ライフサイエンスコーパス: penetration

1 g to tumor tissue and cells, and poor tissue penetration.

2 detoxification mechanism during host cuticle penetration.

3 bilayer bending modulus, and increased water penetration.

4 ch is cytotoxic and poorly suited for tissue penetration.

5 ome compounds displaying unexpected high CNS penetration.

6 cause pmk1 and mps1 mutants are defective in penetration.

7 nanobubble agents to result in improved drug penetration.

8 otherapeutic efficacy of drugs with poor BTB penetration.

9 heterogeneity in regulations and technology penetration.

10 tro activity, metabolic stability, and brain penetration.

11 (iRGD) to enhance tumor targeting and tissue penetration.

12 strategies to overcome them and enhance drug penetration.

13 V) route, which requires blood-brain barrier penetration.

14 Unpigmented BS extensions increase BS light penetration.

15 d:plasma ratio further supported limited CNS penetration.

16 barrier further accelerated and enhanced the penetration.

17 as oocyte transport in the oviduct and sperm penetration.

18 anism of action that extends beyond membrane penetration.

19 nd implicated in Gram-negative cell envelope penetration.

20 ssorium turgor pressure generation, and host penetration.

21 is retained in tumors, and aids in cellular penetration.

22 demonstrated an unacceptable level of brain penetration.

23 e epithelium remained resistant to bacterial penetration.

24 lexibility to enable up to 50% of wind power penetration.

25 is a considerable diffusion barrier for H2O2 penetration.

26 by COR and are highly resistant to bacterial penetration.

27 tically coked zeolites with sample full body penetration.

28 iological system with greatly improved light penetration.

29 while their small size allows better tissue penetration.

30 maxima at around 800 nm, which favors tissue penetration.

31 of photoabsorbing molecules with deep tissue penetration.

32 The Arabidopsis PENETRATION 3 (PEN3) ATP binding cassette (ABC) transpor

33 The skin penetration ability and the efficaciousness of the biose

34 hibits lower phototoxicity and higher tissue penetration ability.

35 xplicit phospholipid membrane revealed water penetration along transmembrane helix 1 with the coopera

36 demonstrate adequate safety through limited penetration and absorption, but limited potential therap

37 The tumor penetration and accumulation of nanoparticle-based drug

38 Paclitaxel exhibits its superiority in drug penetration and accumulation, resulting in the largest e

39 heir in vivo applicability due to poor light penetration and associated phototoxicity on cells and ti

40 lications because visible light has superior penetration and causes far less damage to organic molecu

41 In this study, the penetration and delivery capacity was examined of a repe

42 tumor models frequently used to evaluate the penetration and efficacy of therapeutics.

43 ave been proposed, including direct membrane penetration and endocytosis.

44 C infection were less permissive to parasite penetration and had a greater ability to control L. braz

45 such as GFP and RFP suffers from poor tissue penetration and high background autofluorescence.

46 However, with increased penetration and improved dispatch of renewables, this as

47 lencing phenotypes displaying greater tissue penetration and involving more leaves.

48 , an in vitro platform is used to assess the penetration and metabolism of combination chemotherapies

49 approach was successfully applied to map the penetration and metabolism of oxaliplatin in hyperthermi

50 e fusion protein for mediating targeted cell penetration and non-covalent self-assembly with therapeu

51 le fragment (scFv) antibodies increase brain penetration and offer flexible options for delivery whil

52 in hyphal growth, conidiation, appressorium penetration and pathogenicity, which is similar to the p

53 stances, which prevent oxygen molecules from penetration and physical contact with excited states and

54 tisfies the precondition for efficient tumor penetration and rapid clearance.

