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1 , allowing patients to continue therapy with pembrolizumab.
2 ceptional response to the anti-PD-1 antibody pembrolizumab.
3 treatment of NSCLC before the first cycle of pembrolizumab.
4 of 26 patients received at least one dose of pembrolizumab.
5 erved in patients with melanoma treated with pembrolizumab.
6 the humanized anti-PD-1 monoclonal antibody pembrolizumab.
7 eatment with the immune checkpoint inhibitor pembrolizumab.
8 nts were masked to assignment of the dose of pembrolizumab.
9 (42%) developed cutaneous AEs attributed to pembrolizumab.
10 l benefit of immune checkpoint blockade with pembrolizumab.
11 r cells correlated with improved efficacy of pembrolizumab.
12 erapeutic efficacy of the anti-PD-1 antibody pembrolizumab.
13 d 370 patients received at least one dose of pembrolizumab.
14 to confirm and characterise the activity of pembrolizumab.
15 anoma received one of three dose regimens of pembrolizumab.
16 e-effect profile, and antitumour activity of pembrolizumab.
17 ll-cell lung cancer (NSCLC) before receiving pembrolizumab.
18 e enrolled and received their first cycle of pembrolizumab.
19 keratoacanthomas (KAs) in patients receiving pembrolizumab.
20 likelihood to anti-PD-1 therapies, including pembrolizumab.
21 ts demonstrated an immunological response to pembrolizumab.
22 stribution and pharmacokinetics of (89)Zr-Df-pembrolizumab.
23 As of June 20, 2016, 25 patients received pembrolizumab.
24 arepvec followed by combination therapy with pembrolizumab.
25 I 0.45-0.73; p<0.0001) and those assigned to pembrolizumab 10 mg/kg (0.50, 0.39-0.64; p<0.0001) compa
28 pembrolizumab 2 mg/kg group, 25 (14%) in the pembrolizumab 10 mg/kg group, and 45 (26%) in the chemot
30 R 0.54, 95% CI 0.38-0.77; p=0.0002) and with pembrolizumab 10 mg/kg than with docetaxel (17.3 months
31 R 0.59, 95% CI 0.44-0.78; p=0.0001) and with pembrolizumab 10 mg/kg than with docetaxel (5.2 months v
32 R] 0.71, 95% CI 0.58-0.88; p=0.0008) and for pembrolizumab 10 mg/kg versus docetaxel (0.61, 0.49-0.75
33 s docetaxel (0.88, 0.74-1.05; p=0.07) or for pembrolizumab 10 mg/kg versus docetaxel (HR 0.79, 95% CI
34 eceive pembrolizumab 2 mg/kg, 181 to receive pembrolizumab 10 mg/kg, and 179 to receive chemotherapy.
35 d to pembrolizumab 2 mg/kg, 346 allocated to pembrolizumab 10 mg/kg, and 343 allocated to docetaxel.
36 with pembrolizumab 2 mg/kg, 4.0 months with pembrolizumab 10 mg/kg, and 4.0 months with docetaxel, w
37 with pembrolizumab 2 mg/kg, 12.7 months with pembrolizumab 10 mg/kg, and 8.5 months with docetaxel.
