ライフサイエンスコーパス: pellucida

1 ing sperm are not able to penetrate the zona pellucida.

2 ding, penetration, and signaling by the zona pellucida.

3 d, sperm-binding ligand on the ovulated zona pellucida.

4 ucent shell of the blue-rayed limpet Patella pellucida.

5 or secretion and incorporation into the zona pellucida.

6 sequently to definitive endoderm of the area pellucida.

7 ired for mouse sperm binding to the egg zona pellucida.

8 inner, thick extracellular matrix, the zona pellucida.

9 ecreted prior to incorporation into the zona pellucida.

10 ng sulfated carbohydrates of the oocyte zona pellucida.

11 ytosis, enabling sperm to penetrate the zona pellucida.

12 sites were distributed over the entire zona pellucida.

13 dhesin with differing avidities for the zona pellucida.

14 nant form capable of binding to the pig zona pellucida.

15 ed acrosome reaction, and penetrate the zona pellucida.

16 in ovaries isolated from mice lacking a zona pellucida.

17 olved in the sperm's passage across the zona pellucida.

18 tinct native B cell determinants of the zona pellucida.

19 to secretion and incorporation into the zona pellucida.

20 nd human sperm do not bind to the mouse zona pellucida.

21 nto the oviduct, and binding to the egg zona pellucida.

22 recognition and penetration through the zona pellucida.

23 existence of a P-selectin ligand in the zona pellucida.

24 ctin ligand is expressed in the porcine zona pellucida.

25 long the oviduct and penetration of the zona pellucida.

26 ered by adhesion to the mammalian egg's zona pellucida.

27 ated, adult mZP3-/- females also lack a zona pellucida.

28 tact between the sperm and the oocyte's zona pellucida.

29 oocytes, the oocytes completely lack a zona pellucida.

30 ed hatching of the blastocysts from the zona pellucida.

31 incapable of fusing with eggs that lack zona pellucida.

32 in in the egg's extracellular coat, the zona pellucida.

33 n mediating the binding of sperm to the zona pellucida.

34 binding and/or penetration through the zona pellucida.

35 he interaction of this protein with the zona pellucida.

36 with ADAM3 in sperm binding to the egg zona pellucida.

37 and named for its binding to the oocyte zona pellucida.

38 hese mutant mice cannot bind to the egg zona pellucida.

39 sperm with reduced ability to penetrate zona pellucida.

40 ore thrust to penetrate the cumulus and zona pellucida.

41 ular matrix of mouse eggs, known as the zona pellucida.

42 h the oocyte prior to assembly into the zona pellucida.

43 event that occurs upon contact with the zona pellucida.

44 ically deficient in adhesion to the egg zona pellucida (0.3% of wild type) and to the egg plasma memb

45 thyroid hormone (Pth)-calcitonin (Calc)-zona pellucida 2 (2p2) was established.

46 Autoantibody to a zona pellucida 3 (ZP3) epitope was found to induce autoimmune

47 by regulatory sequences from the mouse zona pellucida 3 (Zp3) gene, which is normally expressed excl

48 on of CPEB after pachytene, we used the zona pellucida 3 (Zp3) promoter to generate transgenic mice e

49 analysis of the pattern of evolution of Zona Pellucida 3 (ZP3), a protein present on the avian egg co

50 pe mice, we have generated human ORMDL3 zona pellucida 3 Cre (hORMDL3(zp3-Cre)) mice that overexpress

51 h the ZP3330-342 peptide of the ovarian zona pellucida 3 glycoprotein, ZP3.

52 epitope-specific autoantibody to murine zona pellucida 3 induces severe ovarian disease in neonatal,

53 macaques immunized with monkey or human zona pellucida 3 peptide (pZP3) in adjuvant, developed T-cell

54 nd in an interaction domain of the ZP3 (zona pellucida 3) protein.

55 immune complex with endogenous ovarian zona pellucida 3, and a pathogenic CD4(+) T cell response is

56 and, given the conserved nature of the zona pellucida, a similar phenotype is expected in other mamm

57 To prevent polyspermy, the zona pellucida, a structure that surrounds mammalian eggs, be

58 template the structure of CUB domain in zona pellucida adhesion protein PSP-I/PSP-II from porcine spe

59 perm to produce a secretory response to zona pellucida agonists.