55 d 8:1 ratios dramatically improved ADC tumor penetration and resulted in twice the improvement in med

56 ve was to explore the kinetics of myocardial penetration and retention after pericardial NP drug deli

57 critical role of Hsc70 in SV40 ER-to-cytosol penetration and reveal how SGTA controls Hsc70 to impact

58 Lack of immune cell penetration and T cell allogeneic priming was observed.

59 The protein is porous to water penetration and the hydration level of the cofactors cha

60 Leaf anatomy influences BS light penetration and therefore constrains C4 cycle functional

61 lex in promoting SV40 ER-to-cytosol membrane penetration and unveils a role of SGTA in controlling th

62 V at acidic tumor tissue, for enhanced tumor penetration and uptake by cells in deep tumor tissue.

63 identify compounds such as 33 with lower CNS penetration, and activity in oral glucose tolerance stud

64 affords high spatial resolution, deep-tissue penetration, and diminished auto-fluorescence due to the

65 Herein, the dependence of the uptake, penetration, and distribution of sixteen polycyclic arom

66 nic network possesses open mesopores for gas penetration, and features a high density of grain bounda

67 een chirality, protease resistance, cellular penetration, and intracellular activity that may be usef

68 t functions to prevent bacterial attachment, penetration, and invasion on PAR4-AP-modified titanium.

69 surfaces would reduce bacterial attachment, penetration, and invasion.

70 receptor affinity, high blood-brain barrier penetration, and the ability to be radiolabeled with (11

71 he bonded interface, the extent of bacterial penetration, and the presence of mechanical loading.

72 mization focused mainly on solubility, brain penetration, and the search for an aminopyrazole metabol

73 mptions regarding the energy penalty of pore penetration are included.

74 potent PDE2A inhibitors with improved brain penetration as compared to current literature compounds.

75 We propose that water penetration as revealed by molecular dynamics may provid

76 med a significant difference in tumor tissue penetration between the 62 and 110nm PEG-coated NPs, as

77 on and dipolar relaxation arising from water penetration, but disentangling lipid composition from me

78 D, reported to be capable of enhancing tumor penetration by drugs, can overcome this limitation to a

79 Membrane penetration by nonenveloped viruses remains enigmatic.

80 We showed that the extent of tumor penetration by SN-38 was significantly higher in mice re

81 human skin, we model the time-dependent drug penetration by the 1D general diffusion equation that ac

82 Taking advantages of the high tissue-penetration capability of near-infrared excitation/emiss

83 transient precorneal retention time and low penetration capacity into intraocular tissues are the ke

84 , a neurotoxic fluorescent dye with membrane penetration characteristics superior to the carbocyanine

85 ical tissue samples, which have unknown cART penetration, contain a comparably diverse spectrum of po

86 ed out with the phantom, including: depth of penetration, dead zone, distance measurement accuracy, r

87 Furthermore, the enhanced penetration depth achieved by this method will directly

88 Image analysis methods were used to measure penetration depth and area of the breach caused by micro

89 ared (NIR) light that offers a deeper tissue penetration depth and better biocompatibility.

90 s, enhanced detection sensitivity, increased penetration depth and improved spatial resolution.

91 cause spherical aberrations that often limit penetration depth and resolution.

92 em of fine resolution ( 100 microm) and deep penetration depth capable of providing both qualitative

93 s probing the temperature-dependent magnetic penetration depth in T d-MoTe2.

94 s used to determine number and relative bead penetration depth into the biofilm.

95 ation, which facilitated high resolution and penetration depth into the specimen, and low phototoxici

96 Penetration depth of electromagnetic wave into samples d

97 developed by taking advantage of the limited penetration depth of light to induce asymmetrical surfac

98 face electrons can be obtained by tuning the penetration depth of optically-generated surface phonons

99 employed a mathematical model to reveal the penetration depth of several proteins within porous nano

100 However, the short penetration depth of soft X-rays imposes stringent const

101 49 lung carcinoma, which is about four times penetration depth of the nontransformable one.

102 Understanding protein penetration depth provides an explanation for the compos

103 avior because of its subcellular resolution, penetration depth through the entire organoid, and funct

104 af/n) coordinates where delta is the viscous penetration depth, a is the particle radius, Deltaf is t

105 ffers superior spatial resolution and tissue penetration depth, but few NIR-IIb probes exist.

