ライフサイエンスコーパス: penetrant

1 Blebb was found to be highly brain penetrant.

2 ide range of mental disorders and are highly penetrant.

3 cases are underdiagnosed and/or incompletely penetrant.

4 ein] and is autosomal dominant and partially penetrant.

5 background but are unlikely to be completely penetrant.

6 ffected by diet and several are incompletely penetrant.

7 p.Glu257Lys variant is considered not fully penetrant.

8 ocyte phenotype in ESET-null mutants is 100% penetrant.

9 variants that cause CPVT are usually highly penetrant.

10 hich causative mutations are rare but highly penetrant.

11 steosarcoma development, which remained 100% penetrant.

12 nducing peptides that are intrinsically cell-penetrant.

13 as a means for rendering peptides more cell-penetrant.

14 types, including those that are incompletely penetrant (2), automated identification of causative mut

15 nd synthesis of potent, selective, and brain penetrant 5-HT(4) agonists.

16 harmacokinetics study, compound 9t was brain-penetrant after oral dosing, but exposure was limited by

17 a novel, highly potent, selective, and brain-penetrant ALK and ROS1 TKI with preclinical activity aga

18 valuation of PF-06463922, a potent and brain-penetrant ALK/ROS1 inhibitor.

19 ease is dosage dependent, where incompletely penetrant alleles influence disease severity.

20 K2V617F combined with Tp53 loss led to fully penetrant AML in vivo.

21 ) bone marrow cells rapidly develop a highly penetrant AML.

22 A selection of penetrant and "nonpenetrant" drugs were dosed to rats vi

23 eens can identify molecules that are at once penetrant and active on the integrated circuitry of a wh

24 ozygous human mutations of NKX2-5 are highly penetrant and associated with varied congenital heart de

25 rum disorder (ASD), yet it is not completely penetrant and can manifest in a wide array of phenotypes

26 he rapid development of an aggressive, fully-penetrant and cell-autonomous myeloid leukaemia in mice,

27 Several examples are brain-penetrant and exhibit balanced multitargeted in vitro ac

28 This new model is highly penetrant and exhibits robust frequency of metastases to

29 32 is CNS-penetrant and highly effective in acute and latent mouse

30 er, telomerase variants are not always fully penetrant and in some families disease-causing variants

31 d i.c.v. administrations of SR11935, a brain-penetrant and JNK2/3 isoform-selective inhibitor, exerte

32 construct drug combinations that yield more penetrant and lasting responses in patients.

33 They are not fully penetrant and offer an opportunity to study their effect

34 late-p1 formation, skeletal defects are less penetrant and often vary in severity, even between the l

35 ction of NB-360, a novel blood-brain barrier penetrant and orally available BACE1 inhibitor, was veri

36 biological studies of ABHD6, including brain-penetrant and peripherally restricted inhibitors that sh

37 The highly penetrant and progressive AV block phenotype seen in hum

38 e murine Nkx2-5 homeodomain (R52G) is highly penetrant and result in pleiotropic cardiac effects.

39 of 14 (PF-06447475), a highly potent, brain penetrant and selective LRRK2 inhibitor which has been f

40 (i.c.v.) administration of SR-3306, a brain-penetrant and selective pan-JNK (JNK1/2/3) inhibitor, re

41 fication of new 1,4-benzodiazepines as brain penetrant and selective triple T-type calcium channel bl

42 Mouse models of fully penetrant and slowly evolving prostate tumorigenesis sho

43 Hearing impairment was more penetrant and stapes malformations were more severe in E

44 rms for the logP and molecular weight of the penetrant and the refractive index of the vehicle mixtur

45 was developed to describe the effects of the penetrant and vehicle mixture properties on the mean dif

46 or suppressor gene, and they provide a fully penetrant animal model for the study of angiosarcoma dev

47 28-day treatment with S 38093, a novel brain-penetrant antagonist/inverse agonist of H3 receptors, on

48 channels (channels for which there are brain-penetrant antagonists approved for human use), a neuropr

49 looking for suppressors of the incompletely penetrant aph-1(zu147) mutation, we identify a new gene,

50 to sterility that results from the early and penetrant apoptotic death observed in Sin3A-deleted germ

51 tiple proliferation biomarkers, indicating a penetrant, arrested state.

