ライフサイエンスコーパス: penile

1 cancer, including cervical, vulvar, vaginal, penile, anal, and head-and-neck cancers.

2 ent malignancies (cervical, vaginal, vulvar, penile, anal, tongue, tonsillar, and oropharyngeal).

3 tly explain the observed association between penile and oral HPV infections.

4 This study examined the concordance of penile and oral human papillomavirus (HPV) infections in

5 hat Fkbp51 is an AR target gene essential to penile and prostate development.

6 Prostatitis-like symptoms such as perineal, penile, and suprapubic discomfort or pain during or afte

7 Congenital penile anomalies (CPAs) are among the most common human

8 Therefore, human penile arginase is a potential target for the treatment

9 e was successfully treated by embolizing the penile artery using an autologous clot.

10 successfully treated by embolization of the penile artery with an autologous clot in two sessions wi

11 red in the diabetic rat penis in response to penile blood flow (shear stress) elicited by electrical

12 widely used to treat impotence by improving penile blood flow via elevation of cGMP.

13 ined target volume, with higher doses to the penile bulb but no significant differences in rectal or

14 ined target volume, with higher doses to the penile bulb but no significant differences in rectal or

15 Analysis of the rectum, bladder, and penile bulb volumes receiving 40 Gy and 60 Gy demonstrat

16 g 40 Gy and 60 Gy demonstrated that only the penile bulb volumes were significantly higher after regi

17 For organs at risk (rectum, bladder, and penile bulb), the volumes receiving 40 Gy and 65 Gy befo

18 , anal (OR, 15.5; 95% CI, 11.0 to 21.9), and penile cancer (OR, 1.8; 95% CI, 0.9 to 3.7).

19 ionally, male circumcision appears to reduce penile cancer and cervical cancer and is likely due to e

20 WES was performed on penile cancer and matched germline DNA from 27 patients

21 y and skin grafting to fashion a neoglans in penile cancer and the Nesbit operation or saphenous graf

22 ated in, respectively, 5 and 6 patients with penile cancer during an SN biopsy procedure using indocy

23 Modern conservative organ-sparing surgery in penile cancer has shown that good oncological control ca

24 Penile cancer is a rare malignancy affecting more than 4

25 Although penile cancer is rare in the developed world, it present

26 Penile cancer localized to the prepuce can be excised us

27 ney, upper tract urothelial, testicular, and penile cancer published in the past 18 months.

28 ly invasive ilioinguinal lymphadenectomy for penile cancer remains exploratory at this time.

29 cedures, phimosis or hypospadias repair, and penile cancer resection.

30 identified recurrent mutations in the novel penile cancer tumor suppressor genes CSN1(GPS1) and FAT1

31 alignancies of renal, bladder, prostate, and penile cancer, a group of anatomically localised disease

32 rehensive analysis of somatic alterations in penile cancer, highlighting the complex landscape of alt

33 Penile cancer, Peyronie's disease and trauma are the thr

34 addition, specific histological subtypes of penile cancer--basaloid and warty--are consistently asso

35 th bulky regional lymph node metastases from penile cancer.

36 the independent genetic events that occur in penile cancer.

37 lence in association with different types of penile cancer.

38 nts to reduce the morbidity and mortality of penile cancer.

39 or radiotherapy, are discussed for advanced penile cancer.

40 rican patients compared with Caucasians with penile cancer.

41 nsights into the diagnosis and management of penile cancer.

42 men and women with the exception of in situ penile cancer.

43 c alterations determining the development of penile cancer.

44 etermine the somatic mutational landscape of penile cancer.

45 ical, 24 anal, 67 vulvar, 12 vaginal, and 24 penile cancers) with prediagnostic blood samples (collec

46 n = 10), a melanoma on the trunk (n = 6), or penile carcinoma (n = 9) who were scheduled for sentinel

47 Metastatic penile carcinoma derived from cholangiocarcinoma (CCA) h

48 only a subset of keratinizing and verrucous penile carcinomas is positive for HPV DNA, and thus thes

49 ial of male circumcision provided exfoliated penile cells from 2 anatomical sites (glans/coronal sulc

50 were examined in primary human explants from penile, cervical, and rectal tissues.