106 By accounting for the effects of penetration depth, environmental variation, and uncertai

107 structure and the consequent small infrared penetration depth.

108 atiotemporal resolution and unlimited tissue penetration depth.

109 are fluorescence-based, which limits imaging penetration depth.

110 ds that have limited temporal resolution and penetration depth.

111 llular resolution and millimeters of optical penetration depth.

112 nfigurations can improve both resolution and penetration depth.

113 e and microdermabrasion and similar vertical penetration depths for microneedling, AFXL, and non-AFXL

114 Transmission Raman Spectroscopy facilitating penetration depths into tissue up to two orders of magni

115 e window (400-700 nm) ensuring better photon penetration, diminished tissue autofluorescence and high

116 opy (SPIM) for rapid scanning and deep axial penetration during zebrafish morphogenesis.

117 copy/mL, and a lower central nervous system penetration-effectiveness score (model P < .001).

118 alyptus oil (1%) was employed to improve the penetration efficacy of the nanogel into stratum corneum

119 l species with high spatial resolution, deep penetration, enhanced temporal responsiveness, and impro

120 he properties of the skin and assess if this penetration enhancement strategy could improve the percu

121 n and this provided evidence that this novel penetration enhancement technique can improve the percut

122 Finally, experiments with often used penetration enhancer thymol shows that this compound int

123 Penetration enhancers coated biodegradable polymeric nan

124 t size, charge, and the presence of chemical penetration enhancers on delivery to GI tissue using ult

125 t the cavity wall surface exceeds the vortex penetration field (Hvp).

126 with magnesium diboride layer on the vortex penetration field.

127 and area of the breach caused by microneedle penetration following staining and optical imaging.

128 stic ultrasound are able to enhance the drug penetration for achieving improved delivery outcomes.

129 The importance of nanosheet penetration for cytotoxicity has direct implications for

130 almost didn't change after methane and argon penetrations for all these samples except Marcellus outc

131 Roots need to exert higher penetration force, resulting in increased penetration st

132 eems to be a significant effect to affect TA penetration from episclera towards retina and vitreous.

133 rrier SPACE-EGF to improve the skin and cell penetration function of the siRNAs and their targeting a

134 spatial selectivity and capability for depth penetration, FUS may confer a unique utility in providin

135 Using the Electrical Penetration Graph (EPG) technique, we found that mycorrh

136 elds, higher resolution, and improved tissue penetration has enabled the precise quantification of ad

137 pre-penetration of the cuticle, and cuticle penetration/hemocoel ingress and proliferation.

138 (iRGD) to enhance tumor targeting and tissue penetration; ii) polyethylene glycol (PEG) chains to pro

139 orylated by PKA both in vitro and after cell penetration in cellulo.

140 t of diffusion limitation and thus substrate penetration in the biofilm.

141 Exo-AAV2 demonstrated deeper penetration in the retina, efficiently reaching the inne

142 importantly, PFP encapsulation improved Dox penetration in the tumor periphery and core and did not

143 o further characterize their functions after penetration, in this study we expressed the Pseudomonas

144 We also considered drug penetration indices into meninges, bone, and peritoneum.

145 ation is difficult, however, as micropipette penetration induces tissue deformation, moving target ce

146 nce plant primary productivity due to deeper penetration into and greater irradiance of the entire ca

147 adsorption capacity at the A/W interface and penetration into egg phosphatidylcholine monolayer compa

148 -functionalized NWs showed robust homing and penetration into malignant lesions, whereas only a backg

149 Future penetration into regions with average charges like Penns

150 ong the three techniques regarding NP and BP penetration into rice plant roots and spICP-MS showed it

151 ation, whereas fibrous side facilitated cell penetration into scaffold.

152 major hindrance, greatly limits therapeutics penetration into the brain.

153 hroughout the bundle and, in particular, its penetration into the bundle core.

154 en results in uneven labeling with very poor penetration into the center of thick specimens; these li

155 asurement under-reading due to limited light penetration into the flow vessel was also observed.