52 ans, the beta2AR agonist salbutamol, a brain-penetrant asthma medication, was associated with reduced

53 PF-06463922, a novel, orally available, CNS-penetrant, ATP-competitive small-molecule inhibitor of A

54 dorsal mesenchymal protrusion, and partially penetrant atrioventricular septal defects, including ost

55 These new, cell-penetrant autophagy inducers and their molecular details

56 primary torsion dystonia (AOPTD) is a poorly penetrant autosomal dominant disorder; most gene carrier

57 nome, is an ideal approach to studying fully penetrant autosomal-recessive diseases, and it has been

58 Alzheimer's disease (FAD) in a nearly fully penetrant, autosomal dominant manner, providing a unique

59 ation in AS, A30P, is associated with highly penetrant, autosomal dominant PD, although the pathogeni

60 nsthyretin (TTR) produces aggressive, highly penetrant, autosomal-dominant systemic amyloidosis in pe

61 When cell death is blocked, partially penetrant axon branching errors are observed in Hox muta

62 ic transformation, and mice develop a highly penetrant B-cell leukaemia with multi-organ infiltration

63 idine analogues, have been found to be brain penetrant BACE-1 inhibitors.

64 nvestigated the effects of a potent nonbrain-penetrant BACE1 inhibitor, delivered directly to the bra

65 ituted oxazine 89, a potent and highly brain penetrant BACE1 inhibitor, was able to reduce significan

66 the discovery of orally bioavailable, brain-penetrant BACE1 inhibitors.

67 (Gt-ex13) heterozygotes exhibit incompletely penetrant BAV, CoA and PDA phenotypes similar to those i

68 it-like genes resulted in a striking, highly penetrant body morphology phenotype in parasite larvae.

69 poietic system, which phenocopied the highly penetrant bone marrow failure seen in Fanconi anaemia pa

70 males, where the phenotype is only partially penetrant, both alternative splicing changes and down-re

71 potent (mGlu1 EC50 = 31.8 nM) and highly CNS penetrant (brain to plasma ratio (Kp) of 1.02) mGlu1 PAM

72 nt in individuals younger than 35 years, 50% penetrant by 58 years, and almost fully penetrant by 80

73 50% penetrant by 58 years, and almost fully penetrant by 80 years.

74 L1 and Ct-dis, rendered cell-penetrant by fusion with the protein transduction domain

75 ort can enhance the overall permeance of the penetrant by up to an order of magnitude, but this gain

76 d the in vivo efficacy of nilotinib, a brain penetrant c-Abl inhibitor, in the acute MPTP-induced mod

77 bolism and retinoid signaling, exhibit fully penetrant CA.

78 gets in Li-Fraumeni syndrome (LFS), a highly penetrant cancer predisposition syndrome associated with

79 ls with Li-Fraumeni syndrome, a rare, highly penetrant cancer predisposition syndrome.

80 positive for pathogenic mutations in highly penetrant cancer susceptibility genes.

81 We investigate the genetic basis of highly penetrant cancer susceptibility in RF/J finding private

82 Specifically, using the brain penetrant catechol-O-methyl transferase (COMT) inhibitor

83 led study in which we administered the brain penetrant catechol-O-methyltransferase inhibitor tolcapo

84 nhibition of microglial targets by centrally penetrant CatS inhibitors and CX(3) CR1 receptor antagon

85 , with a large number of distinct and highly penetrant causal variants identified among a growing lis

86 is a relatively common monogenic and highly penetrant cause of autism spectrum disorder (ASD) and in

87 Both rimonabant and 14g, a potent brain penetrant CB1 receptor antagonist, significantly reduced

88 the BBB spheroids to screen and identify BBB-penetrant cell-penetrating peptides (CPPs).

