62     All samples were tested via unsupervised pattern recognition procedures like hierarchical cluster
63               Here, we identified CFHR5 as a pattern recognition protein that binds to damaged human
64 n initiating serine protease upon binding of pattern recognition proteins to pathogen surfaces is a c
65 gnition proteins (PGRPs) are multifunctional pattern recognition proteins.
66                  In this study, we show that pattern recognition receptor (PRR) ligands, including li
67 tion in macrophages decreases cytokines upon pattern recognition receptor (PRR) restimulation; cytoki
68 ion occurs in response to both virus-induced pattern recognition receptor (PRR) signaling and cellula
69 ntestinal microbes, and proper regulation of pattern recognition receptor (PRR) signaling is critical
70 ch regulates lymphocyte antigen receptor and pattern recognition receptor (PRR) signaling.
71 oorly understand how vitamin D affects viral pattern recognition receptor (PRR)-driven cytokine produ
72 dehydrogenase (SDH) subunit A, and amplifies pattern recognition receptor (PRR)-induced SDH activity,
73                                      Because pattern recognition receptor agonists continue to show m
74 stream of a calcium influx, and required the pattern recognition receptor and adaptor STING but not c
75 strate that langerin not only functions as a pattern recognition receptor but also as an adhesion rec
76  advanced glycation end products (RAGE) is a pattern recognition receptor capable of recognizing mult
77 (oxPCCD36) that are ligands for the platelet pattern recognition receptor CD36.
78 3 inflammasome, a multiprotein intracellular pattern recognition receptor complex that facilitates th
79 ulating the composition of a serine protease-pattern recognition receptor complex, MBL-associated ser
80  fungi induce neutrophilic MDSCs through the pattern recognition receptor Dectin-1 and its downstream
81                    In mice deficient for the pattern recognition receptor dectin-1 but not Toll-like
82 hus, NLRP3 mediated by ASC appears to be the pattern recognition receptor driving HBoV1 infection-ind
83 mune receptor, a member of the peptidoglycan pattern recognition receptor family (PGRP-LC), is requir
84  report serves as the first description of a pattern recognition receptor for CCHFV and highlights a
85 ng 10); however, the mechanism by which this pattern recognition receptor governs DC migration remain
86 ycation end-products (RAGE) is a multiligand pattern recognition receptor implicated in diverse chron
87 ibroblasts showed that RIG-I is the critical pattern recognition receptor needed for the influenza B
88  previously showed an important role for the pattern recognition receptor NOD2 in skin wound repair.
89          Pentraxin 3 (PTX3) is a fluid-phase pattern recognition receptor of the humoral innate immun
90  inflammasomes represent a central cytosolic pattern recognition receptor pathway leading to the gene
91  genetic deletion of Toll-like receptor 4, a pattern recognition receptor responsive to LPS, prevente
92 racterized post-translational consequence of pattern recognition receptor signaling is the assembly o
93  be observed downstream of death receptor or pattern recognition receptor signaling under certain cel
94 rtant role for collaboration between TNF and pattern recognition receptor signals in promoting maxima
95              We used these tools to quantify pattern recognition receptor spatiotemporal distribution
96 nd Mer (TAM) receptors in regulating chronic pattern recognition receptor stimulation and NOD2-induce
97 okines are attenuated after chronic NOD2 and pattern recognition receptor stimulation of macrophages;
98 e cationic protein more similar to a soluble pattern recognition receptor than to conventional cytoki
99  advanced glycation end products (RAGE) is a pattern recognition receptor that interacts with advance
100             Toll-like receptor 2 (TLR2) is a pattern recognition receptor that recognizes many types
101                         NLRP3 is a cytosolic pattern recognition receptor that senses microbes and en
102          TLR2 has been described as the main pattern recognition receptor that senses S. aureus and e
103                                   RIG-I is a pattern recognition receptor that senses viral RNA and i
104  of the differentiated keratinocyte-specific pattern recognition receptor TLR7, the Langerhans cell c
105                                 Although the pattern recognition receptor Toll-like receptor 2 (TLR2)
106  of the ER, acting as a guard receptor and a pattern recognition receptor, capable both of sensing ce
107 pensable for cytokine-dependent induction of pattern recognition receptor, cell adhesion, or chemotax
108 ed gene 5 (MDA-5, IFIH1), a cytosolic innate pattern recognition receptor, functions as a first line
109              Toll-like receptor 3, an innate pattern recognition receptor, is triggered by HRV, drivi
110                            The cytoplasmatic pattern recognition receptor, NOD2 (nucleotide-binding o
111 tivity, and requires no interaction with the pattern recognition receptor, Toll-like receptor 2 (TLR2
112 at the expression of PTX3, a soluble form of pattern recognition receptor, was induced by infection w
113             Immune modulation resulting from pattern recognition receptor-induced responses is a pote
114 inhibition of translation elongation blocked pattern recognition receptor-mediated XBP1 splicing, mim
115 ptor [Ifnar](-/-)) to understand the role of pattern recognition receptor-sensing pathways in arthrit
116 al transduction downstream of this important pattern recognition receptor.