38 nse system to receive pembrolizumab 2 mg/kg, pembrolizumab 10 mg/kg, or docetaxel 75 mg/m(2) every 3
39 neumonitis (each in two [1%]) in those given pembrolizumab 10 mg/kg; and anaemia (nine [5%]), fatigue
42 olizumab, 10 mg/kg, every 3 weeks, P = .001; pembrolizumab, 10 mg/kg, every 2 weeks, P = .003; pembro
43 progression-free intervals in all 3 groups (pembrolizumab, 10 mg/kg, every 3 weeks, P = .001; pembro
44 urvival was improved in patients assigned to pembrolizumab 2 mg/kg (HR 0.57, 95% CI 0.45-0.73; p<0.00
46 eeks for four doses, followed by intravenous pembrolizumab 2 mg/kg every 3 weeks for up to 2 years or
47 events occurred in 20 (11%) patients in the pembrolizumab 2 mg/kg group, 25 (14%) in the pembrolizum
48 -free survival was 34% (95% CI 27-41) in the pembrolizumab 2 mg/kg group, 38% (31-45) in the 10 mg/kg
49 n a block size of six to receive intravenous pembrolizumab 2 mg/kg or 10 mg/kg every 3 weeks or inves
51 erall survival was significantly longer with pembrolizumab 2 mg/kg than with docetaxel (median 14.9 m
52 -free survival was significantly longer with pembrolizumab 2 mg/kg than with docetaxel (median 5.0 mo
53 ocetaxel, with no significant difference for pembrolizumab 2 mg/kg versus docetaxel (0.88, 0.74-1.05;
54 verall survival was significantly longer for pembrolizumab 2 mg/kg versus docetaxel (hazard ratio [HR
55 median overall survival was 10.4 months with pembrolizumab 2 mg/kg, 12.7 months with pembrolizumab 10
56 0 patients were randomly assigned to receive pembrolizumab 2 mg/kg, 181 to receive pembrolizumab 10 m
57 we enrolled 1034 patients: 345 allocated to pembrolizumab 2 mg/kg, 346 allocated to pembrolizumab 10
58 rogression-free survival was 3.9 months with pembrolizumab 2 mg/kg, 4.0 months with pembrolizumab 10
59 interactive voice-response system to receive pembrolizumab 2 mg/kg, pembrolizumab 10 mg/kg, or doceta
60 a (each in two [1%] patients) in those given pembrolizumab 2 mg/kg; hypopituitarism, colitis, diarrho
63 olizumab, 10 mg/kg, every 2 weeks, P = .003; pembrolizumab, 2 mg/kg, every 3 weeks, P = .009) compare
64 grated web response system to receive either pembrolizumab 200 mg every 3 weeks (35 cycles) or invest
67 ractive voice-response system to 4 cycles of pembrolizumab 200 mg plus carboplatin area under curve 5
68 fractory MM (RRMM) received 28-day cycles of pembrolizumab, 200 mg IV every 2 weeks, pomalidomide 4 m
69 we enrolled 86 patients, 84 of whom received pembrolizumab (42 in each disease cohort) and 80 of whom
70 iated with a higher frequency of response to pembrolizumab; 42 (38%, 95% CI 29-48) of 110 patients wi
71 ing to the following therapeutic regimen for pembrolizumab: 43 received 10 mg/kg every 3 weeks, 24 re
72 ty, tolerability, and antitumour activity of pembrolizumab, a humanised anti-programmed death recepto
73 designed to test the efficacy and safety of pembrolizumab, a humanized PD-1-blocking antibody, at a
77 n patients who received one or more doses of pembrolizumab (all-patients-as-treated population); acti
80 ry and radiotherapy underwent treatment with pembrolizumab, an anti-PD-1 antibody, at an academic der
82 e evaluated safety and antitumor activity of pembrolizumab, an anti-PD-1 antibody, in rrPMBCL as part
83 2 study to evaluate the clinical activity of pembrolizumab, an anti-programmed death 1 immune checkpo
84 rm, phase II KEYNOTE-055 study, we evaluated pembrolizumab, an anti-programmed death 1 receptor antib
85 of non-small cell lung cancers treated with pembrolizumab, an antibody targeting programmed cell dea
86 the KEYNOTE-001 (MK-3475) clinical trial of pembrolizumab, an antiprogrammed cell death-1 therapy fo
87 S/QOL score was 6.9 (95% CI 3.3 to 10.6) for pembrolizumab and -0.9 (-4.8 to 3.0) for chemotherapy, f
89 r treatment with the PD-1-targeting antibody pembrolizumab and identify pharmacodynamic changes in ci
90 ted adverse events led to discontinuation of pembrolizumab and ipilimumab in 22 (14%) patients, inclu
91 n patients who received at least one dose of pembrolizumab and the proportion of patients achieving o
92 olled patients received at least one dose of pembrolizumab and were included in the safety analyses.