60 ulted in human sperm penetration of the zona pellucida and accumulation in the perivitelline space, w

61 lacking ZP3 (Zp3(tm/tm)) do not form a zona pellucida and are infertile.

62 3-null mice, which never form a visible zona pellucida and are sterile.

63 d increases at the boundary between the area pellucida and area opaca during elongation.

64 cts causes premature degradation of the zona pellucida and embryo lysis, and wild-type embryos transf

65 for the prospective penetration of the zona pellucida and fusion with the egg.

66 Acrosome reaction, binding to zona pellucida and fusion with the oolemma were lower in Prdx

67 they demonstrate maximal binding to the zona pellucida and greatly increased sensitivity to ionophore

68 specifically reacted with ZP3 of oocyte zona pellucida and its affinity-purified antibodies completel

69 oocytes exhibited irregularities of the zona pellucida and meiotic spindle.

70 bryo transduction protocols (removal of zona pellucida and subzonal microinjection).

71 f ZP2 in mediating sperm binding to the zona pellucida and support a model in which human sperm-egg r

72 Sperm also bind transiently to the egg zona pellucida and the egg plasma membrane and then fuse.

73 s between the cumulus cells outside the zona pellucida and the oocyte within.

74 ncorporated throughout the width of the zona pellucida and the transgenic mice are fertile.

75 dergo capacitation in order to bind the zona pellucida and undergo a Ca(2+) ionophore-induced acrosom

76 uman sperm did not bind to the chimeric zona pellucida, and notwithstanding the absence of mouse ZP3,

77 erm is induced by sperm adhesion to the zona pellucida, and signaling in the egg by gamete fusion.

78 cts with the female reproductive tract, zona pellucida, and the oolemma.

79 known to have binding activity for the zona pellucida, and this action may serve to anchor sperm dur

80 The multimeric forms did not bind the zona pellucida as avidly as did the p105/45 monomer.

81 that the changes that take place in the zona pellucida at fertilization affected the interaction of t

82 These include a zona pellucida binding domain, which is present in a number o

83 Zona pellucida binding protein 1 (ZPBP1), a spermatid and spe

84 ulatory inhibitor subunit 1B (PPP1R1B), zona pellucida binding protein 2 (ZPBP2), and gasdermin B (GS

85 ly of zinc finger 3 (AIOLOS; IKZF3) and zona pellucida binding protein 2 (ZPBP2).

86 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GSDMA])

87 t rabbit proacrosin contains a specific zona pellucida binding site and that the loop containing argi

88 he latter, does not inhibit human sperm-zona pellucida binding under hemizona assay conditions.

89 here was no significant effect on sperm-zona pellucida binding; however, fertilization was reduced fr

90 motility, capacitation, binding to the zona pellucida, binding to the oocyte membrane, and penetrati

91 Many candidates have been proposed as zona pellucida-binding proteins.

92 n mouse eggs is required to produce the zona pellucida block to polyspermy.

93 t with the egg extracellular matrix, or zona pellucida, by the matrix glycoprotein ZP3.

94 Although a zona pellucida composed of ZP2 and ZP3 was formed around grow

95 The mouse zona pellucida consists of three glycoproteins that are synth

96 The mouse egg extracellular coat, or zona pellucida, consists of three glycoproteins, called mZP1-

97 Results show that the ovulated zona pellucida contains at least two distinct ligands for spe

98 The mouse zona pellucida contains three glycoproteins, ZP1, ZP2, and ZP

99 Rgs2(-/-) eggs also underwent premature zona pellucida conversion in vivo.

100 that were sufficient to cause premature zona pellucida conversion.

