ライフサイエンスコーパス: penetratin

1 hore as well as a cell-penetrating sequence (penetratin).

2 ously unnoticed direct binding of CaM to ant/penetratin.

3 nd neutral lipids in their interactions with penetratin.

4 ic residues, Arg(10) and Lys(13), in the CPP penetratin.

5 Thus, it is an intrinsic property of penetratin.

6 of sc(Fv)2 was achieved by administration of penetratin.

7 melittin, magainin II, PGLa, LAK1, LAK3 and penetratin.

8 ell-penetrating peptides (CPPs), HIV TAT and penetratin.

9 d by PNA(TAR)-tat (0.72 microM) and PNA(TAR)-penetratin (0.8 microM).

10 As a first demonstration of principle, penetratin, a 16-residue CPP derived from the Antennaped

11 ration of caveolin bioavailability employing penetratin, a cell-permeable peptide carrier for a bioac

12 We demonstrate that penetratin, an antennapedia-derived peptide, can be disp

13 n was seen for free delivery of Tat (48-58), Penetratin and R9 conjugates of 16mer phosphorothioate O

14 A oligonucleotide conjugates to Tat (48-58), Penetratin and R9F2 was observed in cytosolic compartmen

15 Therefore, the combination of penetratin and scFvs has the potential of improving the

16 tribution of the radiolabeled scFv with both penetratin and TAT in comparison with the control treatm

17 G, to three well-studied CPPs: octaarginine, penetratin and TP10.

18 ed the utility of cell-penetrating peptides, penetratin and transactivator of transcription (TAT).

19 guanidinium-phosphate interactions exist in penetratin, and guanidinium groups play a stronger struc

20 action between the cell-penetrating peptide, penetratin, and solid-supported lipid bilayer membranes

21 on were 7.14, 19.53, and 16.48 with control, penetratin, and TAT treatment, respectively, whereas the

22 -administration with a control (no peptide), penetratin, and TAT were 27.25%, 79.84%, and 48.55%, res

23 ent Raman microscopy to localize a model CPP-penetratin-and determine its secondary structure in diff

24 Interestingly, prenylated peptides lacking penetratin are able to enter cells freely through an ene

25 servations suggest that the dynamic state of penetratin at high temperature is a structured turn inst

26 e electroporation model, which predicts that penetratin binds to only the outer lipid leaflet at low

27 The results showed that penetratin bound to the membrane interface in the alpha-

28 Systemic administration of penetratin-caveolin-1 peptide to mice with bleomycin-ind

29 LNA oligonucleotide or Penetratin peptide to Penetratin conjugate of the same oligonucleotide.

30 tide conjugates where uptake of the PNA(TAR)-penetratin conjugate was most efficient as >90% MTD was

31 (Transportan or a novel chimeric peptide R6-Penetratin) exhibit dose-dependent inhibition of Tat-dep

32 ingly, a potential barrier appeared to block penetratin from translocating across the bilayer.

33 tently, annexin A2 and a cell-internalizing, penetratin-fused version of the selected peptide (LGRFYA

34 Further analysis demonstrated that the Smac-penetratin fusion peptide crossed the cellular membrane,

35 However, we demonstrate here that ant/penetratin fusion to CN27 compromised CaMKII-selectivity

36 Penetratin increased the tumor retention of scFvs withou

37 we found that at low peptide concentrations, penetratin is distributed in both leaflets of the bilaye

38 Our results show that penetratin is mostly alpha-helical in the cytosol and ac

39 3)C spin diffusion experiments indicate that penetratin is oligomerized into beta-sheets in gel-phase

40 hat one such peptide, if chemically fused to penetratin, is internalized receptor-independently, loca

41 conformation of a cell-penetrating peptide, penetratin, is investigated using solid-state NMR spectr

42 When cells were transduced with penetratin-linked AARAApSAPA, we found that this reagent

43 Cell permeable, penetratin-linked peptides encoding wild-type SSeCKS-CY,

44 d formation in equilibrium experiments using penetratin-lipid mixtures.

45 Penetratin maintained the POPE order but disordered POPG

46 IQACRG was linked to penetratin (P-IQACRG) to facilitate cellular uptake.

47 yte apoptosis, a peptide mimic of annexin V (Penetratin (Pen)-VVISYSMPD) that binds to beta5 integrin

48 ity than several other well-known CPPs (TAT, penetratin, Pep-1, and TP10).

49 onjugate of 12mer OMe/LNA oligonucleotide or Penetratin peptide to Penetratin conjugate of the same o

50 motifs in 4E-BPs and eIF4G [9] linked to the penetratin peptide-carrier sequence, which mediates the

51 ast cytosolic compartments was seen for Tat, Penetratin, R9F2 and Transportan conjugates.

52 trol, unrelated peptide attached to the same penetratin sequence had no effect on these cell lines.

53 DIABLO fused to the Drosophila antennapaedia penetratin sequence, a carrier peptide, enhance the indu

54 was attached at its carboxyl terminus to the penetratin sequence, KKWKMRRNQFWVKVQRG, that contains ma

55 Only penetratin showed effective uptake of bovine serum album

56 andom coil structure of TAT and another CPP, penetratin, suggests that the lack of amphipathic struct

57 have conjugated five different MTD peptides, penetratin, tat peptide, transportan-27, and two of its

58 onjugated to the membrane permeable molecule Penetratin to injured sensory afferents.

59 btained upon the binding of a small peptide, penetratin, to solid-supported lipid bilayer membranes.

60 actions with the lipid chains and facilitate penetratin translocation across the bilayer without caus

61 etrating peptide classification and HIV-Tat, penetratin, transportan, and octaarginine represent exte

62 The conjugates with penetratin, transportan-21 and tat-peptides were most ef

63 depending on the presence or absence of the penetratin vehicle and the nature of the prenyl group at

64 When penetratin was incorporated into an egg PC + palmitoylol

65 Carbon-13 labeling of the Phe residue of penetratin was used to shift the intense aromatic ring-b

66 g this method to a cell-penetrating peptide, penetratin, we found that at low peptide concentrations,

67 native mechanism for intracellular import of penetratin, which may involve guanidinium-phosphate comp

68 s confirmed improved tumor localization with penetratin without any increase in the uptake by normal