156 uman tau expression restored MT bundling, MT penetration into the growth cone periphery and close MT

157 show that He ion irradiation leads to oxygen penetration into the irradiated areas, and diffuses alon

158 actions, without specific binding pockets or penetration into the lipid bilayer.

159 ed viscous and buoyant forces resisting slab penetration into the lower mantle and deformation associ

160 stricted compartment to allow sustained drug penetration into the myocardium.

161 Depletion of biota and trawl penetration into the seabed are highly correlated.

162 le: a microsphere undergoes a full conformal penetration into the specimen followed by a rebound whic

163 ent, which are negatively affected by vortex penetration into the superconductor when the peak magnet

164 t the drug out of cells, and suboptimal drug penetration into tuberculosis lesions-are likely crucial

165 Despite ethanol's penetration into urban transportation, observational evi

166 e features enable many applications in which penetrations into the sampled environment are unwanted o

167 inding to RAD51 but not to DNA, whereas cell penetration is linked to DNA binding.

168 ucture of the stratum corneum on transdermal penetration is not yet fully described by existing model

169 in deep-tissue observations, far beyond the penetration limits of modern microscopy.

170 ted MLGEPs on CNTs can obviously enhance the penetration losses of microwaves in foams, leading to a

171 Brain penetration (measured by drug CSF/serum level) of G6 den

172 Also, the BBB penetration mechanisms are concluded in general, emphasi

173 With improvements in depth of tissue penetration, MSOT may hold potential as a sensitive, acc

174 lusion: With improvements in depth of tissue penetration, MSOT may hold potential as a sensitive, acc

175 19.6-fold increase in in vitro percutaneous penetration of a 10,000 molecular weight dextran molecul

176 first study to use MALDI-IMS to analyze drug penetration of a liposomal drug carrier as well as its m

177 ment strategy could improve the percutaneous penetration of a macromolecule.

178 Parallel measurements of the penetration of a model drug across laser-treated nails s

179 nt with tPA resulted in greater intratumoral penetration of a model nanocarrier (Doxil), leading to e

180 remarkably persistent spatial mosaic in the penetration of acidified waters into ecologically-import

181 tion), abscess formation, and root exposure (penetration of bone surface) were indistinguishable amon

182 by severe systemic toxicity and inefficient penetration of brain tumor tissue even when it is placed

183 e and insufficient blood-brain barrier (BBB) penetration of chemotherapeutics.

184 ings confirmed the voltage dependence of the penetration of chitohexaose molecules into and their rel

185 nversely, the intact BBB restricts efficient penetration of CNS-targeted drugs.

186 have been suggested to be important for the penetration of cockroach allergens through epithelial ce

187 y GC-4 suppresses lateral dispersal and cell penetration of collagen gels.

188 ive micro-tracks are not sufficient for cell penetration of collagen matrices in the absence of Ncad.

189 d used it to quantitatively compare the cell penetration of DD5-o and other autophagy-inducing peptid

190 , nanocrystals significantly accelerated the penetration of Dex.

191 siology can influence tumor accumulation and penetration of different sized nanoparticles.

192 ht absorption profiles, we found that weaker penetration of diffuse versus direct light into the meso

193 This study evaluates the penetration of doxorubicin-encased liposomes into three-

194 n of caErbB2-expressing SCs, enabling robust penetration of DR axons into the spinal cord.

195 k delivery and fluorescent label established penetration of drug over finer spatial domain in serial

196 ly used for brain delivery and cell membrane penetration of drugs.

197 Penetration of flow signal in normal iris depended on ir

198 Following treatment, we observed penetration of folinic acid to the core of spheroids and

199 fungin, likely through increasing antifungal penetration of hyphae.

200 gginsianum, a fungal pathogen showing direct penetration of leaf epidermal cells comparable to G. oro

201 defects on the CNTs surface that could allow penetration of Li(+) and Mn(4+) through the tube wall an

202 copy techniques because of the limited depth penetration of light caused by the high level of light s

203 r phototoxicity of lasers and limited tissue penetration of light.

