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1 Median age 31 (1-84), 84.5% male, 51.3% penetrating.
2 H4-L1 exhibits antimicrobial and potent cell-penetrating activities for a wide variety of cargo inclu
3 we found that PepB2 had more efficient cell-penetrating activity than several other well-known CPPs
4 implication other SBFS species) from a plant-penetrating ancestor to a non-invasive ectophyte, displa
6 l adhesion motifs, structural peptides, cell-penetrating and tumor-homing peptides, antimicrobial pep
9 sed to follow the adsorption of the membrane-penetrating antimicrobial peptide Temporin L in differen
11 h the epidermis and dermis and that the skin-penetrating aptamer retains its biologically active conf
13 ies in cats, as well as surface arteries and penetrating arterioles in rat visual cortex (where orien
14 ide (T7) and stroke homing peptide (SHp) for penetrating BBB and targeting ischemia area, respectivel
15 to both small compounds and macro-molecules penetrating BBB through various mechanisms besides passi
16 ple of 112 Vietnam War veterans who suffered penetrating brain injury and 33 healthy controls who als
21 (1B), great vessel disease and injury (2C), penetrating chest trauma (1C) and for use of contrast (1
22 patients for a possible cardiac injury after penetrating chest trauma by detecting blood in the peric
26 ti-TNFalpha therapy were less likely to have penetrating complications (hazard ratio [HR] 0.30, 95% C
30 closure of the PVS around surface as well as penetrating cortical arteries and veins lasting several
31 rring that involved the subpial glial plate, penetrating cortical blood vessels, grey-white matter ju
33 a highly scattering medium are incapable of penetrating deep into the medium due to the multiple sca
35 apsulated EtNBS nanoparticles are capable of penetrating deeply into the hypoxic and acidic cores of
36 nd to PyR1 and PyR2 in similar orientations, penetrating deeply into the respective domain interfaces
37 also discovered that these PBAE-based mucus-penetrating DNA nanoparticles (PBAE-MPPs) provided unifo
39 order, while proteins with reported membrane-penetrating domains show preference for disordered membr
41 cancer therapy revealed PD325901 as a brain-penetrating drug that blocks ERK signalling in the nanom
43 Further applications, such as transparent penetrating electrode arrays, multi-electrode electroret
45 RNA-directed oligonucleotides with such skin-penetrating epidermal agents will drive the development
49 Pentacam HR; Oculus, Wetzlar, Germany) after penetrating femtosecond laser-assisted keratotomy (pFLAK
50 re of the right lateral pterygoid plate by a penetrating foreign body (wooden twig) in an adult male
53 re associated with moderate to severe TBI or penetrating head injury, but other visual field deficits
54 terior cavity, and chemically attaching cell penetrating HIV-Tat peptide on the exterior of the capsi
56 hat hemostatic thrombi formed in response to penetrating injuries have a core of densely packed, fibr
57 cluding two with maximum risk exposures from penetrating injuries with freshly used hollow-bore needl
59 olled for sex; mechanism of injury (blunt vs penetrating); injuries sustained, based on the Abbreviat
60 nt above 80 mg/dL (P < 0.0001), and suffer a penetrating injury (P < 0.0001) compared with nonrecidiv
61 race, and elevated blood alcohol content and penetrating injury are associated with trauma recidivism
62 re more likely to be injured by a blunt than penetrating injury mechanism (91.4%) compared with those
64 (40%) of 16 patients diagnosed with RD after penetrating injury whose surgery involved 360 degree ret
66 uantum interference device to image vortices penetrating into a superconducting Pb film at rates of t
69 complementarity-determining region 3 deeply penetrating into the active site cleft, highly reminisce
70 ned to penetrate through the sclera, without penetrating into the choroid/retina, in order to target
71 rated acyl chains of another phospholipid by penetrating into the hydrophobic core of the membrane.
72 to epicardial layers, BODIPY was capable of penetrating into the myocardium, resulting in a transmur
73 that prevented the acid-foulant mixture from penetrating into the porous support during acid treatmen
75 r that slows the growth of lithium dendrites penetrating into the separator is produced by sandwichin
76 tic modulating effect on the solar radiation penetrating into the subsurface layers, which induces di
81 included post-cataract surgery (n = 6), post-penetrating keratoplasty (n = 2), and post-trabeculectom
82 e likely to perforate or require therapeutic penetrating keratoplasty (odds ratio: 6.27; 95% CI: 2.73
83 djusted hazard ratio [HR], 1.56; P < 0.001), penetrating keratoplasty (PK) (adjusted HR, 1.12 vs. ALK
84 tomated endothelial keratoplasty (DSAEK) and penetrating keratoplasty (PK) for Fuchs endothelial dyst
86 hy (PBK), or keratoconus who had undergone a penetrating keratoplasty (PK), endothelial keratoplasty
89 nking (CXL) and conventional management with penetrating keratoplasty (PKP) when indicated in managin
90 utcomes of patients that underwent pediatric penetrating keratoplasty (PPK) for herpes simplex virus
93 nts diagnosed with microbial keratitis after penetrating keratoplasty at the National Taiwan Universi
94 ears of age or younger who underwent primary penetrating keratoplasty at Wills Eye Hospital Cornea Se
95 creased hazard of perforation or therapeutic penetrating keratoplasty compared with placebo after con
99 red thirty-nine eyes (96 corneal grafts post penetrating keratoplasty or Descemet stripping automated
100 a (122 eyes, group 2), and in cases in which penetrating keratoplasty was associated with vitrectomy
103 and other anterior segment-related (eg, post-penetrating keratoplasty), bleb-associated, glaucoma dra
104 d FECD, defined by a need for endothelial or penetrating keratoplasty, has not been investigated.