117 ulate that NKp46/NCR1 may be a novel type of pattern recognition receptor.
118 y shows that a metabolic enzyme can act as a pattern recognition receptor.
119 lectin receptor langerin that functions as a pattern recognition receptor.
120 somes, HIV-1 somehow evades detection by the pattern-recognition receptor (PRR) Toll-like receptor 8
121  of JAK2 expression and signaling determined pattern-recognition receptor (PRR)-induced outcomes; whe
122 tory signalling and are a repository for the pattern-recognition receptor cyclic GMP-AMP synthase (cG
123             Animals have evolved an array of pattern-recognition receptor families essential for reco
124 t that the Toll-like receptor 9 (TLR9)-MyD88 pattern-recognition receptor pathway is uniquely capable
125 mmasomes, and each is influenced by a unique pattern-recognition receptor response.
126                             Reprogramming of pattern-recognition receptor signaling also occurred aft
127 e highlight these aspects of cell biology in pattern-recognition receptor signaling by focusing on si
128 l infection critically modifies responses to pattern-recognition receptor stimulation.
129                          CD14, a multiligand pattern-recognition receptor, is involved in the activat
130 sense microbial signatures via activation of pattern recognition receptors (PPRs), which trigger a ra
131                                              Pattern recognition receptors (PRR) promote pathogen era
132 ecular patterns (PAMPs) by surface-localized pattern recognition receptors (PRRs) activates the NADPH
133 PAMPs/MAMPs) are detected as nonself by host pattern recognition receptors (PRRs) and activate patter
134                                              Pattern recognition receptors (PRRs) and cytokine recept
135                      During viral infection, pattern recognition receptors (PRRs) and their associate
136                                         Host pattern recognition receptors (PRRs) are critical in reg
137                                          The pattern recognition receptors (PRRs) in epithelial cells
138 ar patterns (MAMPs) by cell-surface-resident pattern recognition receptors (PRRs) induces rapid, robu
139 sociated molecular patterns (PAMPs/MAMPs) by pattern recognition receptors (PRRs) is a key component
140             The interaction of microbes with pattern recognition receptors (PRRs) is essential for pr
141 ge-associated molecular patterns (DAMPs) for pattern recognition receptors (PRRs) may represent one s
142 rtance of DAMPs, which signal through innate pattern recognition receptors (PRRs) or DAMP-specific re
143                      From plants to mammals, pattern recognition receptors (PRRs) specifically recogn
144                    Plasma membrane-localized pattern recognition receptors (PRRs) such as FLAGELLIN S
145 have been made to therapeutically target the pattern recognition receptors (PRRs) such as the Toll-li
146  consist of two distinct groups of proteins: pattern recognition receptors (PRRs) that detect viral i
147 obe-associated molecular patterns (MAMPs) by pattern recognition receptors (PRRs) that initiate quant
148 ular patterns (PAMPs) that are recognized by pattern recognition receptors (PRRs) to activate pattern
149 s (RKs) and receptor-like proteins (RLPs) as pattern recognition receptors (PRRs) to monitor their ap
150 s (RKs) and receptor-like proteins (RLPs) as pattern recognition receptors (PRRs) to sense pathogen-a
151 ammatory disorders is understanding how host pattern recognition receptors (PRRs), specifically toll-
152      Inflammation is commonly triggered when pattern recognition receptors (PRRs), such as Toll-like
153 en shown to be recognized by two families of pattern recognition receptors (PRRs), Toll-like receptor
154 cular patterns (PAMPs) are detected by plant pattern recognition receptors (PRRs), which gives rise t
155 cargos of plant trafficking pathways are the pattern recognition receptors (PRRs), which must be pres
156 eby suggesting their recognition by specific pattern recognition receptors (PRRs).