204 Herein, we report that the cytosolic penetration of linear polyarginine peptides is dependent

205 salts in the scale material that mediate the penetration of liquid through putative micropores.

206 In the current work, we introduce penetration of mAbs into microtumors with radii of up to

207 ement technique can improve the percutaneous penetration of macromolecules after topical application

208 racks or the result of differential depth of penetration of manus and pes tracks, but otherwise showe

209 Experimental measurements of the penetration of nanoparticles having diameters down to ca

210 is compounded on porous nanoparticles due to penetration of proteins within the porous network.

211 This was due to the deeper penetration of red light in cardiac tissue compared with

212 of human BCRP in limiting absorption and BBB penetration of substrate compounds and to investigate cl

213 g microscopy technique to image steady-state penetration of super-fast vortices into a superconductin

214 t in healthy adult human ears, deeper tissue penetration of SWIR light allows better visualization of

215 f the Ca(2+)-binding sites, resulting in the penetration of synaptotagmin-1 into the membrane, via bi

216 Results demonstrate penetration of the aptamer into freshly excised human sk

217 The good penetration of the blood-brain barrier by AZD3759, and i

218 n tumour lesions of lung cancer patients, as penetration of the blood-brain barrier is important for

219 bone resorption, abscess formation, and root penetration of the bone surface and analyzed by analysis

220 -based macrocycle of TP10 exhibits increased penetration of the brain parenchyma following intravenou

221 ied a BIM BH3 analogue that showed increased penetration of the brain tissue in mice.

222 d chemical mechanisms both require nanosheet penetration of the cell membrane, suggesting that the en

223 ematical model describes the different axial penetration of the components of a jet-gas mixture and e

224 spore attachment, fungal germination and pre-penetration of the cuticle, and cuticle penetration/hemo

225 the esophageal wall with partial endoluminal penetration of the device occurred.

226 on of cells in the liquid state and ensuring penetration of the electrolyte between the electrode act

227 ng chains of the microgel rather than a deep penetration of the enzyme into the microgels.

228 nstream events and resulting in the physical penetration of the erythrocyte, powered by the parasite'

229 t are essential for receptor binding and the penetration of the Escherichia coli outer membrane.

230 nstrated that the mutant was not impaired in penetration of the host cell or in trafficking of the ca

231 n tectonic activity is triggered by downward penetration of the Indian plate beneath the Asian plate.

232 However, the penetration of the NP was less than the molecular drug d

233 Penetration of the OCT beam remains a limitation for hig

234 ction of the enzyme cutinase 2, resulting in penetration of the plant host.

235 cell wall collectively drive turgor-mediated penetration of the rice leaf.

236 afety, tolerability, and cerebrospinal fluid penetration of the Src family kinase inhibitor saracatin

237 This selective penetration of the tumor extracellular fluid translated

238 in the electrostatic properties and solvent penetration of the two active sites and, most critically

239 CAs exhibit rapid lateral dispersal prior to penetration of three-dimensional collagen matrices.

240 kin pretreatment is recommended for adequate penetration of topical photosensitizing agents and subse

241 Ex vivo intradermal neonatal porcine skin penetration of VD3 NMP from bilayer MN was quantitativel

242 tacle in luminescence imaging is the limited penetration of visible light into tissues and interferen

243 ng (i) the frequency and depth of convective penetration of water into the stratosphere over the Unit

244 With high penetration of wet recirculating cooling, consumptive wa

245 ns to the grid reliability problem with 100% penetration of WWS [wind, water and solar power] across

246 e of IVC thrombosis, device migration, caval penetration, or pulmonary embolism.

247 ceutical industries as a high-throughput BBB penetration oriented screening method.

248 in regions with high and growing renewables penetration, particularly as renewable energy policy see

249 on cell, leading to the formation of a rigid penetration peg.

250 rupture the rice leaf cuticle using a rigid penetration peg.

251 oad does not significantly impact on MN skin penetration performance.

252 g brain signaling suffer from limited tissue penetration, poor resolution, or lack of specificity for

253 tology of the porcine skin revealed enhanced penetration potential of eucalyptus oil coated PLGA-chit

254 vo screening was performed for assessing the penetration potential of the nanogels.