105 rticipants with a history of glaucoma before penetrating keratoplasty, particularly with prior glauco
107 ieving visual results comparable to those of penetrating keratoplasty, while sparing a healthy endoth
116 emonstrated that MDMs and DCs are capable of penetrating large-pore membranes but not small-pore memb
117 us operations, predefined strictures, and/or penetrating lesions of maximal severity (grades 1-3), an
118 bowel damage, including stricturing lesions, penetrating lesions, and surgical resection, for measuri
120 nine, a dermis-localizing peptide and a skin penetrating linear peptide) and a model hydrophobic macr
122 techniques with an unfolded hippocampus and penetrating microelectrode array to record and analyze n
123 ghout the unfolded rodent hippocampus with a penetrating microelectrode array, we have shown that fas
124 ion of a new family of highly effective cell-penetrating molecular transporters, guanidinium-rich oli
125 uenced BODIPY distribution, with fluorophore penetrating more readily into atria than ventricles.
126 A peptide drug is fused with a short cell-penetrating motif and converted into a conformationally
127 -PEG blended nanocomplexes (DNA-loaded brain-penetrating nanocomplexes, or DNA-BPN) was uniform throu
128 s a blood-brain barrier-/blood-tumor barrier-penetrating nanoconjugate to deliver small interfering (
132 hanced when cisplatin was delivered in brain penetrating nanoparticles (median survival not reached;
134 microbubbles and using highly compact "brain penetrating" nanoparticles (BPN) coated with a dense pol
135 gy can be translated in vivo by using deeply penetrating near-infrared light for transdermal stiffnes
137 grading of these distinctive neoplasms.Deep penetrating nevi (DPN) are unusual melanocytic neoplasms
141 ss-penetrating polymers push the more easily penetrating ones into nanosize channels in excess of the
143 ts, a total of 50 patients (25.5%) underwent penetrating or anterior lamellar keratoplasty, 10 of who
144 , the procedure may be performed to postpone penetrating or deep anterior lamellar keratoplasty.
146 uniformly transported non-mucoadhesive mucus-penetrating particles (MPP) to epithelial surfaces, incl
147 entified as an orally bioavailable and brain penetrating PDE1B enzyme inhibitor with potent memory-en
149 the current study, we have developed a cell-penetrating peptide (CPP) conjugate of the HIV TAT prote
151 ow molecular weight protamine (LMWP), a cell penetrating peptide (CPP), insulin showed greatly improv
152 mong those strategies, enzyme-triggered cell penetrating peptide (CPP)-mediated systems seem to be a
154 (MMP2)-sensitive peptide linker (pp), a cell penetrating peptide (TAT), and a model drug (doxorubicin
156 ar peptidyl ligands through fusion to a cell-penetrating peptide and cyclization of the fusion peptid
157 tion, Yan et al validated the use of a tumor-penetrating peptide and thermosensitive doxorubicin (DOX
159 hacrylamide (HPMA) copolymer drugs and tumor-penetrating peptide conjugates (P-DOX-PLGLAG-iRGD).