101 nels during gamete interaction inhibits zona pellucida-dependent Ca2+ elevations, as demonstrated by

102 ZP3, the glycoprotein agonist of the zona pellucida, depolarizes sperm membranes by activating a p

103 DPY, and terminating in a crosslinking zona pellucida domain and membrane anchor sequence.

104 light-responsive and membrane-anchored Zona Pellucida domain protein that supports light-dependent T

105 possess an N-terminal signal peptide, a zona pellucida domain, a consensus furin-like cleavage site (

106 ructure and contained peptides from the zona pellucida domain, which is involved in cell differentiat

107 7 contain, respectively, zonadhesin and zona pellucida domains, and DYF-7 self-associates into multim

108 In the absence of the zona pellucida, embryos lacking CTNNB1 undergo fission and th

109 Second, misexpression of Wnt1 in the area pellucida enables this region to form a primitive streak

110 the in vitro binding of murine sperm to zona pellucida-enclosed eggs.

111 capacitation, the ability to undergo a zona pellucida-evoked acrosome reaction, develops more slowly

112 tgun cell adhesion protein gene and the zona pellucida family transmembrane protein gene, CG13196.

113 parisons to be made with the process of zona pellucida formation in mammals.

114 Oocyte growth and zona pellucida formation proceed normally, but other aspects

115 Treatment of zona pellucida-free eggs with chymotrypsin reduces the abilit

116 mal when null spermatozoa were added to zona pellucida-free eggs, but in the presence of the extracel

117 oocyte membrane, and penetration of the zona pellucida-free oocyte.

118 ility of Tenr mutant sperm to fertilize zona pellucida-free oocytes and to bind to, but not fertilize

119 demonstrate that a genetic defect in a zona pellucida gene causes infertility and, given the conserv

120 isexpression of chordin in the anterior area pellucida generates an ectopic primitive streak that exp

121 oordinating the expression of the three zona pellucida genes during oogenesis.

122 teins in this regard because only human zona pellucida glycoprotein 3 (ZP3) and bovine proopiomelanoc

123 3-galactosyltransferase 1 (C1galt1)(FF):zona pellucida glycoprotein 3 Cre (ZP3Cre)] and Control (C1ga

124 o specific O-linked oligosaccharides on zona pellucida glycoprotein 3.

125 Each zona pellucida glycoprotein is synthesized in growing oocytes

126 located at the sperm combining site of zona pellucida glycoprotein mZP3.

127 a cell-surface receptor for the murine zona pellucida glycoprotein ZP3, standard immunoelectron micr

128 ZP3, an egg zona pellucida glycoprotein, produces a sustained increase of

129 in that functions as a receptor for the zona pellucida glycoprotein, ZP3, and as an inducer of the ac

130 ific oligosaccharide ligands within the zona pellucida glycoprotein, ZP3, via beta1,4-galactosyltrans

131 Zona pellucida glycoproteins are responsible for species-rest

132 glycoprotein ligand-1 (PSGL-1) and from zona pellucida glycoproteins of porcine oocytes indicate the

133 hese female fertilization proteins, the zona pellucida glycoproteins ZP2 and ZP3, are part of the mam

134 (approximately 83 000 Mr), one of three zona pellucida glycoproteins, and once bound undergo the acro

135 alTase bound ZP3 but did not bind other zona pellucida glycoproteins.

136 s and reveal novel functions for murine zona pellucida glycoproteins.

137 is extracellular matrix is known as the zona pellucida in eutherian mammals and consists of three gly

138 This matrix is known as the zona pellucida in mammals and is critically important for the

139 y induced Ab to ZP3335-342 bound to the zona pellucida in the functional and degenerative ovarian fol

140 These embryos do not hatch from the zona pellucida in vitro, fail to grow in culture, and exhibit

141 produced antibody that bound to native zona pellucida in vivo.

142 o the extracellular coat of the egg, or zona pellucida, in a species-specific manner.

143 tyrosine phosphorylation as well as the zona pellucida-induced acrosome reaction.

144 media and in their ability to fertilize zona pellucida-intact eggs.

145 ytes and to bind to, but not fertilize, zona pellucida-intact oocytes suggests that the normal-appear

146 ied antibodies completely blocked sperm-zona pellucida interaction in mice.

