ライフサイエンスコーパス: pedunculopontine

1 The role of the pedunculopontine and cuneiform nuclei, and related brain

2 c reticular formation (MRF) is formed by the pedunculopontine and cuneiform nuclei, two neuronal stru

3 phalic reticular formation (MRF), namely the pedunculopontine and cuneiform nuclei.

4 ressors on brainstem (upper pons, containing pedunculopontine and lateraldorsal tegmental nuclei; BS)

5 The mesopontine tegmentum, including the pedunculopontine and laterodorsal tegmental nuclei (PPN

6 in the gigantocellular region, in the caudal pedunculopontine and laterodorsal tegmental nuclei, dors

7 NC, as noted above, and to medial tegmentum, pedunculopontine and laterodorsal tegmental nuclei, dors

8 lateral geniculate, deep mesencephalic, red, pedunculopontine and laterodorsal tegmental, cuneiform,

9 raphe, parabrachial complex, pontine oralis, pedunculopontine and ventral tegmental area.

10 gray, the cuneiform, and the lateral dorsal, pedunculopontine, and subpeduncular pontine tegmental nu

11 ion of inputs originating from dorsal raphe, pedunculopontine, and subthalamic nuclei were tested for

12 Parkinson's disease, the additional loss of pedunculopontine cholinergic neurones, which control REM

13 timulation of the dopaminergic region evoked pedunculopontine dopamine release in vivo.

14 y of dopamine neurons, whereas activation of pedunculopontine inputs increased burst firing.

15 The pedunculopontine-laterodorsal tegmental nuclear complex

16 Available sleep-relevant areas (pedunculopontine/laterodorsal tegmentum, nucleus basalis

17 neurons in the basal forebrain, striatum and pedunculopontine nuclei, i.e. the neurons that innervate

18 c zone of the laterodorsal tegmentum and the pedunculopontine nuclei, referred to as rapid eye moveme

19 c zone of the laterodorsal tegmentum and the pedunculopontine nuclei, referred to as Wake/REM-on neur

20 ions with dramatic enrichment of both in the pedunculopontine nuclei, the accessory olfactory bulb, a

21 striatal projection neurons by the raphe and pedunculopontine nuclei.

22 Collaterals from the pedunculopontine nucleus (Ch5 area) to rostral [vasopres

23 c locomotor region (MLR), which includes the pedunculopontine nucleus (PPN) and the cuneiform nucleus

24 Cholinergic neuronal loss in the pedunculopontine nucleus (PPN) associates with abnormal

25 Whereas cholinergic neurons of the pedunculopontine nucleus (PPN) carry an associative/moto

26 The pedunculopontine nucleus (PPN) has long been considered

27 dies, mainly in animals, have shown that the pedunculopontine nucleus (PPN) in the upper brainstem ha

28 The pedunculopontine nucleus (PPN) is a promising new target

29 The pedunculopontine nucleus (PPN) located in the mesopontin

30 Because the pedunculopontine nucleus (PPN) plays an important role i

31 Because the pedunculopontine nucleus (PPN) regulates sleep and arous

32 es that preserved subcortical axons from the pedunculopontine nucleus (PPN) to the VTA, we compared t

33 tamate afferents: dorsal raphe nucleus (DR), pedunculopontine nucleus (PPN), and subthalamic nucleus

34 rons in the rostral brainstem, including the pedunculopontine nucleus (PPN), are critical for switchi

35 The pedunculopontine nucleus (PPN), the cholinergic arm of t

36 In terms of topography in the tegmental pedunculopontine nucleus (PPN), Type I neurons were disp

37 These brainstem structures include the pedunculopontine nucleus (PPN), which is traditionally c

38 rticularly within a brainstem structure, the pedunculopontine nucleus (PPN).

39 nce of modulatory input from the cholinergic pedunculopontine nucleus (PPN).

40 arise in various brain nuclei, including the pedunculopontine nucleus (PPN).

41 in both the thalamus (rho=-0.88, P<.001) and pedunculopontine nucleus (rho=-0.80, P<.010) were invers

42 were positively correlated with those in the pedunculopontine nucleus (rho=0.81, P<.004) and binding

43 Inclusions were detected in neurons of the pedunculopontine nucleus and in other brain stem regions

44 s from other cholinergic nuclei, such as the pedunculopontine nucleus and nucleus basalis of Meynert.