96 complete remission after discontinuation of pembrolizumab, and the low incidence of relapse after me
97 ived no previous systemic therapy to receive pembrolizumab (anti-PD-1) at a dose of 2 mg per kilogram
102 These conclusions further support the use of pembrolizumab as a standard of care for advanced melanom
103 e head and neck, supporting further study of pembrolizumab as anticancer therapy for advanced head an
106 on schedule (1:1 final ratio) to intravenous pembrolizumab at 2 mg/kg every 3 weeks or 10 mg/kg every
110 dvanced melanoma in a 1:1:1 ratio to receive pembrolizumab (at a dose of 10 mg per kilogram of body w
113 he phase 3 KEYNOTE-024 trial, treatment with pembrolizumab conferred longer progression-free survival
114 ults of the interim analyses of KEYNOTE-006, pembrolizumab continued to provide superior overall surv
115 ligand 1-positive advanced cervical cancer, pembrolizumab demonstrated antitumor activity and exhibi
117 ponses in patients who received at least one pembrolizumab dose and who either had a post-baseline sc
118 We assessed the efficacy and safety of two pembrolizumab doses versus investigator-choice chemother
120 and randomly assigned to receive intravenous pembrolizumab every 2 weeks (n=279), intravenous pembrol
121 Patients were given 10 mg/kg intravenous pembrolizumab every 2 weeks until disease progression, u
123 hazard ratio [HR] 0.68, 95% CI 0.53-0.87 for pembrolizumab every 2 weeks vs ipilimumab; p=0.0009 and
124 2%, respectively (hazard ratio for death for pembrolizumab every 2 weeks, 0.63; 95% CI, 0.47 to 0.83;
125 ogression-free-survival rates were 47.3% for pembrolizumab every 2 weeks, 46.4% for pembrolizumab eve
126 rolizumab every 2 weeks (n=279), intravenous pembrolizumab every 3 weeks (n=277), or intravenous ipil
127 ipilimumab; p=0.0009 and 0.68, 0.53-0.86 for pembrolizumab every 3 weeks vs ipilimumab; p=0.0008).
128 CI, 0.47 to 0.83; P=0.0005; hazard ratio for pembrolizumab every 3 weeks, 0.69; 95% CI, 0.52 to 0.90;
129 % for pembrolizumab every 2 weeks, 46.4% for pembrolizumab every 3 weeks, and 26.5% for ipilimumab (h
133 regression in response to anti-PD-1 therapy (pembrolizumab) followed by disease progression months to
135 trexed 500 mg/m(2) every 3 weeks followed by pembrolizumab for 24 months and indefinite pemetrexed ma
139 d a potentially acceptable safety profile of pembrolizumab given every 2 weeks to patients with heavi
141 nonrandomized phase Ib trial of single-agent pembrolizumab given intravenously at 10 mg/kg every 2 we
142 n overall survival was not reached in either pembrolizumab group and was 16.0 months with ipilimumab
143 eported in five (3%) patients in the 2 mg/kg pembrolizumab group, was the only drug-related grade 3 t
144 s of grade 3 to 5 severity were lower in the pembrolizumab groups (13.3% and 10.1%) than in the ipili
145 tment-related grade 3-4 adverse event in the pembrolizumab groups was fatigue (two [1%] of 178 patien
147 or metastatic PD-L1-positive gastric cancer, pembrolizumab had a manageable toxicity profile and prom
149 tivity was assessed in patients who received pembrolizumab, had measurable disease at baseline, and h
150 tients who had received at least one dose of pembrolizumab, had measurable disease at baseline, and o
151 use of PD-1 inhibitors such as nivolumab and pembrolizumab has a lower incidence of irAEs compared wi
152 patients demonstrate that PD-1 blockade with pembrolizumab has a manageable safety profile and promis
153 ed-dose ipilimumab followed by standard-dose pembrolizumab has a manageable toxicity profile and prov
157 -programmed-death-receptor-1 (PD-1) antibody pembrolizumab has shown potent antitumour activity at di
158 antibodies blocking PD-1 ligation, including pembrolizumab, have recently received Food and Drug Admi
159 gs, such as the anti-programmed death-1 drug pembrolizumab, have shown promising results in trials, a
161 esigned to assess the safety and efficacy of pembrolizumab in 20 programmed death ligand 1-positive,
162 al RECIST might underestimate the benefit of pembrolizumab in approximately 15% of patients; modified
163 sessed the activity and safety of first-line pembrolizumab in cisplatin-ineligible patients with loca
164 ty and anti-tumour activity of standard-dose pembrolizumab in combination with reduced-dose ipilimuma
166 ogrammed cell death 1 (PD-1) inhibition with pembrolizumab in patients with advanced non-small-cell l
168 safety and activity of an anti-PD-1 antibody pembrolizumab in patients with locally advanced or metas
169 afety and activity of the anti-PD-1 antibody pembrolizumab in patients with PD-L1-positive recurrent
170 he activity and safety of the PD-1 inhibitor pembrolizumab in patients with untreated brain metastase
173 with advanced melanoma who were treated with pembrolizumab in the phase Ib KEYNOTE-001 study (clinica
176 ody distribution of (89)Zr-deferoxamine (Df)-pembrolizumab in two rodent models (mice and rats).