51 welling that led to the onset of the ventral penile cleft.

52 ases) was detected in 17/59 (29%) PSCCs; all penile condylomata (8/8) were positive for low-risk HPV6

53 PV was rare and was not associated with oral-penile contact.

54 asibility of engineering the entire pendular penile corporal bodies in a rabbit model.

55 sly demonstrated that a short segment of the penile corporal body can be replaced using naturally der

56 corpora can be engineered for total pendular penile corporal body replacement.

57 nine bioavailability to NO synthase in human penile corpus cavernosum smooth muscle, the inhibition o

58 -dependent smooth muscle relaxation in human penile corpus cavernosum tissue that is required for ere

59 In rabbit penile corpus cavernosum, intracellular cGMP was determi

60 chniques such as near-infrared spectroscopy, penile cuff compression and computational flow modelling

61 Ventral penile curvature occurs in both hypospadias and so-calle

62 commonly used methods to straighten ventral penile curvature.

63 particularly in cases of severe and complex penile curvature.

64 nd is generally reserved for men with severe penile deformities that impede satisfactory sexual inter

65 uite beneficial for patients who suffer from penile deformity and can greatly improve their quality o

66 Clinical manifestations include penile deformity and possible erectile dysfunction.

67 of procedures have been developed to correct penile deformity secondary to Peyronie's disease.

68 The correction of acquired penile deformity seen in Peyronie's disease patients can

69 lymphedema develops after a prepuce-sparing penile degloving procedure.

70 repuce can be preserved in selected cases of penile degloving procedures, phimosis or hypospadias rep

71 The neonatal phase of penile development is controlled by the balance of AR to

72 ction as reflected by anogenital distance or penile dimensions at birth.

73 Measurements of anogenital distance and penile dimensions were taken, and a sample of the mother

74 associated protein kinase (ROCK) increase in penile endothelial and smooth muscle cells.

75 that EETs, produced by CYP epoxygenases, in penile endothelial cells serve as vasodilators.

76 d risk factors are a potential threat to the penile endothelium and the smooth muscle tissue leading

77 scribed mechanism for the down-regulation of penile eNOS in diabetes mediated by activation of the Rh

78 f non-sexually transmitted infection GUD and penile epithelial trauma is needed, as both are commonly

79 limited correlation between HSV-2, GUD, and penile epithelial trauma suggests that these are distinc

80 HIV) infection, genital ulcer disease (GUD), penile epithelial trauma, multiple recent sex partners,

81 ieved blockbuster status in the treatment of penile erectile dysfunction (PED).

82 data implicate the MC4R in the modulation of penile erectile function and provide evidence that MC4R-

83 of high-flow priapism and for restoration of penile erectile function.

84 that adenosine was induced during sustained penile erection and contributes to PI3K/AKT activation a

85 ctive dopamine receptor agonist, facilitates penile erection and is effective in patients suffering f

86 apism is featured with prolonged and painful penile erection and is prevalent among males with sickle

87 spliced forms of nNOS are major mediators of penile erection and so may be targets for therapeutic in

88 Sildenafil (Viagra) potentiates penile erection by acting as a nonhydrolyzable analog of

89 Sustained penile erection elicited by either intracavernous forsko

90 Penile erection elicited by papaverine is reduced profou

91 NOS phosphorylation, and subsequent impaired penile erection featured with the reduction of ratio of

92 Priapism, abnormally prolonged penile erection in the absence of sexual excitation, is

93 Priapism is a condition of persistent penile erection in the absence of sexual excitation.

94 g, that Rho-kinase antagonism stimulates rat penile erection independently of nitric oxide, introduce

95 Penile erection is dependent on the nitric oxide (NO)/cG

96 Normal penile erection is under the control of multiple factors

97 A key role for nitric oxide (NO) in penile erection is well established, but the relative ro

98 Subsequent evaluation of 59a in the rat penile erection model revealed in vivo activity, compara

99 In vivo penile erection paradigm supports the physiologic releva

100 Control of penile erection requires the coordination of the hypotha

101 C6' treatment reversed abnormalities in key penile erection signaling molecules, including phosphodi

102 istent inability to obtain and/or maintain a penile erection sufficient for adequate sexual relations