89 racterized adgra2 mutants and exhibit highly penetrant cerebrovascular defects.

90 e of multisystem disorders, including highly penetrant cerebrovascular disease and intracerebral hemo

91 Here we characterize a rapid and fully penetrant cessation of feeding of Caenorhabditis elegans

92 smatch repair deficiency (bMMRD) is a highly penetrant childhood cancer syndrome often resulting in G

93 up15q syndrome is one of the most common and penetrant chromosomal abnormalities observed in individu

94 novel NFKB2 GOF mutations produce a nonfully penetrant CID phenotype through a different pathophysiol

95 lly, Cdc42 NCC knockout embryos showed fully penetrant cleft lips and short snouts.

96 les with ASD were more likely to have highly penetrant CNVs (p = 0.017) and were also overrepresented

97 variability between treatments (vehicle and penetrant combinations) as well as noise within treatmen

98 l-3-pyridincarboxamides, including the brain-penetrant compound 14G: [5-(4-chlorophenyl)-6-(cycloprop

99 esulted in a highly potent, selective, brain penetrant compound 71 (PF-05085727) that effects in vivo

100 ication of a potent, orally bioavailable CNS penetrant compound that exhibited in vivo efficacy.

101 e, orally bioavailable, and adequately brain penetrant compounds with no hERG liability.

102 were given a single 200-mg dose of the brain-penetrant COMT inhibitor tolcapone or placebo in a rando

103 toderm (NNE) and Grhl2 loss results in fully penetrant cranial neural tube defects (NTDs) in mice.

104 ly deleted in neural crest demonstrate fully penetrant craniofacial abnormalities, including microcep

105 l that includes genes associated with highly penetrant CRCP syndromes in addition to Lynch syndrome g

106 genes and other genes associated with highly penetrant CRCP syndromes led to an average increase of 0

107 ated pexacerfont, an orally available, brain penetrant CRH1 antagonist for its ability to suppress st

108 bryos lacking this enhancer display variably penetrant defects in anterior-posterior axis orientation

109 l patterns of inheritance and contain highly penetrant deleterious variation in specific genes.

110 ho are buffering the effects of rare, highly penetrant, deleterious mutations.

111 or (GR)50 during development caused a highly penetrant developmental arrest, while post-developmental

112 .1 TCR Tg mice develop accelerated and fully penetrant diabetes.

113 fect of the length of exposure to less brain-penetrant dihydropyridines (amlodipine) and more brain-p

114 dihydropyridines (amlodipine) and more brain-penetrant dihydropyridines (eg, nifedipine, felodipine)

115 and infection underlie FSGS; however, highly penetrant disease genes have been identified in a small

116 incompatible with pathogenicity for a fully penetrant disease like NSHL.

117 stargeting alleles caused more severe (fully penetrant) disease.

118 Although yielding few, usually highly penetrant, disease gene mutations, these discoveries pro

119 n selected individuals with familial, highly penetrant disorders.

120 the strongest mutant displayed a near fully penetrant disruption of FG development, and the weakest

121 gy") or (2) the combination of multiple less penetrant disruptions of nonembryonic, synaptic FMRP tar

122 The development of novel CNS penetrant drugs that are particularly effective at inhib

123 AD, who were affected carriers of the fully penetrant E280A mutation in the presenilin-1 (PSEN1) gen

124 The highly penetrant, early onset, and severe nature of this model

125 c deficiency in mice resulted in a partially penetrant embryonic or perinatal lethal phenotype, with

126 We also discovered penetrant enhanced synaptic plasticity across mouse mode

127 expression (ASE) are associated with highly penetrant familial cancers, but their role in common spo

128 e mutation in titin as the cause of a highly penetrant familial cardiomyopathy with features of left

129 Z1-null mice, although viable, display fully penetrant female-specific lymphoproliferative disorder.

130 ms that are downstream targets of highly ASD-penetrant FMR1 and CHD8 genes are also heavily affected

131 This fully penetrant folate-pathway mouse model does not require fe

132 haploinsufficiency in these genes is highly penetrant for ASD and intellectual disability (ID).

