ライフサイエンスコーパス: penicillin-binding protein

1 proteins, and SpoVD, a nonessential class B penicillin binding protein.

2 gene that encodes the methicillin-resistant penicillin binding protein.

3 is a bacterial low molecular weight class C penicillin-binding protein.

4 tro and in vivo with the major bi-functional penicillin-binding protein.

5 lysine to 8.0-8.5 from that of the parental penicillin-binding protein.

6 values was found for a beta-lactam-resistant penicillin-binding protein.

7 ally encodes a high-molecular-weight class A penicillin-binding protein.

8 d scoring against the crystal structure of a penicillin-binding protein.

9 d-Ala analogues and to prevent the action of penicillin binding proteins.

10 amidases, or any of the low-molecular-weight penicillin binding proteins.

11 ocks peptidoglycan polymerization by class A penicillin-binding proteins.

12 eB promotes the transglycosylase activity of penicillin-binding proteins.

13 milarity to a noncatalytic domain of class B penicillin-binding proteins.

14 cellular multiprotein complexes that include penicillin-binding proteins.

15 to any other beta-lactamases or the related penicillin-binding proteins.

16 g all active-site serine beta-lactamases and penicillin-binding proteins.

17 ding determinations for penicillin-sensitive penicillin-binding proteins.

18 ated by structural changes in transpeptidase penicillin-binding proteins.

19 th sequence homology to low-molecular-weight penicillin-binding proteins.

20 biosynthesis and one encodes a homologue of penicillin-binding proteins.

21 The ponA gene encoding penicillin-binding protein 1 (PBP 1) from Neisseria gono

22 ptibility to penicillin: ponA, which encodes penicillin-binding protein 1 (PBP 1), and the pilMNOPQ o

23 e shown that Bacillus subtilis cells lacking penicillin-binding protein 1 (PBP1), encoded by ponA, ha

24 Bacillus subtilis strains lacking penicillin-binding protein 1 (PBP1), encoded by ponA, re

25 work has shown that the ponA gene, encoding penicillin-binding protein 1 (PBP1), is in a two-gene op

26 n through recombination events involving the penicillin binding protein 1a (pbp1a) gene, have cpsB se

27 ppressors eliminates the function of class A penicillin binding protein 1a (PBP1a).

28 this is caused by RSV G glycoprotein binding penicillin binding protein 1a.

29 ffects of inactivation of the genes encoding penicillin-binding protein 1a (PBP1a), PBP1b, and PBP2a

30 ng the Rcs stress response and those lacking penicillin binding protein 1B (PBP1B) or LpoB could not

31 Penicillin-binding protein 1b (PBP 1b) of the gram-posit

32 examined the inhibition of Escherichia coli penicillin-binding protein 1b (PBP1b) by moenomycin as w

33 Inhibiting penicillin binding protein 2 (PBP 2) alone produced the

34 Isolates harbouring the mosaic penicillin binding protein 2 (PBP2)-considered a key mec

35 inhibits the cell elongation transpeptidase penicillin binding protein 2 in Escherichia coli, exhibi

36 ) on Mueller-Hinton agar, an immunoassay for penicillin binding protein 2' (Denka Seiken Co., Tokyo,

37 Mutations in penicillin-binding protein 2 (PBP 2) encoded by mosaic p

38 Penicillin-binding protein 2 (PBP2) also formed band-lik

39 Penicillin-binding protein 2 (PBP2) from N. gonorrhoeae

40 The essential function of penicillin-binding protein 2 (PBP2) in methicillin-susce

41 antibiotic with high selective affinity for penicillin-binding protein 2 (PBP2) of Staphylococcus au

42 ting cells with amdinocillin, which inhibits penicillin-binding protein 2 (PBP2), allowed PG glycan s

43 ired for cell division, or in the absence of penicillin-binding protein 2 (PBP2), which is required f

44 linic, and presence or absence of the mosaic penicillin-binding protein 2 (penA) allele.