255 The combination of the hard x-ray's superior penetration power, high sensitivity to elemental composi

256 , and freely downloadable) we simulate light penetration profiles and rates of ATP production in BS a

257 and 2) a novel DiI formulation with improved penetration properties and staining efficiency.

258 rt as well as those documenting the membrane penetration properties of this protein.

259 kes this material an excellent candidate for penetration protection applications such as armors.

260 red spectrum, thereby allowing deeper tissue penetration, quicker image acquisition without the need

261 For lower specific activities, the penetration rate and dose distribution will be more favo

262 utant invading growth without increasing the penetration rate.

263 Antiretroviral tissue:blood penetration ratios were above the 50% inhibitory concent

264 ndicate that MakatG1 plays a pivotal role in penetration, reacting to and detoxifying specific cuticu

265 r comprehensive study of drug efficacy, drug penetration, receptor targeting, and cell recruitment ab

266 NIR-II, 1,000-1,700 nm) features deep tissue penetration, reduced tissue scattering, and diminishing

267 y performed at 330 nm, whereas at high light penetration regimes at lower concentrations (c = 0.3 mmo

268 delivers similar potency and improved brain penetration relative to the amide moiety.

269 ormal iris depended on iris color, with best penetration seen in light to moderately pigmented irides

270 40 ER-to-cytosol transport by constructing a penetration site on the ER membrane called a 'focus'.

271 otor is exploited to create a viral membrane penetration site.

272 p geometry is a pivotal trait governing root penetration stress and root elongation rate in soils of

273 er penetration force, resulting in increased penetration stress when elongating in soils of greater s

274 ller root tip radius-to-length ratio reduced penetration stress, thus enabling higher root elongation

275 lved the surface pressure-area measurements, penetration studies and Brewster Angle Microscopy analys

276 eptible to RKN without compromising nematode penetration, suggesting a requirement of cytokinin signa

277 ty, as well as a greater resistance to water penetration than the prototypical inorganic-organic lead

278 We also developed a novel assay for cell penetration that reports exclusively on cytosolic access

279 herapy (PDT), including low depths of tissue penetration that restrict PDT to superficial lesions, in

280 Antigen penetration through a compromised barrier likely leads t

281 gth has significantly greater capability for penetration through organic tissue.

282 cates that antiretroviral drugs with optimal penetration through the blood-brain barrier should be co

283 The observed current is due to H2O2 penetration through the outermost skin barrier (referred

284 etter visualization of tumor vasculature and penetration through thicker tumors than at 840 nm.

285 1R blockade is characterized by enhanced TAM penetration throughout and within tumours.

286 -based MN by crosslinking to facilitate skin penetration, thus supporting painless and non-invasive t

287 l viral replication or deficient tissue drug penetration to account for delayed gastrointestinal-asso

288 g to a positive surface charge for efficient penetration to and retention in the interstitial space t

289 f plaques, yet cannot provide adequate depth penetration to resolve the size of the lipid pool.

290 condition for a long time and promoting cell penetration upon accumulation at the tumor site and desh

291 bility with high spatial resolution and deep penetration via in vivo NIRF/PA dual-modal imaging.

292 Assessment of antimicrobial penetration was determined by calculating the killing de

293 Drug penetration was visualized by Matrix-Assisted Laser Deso

294 gy, and depth of interface plasmon-polariton penetration were studied by scanning reflected electron

295 Thereby we can predict short-time drug penetration, where experimental measurements are not fea

296 of living subjects offers increased depth of penetration while maintaining high spatial resolution wh

297 In an effort to reduce the level of brain penetration while maintaining the overall profile, SAR w

298 astases of breast cancer because of poor CNS penetration, while the similar sized antibody bevacizuma

299 ultiphoton microscopy allows for deep tissue penetration with relatively minor phototoxicity, renderi

300 s of large levels of solar photovoltaic (PV) penetration within the services areas of the Duke Energy