133 1.2 microdeletions, a genetic variant highly penetrant for schizophrenia.

134 inding domain) missense mutations are highly penetrant for varied congenital heart defects, including

135 els in cells that lack centrioles led to the penetrant formation of de novo centrioles that gained th

136 ating genetic data from families with highly penetrant forms of disease together with genetic data fr

137 tify healthy individuals resilient to highly penetrant forms of genetic childhood disorders.

138 neage-restricted progenitors to induce fully penetrant GBM using CNS progenitor-specific inducible Cr

139 3T-SNCA mouse model) were exposed to a brain-penetrant GCS inhibitor, GZ667161.

140 One-fourth of the non-penetrant gene carriers showed abnormalities on MRI.

141 ns of 269 symptomatic individuals and 19 non-penetrant gene carriers were assessed.

142 he excess of inherited risk resides in lower-penetrant genes.

143 Specific highly penetrant genetic causes can often be shared by a subset

144 ed variants in BRCA2 as the most common high-penetrant genetic factor associated with pancreatic canc

145 ourse may be influenced by more common, less penetrant genetic variants.

146 lly arose from work identifying rare, highly penetrant germline mutations causing 'hereditary' cancer

147 tified the first orally bioavailable and CNS penetrant glucagon-like peptide-1 receptor (GLP-1R) nonc

148 dentified the first highly selective and CNS penetrant glucagon-like peptide-1R (GLP-1R) positive all

149 s-of-function alleles causes an incompletely penetrant, haploinsufficiency disorder.

150 2:133,196,029, which cosegregated with fully penetrant hearing loss in the index family, and also app

151 harbors in-frame exon deletions in partially penetrant hereditary retinoblastomas and is known to imp

152 Brain-penetrant histone deacetylase 6 inhibitors increase Hsp9

153 discovery of our first neuroprotective brain penetrant hit compound MPAQ (5c).

154 ery of the highly potent and selective brain-penetrant hV1a antagonist RO5028442 (8) suitable for hum

155 that Col4a2 mutant mice also have completely penetrant ICH and that mutations in mouse and human lead

156 ions in glioma highlights the need for brain-penetrant IDH1 mutant-selective inhibitors as an alterna

157 rst time the effect of a blood-brain barrier-penetrant IMPase inhibitor on human central nervous syst

158 treating a very complex spectrum of disease, penetrant in a variety of organ systems.

159 auses embryonic defects, which are partially penetrant in an inbred strain but fully lethal in non-in

160 The pathogenic expansion was non-penetrant in individuals younger than 35 years, 50% pene

161 esirable to advance a molecule which was CNS penetrant in order to treat brain metastases.

162 gene disruption, the phenotype appeared very penetrant in stable F1 fish.

163 ately selective, orally available, and brain-penetrant in wild-type mice, and confirmation of target

164 In the whole animal, ZCZ011 is brain penetrant, increased the potency of these orthosteric ag

165 hese synaptic phenotypes are not universally penetrant, indicating that other core facets of ProSAP2/

166 ion levels to be significantly higher in the penetrant individuals.

167 Our model demonstrates that penetrant-induced plasticization of polymer chains parti

168 phyxiating thoracic dystrophy with partially penetrant inheritance.

169 t, highly selective, orally available, brain-penetrant inhibitor of LRRK2.

170 nd, we have developed a small-molecule brain-penetrant inhibitor with activity against mixed-lineage

171 hat disruption of 2-HG production with brain-penetrant inhibitors in IDH1 mutant gliomas may have sub

172 t for the design of a class of potent, brain penetrant inhibitors of T. brucei NMT.