45 y be the product of the abnormal activity of penicillin-binding protein 2 which has grossly reduced a

46 rphisms of the penA gene encoding a modified penicillin-binding protein 2.

47 The expression of penicillin binding protein 2a (PBP2a) is the basis for t

48 The penicillin binding protein 2a (PBP2a) latex agglutinatio

49 d, Basingstoke, United Kingdom) that detects penicillin binding protein 2a (PBP2a) with MicroScan con

50 S. aureus is the production of a distinctive penicillin binding protein 2a (PBP2a), which exhibits lo

51 We studied the utility of performing a penicillin binding protein 2a latex agglutination (PBP-L

52 us infection in which a false-positive rapid penicillin binding protein 2a latex test in conjunction

53 CA-MRSA typically express less penicillin-binding protein 2a (encoded by mecA), allowin

54 onferring beta-lactam antibiotic resistance, penicillin-binding protein 2A (encoded by the mecA gene)

55 enzymes, and the other is the expression of penicillin-binding protein 2a (PBP 2a), which is not sus

56 acquisition of the gene mecA, which encodes penicillin-binding protein 2a (PBP 2a).

57 f a beta-lactamase, and the other is that of penicillin-binding protein 2a (PBP 2a).

58 glycan, down-regulation of the production of penicillin-binding protein 2A (PBP2A) and PBP4, and hype

59 hylococcus aureus (MRSA), is able to inhibit penicillin-binding protein 2a (PBP2a) by triggering an a

60 The performance of a rapid penicillin-binding protein 2a (PBP2a) detection assay, t

61 Penicillin-binding protein 2a (PBP2a) is the primary bet

62 antibiotics, the oxadiazoles, which inhibit penicillin-binding protein 2a (PBP2a) of MRSA.

63 Penicillin-binding protein 2a (PBP2a) of Staphylococcus

64 (eg, oxacillin) depends on the production of penicillin-binding protein 2a (PBP2a), encoded by mecA M

65 ith monoclonal antibody prepared against the penicillin-binding protein 2A (PBP2A), i.e., the gene pr

66 An enzyme, called penicillin-binding protein 2a (PBP2a), is brought into t

67 on the acquisition of the mecA gene encoding penicillin-binding protein 2a (PBP2a).

68 ous aqueous solution showed that solubilized penicillin-binding protein 2a (sPBP2a) of methicillin-re

69 beta-Lactamase and penicillin-binding protein 2a mediate staphylococcal res

70 The Alere penicillin-binding protein 2a test accurately detected a

71 n is derepressed for both beta-lactamase and penicillin-binding protein 2a.

72 d to monoclonal antibodies (MAb) specific to penicillin-binding-protein 2a of methicillin resistant (

73 The assay amplifies a lytA gene target and a penicillin binding protein 2b (pbp2b) gene target in pen

74 Depletion of penicillin-binding protein 2B (PBP2B) in B. subtilis cel

75 ntigen (SAG1350), lipoprotein (SAG0971), and penicillin-binding protein 2b (SAG0765) each bound to ME

76 antigen (SAG1350), a lipoprotein (SAG0971), penicillin-binding protein 2b (SAG0765), glyceraldehyde-

77 ctrophoresis, multilocus sequence typing and penicillin-binding protein 2b amplicon-restriction profi

78 ibiotics, we purified a penicillin-resistant penicillin-binding protein 2x (R-PBP2x) and a penicillin

79 Cells lacking penicillin binding protein 3 and sigmaS had a survival d

80 that inactivation of the ftsI gene product, penicillin binding protein 3, by either beta-lactam anti

81 A soluble form of penicillin-binding protein 3 (PBP 3) from Neisseria gono

82 rict linkage disequilibrium in the S. aureus penicillin-binding protein 3 (pbp3) gene were also found

83 Penicillin-binding protein 3 (PBP3; also called FtsI) is

84 One of these, FtsI (also called penicillin-binding protein 3) of Escherichia coli, consi

85 glycan synthesis by the transpeptidase FtsI (penicillin-binding protein 3).