103 The ability of ABT-724 to facilitate penile erection together with the favorable side-effect

104 itric oxide (NO) pathway is known to mediate penile erection under normal conditions, we hypothesized

105 Priapism is a disorder of persistent penile erection unrelated to sexual interest or desire.

106 aling via A(2B)R activation, contributing to penile erection via PI3K/AKT-dependent eNOS activation.

107 ABT-724 dose-dependently facilitates penile erection when given s.c. to conscious rats, an ef

108 ions, including micturition, defecation, and penile erection, as well as to brain networks controllin

109 ted by neuronal NO synthase (nNOS) initiates penile erection, but has not been thought to participate

110 mediates both initiation and maintenance of penile erection, implying unique approaches for treating

111 gnaling is implicated in normal and abnormal penile erection, the exact role and the underlying mecha

112 red for elevated adenosine-induced prolonged penile erection.

113 nd peripherally, notably through its role in penile erection.

114 m by the NO-cGMP pathway is important during penile erection.

115 thalamic and spinal cord regions involved in penile erection.

116 vivo efficacy in anesthetized dog model for penile erection.

117 established model of electrically stimulated penile erection.

118 ry potent and efficacious in vivo, eliciting penile erections in rats at a dose of 0.03 micromol/kg,

119 olonged immobility, 22-kHz vocalization, and penile erections.

120 Penile exposure to more concentrated virus inocula produ

121 challenged with a series of escalating dose penile exposures to SIVmac 251.

122 an essential role of increased adenosine in penile fibrosis and a novel therapeutic possibility for

123 urgent condition, given its association with penile fibrosis and eventual erectile dysfunction.

124 y ADA enzyme therapy successfully attenuated penile fibrosis in both mouse models, indicating an esse

125 nderstanding of the molecular mechanisms for penile fibrosis in priapism.

126 is a novel causative factor contributing to penile fibrosis in two independent animal models of pria

127 f increased adenosine in the pathogenesis of penile fibrosis via A(2B)R signaling and offer a potenti

128 ntial target for prevention and treatment of penile fibrosis, a dangerous complication seen in priapi

129 mechanism responsible for adenosine-mediated penile fibrosis, we purified corpus cavernosal fibroblas

130 imilar signaling pathways for progression to penile fibrosis.

131 R is essential for excess adenosine-mediated penile fibrosis.

132 e in cavernosal vasoconstriction to maintain penile flaccidity.

133 nodeficiency virus (SIV) strain SIVmac251 by penile foreskin exposure.

134 secondary to penetrating gunshot wounds and penile fracture requires immediate surgical exploration

135 ) receptor plays a role in the regulation of penile function.

136 We found that penile (glans, foreskin, coronal sulcus) T cells and, to

137 nile stump of the recipient and attached the penile graft.

138 a prospective observational study to assess penile HIV shedding after MC.

139 kines had a greater likelihood of detectable penile HIV shedding at the subsequent visit, compared to

140 Penile HIV shedding is significantly reduced after heali

141 Among men with a detectable plasma VL, penile HIV shedding was detected at 136 visits (16.8%).

142 dose-dependent and temporal association with penile HIV shedding, suggesting that genital immune acti

143 Among men with detectable penile HIV shedding, the median log10 HIV copies/millili

144 amination Survey and had results of oral and penile HPV DNA testing were examined.

145 The proportion of men with penile HPV increased from 3.7% in men reporting no prior

146 er among those with than among those without penile HPV infection (19.3% vs 4.4%; prevalence ratio, 4

147 objective was to determine the prevalence of penile HPV infection in the United States.

148 Prevalence of penile HPV infection increases with increasing age.

149 hts to estimate the population prevalence of penile HPV infection.