157 g by several Toll-like receptors (TLRs), key pattern recognition receptors (PRRs).
158 l pathways that contain cytokine QTLs map to pattern recognition receptors (TLR1-6-10 cluster), cytok
159                                      Through pattern recognition receptors (Toll-like receptor 7 and
160 o trigger type I interferon (IFN) responses, pattern recognition receptors activate signaling cascade
161                                              Pattern recognition receptors allow the innate immune sy
162                                         Some pattern recognition receptors also sense endogenous liga
163               CD14, a coreceptor for several pattern recognition receptors and a widely used monocyte
164 be-associated molecular patterns (MAMPs) via pattern recognition receptors and activate innate immune
165                                              Pattern recognition receptors and IFN-stimulated genes h
166       NLRX1 is a member of the NLR family of pattern recognition receptors and is a potent negative r
167 ve mutants via a pathway requiring cytosolic pattern recognition receptors and NF-kappaB.
168 copy, we observed differential expression of pattern recognition receptors and robust upregulation of
169 onse to bacteria, including acting as hybrid pattern recognition receptors and TCR coreceptors, and t
170                                              Pattern recognition receptors are activated following in
171                      Restriction factors and pattern recognition receptors are important components o
172 tion, which established danger signaling via pattern recognition receptors as a new concept of kidney
173  studies have demonstrated that signaling by pattern recognition receptors can regulate metabolic pro
174        Distinct families of germline-encoded pattern recognition receptors can sense both microbial a
175                Toll-like receptors (TLR) are pattern recognition receptors classically associated wit
176 s of most cytokines following stimulation of pattern recognition receptors compared with whole blood
177                             Germline-encoded pattern recognition receptors detect molecular patterns
178 lso activate microglia via interactions with pattern recognition receptors expressed on microglia.
179 tly to infectious Ags through stimulation of pattern recognition receptors expressed on their surface
180 f the C-type lectin receptor family serve as pattern recognition receptors facilitating pathogen upta
181 ce of human cells is decorated with numerous pattern recognition receptors for a variety of mycobacte
182 n receptors (CLRs) have emerged as important pattern recognition receptors for infectious danger.
183 athogenic Th cell types via the signaling of pattern recognition receptors for innate immune response
184 d TLRs, the signals emanating from different pattern recognition receptors have to be integrated to a
185                   Following interaction with pattern recognition receptors in cross-talk with various
186 e of transcriptional responses downstream of pattern recognition receptors in informing the adaptive
187 h trigger inflammatory responses by engaging pattern recognition receptors in macrophages.
