ライフサイエンスコーパス: pentacyclic

1 ominated phthalide to generate a substituted pentacyclic 12H-5,11a-diazadibenzo[b,h]fluoren-11-one in

2 The occurrence of triterpene pentacyclic acids in plants is extensive, but little is

3 The pentacyclic acridinium salt RHPS4 displays anti-tumour p

4 A synthesis route to the pentacyclic alkaloid (-)-gilbertine, which features a cy

5 The pentacyclic alkaloid calothrixin B (1) has been synthesi

6 The convergent synthesis of two pentacyclic analogues of the polyether monensin A is des

7 ial lanosterol synthase enabled synthesis of pentacyclic arborinols in addition to tetracyclic sterol

8 key reactions used in the synthesis of this pentacyclic Aspidosperma alkaloid were a deracemizing im

9 tructures via oxidation of the corresponding pentacyclic C19-iminium ions.

10 Two series of pentacyclic carbazolones, 22 and 23, have been synthesiz

11 atalyzed cleavage of the ester side chain of pentacyclic cinnamyl ester 15.

12 enzothiophene, the anti and syn isomers of a pentacyclic compound consisting of alternating thiophene

13 With an overall yield of 6.4%, this pentacyclic compound has been synthesized by utilizing o

14 and heteroaromatic pi-bonds to provide novel pentacyclic compounds in good yield and in a stereocontr

15 Hopanoids are triterpenoic, pentacyclic compounds that are structurally similar to s

16 A concise preparation of the prochiral pentacyclic core of (+)-salvileucalin B is presented.

17 establish the remaining stereocenters in the pentacyclic core of (-)-citrinadin A.

18 ype reaction for the construction of the key pentacyclic core of both targets, bearing either the nat

19 establish the remaining stereocenters in the pentacyclic core of the citrinadins.

20 The route to the pentacyclic core relies on a new regioselective alkenyla

21 After C21-oxygenation, the pentacyclic core was accessed by electrophilic C19-amide

22 chloride to generate the generic celastroid pentacyclic core.

23 deuterium atoms can be incorporated into the pentacyclic crambescidin core.

24 cloeucalenol cycloisomerase (EC ) to convert pentacyclic cyclopropyl sterols to conventional tetracyc

25 de with 2,3-dichloronaphthoquinone to give a pentacyclic dinaphthofuran directly, followed by convers

26 A new class of pentacyclic diquinoid compounds has been synthesized wit

27 ize the cyclic structures of many tetra- and pentacyclic diterpenes, including ent-beyerene, ent-kaur

28 uction of a late-stage protecting-group-free pentacyclic enol triflate coupling partner, from which a

29 The rapid synthesis of this key pentacyclic enol triflate was achieved by a highly conve

30 e (1) at the 2,3- and 3,4-positions gave two pentacyclic enones (7 and 10) that contain A/B-cis-fused

31 (d) base-promoted skeletal rearrangement of pentacyclic equatorial alcohol 82 to form the oxacyclic

32 mpounds 8 and 32, each of which embodies the pentacyclic framework and much of the functionality asso

33 c aniline onto the oxindole moiety to form a pentacyclic framework containing the southern aminal, a

34 annelated ring size led to formation of the pentacyclic framework with complete diastereoselectivity

35 With access to a C-3 epi-pentacyclic framework, 3-epi-jorumycin (32) and 3-epi-re

36 indoline and construct the natural product's pentacyclic framework.

37 aloid bearing a 2-acylindoline moiety in its pentacyclic framework.

38 of chiral polycyclic molecules (tricyclic to pentacyclic) from achiral polyene precursors by enantios

39 pening of the spirocyclic ether rings of the pentacyclic guanidinium moiety.

40 rom the endo-oriented nitrile substituent of pentacyclic Heck product 18 were unsuccessful.

41 hexenyl radical derived from 48 produces the pentacyclic heterocycle 50 by either a direct 6-endo tri

42 Diels-Alder reaction to rapidly assemble the pentacyclic heteroyohimboid derivative 8 from the readil

43 etracyclic carbon skeleton and the 6,6,6,6,5-pentacyclic hopanoids.