150 Our findings indicate that penile HPV is common among men in the United States.

151 Detectable penile HSV-2 shedding was present in 9.7% of men (17 of

152 weekly penile lavage samples were tested for penile HSV-2 shedding.

153 The epidemiology of penile human papillomavirus (HPV) infection is not well

154 defects in select reproductive organs (e.g. penile hypospadias and prostate dysgenesis but normal te

155 r and vigorous sexual activity might lead to penile implant extrusion.

156 es using free vascularised tissue flaps with penile implants are undesirable in this often socioecono

157 innovations have continually improved these penile implants since that time.

158 Electrical stimulation of the penile innervation increases S1412 phosphorylation that

159 is study, we determined that, by day 7 after penile inoculation, SIV has moved first to the inguinal

160 ocation of all the spinal pathways conveying penile input to the rostral medulla is not known.

161 esions of the T8 spinal cord and loss of all penile inputs after lesioning the dorsal three-fifths of

162 rated the loss of low but not high threshold penile inputs to medullary reticular formation (MRF) neu

163 ion in men exposed to the virus by insertive penile intercourse is likely to help with the rational d

164 sions (EGLs) in men, including condyloma and penile intraepithelial neoplasia (PeIN).

165 Penile involvement is a rare, self-limiting, benign geni

166 Penile lavage samples collected from the coronal sulcus

167 Preoperative and weekly penile lavage samples were tested for penile HSV-2 shedd

168 Preoperative and weekly penile lavages collected for 6 wk and then at 12 wk were

169 If there is ample penile length and the deformity is mild to moderate in s

170 type of deformity, erectile dysfunction, and penile length are all characteristics that are assessed

171 e hypospadias and cryptorchidism and altered penile length in male rats, all of which correlated with

172 Mean penile length SDS decreased as the severity of hypospadi

173 ys with hypospadias had shorter mean AGD and penile length SDS than healthy boys (both p < 0.0001).

174 Mean AGD and penile length SDS values in boys with cryptorchidism wer

175 In the study population, AGD and penile length were reduced in boys with hypospadias or c

176 Transgenic mice also exhibited reduced penile length, focal spermatogenic anomalies, diminished

177 ery of erectile function and prevent loss of penile length, penile rehabilitation should be initiated

178 a tertiary center for measurement of AGD and penile length; they were compared with 487 healthy full-

179 cytokines was also associated with a higher penile log10 HIV VL at the subsequent visit among HIV sh

180 The psychosociological effects of penile loss in a young man are devastating and replacing

181 omplicated by gangrene is a leading cause of penile loss in young men in South Africa.

182 )] were tested in neuronal cell cultures and penile lysates for NO release (Griess assay) and biologi

183 antiandrogenic and estrogenic signals induce penile malformations and demonstrate that the timing of

184 ow that conditional deletion of Ihh inhibits penile masculinization.

185 article represents the first case report of penile metastasis from CCA.

186 this case report, we want to present a rare Penile Mondor's disease with literature review.

187 The step-by-step movement of SIV from penile mucosal surfaces to the draining lymph nodes may

188 e all been located in the pelvic ganglia and penile nerves, this work aims to determine whether these

189 Because variants of nNOS (penile nNOS: PnNOS) and the N-methyl-D-aspartate recepto

190 No partners reported penile numbness.

191 he past year, no history of genital warts or penile or anal cancer, and no current diagnosis of a sex

192 To date, there is no case of penile or urogenital system metastasis from CCA describe

193 Pearly penile papules (PPPs) are benign, dome-shaped lesions fo

194 mediated ADORA2B signaling underlies reduced penile PDE activity by decreasing PDE5 gene expression i

195 m in both ADA(-/-) and SCD mice by restoring penile PDE5 gene expression to normal levels.

196 erlying mechanism for adenosine signaling in penile physiology remain elusive.