188              Thus, the activation of diverse pattern recognition receptors in mice causes a more seve
189      DAP12, a signaling adapter for multiple pattern recognition receptors in myeloid and natural kil
190     We further show that IRGM interacts with pattern recognition receptors including NOD2.
191 us mouse hepatitis virus (MHV) activates the pattern recognition receptors melanoma differentiation-a
192 ic microbes, but mounting data suggest these pattern recognition receptors might also play key roles
193 stream signaling following activation of the pattern recognition receptors NOD1 and NOD2, leading to
194                            NOD1 and NOD2 are pattern recognition receptors of the innate immune syste
195 ival correlated with decreased expression of pattern recognition receptors on host phagocytes known t
196    Misfolded and aggregated proteins bind to pattern recognition receptors on microglia and astroglia
197  in individuals carrying genetic variants in pattern recognition receptors or adaptors would result i
198 esignated biological binding partners, be it pattern recognition receptors or carbohydrate binding le
199 te that differences in the activation of key pattern recognition receptors resulted in the induction
200                                Innate immune pattern recognition receptors sense nucleic acids from m
201  analysis of the influence of human aging on pattern recognition receptors signaling and monocyte fun
202 ated molecular patterns (DAMPS) by cytosolic pattern recognition receptors such as NOD-like receptors
203                The innate immune system uses pattern recognition receptors such as RIG-I and NLRP3 to
204 ular relevance to viral infections are those pattern recognition receptors that activate type I inter
205 epeat (NLR) proteins are a diverse family of pattern recognition receptors that are essential mediato
206 l IgM antibodies represent a class of innate pattern recognition receptors that recognize danger-asso
207  Toll-like receptors (TLR) are transmembrane pattern recognition receptors that recognize microbial l
208 e response" is mediated by germ line-encoded pattern recognition receptors that trigger activation of
209        We sought to identify the ligands and pattern recognition receptors through which L lactis G12
210                    Dendritic cells (DCs) use pattern recognition receptors to detect microorganisms a
211 lipoteichoic acid (LTA), which interact with pattern recognition receptors to mobilize immune respons
212 molecular patterns (DAMPs) and interact with pattern recognition receptors to modulate inflammatory r
213 lectins, such as galectin-1, can function as pattern recognition receptors to reduce infection and in
214 protein-mediated signaling through cytosolic pattern recognition receptors was required for polyinosi
215                      Pyramiding cell surface pattern recognition receptors with intracellular immune
216  recognize a wide array of self-antigens via pattern recognition receptors, adaptive immunity activat
217 ncRNAs expressed in cancer cells with innate pattern recognition receptors, and thereby assign a prev
218       Bacteria are recognized by innate host pattern recognition receptors, and we previously showed
219 l-like receptors (TLRs), first identified as pattern recognition receptors, are now recognized to ser
220 e endocytic C-type lectin receptors serve as pattern recognition receptors, detecting pathogens by th
221 zed by distinct families of germline-encoded pattern recognition receptors, endogenous and pathogen-d
222 ely activate distinct subtypes of macrophage pattern recognition receptors, including bacterial toll-
223  their environment through the expression of pattern recognition receptors, including Toll-like recep
224    The interplay between Candida species and pattern recognition receptors, interleukins, kynurenine,
225 ber of the Nod-like receptor (NLR) family of pattern recognition receptors, is a bacterial sensor tha
226 autophagy induced by nutrient deprivation or pattern recognition receptors, less is known about the e
227 nia, lung neutrophils increase expression of pattern recognition receptors, receptors for inflammator
228 tified 129 immunity-related genes, including pattern recognition receptors, signal modulators, few me
229                                              Pattern recognition receptors, such as the Toll-like rec
230 , rhIFN-gamma increased expression levels of pattern recognition receptors, such as Toll-like recepto
231  Pellino-mediated regulation of signaling by pattern recognition receptors, T-cell and B-cell recepto
232 signals released by dying cells, the role of pattern recognition receptors, the diverse subtypes of r
233 mes containing unshielded RNAs that activate pattern recognition receptors, thereby promoting tumor g
234 ecular patterns (PAMPs) by surface-localized pattern recognition receptors, which initiates a series
235 n immune system utilizes several families of pattern recognition receptors, which survey the intracel
236 he innate immune system is activated through pattern recognition receptors-which include transmembran
237 r alarmins that can trigger inflammation via pattern recognition receptors.
238 ne system recognizes microbial pathogens via pattern recognition receptors.
239 eractions between TLR and Siglec families of pattern recognition receptors.
240  responses after engagement and signaling by pattern recognition receptors.
241 the retinoic acid-inducible gene I family of pattern recognition receptors.
242 ensive and direct interactions between these pattern recognition receptors.