173 loss, the mice developed accelerated, highly penetrant invasive prostate cancer.

174 al and DMPK properties to afford the non-CNS penetrant inverse agonist 22 (AZ-GHS-22) and the CNS pen

175 t inverse agonist 22 (AZ-GHS-22) and the CNS penetrant inverse agonist 38 (AZ-GHS-38).

176 heterozygous condition exhibited a partially penetrant late lethality.

177 ns in Tet2 and Flt3, which resulted in fully penetrant, lethal AML.

178 induced myeloid transformation, with a fully penetrant, lethal chronic myelomonocytic leukemia (CMML)

179 a single locus, miR-1-2, causes incompletely penetrant lethality and subtle cardiac defects.

180 t LXR-623, a clinically viable, highly brain-penetrant LXRalpha-partial/LXRbeta-full agonist selectiv

181 low-clearance, orally bioavailable, and CNS-penetrant M1-selective PAM with minimal agonist activity

182 bolic infection state responsible for highly penetrant male-restricted hepatic carcinogenesis.

183 Peripheral administration of the brain penetrant MC3/4R receptor peptide agonist, Melanotan II

184 Atoh1 transgene expression developed highly penetrant medulloblastoma at a young age with extensive

185 deletion of Pten and Trp53 resulted in fully penetrant medulloblastoma originating from the perivascu

186 s in this model led to accelerated and fully penetrant melanomagenesis and synchronous tumor formatio

187 illness are not exclusively caused by highly penetrant Mendelian mutations, but can also be contribut

188 genetically engineered mouse model of highly penetrant, metastatic prostate cancer.

189 These studies describe a potent brain penetrant mGluR2 positive allosteric modulator (PAM), SA

190 Zic2 expression cause moderate, incompletely penetrant mispatterning of the NC-derived jaw precursors

191 Consistent with a fully penetrant model for these genes, we found no significant

192 Compound 26 is a centrally penetrant molecule which possesses good biopharmaceutica

193 With a CNS penetrant molecule, kinase selectivity is a key consider

194 ostmigratory NC lineages resulted in a fully penetrant mouse model of diminished sympathetic cardiac

195 hus far epothilone D has been the only brain-penetrant MT-stabilizer to be evaluated in tau transgeni

196 be here an interventional study of the brain-penetrant MT-stabilizing agent, epothilone D (EpoD), in

197 As brain-penetrant MT-stabilizing agents have proven effective ag

198 These data reveal that brain-penetrant MT-stabilizing drugs hold promise for the trea

199 tly, administration of Epothilone D, a brain-penetrant MT-stabilizing natural product, was found to r

200 y is sufficient for the development of fully-penetrant, multifocal carcinomas, closely mimicking huma

201 on because affected individuals, but not non-penetrant mutation carriers, have a greater reduction of

202 ease caused by an autosomal dominant, highly penetrant mutation in the presenilin-1 (PSEN1) gene, and

203 Rare fully penetrant mutations in AKT2 are an established cause of

204 ic disorders - whether caused by rare highly penetrant mutations or sporadic forms - and holds promis

205 e of these families there may be rare highly penetrant mutations that segregate with illness.

206 chments in genes known to harbor rare highly penetrant mutations.

207 n that AIRAPL-deficient mice develop a fully-penetrant myeloproliferative neoplastic process.

208 Existing strategies that use tissue-penetrant near-infrared light for the targeted treatment

209 small molecules using cytocompatible, tissue penetrant near-IR light.

210 d succumb to a rapidly progressing and fully penetrant neonatal myeloid disease.

211 een previously identified as a potent, brain-penetrant NK1 receptor antagonist with a long duration o

212 n CDH1 mutation-positive families, including penetrants, non-penetrants or non-carriers for NSCLP.