86 FtsI, also known as penicillin-binding protein 3, is a transpeptidase requir

87 substrate preferences for the endopeptidase penicillin binding protein 4.

88 Penicillin-binding protein 4 (PBP4) is a nonessential tr

89 evate AmpC expression is loss of function of penicillin-binding protein 4 (PBP4).

90 oglycan composition is related to defects in penicillin-binding protein 4 (PBP4); no PBP4 was detecta

91 tivity of a soluble form of Escherichia coli penicillin-binding protein 5 (PBP 5) against the classic

92 Penicillin-binding protein 5 (PBP 5) from Escherichia co

93 Penicillin-binding protein 5 (PBP 5) of Escherichia coli

94 Penicillin-binding protein 5 (PBP 5) of Escherichia coli

95 Penicillin-binding protein 5 (PBP 5) of Escherichia coli

96 Penicillin-binding protein 5 (PBP 5) of Escherichia coli

97 The contribution of penicillin-binding protein 5 (PBP5) and the PBP5 synthes

98 Finally, deletion of penicillin-binding protein 5 from amidase mutants exacer

99 peptidase substrate Ac2-L-Lys-D-Ala-D-Lac by penicillin-binding protein 5 from Escherichia coli.

100 n enterococcal strain devoid of low-affinity penicillin-binding protein-5 (significantly increasing i

101 Penicillin-binding protein 6 (PBP6) is one of the two ma

102 hich encodes the putative low-molecular-mass penicillin-binding protein 7/8 (PBP-7/8).

103 Penicillin-binding protein A (PBPA) is a class B penicil

104 MreC controls the spatial orientation of the penicillin binding proteins and a lytic transglycosylase

105 StkP localization depends on its penicillin-binding protein and Ser/Thr-associated domain

106 (ECD) consists of four repeats homologous to penicillin-binding protein and serine/threonine kinase a

107 Both the PonA2 and PonA3 proteins contain a penicillin-binding protein and serine/threonine protein

108 ng of 1.2 million compounds for binding to a penicillin-binding protein and the subsequent demonstrat

109 Fluorescein-meropenem binds both penicillin-binding proteins and beta-lactam sensors and

110 treptococcus pneumoniae contain low affinity penicillin-binding proteins and often also produce abnor

111 ral non-beta-lactam antibiotic that inhibits penicillin-binding proteins and serine beta-lactamases.

112 result from the presence of a reduced set of penicillin-binding proteins and the absence of a wblC ge

113 The family of bacterial Penicillin-binding-protein And Serine/Threonine kinase-A

114 ansmembrane proteins that have extracellular penicillin-binding-protein and serine/threonine kinase-a

115 other than inhibition of protein synthesis, penicillin-binding proteins, and DNA topoisomerases; amo

116 wall assembly mechanism assume that class A penicillin-binding proteins (aPBPs), the targets of peni

117 Beta-lactamases and penicillin-binding proteins are bacterial enzymes involv

118 DCW gene clusters, including the presence of penicillin-binding proteins at the left ends and ftsA an

119 MRSA strains have acquired a non-native penicillin-binding protein called PBP2a that cross-links

120 ces R61 dd-peptidase, a functional model for penicillin-binding proteins, catalyzes the hydrolysis an

121 erived genomes possess mutations targeting a penicillin-binding protein coding gene (mrcA) that had n

122 We report herein the structure of a penicillin-binding protein complexed with a cephalospori

123 characterize the hydrolysis of the standard penicillin-binding protein/DD-carboxypeptidase substrate

124 ked by the pbp2x and pbp1a genes, coding for penicillin-binding proteins, enzymes involved in cell wa

125 as identified previously for genes encoding penicillin binding proteins, evolved by recombination wi

126 s for the direct detection of IgE and of the penicillin-binding protein from Staphylococcus aureus (P

127 ferase domain of class A high-molecular-mass penicillin-binding proteins from different species.

128 ulosis CrgA with FtsZ, FtsQ, and the class B penicillin-binding proteins, FtsI (PBPB) and PBPA.