243 timulatory effects through the activation of pattern recognition receptors; however, synthetic versio
244       The interactions between the different pattern-recognition receptors (PRRs) and cell wall patho
245         Toll-like receptors (TLRs) and other pattern-recognition receptors (PRRs) sense microbial lig
246 ude cell-intrinsic innate responses that use pattern-recognition receptors (PRRs) to detect viral pat
247 roduction of type I interferons triggered by pattern-recognition receptors (PRRs), but not that of th
248 he detection of viral double-stranded RNA by pattern-recognition receptors (RIG-I/MDA-5) and that NKG
249 s revealed that ALV infection is detected by pattern-recognition receptors (TLR9 and TLR3) leading to
250 hat the Brassicaceae may have evolved unique pattern-recognition receptors and antimicrobial root met
251             These include elevated levels of pattern-recognition receptors and dormant signaling enzy
252 l established; this is mediated primarily by pattern-recognition receptors and is central to the acti
253                                Expression of pattern-recognition receptors and microRNAs was evaluate
254 infection is sensed by a variety of cellular pattern-recognition receptors and triggers the synthesis
255                     Pathway analyses defined pattern-recognition receptors as the most sexually dimor
256 uitination of dectin-1 and dectin-2, two key pattern-recognition receptors for sensing Candida albica
257  a previously unknown function for microbial pattern-recognition receptors in the downregulation of i
258 ball-induced musculoskeletal trauma activate pattern-recognition receptors of the innate immune syste
259          Type I IFN activation is induced by pattern-recognition receptors of the innate immune syste
260 ic activities and abilities to engage innate pattern-recognition receptors such as TLR4.
261 d induction is a consequence of signaling by pattern-recognition receptors that have been selected ov
262 panded cnidarian-specific family of putative pattern-recognition receptors that might be involved in
263 spond to the gut microbiota through multiple pattern-recognition receptors, including TLRs and NLRs.
264 edicago truncatula possess very similar LysM pattern-recognition receptors, LjLYS6/MtLYK9 and MtLYR4,
265  profiling by MSI-CE-MS with temporal signal pattern recognition revealed new biomarkers for early de
266 cular diseases, but the microbiota-triggered pattern recognition signaling mechanisms that impact thr
267       Proprioceptive reinforcement of fundus pattern recognition significantly reduced the need for r
268 in diseases is based primarily on the visual pattern recognition skills and expertise of the physicia
269 duction technique as a part of an integrated pattern recognition solution capable of identifying adul
270 dy was to examine the relative importance of pattern recognition systems and downstream mediators in
271 tic model of a cerebellar Purkinje cell in a pattern recognition task show that, in the absence of no
272 tems based on such probabilistic neurons for pattern recognition tasks in presence of lateral inhibit
273 100% by applying a random forest statistical pattern recognition technique to analytical data acquire
274 underlying habitats; and (2) an unsupervised pattern recognition technique to recover the temporal co
275 e analytical data were collected, supervised pattern recognition techniques such as linear discrimina
276 yzed using a combination of graph theory and pattern recognition techniques that resolve data structu
277         In a second step, several supervised pattern recognition techniques were used to construct ma
278 uNPs upon OP addition has been analyzed with pattern recognition techniques, including hierarchical c
279 l component analysis (PCA), three supervised pattern recognition techniques, Partial Least Squares Di
280  German propolis samples were analyzed using pattern recognition techniques, principal component anal
281 lyzed using mass univariate and multivariate pattern recognition techniques.
282  imaging with probabilistic tractography and pattern recognition techniques.
283 d in schizophrenia (SCZ), using multivariate pattern recognition techniques.
284 und to outperform any other state-of-the-art pattern recognition techniques.
285 different honeys was developed through three-pattern recognition techniques: principal component anal
286 n three pillars: (i) the use of multivariate pattern-recognition techniques to develop brain signatur
287 ects of TMR may be enhanced when paired with pattern recognition technology.
288 itiate the cascade more specifically through pattern recognition, their activity still needs to be ti
289 s, and oscillatory computing, which performs pattern recognition through synchronization of coupled o
290  omics data analysis covering normalization, pattern recognition, time-series analysis, cross-omics c
291 n theory and artificial neural network (ANN) pattern recognition to classify exposure source based on
292       This study confirms that combining MRI pattern recognition to define small, homogeneous patient
293 ing nonredundant complementary mechanisms of pattern recognition to enact these functions.
294  identify all studies that used multivariate pattern recognition to identify patterns of brain altera
295 esulting 2D fingerprints were interpreted by pattern recognition tools (i.e. template matching finger
296 n exponentially, with an increased number of pattern recognition tools and an increase in data set si
297                                              Pattern recognition underpins innate immunity; the accur
298  This work has largely emphasized object and pattern recognition, which suggests that these are more
299                                              Pattern recognition with chemometrics using principal co
300 al and statistical significance in comparing pattern recognition with direct control.

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