197 ninvasive surrogates for cystometry, such as penile plethysmography, lack sufficient evidence to allo

198 Inflatable penile prostheses are associated with decreasing risks o

199 Because inflatable penile prostheses are vastly preferred by patients over

200 Because of this, inflatable penile prostheses remain a viable tertiary treatment opt

201 (53% [95% CI, 50%-56%]) of patients without penile prostheses reported use of medications or other d

202 However, early placement of a penile prosthesis following radical prostatectomy is now

203 niques allow safe placement of a three-piece penile prosthesis in patients with a history of pelvic s

204 Concurrent implantation of a penile prosthesis is an option for certain patients who

205 s not successful, surgical implantation of a penile prosthesis may be considered.

206 Manual modeling of the deformed penis over a penile prosthesis may prevent some patients from needing

207 Penile prosthesis placement results in early return to s

208 ecent advancements in three-piece inflatable penile prosthesis technology of interest to surgeons who

209 Although the first inflatable penile prosthesis was introduced over 30 years ago for t

210 The implantation of a penile prosthesis, with or without excision/incision of

211 grafting procedures; and the placement of a penile prosthesis.

212 or all physicians, who implant life-changing penile prosthetics, to understand the most recent advanc

213 ng coitus may contribute to both vaginal and penile protection by trapping HIV before it can reach ta

214 was conducted to assess the current state of penile reconstruction and transplantation options, as we

215 The current operations of choice in penile reconstruction are glansectomy and skin grafting

216 , and urinary function in patients requiring penile reconstruction.

217 onsiderable potential for patients requiring penile reconstruction.

218 ction and cosmesis of the penis using modern penile reconstructive techniques.

219 cess to a new host predominantly through the penile, rectal, or vaginal/cervical mucosal tissue after

220 leus in the lumbar spinal cord that controls penile reflexes involved with copulation.

221 w of the current state of science supporting penile rehabilitation after radical prostatectomy.

222 g once per day was commenced after 1 week as penile rehabilitation and was continued for 3 months.

223 Penile rehabilitation is defined as the use of any drug

224 The purpose of penile rehabilitation is to prevent corpus cavernosal sm

225 function and prevent loss of penile length, penile rehabilitation should be initiated expeditiously

226 Penile rehabilitation strategies have been developed wit

227 as the components that are often included in penile rehabilitation strategies.

228 Although penile rehabilitation with medical modalities show good

229 collection, semen quality is higher with the penile robe electrical stimulus method compared with the

230 infections were performed; and cervical and penile scrapings were tested for human papillomavirus (H

231 We examined the baseline prevalence of penile, scrotal, perineal/perianal, and intra-anal human

232 HPV detection was highest at the penile shaft (49.9% for the full cohort and 47.9% for th

233 cted specimens; detection was highest in the penile shaft (51.2% and 51.5%, respectively, P = 0.96),

234 At a minimum, the penile shaft and the glans penis/coronal sulcus should b

235 les ranged from 67.2% (kappa = 0.34) for the penile shaft to 95.0% (kappa = 0.89) for the foreskin.

236 in samples from 104 men (33%): 24% from the penile shaft, 16% from the glans, 28% from the foreskin,

237 line-wetted Dacron swabs were used to obtain penile shaft, glans, foreskin, and scrotum samples from

238 did not differ by genital site (i.e., glans, penile shaft, or scrotum) of initial detection (P=.86).

239 lence in the glans penis and coronal sulcus, penile shaft, scrotum, semen, and urine was compared by

240 infection of the urethra, glans/corona, and penile shaft.

241 alence ranged from 6% in semen to 52% in the penile shaft.

242 corona, and 0.53 (95% CI, 0.28-0.99) for the penile shaft.

243 Urethral, glans penis/coronal sulcus, penile shaft/prepuce, scrotal, perianal, anal canal, sem

244 pism requiring a surgically performed distal penile shunt.

245 8), vaginal (SIR, 5.9), cervical (SIR, 1.5), penile (SIR, 8.2), and head and neck cancer (SIR, 2.8),

246 cine did not protect vaccinated animals from penile SIV challenge.

247 mph nodes could help prevent infection after penile SIV challenge.