213 pharmacology of a novel, selective and brain penetrant NPSR antagonist with nanomolar affinity for th

214 entify a significant cellular effect of rare penetrant NRXN1 mutations in human neurons, which was fo

215 ntral motor neurons, resulting in completely penetrant NT defects, while excision after embryonic day

216 Mutant embryos develop partially penetrant NTDs while surviving mice exhibit post-natal f

217 orders that are also characterized by highly penetrant obesity, a major additional risk factor, is un

218 Hirschsprung disease (HSCR) is a partially penetrant oligogenic birth defect that occurs when enter

219 ic manifestations of FFDD Type IV can be non-penetrant or underascertained.

220 positive families, including penetrants, non-penetrants or non-carriers for NSCLP.

221 CNS targets and classified as either "brain penetrant" or "peripherally restricted" on the basis of

222 yridines that are potent and selective brain penetrant P2X7 antagonists are described.

223 BKM-120 is a CNS-penetrant pan-class I phosphatidyl-inositol-3 kinase (PI

224 Over 200 rare and fully penetrant pathogenic mutations in amyloid precursor prot

225 deletions at 16p13.11 represent incompletely penetrant pathogenic mutations that predispose to a rang

226 Over 200 highly penetrant pathogenic variants in the genes APP, PSEN1, a

227 autosomal genes as well as into the variably penetrant pathophysiological spectrum of phenotypes obse

228 ceptor-mediated transcytosis using the brain-penetrant peptide Angiopep-2 (An2), which targets LDL re

229 These results show that a cell-penetrant peptide is capable of delivering a functional

230 A cell-penetrant peptide that disrupts this interaction downreg

231 the anterior hypothalamus results in a fully penetrant phenotype characterised by a complete arrest o

232 These mice displayed a fully penetrant phenotype characterized by growth enhancement

233 paired formation of the DMP and a completely penetrant phenotype of ostium primum defect, a hallmark

234 deletion of ZFP57 in mice presents a highly penetrant phenotype with no animals surviving to birth.

235 oid for Pals1) in nephrons developed a fully penetrant phenotype, characterized by cyst formation and

236 ghts into the genetic mechanism for a highly penetrant phenotype.

237 d micrognathia, thus recapitulating the most penetrant phenotypes of the syndrome.

238 NA loss-of-function rarely results in highly penetrant phenotypes, but rather, influences cellular re

239 Our data suggest the CNS-penetrant PI3K inhibitor BKM-120 may have anti-invasive

240 h-risk gene variants in a family with highly penetrant pleiotropic CHD.

241 ockin model, in which we demonstrated highly penetrant, pleiotropic cardiac anomalies.

242 t-specific deletion of Lkb1 results in fully penetrant polyposis in mice.

243 MYC activation results in highly penetrant pRCC tumours (MYC), while MYC activation, when

244 isease [KD]), a central nervous system (CNS)-penetrant protective agent rescued myelin and oligodendr

245 king defects that are associated with highly penetrant pulmonary fibrosis.

246 Following the discovery of cell penetrant pyridine-4-carboxylate inhibitors of the KDM4

247 l generation of central nervous system (CNS) penetrant radiometabolites, improved brain uptake, and w

248 We identify highly penetrant rare mutations in 16% of familial CRC.

249 In addition to well known, highly penetrant rare mutations that cause mendelian disorders

250 A fully penetrant recessive 4-bp deletion was identified in the

251 eveloped more severe pyelonephritis and 100% penetrant renal abscess (a complication that is rare in

252 MCRPE is an autosomal dominant, fully penetrant retinal dystrophy with a preclinical stage, an

253 ions contribute to the etiology of partially penetrant retinoblastomas.