44 a nanomolar inhibitor of Ca2+-ATPase, has a pentacyclic indole tetramic acid scaffold that arises fr

45 lar inhibitor of Ca(2+)-ATPase with a unique pentacyclic indole tetramic acid scaffold, is assembled

46 BS resulted in the formation of the required pentacyclic indoline framework of the target alkaloid.

47 Alstonine and serpentine are pentacyclic indoloquinolizidine alkaloids (referred to a

48 A prototype pentacyclic inhibitor 32 (AKI-001) derived from two earl

49 (-)-deoxoapodine are detailed from a common pentacyclic intermediate 15, enlisting the late-stage fo

50 neram (11) were also achieved via the common pentacyclic intermediate 16.

51 chanism involves the formation of a putative pentacyclic intermediate formed by a 1,3 dipolar cyclo-a

52 e synthesis, in which the structure of a key pentacyclic intermediate is corroborated by X-ray crysta

53 This pentacyclic intermediate was subsequently transformed to

54 yclization precursor, leading to a versatile pentacyclic intermediate.

55 ltimate C21 functionalized Aspidosperma-like pentacyclic intermediate.

56 efficient aza-Cope/Mannich reaction to give pentacyclic ketone rac-44.

57 fragmentation products were synthesized from pentacyclic ketones 3 and 4 via Baeyer-Villiger oxidatio

58 4 and, after oxidation of the olefin 16, the pentacyclic lactam 17 with a brigehead double bond.

59 n Ullmann-type lactone ring closure into the pentacyclic lamellarin skeleton.

60 exceptionally efficient way to construct the pentacyclic nucleus of the Daphniphyllum alkaloids.

61 iously in the 3-, 6-, or 10-positions of the pentacyclic nucleus.

62 from the angular methyl configuration of the pentacyclic or 6-6-6-6 tetracyclic product.

63 in the presence of silver phosphate to form pentacyclic product 69 having the unnatural configuratio

64 this material to SnCl4 then gave the desired pentacyclic product, which was identical to that previou

65 cess in good overall yield, leading to novel pentacyclic products.

66 , with production of tetracyclic rather than pentacyclic products.

67 The reaction forming a pentacyclic propellane was calculated to have DeltaH = -

68 ed in solution in complex with a fluorinated pentacyclic quino[4,3,2-kl]acridinium cation (RHPS4).

69 Two short routes to novel methylated pentacyclic quinoacridinium salts have been devised.

70 A small library of pentacyclic quinoid compounds, called KuQuinones (KuQs),

71 inear array of 10 five-membered rings in two pentacyclic regions that derive from ribosomal peptide s

72 -oxadiazole that provided the functionalized pentacyclic ring system 15 in a single step in which the

73 hree rings and four C-C bonds central to the pentacyclic ring system setting all six stereocenters an

74 hree rings and four C-C bonds central to the pentacyclic ring system setting all six stereocenters an

75 nds are formed central to the characteristic pentacyclic ring system setting all six stereocenters an

76 d 2 possess an unprecedented 5/5/7/5/5-fused pentacyclic ring system.

77 metabolite with a previously uncharacterized pentacyclic ring system.

78 broad tolerance towards substitutions in the pentacyclic ring that acted as a plug of the active site

79 novel class of Aurora inhibitors based on a pentacyclic scaffold.

80 l-type sesterterpenes with tri-, tetra-, and pentacyclic scaffolds, and notably (-)-ent-quiannulatene

81 ents are identified as spiroborates with two pentacyclic sec-butyl-trihydroxy-methyl-benzo[gh]tetraph

82 enes, revealing the cyclization path for the pentacyclic sesterterpene (-)-retigeranin B.