248 hesus macaques at 1, 3, 7, and 14 days after penile SIV inoculation and quantified the levels of unsp

249 bertal stage was Tanner 4 for pubic hair and penile size, which contrasted with small testes (4.5 mL)

250 Penile skin swabs were assessed for HPV DNA using polyme

251 ated ED and the mechanism involves increased penile smooth muscle contractility through inhibition of

252 One deletion removes a sensory vibrissae and penile spine enhancer from the human androgen receptor (

253 of androgen-dependent sensory vibrissae and penile spines in the human lineage.

254 Penile squamous cell carcinoma (PeSCCA) is a rare malign

255 Penile squamous cell carcinoma (PSCC) is a rare tumor as

256 Men with penile squamous cell carcinoma and regional lymph node i

257 onded to colon distension, 100% responded to penile stimulation (and DNP), and 85% responded to vagal

258 For penile strictures, a ventral onlay procedure using skin

259 and psychological characteristics, including penile stump length, and emotional suitability for the p

260 We surgically prepared the penile stump of the recipient and attached the penile gr

261 und in and under the epithelium covering all penile surfaces, the presence of antiviral effector B an

262 Participants provided a self-collected penile swab sample for HPV genotyping (Roche Linear Arra

263 Penile swab samples were collected from men aged 18-59 y

264 DNA was extracted from self-collected penile swab specimens, and HPV genotyping was performed

265 Oral rinse, penile swab, and vaginal swab specimens were evaluated b

266 se chain reaction was performed on mouth and penile swabs before and at days 5 and 10 after transplan

267 Using penile swabs from males aged 14-59 years, we estimated t

268 'Watering can penis' as a result of penile TB is a very rare clinical entity.

269 'watering can penis' was noted secondary to penile TB.

270 similar fibrotic gene expression profile in penile tissue (including procollagen I, TGF-beta(1), and

271 ocedures are limited by a shortage of native penile tissue.

272 us in rectal tissue compared to cervical and penile tissues and enhanced replication in tonsillar tis

273 and PDE activity is significantly reduced in penile tissues of two independent priapic models: SCD mi

274 ciently by migratory cells from cervical and penile tissues to CD4(+) T cells than individual acute E

275 TRIM5 to establish a novel nonhuman primate penile transmission model for AIDS mucosal pathogenesis

276 valuated the effect of TRIM5 genotype on the penile transmission of SIVsmE660.

277 Guidelines should be developed to address penile transplantation and must cover the donation of ti

278 We first performed a cadaver-to-cadaver penile transplantation as preparation.

279 r men with significant genitourinary injury, penile transplantation is being considered as an option

280 The state of penile transplantation is elementary.

281 INTERPRETATION: Penile transplantation restored normal physiological fun

282 scholarly literature assessing the ethics of penile transplantation.

283 esearch addressing the ethical dimensions of penile transplantation.

284 guidelines are established and disseminated, penile transplants should not be undertaken.

285 A 'watering can penis' secondary to penile tuberculosis is an extremely rare clinical entity

286 low into the corpora cavernosa that leads to penile tumescence.

287 mizing the need for disfiguring treatment of penile tumors in some patients and (2) reducing the numb

288 -arousing video clips and a regression using penile turgidity as the covariate of interest were perfo

289 Data on penile turgidity was collected using a custom-built pneu

290 ong activations specifically associated with penile turgidity were observed in the right subinsular r

291 sian man consulted us after having undergone penile ultrasonography for pain and increased thickness

292 i.e. linear incomplete filling defect in the penile urethra and associated mild dilatation of the ant

293 The penile urethra has been reported to develop from two cel

294 tal malformation in which the opening of the penile urethra occurs on the ventral side of the penis)

295 affect mucosal tissues in the mouth and the penile urethra.

296 ized, oversized, or multiple openings of the penile urethra.

297 ility, proceeding ethically with research on penile vascularized composite allotransplantation will r

298 CT-1 was injected through the penile vein 30 min before clamping release and its effec

299 riapism when mating due to thrombosis of the penile vein, but neither Mrc1(-/-) nor Asgr2(-/-) mice d

300 ion of galaninergic neurons, the ability for penile vibratory stimulation (PVS) to elicit ejaculation

301 the development of various cancers including penile, vulva, oropharyngeal and cervical cancers.