177 okinetics, biodistribution, and dosimetry of pembrolizumab in vivo, accomplished through radiolabelin
178 kinetics and biodistribution of radiolabeled pembrolizumab in vivo, while providing detailed dosimetr
179 ort the cases of 3 consecutive patients with pembrolizumab-induced eruptive KAs and their management.
183 tuximab, checkpoint inhibitors nivolumab and pembrolizumab, lenalidomide, everolimus, or observation
187 h locally advanced cSCC who was treated with pembrolizumab, nearly complete tumor regression was obse
188 ued ipilimumab only and 14 (9%) discontinued pembrolizumab only because of treatment-related adverse
189 consecutive HL patients treated by anti-PD1 (pembrolizumab or nivolumab) at Gustave Roussy from 2013
190 treated with anti-PD1 monoclonal antibodies (pembrolizumab or nivolumab), 10 (2.9%) developed subacut
192 linicians should use single-agent nivolumab, pembrolizumab, or atezolizumab; if tumor has negative or
193 pants (1:1:1) to one of two dose regimens of pembrolizumab, or one regimen of ipilimumab, using a cen
196 ration-approved immune checkpoint inhibitors-pembrolizumab (PEM), nivolumab (NIVO), and ipilumumab (I
197 33 (55%; 95% CI 42-68) of 60 patients in the pembrolizumab plus chemotherapy group achieved an object
198 tween groups (23 [39%] of 59 patients in the pembrolizumab plus chemotherapy group and 16 [26%] of 62
199 e enrolled; 60 were randomly assigned to the pembrolizumab plus chemotherapy group and 63 to the chem
201 orse treatment-related adverse events in the pembrolizumab plus chemotherapy group were anaemia (seve
202 110 (72%) of 153 patients received all four pembrolizumab plus ipilimumab doses; 64 (42%) remained o
209 disease progression, 0.58; P<0.001 for both pembrolizumab regimens versus ipilimumab; 95% confidence
210 rogrammed death ligand 1 (PD-L1) expression, pembrolizumab should be used alone; if the patient has l
214 d on data from different clinical studies of pembrolizumab, starting with a small pilot of 19 melanom
216 related adverse events were less common with pembrolizumab than with docetaxel (43 [13%] of 339 patie
222 port study of 3 patients from 2 centers with pembrolizumab-treated cancer who all developed eruptive
226 tients with metastatic melanoma who received pembrolizumab treatment in the context of a phase 1 stud
228 sion-free survival and overall survival with pembrolizumab treatment than that seen in patients who d
233 btained before and during anti-PD-1 therapy (pembrolizumab) using quantitative immunohistochemistry,
234 ort the prespecified exploratory endpoint of pembrolizumab versus chemotherapy on patient-reported ou
235 ior overall and progression-free survival of pembrolizumab versus ipilimumab in patients with advance
239 of concept, the biodistribution of (89)Zr-Df-pembrolizumab was further investigated in a humanized mu
244 Common side effects that were attributed to pembrolizumab were fatigue, pruritus, and decreased appe
245 Patients who received at least one dose of pembrolizumab were included in the safety analysis and p
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