129 somal macrorestriction profile and identical penicillin-binding-protein gene restriction profiles cha

130 fragment length polymorphism types of their penicillin binding protein genes 1A, 2X, and 2B.

131 on fragmentation length polymorphisms of the penicillin-binding protein genes pbp1a, pbp2x, and pbp2b

132 A included the capsular locus and the nearby penicillin-binding protein genes pbp2x and pbp1a.

133 , sometimes including the capsular locus and penicillin-binding protein genes, predated both vaccine

134 High-molecular-mass penicillin-binding proteins (HMM PBPs) are essential for

135 glycan synthesis and degradation mediated by penicillin binding proteins in the forespore and a cell

136 acylation and provide further evidence that penicillin-binding proteins in apo form can occupy diffe

137 of carbenicillin (Cb) to assess the role of penicillin-binding proteins in growth and cell division.

138 r, these results identify a novel role for a penicillin-binding-protein in compartmentalizing a bacte

139 red substrate preference of transpeptidases (penicillin-binding proteins) in the pneumococcal variant

140 The transglycosylase domain of penicillin-binding proteins is especially important, as

141 s the archetypal class C, low molecular mass penicillin binding protein (LMM-PBP) and possesses both

142 Four low-molecular-weight penicillin binding proteins (LMW PBPs) of Escherichia co

143 The biological roles of low molecular weight penicillin-binding proteins (LMW PBP) have been difficul

144 chia coli cells lacking low-molecular-weight penicillin-binding proteins (LMW PBPs) exhibit morpholog

145 ane, these new cell wall components regulate penicillin-binding proteins located at the inner membran

146 on is penicillin sensitive and assigned to a penicillin-binding protein motif.

147 Certain penicillin binding protein mutants of Escherichia coli g

148 erved in Gram-positive bacterial species for penicillin-binding protein mutants.

149 The high-molecular mass penicillin binding proteins of bacteria catalyze in sepa

150 ence exceeds that observed for blocks in the penicillin-binding proteins of S. pneumoniae or in many

151 otluri et al. show that low molecular weight penicillin binding proteins, particularly PBP5, have a r

152 that controls activity of the bi-functional penicillin binding protein PBP A1, we discovered that Gp

153 We have characterized the role of the penicillin-binding protein PBP 2B in cell division of Ba

154 Penicillin-binding protein PBP 2B is a key cell division

155 ates also potently inhibit the non-essential penicillin-binding protein PBP 5 by the same mechanism o

156 Penicillin binding protein (PBP) 5, a DD-carboxypeptidas

157 nts for acylation and deacylation of soluble penicillin binding protein (PBP) constructs by compounds

158 ectrophoresis (PFGE) of chromosomal digests, penicillin binding protein (PBP) gene fingerprinting, an

159 onstructed a set of mutants from which eight penicillin binding protein (PBP) genes were deleted in 1

160 DNA fragments that do not contain any known penicillin binding protein (PBP) genes, indicating that

161 The approach uses a recombinant bacterial penicillin binding protein (PBP) tagged by an N-terminal

162 nctional enzyme, known as a high MW, class A penicillin binding protein (PBP).

163 rmined that expression of the well-conserved penicillin-binding protein (PBP) 1A, prevented LOS-defic

164 erved heterogeneous localization dynamics of penicillin-binding protein (PBP) 1A, the synthase predom

165 otein LpoB is required for the activation of penicillin-binding protein (PBP) 1B, which is a major, b

166 Imipenem, which has a greater affinity for penicillin-binding protein (PBP) 2, induced less IL-6 re

167 y cell division protein FtsZ, which recruits penicillin-binding protein (PBP) 2.

168 Penicillin-binding protein (PBP) 2a latex agglutination

169 The loss of Bacillus subtilis penicillin-binding protein (PBP) 2a, encoded by pbpA, wa

170 y functional assays, showing binding of 2 to penicillin-binding protein (PBP) 2a.