147 t sp56 may function in acrosomal matrix-zona pellucida interactions during and immediately following

148 esion event between mouse sperm and the zona pellucida is a high affinity event which is sufficient t

149 The mammalian zona pellucida is an egg extracellular matrix to which sperm

150 The zona pellucida is an extracellular matrix consisting of three

151 The zona pellucida is an extracellular matrix that mediates taxon

152 The mouse zona pellucida is composed of three glycoproteins (ZP1, ZP2 a

153 The mouse zona pellucida is composed of three glycoproteins (ZP1, ZP2,

154 The mouse zona pellucida is composed of three glycoproteins (ZP1, ZP2,

155 In mice, the zona pellucida is composed of three glycoproteins, but the pr

156 The mouse zona pellucida is composed of three glycoproteins, ZP1, ZP2 a

157 The mouse egg zona pellucida is constructed of three glycoproteins, called

158 itive streak formation in the posterior area pellucida is influenced by the adjacent posterior margin

159 After fertilization, the zona pellucida is modified ad minimus by cleavage of ZP2, and

160 mes indicates that sperm binding to the zona pellucida is not sufficient to induce acrosome exocytosi

161 yos, these data are consistent with the zona pellucida maintaining interactions between granulosa cel

162 esicle-intact oocytes but that lacked a zona pellucida matrix and had a disorganized corona radiata.

163 ent in MVA and is incorporated into the zona pellucida matrix of transgenic mice.

164 tated to prevent incorporation into the zona pellucida matrix, complementing earlier studies indicati

165 domain and assembled into the insoluble zona pellucida matrix.

166 Via its bipartite zona pellucida module (ZP-N/ZP-C), UMOD forms extracellular f

167 nitiate fertilization by binding to the zona pellucida (mZP), the specialized extracellular matrix of

168 covering of the egg known as the murine zona pellucida (mZP).

169 ich the supramolecular structure of the zona pellucida necessary for sperm binding is modulated by th

170 The antiserum also failed to label the zona pellucida of oocytes examined by laser scanning confocal

171 mediate recognition and binding to the zona pellucida of the egg are still not understood.

172 ty interferes with sperm binding to the zona pellucida of the ovum.

173 Recombinant ZP3R/sp56 bound to the zona pellucida of unfertilized eggs but not to 2-cell embryos

174 SED1 binds specifically to the zona pellucida of unfertilized oocytes, but not to the zona o

175 fic manner to the extracellular matrix (zona pellucida) of the oocyte.

176 The extracellular coat, or zona pellucida, of the mouse egg consists of three glycoprote

177 t constitute the extracellular coat, or zona pellucida, of the oocyte.

178 BMP-4 is misexpressed in the posterior area pellucida, primitive streak formation is inhibited.

179 Adhesion to the egg's zona pellucida promotes Ca2+ influx through voltage-sensitive

180 is closely related to that of the mouse zona pellucida protein ZP2.

181 o not acrosome-react in response to egg zona pellucida proteins and have reduced fertilizing ability,

182 phore conjugated to solubilized porcine zona pellucida proteins to observe zona receptors on live boa

183 pectrometric analysis of the native rat zona pellucida proteome (defined as the fraction of the total

184 e transient immunocontraceptive porcine zona pellucida (PZP), and found that repeated vaccinations ex

185 ever, the sperm proteins that recognise zona pellucida receptors remain contentious despite longstand

186 Sperm at the surface of the zona pellucida remained acrosome-intact for more than 2 hours

187 liculogenesis and those that encode the zona pellucida required for fertilization and early embryonic

188 ent in a number of proteins such as the zona pellucida sperm binding proteins, and uromodulin, In add

189 ur until the morula stage, and that the zona pellucida suffices to maintain blastomere proximity.

190 The extracellular zona pellucida surrounding mammalian eggs is formed by intera

191 ired for formation of the extracellular zona pellucida surrounding mouse eggs.

192 The mammalian zona pellucida surrounding ovulated eggs mediates sperm bindi

193 in mammals is mediated primarily by the zona pellucida surrounding ovulated eggs.

194 The zona pellucida surrounding ovulated mouse eggs contains three

195 ilization occurs when sperm contact the zona pellucida surrounding the egg.

196 barriers and penetrate the cumulus and zona pellucida surrounding the egg.