45 Impaired integrity of pedunculopontine nucleus cholinergic neurons and their t

46 tion of cholinergic neurons in the brainstem pedunculopontine nucleus complex and their thalamic effe

47 during gait, and suggest that differences in pedunculopontine nucleus connectivity contribute to poor

48 Local field potentials recorded from pedunculopontine nucleus electrodes in such patients hav

49 Structural connectivity of the pedunculopontine nucleus has been related to freezing an

50 lation of the hypothalamus, basal ganglia or pedunculopontine nucleus in decorticate animals results

51 we recorded local field potentials from the pedunculopontine nucleus in parkinsonian patients during

52 g to quantify structural connectivity of the pedunculopontine nucleus in patients with Parkinson's di

53 Excitatory inputs from the pedunculopontine nucleus interact with timed inhibitory

54 The pedunculopontine nucleus is one of the major nuclei of t

55 l deep brain stimulation targets such as the pedunculopontine nucleus may help treat the balance and

56 We also chose the pedunculopontine nucleus region (PPN) due to mounting ev

57 Alpha power was maximal in the caudal pedunculopontine nucleus region and beta power was maxim

58 hic distribution of neuronal activity in the pedunculopontine nucleus region and concur with animal d

59 rkinsonian patients, stimulation of a caudal pedunculopontine nucleus region selectively improves gai

60 ility that stimulation of caudal and rostral pedunculopontine nucleus regions may differ in their cli

61 Chronic pedunculopontine nucleus stimulation improved Freezing o

62 Pedunculopontine nucleus stimulation improved objective

63 Pedunculopontine nucleus stimulation is an emerging ther

64 In Parkinson's disease, pedunculopontine nucleus stimulation is an emerging trea

65 However, the efficacy and precise effects of pedunculopontine nucleus stimulation on Parkinsonian gai

66 essed the impact of unilateral and bilateral pedunculopontine nucleus stimulation on triggered episod

67 Pedunculopontine nucleus stimulation restored StartReact

68 g; however, these deficits were unchanged by pedunculopontine nucleus stimulation.

69 eezing and postural instability, relieved by pedunculopontine nucleus stimulation.

70 es of Parkinsonian disorders, treatable with pedunculopontine nucleus stimulation.

71 nts with severe gait freezing implanted with pedunculopontine nucleus stimulators below the pontomese

72 We also assessed asymmetry of pedunculopontine nucleus structural connectivity via dif

73 nterference was correlated with asymmetry of pedunculopontine nucleus structural connectivity, Go-NoG

74 ces in executive dysfunction were related to pedunculopontine nucleus structural network connectivity

75 ra-striatal cholinergic projections from the pedunculopontine nucleus to the substantia nigra pars re

76 hat the more left hemisphere-lateralized the pedunculopontine nucleus tract volume, the poorer the pe

77 We report reduced connectivity of the pedunculopontine nucleus with the cerebellum, thalamus a

78 tegmentum, superior and inferior colliculi, pedunculopontine nucleus), and in the lumbosacral spinal

79 The pedunculopontine nucleus, a component of the reticular f

80 ojecting to the striatum also innervated the pedunculopontine nucleus, a known locomotor center, and

81 ger-Westphal nucleus, parabigeminal nucleus, pedunculopontine nucleus, and laterodorsal tegmental nuc

82 c and glutamatergic neurons in the tegmental pedunculopontine nucleus, and/or inhibitory GABAergic pr

83 a, various thalamic and hypothalamic nuclei, pedunculopontine nucleus, Barrington's nucleus, retrofac

84 However, a dopaminergic innervation of the pedunculopontine nucleus, considered part of the MLR, wa

85 within cholinergic and other neurons in the pedunculopontine nucleus, cuneiform nucleus, and griseum

86 of the substantia nigra and extended to the pedunculopontine nucleus, red nucleus and subthalamic nu

87 ections between the spinal cord, cerebellum, pedunculopontine nucleus, subcortical and frontal/prefro

88 basis pontis, numerous thalamic nuclei, the pedunculopontine nucleus, the oculomotor nucleus, the hi

89 a thalamocortical system, in particular, the pedunculopontine nucleus, to address gait disorders that

90 Using seed regions from the pedunculopontine nucleus, we were able to delineate whit

91 cts with Parkinson's disease is modulated by pedunculopontine nucleus-thalamic but not cortical choli

92 beled WGA-HRP/ChAT neurons were found in the pedunculopontine nucleus.

93 y, we found dopaminergic fibers in the human pedunculopontine nucleus.

94 nuclei of the basal ganglia, as well as the pedunculopontine (PPN) and cuneiform (Cnf) nuclei.

95 Cholinergic neurons of the pedunculopontine (PPN) and laterodorsal tegmental (LDT)

96 holinergic output neurons located within the pedunculopontine (PPT) and laterodorsal tegmental (LTD)

97 rons in the laterodorsal tegmental (LDT) and pedunculopontine (PPT) nuclei has been implicated in man

98 Morphological features of rat pedunculopontine projection neurons were investigated in

99 he mesopontine tegmental area, including the pedunculopontine tegmental (PPT) and lateral dorsal tegm

100 ntracellular signaling mechanisms within the pedunculopontine tegmental (PPT) nucleus for the regulat

101 The pedunculopontine tegmental (PPT) nucleus has long been c

102 The pedunculopontine tegmental (PPT) nucleus has long been i

103 e brain with the highest levels found in the pedunculopontine tegmental area, the lateral dorsal tegm

104 ibuted within the laterodorsal tegmental and pedunculopontine tegmental nuclei (LDT and PPT), choline

105 distributed throughout the laterodorsal and pedunculopontine tegmental nuclei (LDT and PPT).