171 We evaluated the impact of resistant penicillin-binding protein (PBP) allele acquisition on t

172 The gene product of mecA from MRSA is a penicillin-binding protein (PBP) designated PBP 2a.

173 n fragment length polymorphism (RFLP) of the penicillin-binding protein (PBP) genes 1A, 2X, and 2B, a

174 of Streptococcus pneumoniae contain altered penicillin-binding protein (PBP) genes and occasionally

175 osporin drug ceftazidime caused by loss of a penicillin-binding protein (PBP) in a Gram-negative baci

176 Expression of penicillin-binding protein (PBP) in E. chaffeensis was a

177 that inactivation of the major bi-functional penicillin-binding protein (PBP) PBP1 of B. subtilis res

178 The penicillin-binding protein (PBP) targets in penicillin-r

179 Mycobacterium tuberculosis is a class B-like penicillin-binding protein (PBP) that is not essential f

180 ed motifs of a class B high-molecular-weight penicillin-binding protein (PBP), including the transpep

181 We report the first crystal structures of a penicillin-binding protein (PBP), PBP3, from Pseudomonas

182 of this resistance mechanism: the "acquired" penicillin-binding protein (PBP)-2A, which has unusual l

183 the United States, restriction profiles of 3 penicillin-binding protein (PBP)-gene amplicons and the

184 e T. pallidum 47-kDa lipoprotein (Tp47) as a penicillin-binding protein (PBP).

185 The surface-localized penicillin-binding protein (PBP)1a, encoded by ponA, is

186 The low-molecular-weight (LMW) penicillin-binding protein, PBP 5, plays a dominant role

187 eptidase (TP) activities of Escherichia coli penicillin binding proteins PBP1A and PBP1B and show tha

188 Cell wall morphogenetic protein RodA and penicillin-binding protein PBP1a also change their spati

189 ponA encodes an extra-cytoplasmic penicillin-binding protein PBP1a, a newly identified vir

190 is model, we found that a surface-associated penicillin-binding protein (PBP1a), encoded by ponA, pla

191 cholerae high-molecular-weight bifunctional penicillin binding proteins, PBP1a and PBP1b, in the fit

192 Staphylococcus aureus penicillin-binding protein PBP2 is an enzyme involved in

193 The penicillin-binding protein PBP2, which is commonly brand

194 he expression of mecA, the gene encoding the penicillin binding protein PBP2a.

195 is of tryptic peptides derived from purified penicillin-binding protein PBP2a of Bacillus subtilis id

196 istant S. aureus strain expressing the extra penicillin-binding protein PBP2A, a protein of extraspec

197 of the crystal structure of the low-affinity penicillin-binding protein PBP2a, which mediates beta-la

198 mediated by mecA and blaZ, genes encoding a penicillin-binding protein (PBP2a) with low beta-lactam

199 e acquisition of a nonnative gene encoding a penicillin-binding protein (PBP2a), with significantly l

200 ls and is catalyzed by the essential class B penicillin-binding protein PBP2b transpeptidase (TP).

201 he relative localization patterns of class B penicillin-binding proteins Pbp2x and Pbp2b were used as

202 al sideromimic conjugated compounds bound to penicillin binding proteins PBP3 and PBP1a from Pseudomo

203 Penicillin-binding protein PBP3, a key therapeutic targe

204 ght to work in concert with the PG synthases penicillin-binding proteins PBP3 and PBP1b.

205 can is dependent on the low-molecular-weight penicillin-binding protein PBP4.