197 The zona pellucida surrounding the pig oocyte contains two Mr 55,

198 The extracellular zona pellucida surrounds mammalian eggs and mediates taxon-sp

199 The extracellular zona pellucida surrounds ovulated eggs and mediates gamete re

200 high K(+) or by addition of solubilized zona pellucida (sZP).

201 s and secreted to form an extracellular zona pellucida that mediates sperm binding and fertilization.

202 Specific binding of spermatozoa to the zona pellucida that surrounds mammalian eggs is a key step in

203 malian oocytes synthesize and secrete a zona pellucida that surrounds the growing oocytes, ovulated e

204 is a protein in the mammalian egg coat (zona pellucida) that binds sperm and stimulates acrosomal exo

205 nded by a thick extracellular coat, the zona pellucida, that plays important roles during early devel

206 elatively thick extracellular coat, the zona pellucida, that plays vital roles during oogenesis, fert

207 BSA, as measured by the ability of the zona pellucida to induce the acrosome reaction and by success

208 red for the structural integrity of the zona pellucida to minimize precocious hatching and reduced fe

209 the mammalian egg extracellular matrix (zona pellucida) to allow penetration of the egg coat.

210 out 75-80% of the murine sperm bound to zona pellucida under well defined in vitro conditions is carb

211 t sperm and shown to bind to homologous zona pellucida using an in vitro assay.

212 lthough porcine sperm first contact the zona pellucida via their plasma membrane, the regions of the

213 rm were able to fertilize eggs once the zona pellucida was removed but displayed persistent abnormal

214 fertilization, mouse sperm bind to the zona pellucida (which consists of glycoproteins ZP1, ZP2, and

215 associate with the inner aspect of the zona pellucida, which is distinct from the plasma membrane.

216 ablish a tenacious association with the zona pellucida, yet they are capable of fertilization.

217 r extracellular segment that includes a zona pellucida (ZP) domain and several plasminogen N-terminal

218 Proteins harboring a zona pellucida (ZP) domain are prominent components of verteb

219 The zona pellucida (ZP) domain is a bipartite protein structural

220 s; the Tecta(L1820F,G1824D/+) mouse for zona pellucida (ZP) domain mutations causing stable mid-frequ

221 tein, bone morphogenetic protein-1) and zona pellucida (ZP) domain-containing protein we find promine

222 ludes a domain of eight cysteines and a zona pellucida (ZP) domain.

223 eins share a sequence designated as the zona pellucida (ZP) domain.

224 ents and extracellular matrices through zona pellucida (ZP) domains.

225 se proteins is related to mammalian egg zona pellucida (ZP) glycoproteins ZP1-3 and possesses an N-te

226 OMD), cortical granule (CG) status, and zona pellucida (ZP) hardening as well as the integrity of the

227 OMD), cortical granule (CG) exocytosis, zona pellucida (ZP) hardening, and spindle/chromatin integrit

228 olved directly in binding to the female zona pellucida (ZP) in a species-specific manner.

229 The zona pellucida (ZP) is a highly organized extracellular coat

230 essential to fertilization, and the egg zona pellucida (ZP) is generally believed to be an in vivo in

231 ading to conformational activation of a Zona Pellucida (ZP) polymerisation domain.

232 All mutant oocytes had an altered zona pellucida (ZP) that was thinner than the control ZP, and

233 ation the spermatozoon binds to the egg zona pellucida (ZP) via sperm receptor(s) and undergoes an ac

234 mammalian sperm must first bind to the zona pellucida (ZP), a glycoprotein matrix surrounding the eg

235 ession of an antibody that binds to the zona pellucida (ZP), a glycoprotein matrix that surrounds the

236 The zona pellucida (ZP), an ovarian extracellular structure, cont

237 matozoa bound tightly or penetrated the zona pellucida (ZP), and fewer underwent acrosome reactions.

238 -EC) binds to the microvillar region of zona pellucida (ZP)-free eggs, the region of the membrane to

239 rix coating of the oocyte, known as the zona pellucida (ZP).

240 s-specific binding activity for the egg zona pellucida (ZP).

241 fertilization, spermatozoa bind to the zona pellucida (ZP1, ZP2, ZP3) surrounding ovulated mouse egg