106 The laterodorsal and pedunculopontine tegmental nuclei (LDT-PPT) are involved

107 hese include the locus coeruleus, dorsal and pedunculopontine tegmental nuclei, dorsal raphe, and lat

108 sure, parabrachial nucleus, laterodorsal and pedunculopontine tegmental nuclei, nucleus incertus, and

109 9%), oral pontine reticular nucleus (64.5%), pedunculopontine tegmental nucleus (55.7%), and dorsal r

110 131%); laterodorsal tegmental nucleus (56%); pedunculopontine tegmental nucleus (86%); dorsal raphe n

111 The SNr is reciprocally connected with the pedunculopontine tegmental nucleus (PPN) in the brainste

112 glia are more highly interconnected with the pedunculopontine tegmental nucleus (PPN) than with any o

113 n as an important source of afferents to the pedunculopontine tegmental nucleus (PPN).

114 he periventricular gray corresponding to the pedunculopontine tegmental nucleus (PPT), the laterodors

115 ia projections to cholinergic neurons of the pedunculopontine tegmental nucleus (PPT).

116 olateral mesopontine tegmentum comprises the pedunculopontine tegmental nucleus (PPT).

117 d by either medial forebrain bundle (MFB) or pedunculopontine tegmental nucleus (PPTg) activation of

118 The pedunculopontine tegmental nucleus (PPTg) has been propo

119 The pedunculopontine tegmental nucleus (PPTg) is a brainstem

120 The pedunculopontine tegmental nucleus (PPTg) is defined by

121 Pedunculopontine tegmental nucleus (PPTg) lesions in rod

122 carbachol (5 micrograms in 250 nl) into the pedunculopontine tegmental nucleus (PPTg) or the nucleus

123 Cholinergic projections from the pedunculopontine tegmental nucleus (PPTg) to the rostral

124 We focused on activity in the pedunculopontine tegmental nucleus (PPTg), a mesencephal

125 GABA into the ventral tegmental area (VTA), pedunculopontine tegmental nucleus (PPTg), and oral pont

126 5-HT(1A)) receptor-responsive neurons in the pedunculopontine tegmental nucleus (PPTn) become maximal

127 omical and neurophysiological data about the pedunculopontine tegmental nucleus (PPTN), lateral hypot

128 ntified cholinergic neurons in the brainstem pedunculopontine tegmental nucleus and basal forebrain.

129 e in the cholinergic cell body region of the pedunculopontine tegmental nucleus and in the cholinocep

130 The findings support a critical role for pedunculopontine tegmental nucleus glutamate neurotransm

131 ntion and arousal.SIGNIFICANCE STATEMENT The pedunculopontine tegmental nucleus is the source of chol

132 We used optogenetics to demonstrate that the pedunculopontine tegmental nucleus sends glutamatergic p

133 aqueductal gray matter, reticular formation, pedunculopontine tegmental nucleus, and dorsal raphe nuc

134 inger-Westphal nucleus, periaqueductal gray, pedunculopontine tegmental nucleus, caudal ventrolateral

135 ze prodynorphin-derived peptides, except the pedunculopontine tegmental nucleus, the accessory trigem

136 gmental area, the retrorubral field, and the pedunculopontine tegmental nucleus.

137 ction from the deep mesencephalic reticular, pedunculopontine tegmental, dorsal raphe, median raphe,

138 y ipsilateral labeling in the paralemniscal, pedunculopontine tegmental, Kolliker-Fuse, and parabrach

139 arify the role of cholinergic neurons in the pedunculopontine tegmentum (PPT) and laterodorsal tegmen

140 Cells in the pedunculopontine tegmentum (PPT) play a key role in the

141 study examines the effects of lesioning the pedunculopontine tegmentum (PPTg) and laterodorsal tegme

142 s that projected to the visual thalamus: the pedunculopontine tegmentum and, to a lesser extent, the

143 ivity, and at 6 and 12 months the numbers of pedunculopontine tegmentum choline acetyltransferase-pos

144 The pedunculopontine tegmentum nucleus (PPT) is critically i

145 ne acetyltransferase-positive neurons in the pedunculopontine tegmentum of Tg2576 mice at 2 months ev

146 dbrain circuit, including the input from the pedunculopontine tegmentum to the VTA.

147 nt cholinergic/nitrergic projection from the pedunculopontine tegmentum, gamma-aminobutyric acid (GAB

148 n of sleep, including the lateral dorsal and pedunculopontine tegmentum.