206 The sigma W regulon includes a penicillin binding protein (PBP4*) and a co-transcribed

207 g a forward genetics approach, we identify a penicillin-binding-protein, PbpC, which is required for

208 precise temporal and spatial organization of penicillin binding proteins (PBPs) and associated protei

209 Penicillin binding proteins (PBPs) and beta-lactamases a

210 Penicillin binding proteins (PBPs) are responsible for s

211 depends not only on the reduced affinity of penicillin binding proteins (PBPs) but also on the funct

212 isolated from strains lacking three or four penicillin binding proteins (PBPs) but not from a mutant

213 Penicillin binding proteins (PBPs) catalyze steps in the

214 at Escherichia coli mutants lacking multiple penicillin binding proteins (PBPs) display extensive mor

215 Beta-lactam antibiotics inhibit penicillin binding proteins (PBPs) involved in peptidogl

216 iotics, the transpeptidase activity of their penicillin binding proteins (PBPs) is lost as a result o

217 e been ascribed to the high-molecular-weight penicillin binding proteins (PBPs) of Escherichia coli,

218 The penicillin binding proteins (PBPs) synthesize and remode

219 Escherichia coli has 12 recognized penicillin binding proteins (PBPs), four of which (PBPs

220 al targets are the transpeptidase domains of penicillin binding proteins (PBPs), which catalyze the c

221 f the bacterial cell wall, is synthesised by penicillin binding proteins (PBPs).

222 he surrounding medium, a process mediated by penicillin binding proteins (PBPs).

223 Penicillin-binding proteins (PBPs) and beta-lactamases a

224 ation rates for acyl-enzyme intermediates in penicillin-binding proteins (PBPs) and beta-lactamases h

225 d low throughput assays of the activities of penicillin-binding proteins (PBPs) and beta-lactamases,

226 nal d,d-transpeptidases belonging to class B penicillin-binding proteins (PBPs) and monofunctional gl

227 Penicillin-binding proteins (PBPs) and PBP genes from re

228 We determined the patterns of penicillin-binding proteins (PBPs) and the peptidoglycan

229 The penicillin-binding proteins (PBPs) are a set of enzymes

230 Penicillin-binding proteins (PBPs) are bacterial enzymes

231 High molecular weight penicillin-binding proteins (PBPs) are bifunctional enzy

232 Penicillin-binding proteins (PBPs) are enzymes involved

233 High-molecular-weight penicillin-binding proteins (PBPs) are essential integra

234 Penicillin-binding proteins (PBPs) are involved in the f

235 Penicillin-binding proteins (PBPs) are involved in the s

236 Class A penicillin-binding proteins (PBPs) are large, bifunction

237 Penicillin-binding proteins (PBPs) are responsible for t

238 Penicillin-binding proteins (PBPs) are the molecular tar

239 The penicillin-binding proteins (PBPs) are ubiquitous bacter

240 Penicillin-binding proteins (PBPs) are ubiquitous bacter

241 subtilis, where it plays a role in shuttling penicillin-binding proteins (PBPs) between septal and si

242 Class B penicillin-binding proteins (PBPs) carry a transpeptidas

243 Penicillin-binding proteins (PBPs) catalyze the crosslin

244 Penicillin-binding proteins (PBPs) catalyze the final, e

245 The bacterial DD-peptidases or penicillin-binding proteins (PBPs) catalyze the formatio

246 the first crystal structures of A. baumannii penicillin-binding proteins (PBPs) covalently inactivate

247 fluorescent protein (GFP) fusions to all 11 penicillin-binding proteins (PBPs) expressed during vege

248 iotics is the D,D-transpeptidase activity of penicillin-binding proteins (PBPs) for synthesis of 4-->

249 -tagged beta-lactam antibiotics to visualize penicillin-binding proteins (PBPs) in sporulating cultur

250 Escherichia coli low molecular mass penicillin-binding proteins (PBPs) include PBP4, PBP5, P

251 The four class A penicillin-binding proteins (PBPs) of Bacillus subtilis

252 The penicillin-binding proteins (PBPs) polymerize and modify

253 mutants in Escherichia coli lacking multiple penicillin-binding proteins (PBPs) produce misshapen cel

254 erence affects the cross-linking activity of penicillin-binding proteins (PBPs) that assemble peptido

255 ave long been known to target enzymes called penicillin-binding proteins (PBPs) that build the bacter

256 crescentus, MreC physically associates with penicillin-binding proteins (PBPs) which catalyse the in

257 jor synthases of this exoskeleton are called penicillin-binding proteins (PBPs)(1,2).