160 xperiments from 'Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drug
161 from the paper "Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drug
162 show that targeting of p32 with linTT1 tumor-penetrating peptide improves tumor selectivity and antit
163 iu and colleagues show that the cyclic tumor-penetrating peptide iRGD, reported to be capable of enha
165 an be internalized via conjugation with cell-penetrating peptide moieties; and Cas9 ribonucleoprotein
168 se data may also explain variability in cell-penetrating peptide performance in different experimenta
169 elivered to tumors using an activatable cell-penetrating peptide targeting matrix metalloproteinases
170 oparticle surface modification with the cell penetrating peptide TAT facilitates brain-specific deliv
171 modification of nanoparticles with the cell-penetrating peptide TAT increases their biophysical asso
174 ere, we explore the utility of iRGD, a tumor-penetrating peptide, for improved tumor-specific penetra
175 We have developed an AAC-11-derived cell-penetrating peptide, herein named RT53, mimicking in par
176 ting transcriptional activator (TAT), a cell-penetrating peptide, is extensively used for facilitatin
179 roteins interaction and, if linked to a cell-penetrating peptide, reduces glutamate release in acute
180 for PCI by conjugating the chlorin to a cell penetrating peptide, using bioorthogonal ligation chemis
181 arrestin signaling process with a novel cell-penetrating peptide, we were able to inhibit both thromb
182 ane helices 5 and 6 of CB1R, fused to a cell-penetrating peptide, were able to disrupt receptor heter
184 protein either by electroporation or by cell-penetrating peptide-mediated import leads to formation o
186 n and their ability to be conjugated to cell penetrating peptides (CPP) to overcome challenging deliv
187 e the delivery of cargoes into cells by cell-penetrating peptides (CPPs) and the bactericidal activit
193 Hundreds of cationic antimicrobial and cell-penetrating peptides (CPPs) form amphipathic alpha-helic
194 ransduction domains (PTDs), also called cell-penetrating peptides (CPPs), can promote uptake of macro
200 pecific GE11 peptide), acid-activatable cell-penetrating peptides (i.e., TH peptide), and imaging pro
204 vivo utility of technologies employing cell penetrating peptides and bioportides may be compromised
206 has a predicted structural analogy with cell-penetrating peptides and that both the entire protein an
208 enhanced by the action of targeting and cell-penetrating peptides attached to the calcium silicate sh
212 ses that are involved in processing of tumor penetrating peptides identified using phage display are
213 ange studies in solution, activation of cell-penetrating peptides in vesicles, and computational anal
214 These attributes suggest that related, cell-penetrating peptides should effectively inhibit active G
215 onstrates the feasibility of designing tumor-penetrating peptides that are activated by a specific tu
216 polymer-coated QDs have been coupled to cell-penetrating peptides to facilitate intracellular uptake,
217 iciencies with which three families of "cell-penetrating peptides" traffic to the cytosol of mammalia
218 livery, previous studies have relied on cell penetrating peptides, nanoparticles or specific biomarke
219 t miRNA function using vehicles such as cell penetrating peptides, spherical nucleic acids, deformabl
227 ere, we introduce a technology based on cell-penetrating poly(disulfide)s that solves this problem: w
228 on is based on the idea that relatively less-penetrating polymers push the more easily penetrating on
229 of this transition by designing smart, cell-penetrating polymers that undergo acid-activated endosom
230 e arrays and flexible, multifunctional depth-penetrating probes illustrate the power of these concept
232 s, including those requiring agents with CNS-penetrating properties, as well as for overcoming crizot
235 light detection and ranging (LiDAR), ground penetrating radar (GPR), and archaeological surveys, has
237 ures were mapped from high-resolution ground penetrating radar images of the subsurface and transform
239 edrock scarps, mapped using LiDAR and ground penetrating radar, and compare these rates to those infe
240 ent high-resolution maps, acquired using ice-penetrating radar, of the bed topography across parts of
241 te of spontaneous emission of characteristic penetrating radiation and the ease of its shielding.
242 ly packed soils highlighted the impacts of a penetrating root system in changing the surrounding poro
244 Mutation in COP1 causes severe defects in penetrating soil, due to decreased level of EIN3, a mast
249 ssociated with nerve fiber branching points, penetrating the basement membrane and reaching into the
250 s suggest that kinase inhibitors, capable of penetrating the BBB to reach their target, would be desi
253 infection induces the formation of channels penetrating the compacted layer of cellular chromatin an
255 3CR1(-/-) mice the numbers of S. Typhimurium penetrating the epithelium were significantly higher.
261 whereby the particles behave as projectiles penetrating the oil droplets to depths varying from appr
262 genous cytoplasmic alphaS by either directly penetrating the plasma membrane or via endocytosis-media
265 depletion, removing 6% of biota per pass and penetrating the seabed on average down to 2.4 cm, wherea
266 terface would entail communicative knowledge penetrating the sensorimotor system and directly affecti
268 and resident cells through blood vessels by penetrating the tightly organized blood-brain barrier.
270 interrogating electromagnetic radiation from penetrating, thus denying the detection of any eventual
271 (no signals scattering and only mean values penetrating to the cloak's interior), the sensitivity of
272 ate of multidetector CT as a triage tool for penetrating torso trauma and the primacy of trajectory e
273 underwent 40- or 64-row multidetector CT for penetrating torso trauma below the diaphragm and had sur
274 y (CT) for hemodynamically stable victims of penetrating torso trauma continues to increase but remai
275 hly effective class of guanidinium-rich cell-penetrating transporters and methodology for their singl
276 D] age, 47 [19] years) and 324 patients with penetrating trauma (mean [SD] age, 35 [15] years), the r
279 ted of 90 patients, including both blunt and penetrating trauma victims with a median injury severity
283 ree percent (66 of 90) of patients sustained penetrating trauma, 82% (74 of 90) of whom were male.
285 e same in patients who experienced blunt and penetrating trauma, the independent risk factors for VTE
294 GFR inhibitor resulted in the development of penetrating ulcers, further demonstrating that VEGF is c
297 mparative investigations identified two cell penetrating vectors, Tat and C105Y, which readily transl
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