254 utations in established moderately or highly penetrant risk genes for breast cancer (BC) and/or ovari

255 Rare, highly penetrant risk genes such as the 22q11.2 microdeletion a

256 Identifying rare, highly penetrant risk mutations may be an important step in dis

257 This extreme phenotype likely harbors highly penetrant risk variants, making it primed for discovery

258 essing (Myf5-expressing) cells develop fully penetrant sarcomagenesis, suggesting skeletal muscle pro

259 xplored the impact of one of the most highly penetrant schizophrenia risk genes, DISC1, upon the medi

260 ion syndrome is associated with incompletely penetrant severe cardiac defects and craniofacial anomal

261 stinct etiologies: (1) ultra-rare and highly penetrant single disruptions of embryonically upregulate

262 s neurodegenerative disorder caused by fully penetrant single gene mutations in a minority of cases,

263 ed risk stratification utility of common low penetrant single nucleotide polymorphisms (SNPs) and epi

264 version in Huntington disease (HD), a highly penetrant, single-gene disorder, is unknown.

265 onditional gene targeting to develop a fully penetrant small animal model of this disease that recapi

266 ological stabilization of p53 with the brain-penetrant small molecule idasanutlin resulted in synthet

267 high demand for potent, selective, and brain-penetrant small molecule inhibitors of leucine-rich repe

268 imized ligand-efficient, selective, and cell-penetrant small molecules (molecular weight approximatel

269 There is an urgent need for new, brain penetrant small molecules that target the central nervou

270 01-2-151SRM (MW151) is a blood-brain barrier penetrant, small-molecule anti-neuroinflammatory that at

271 Consequently, brain penetrant specific CK-1 inhibitors may provide a new the

272 ammatory gene expression, and enabled highly penetrant spontaneous pulmonary metastasis.

273 that simvastatin and, possibly, other brain penetrant statins bear high therapeutic promise in early

274 e common risk variants and rarer more highly penetrant submicroscopic chromosomal deletions and dupli

275 tors, although orally bioavailable and brain-penetrant, suffer from unfavorable off-target binding to

276 t disease-causing BMPR2 mutation is only 20% penetrant, suggesting that genetic variation provides mo

277 ng the basis of microcephaly in AS, a highly penetrant syndromic feature with early postnatal onset,

278 ellular APL-1 fragment, show an incompletely penetrant temperature-sensitive embryonic lethality.

279 h longer half-life and to be much more brain penetrant than SKA-121, not only lowered blood pressure

280 buted across many genes and are incompletely penetrant (that is, not necessarily sufficient for disea

281 ive on ALK-dependent cell lines, efficiently penetrant the blood-brain barrier (BBB) in different ani

282 Free-volume of polymers governs transport of penetrants through polymeric films.

283 gesting that molecules do not need to be CNS-penetrant to block these receptors.

284 es are nonimmunogenic, are freely and deeply penetrant to human OA cartilage, and persist in chondroc

285 ence that systemic administration of a brain-penetrant TrkB antagonist (tat-cyclotraxin-B) reduces se

286 show that systemic administration of a brain-penetrant TrkB antagonist leads to brain region-specific

287 The completely penetrant tumors were indistinguishable from human ASPS

288 Remarkably, the mice develop highly penetrant tumours with OCCC-like histopathology, culmina

289 al triplications cause a frequent and highly penetrant type of autism linked to increased gene dosage

290 Here we used brain penetrant tyrosine kinase inhibitors (TKIs), including n

291 riant in TRIM63 is not likely to be a highly penetrant variant causing hypertrophic cardiomyopathy.

292 Although countless highly penetrant variants have been associated with Mendelian d

293 al appearances, but may still represent less penetrant variants.

294 e sequencing to probe for other rare, highly penetrant variants.

295 c for evaluating vaccine responses to highly penetrant viruses with cross-reactive serotypes.

296 ariants are currently thought to be variably penetrant, we hypothesise that when disorders encompasse

297 ency may evolve over time or is incompletely penetrant, while 2 developed subclinical cytopenias or e

298 It is orally bioavailable and brain penetrant with robust preclinical efficacy.

299 Heritable PAH is not completely penetrant within families, with approximately 20% concur

300 dines that are orally bioavailable and brain-penetrant without disruption of Pgp function.