258 Production of low-affinity forms of penicillin-binding proteins (PBPs), although essential,

259 Penicillin-binding proteins (PBPs), biosynthetic enzymes

260 In Escherichia coli , the bifunctional penicillin-binding proteins (PBPs), PBP1A and PBP1B, pla

261 at MreC Interacts with high-molecular-weight penicillin-binding proteins (PBPs), rather than with low

262 ne of very few compound classes that inhibit penicillin-binding proteins (PBPs), SBLs and, as recentl

263 The Bacillus subtilis genome encodes 16 penicillin-binding proteins (PBPs), some of which are in

264 Penicillin-binding proteins (PBPs), the target enzymes o

265 Synthases called penicillin-binding proteins (PBPs), the targets of penic

266 To identify new compounds that inhibit penicillin-binding proteins (PBPs), which are proven tar

267 The bifunctional high molecular weight (HMW) penicillin-binding proteins (PBPs), which contain both g

268 pressing variants of its target enzymes, the penicillin-binding proteins (PBPs), with many amino acid

269 hesized by polysaccharide polymerases called penicillin-binding proteins (PBPs).

270 ycan layer by a series of enzymes called the penicillin-binding proteins (PBPs).

271 l, the synthesis of which is orchestrated by penicillin-binding proteins (PBPs).

272 ll (peptidoglycan) synthesizing complexes of penicillin-binding proteins (PBPs).

273 doglycan (PG) exoskeleton synthesized by the penicillin-binding proteins (PBPs).

274 ll wall biosynthesis through inactivation of penicillin-binding proteins (PBPs).

275 catalyzed by high-molecular-weight, class A penicillin-binding proteins (PBPs).

276 The Helicobacter pylori genome encodes four penicillin-binding proteins (PBPs).

277 s that possessed preferential affinities for penicillin-binding proteins (PBPs).

278 tagged mimics of the endogenous substrate of penicillin-binding proteins (PBPs).

279 is of the bacterial cell wall (also known as penicillin-binding proteins, PBPs) have evolved to bind

280 ors), aceA (isocitrate lyase), ponA (class I penicillin-binding protein), pks2 (polyketide synthase),

281 an additional gene encoding a third class A penicillin-binding protein, PonA3, which is a paralog of

282 Penicillin-binding proteins represent well-established,

283 The Bacillus subtilis spoVD gene encodes a penicillin-binding protein required for spore morphogene

284 to different target enzymes (DNA gyrase and penicillin-binding proteins, respectively) and in 41 sin

285 ent that preferentially binds to the altered penicillin binding protein responsible for diminished pe

286 n that provides high-affinity binding to the penicillin-binding proteins responsible for bacterial re

287 elevant class A, C and D beta-lactamases and penicillin-binding proteins, resulting in intrinsic anti

288 The localization of FtsI (PBP3), a penicillin-binding protein specifically required for cel

289 demonstrates that the high-molecular-weight penicillin-binding protein SpoVD, which contains two exp

290 can cell wall is synthesized by bifunctional penicillin-binding proteins such as PBP1b that have both

291 BP2 co-immunoprecipitated with several other penicillin-binding proteins, suggesting that these prote

292 cillin-binding protein A (PBPA) is a class B penicillin-binding protein that is important for cell di

293 that link the cytoskeletal elements with the penicillin-binding proteins that carry out peptidoglycan

294 These enzymes are members of the family of penicillin-binding proteins, the targets of beta-lactam

295 is the first purified gram-positive class A penicillin-binding protein to show good transglycosylase

296 For many years, the penicillin-binding proteins were thought to be the key e

297 an approximately 59-kDa membrane-associated penicillin-binding protein which is highly toxic when ov

298 nce in staphylococci is mediated by PBP2a, a penicillin binding protein with low affinity for beta-la

299 lied to other classes of beta-lactamases and penicillin-binding proteins with the SXXK motif.

300 ional members of the sigma(X) regulon, pbpX (penicillin-binding protein), ywnJ, the dlt operon (D-ala