83 n cascade of a 1,3,4-oxadiazole in which the pentacyclic skeleton and all the stereochemistry of the

84 ype Ergot alkaloid noteworthy for its unique pentacyclic skeleton featuring a 3-azabicyclo[3.1.0]hexa

85 n alpha-diazo indoloamide which delivers the pentacyclic skeleton of the natural product in excellent

86 -scholarisine G (9) with a [6.5.6.6.5] fused pentacyclic skeleton, respectively.

87 roblem of assembling the final D-ring of the pentacyclic skeleton.

88 Detailed experimental approaches toward the pentacyclic Stemona alkaloids tuberostemonine and didehy

89 Reduction of these enones gave the pentacyclic steroidal ketones 2 alpha,3beta- (8) and 2 a

90 cation-pi cyclization stages to generate the pentacyclic structure with complete stereocontrol.

91 oxidations at different positions across the pentacyclic structure.

92 ation that converts the cyclopentenes to the pentacyclic structures of the natural products.

93 ives utilized Pummerer chemistry to generate pentacyclic structures related to the palau'amine family

94 oles 15, 22, and 26 and their elaboration to pentacyclic structures via a conjugate addition, dipolar

95 We have synthesized four novel pentacyclic Strychnos alkaloids alstolucines B (2), F (3

96 lding conversion of the ABDE tetracycle into pentacyclic target rac-1 relied on intramolecular indole

97 ic therapeutic plant Boswellia serrata, is a pentacyclic terpenoid active against a large number of i

98 oleum biomarkers (steranes, diasteranes, and pentacyclic triterpanes) naturally occurring in crude oi

99 n-alkanes, polycyclic aromatic hydrocarbons, pentacyclic triterpanes, compound specific isotope analy

100 Ursolic acid, a pentacyclic triterpene acid, has been shown to suppress

101 ed light on the spatiotemporal regulation of pentacyclic triterpene biosynthesis in sweet basil.

102 ing methods, we discovered that Celastrol, a pentacyclic triterpene extracted from the roots of Tript

103 UA is a pentacyclic triterpene found too in several traditional

104 Maslinic acid, a pentacyclic triterpene from Olea europaea L., exerts hyp

105 key intermediate 2 for the synthesis of the pentacyclic triterpene germanicol 1 have been developed.

106 Betulinic acid (BA), a pentacyclic triterpene isolated from the bark of the whi

107 iacin (olean-18-en-3beta-ol methyl ether), a pentacyclic triterpene methyl ether that is enriched in

108 Betulinic acid is a pentacyclic triterpene natural product initially identif

109 e of modifying both the C and D rings of the pentacyclic triterpene scaffold to give 12,13beta-epoxy-

110 t that celastrol, a potent anti-inflammatory pentacyclic triterpene, binds Nur77 to inhibit inflammat

111 Lupeol, a pentacyclic triterpene, from the hexane extract of Solan

112 Pentacyclic triterpenes are minor, but very relevant com

113 r the simultaneous determination of the main pentacyclic triterpenes from Olea europaea L. in rat pla

114 elin, the most drastically rearranged of the pentacyclic triterpenes, involves a complex nonstop proc

115 precursors of oleanane-type and ursane-type pentacyclic triterpenes, respectively.

116 ally important ursane-type and oleanane-type pentacyclic triterpenes.

117 eering strategies for enhanced production of pentacyclic triterpenes.

118 Table olives are especially rich in pentacyclic triterpenic compounds, which exert several b

119 h displays equal or greater potency than the pentacyclic triterpenoid CDDO in inflammation and carcin

120 strength, quality, and mass: ursolic acid (a pentacyclic triterpenoid found in apples) and tomatidine

121 estigated the effect of ursolic acid (UA), a pentacyclic triterpenoid found in rosemary and holy basi

122 re, we report the identification of escin, a pentacyclic triterpenoid from horse chestnut that exhibi

123 Oleanolic acid (OA), a pentacyclic triterpenoid, has been shown to modulate mul

124 ds, only ursolic acid, a naturally occurring pentacyclic triterpenoid, successfully inhibited binding

125 ys, the simple structure is more potent than pentacyclic triterpenoids (e.g., CDDO and bardoxolone me

126 Various ursanic, oleanic and lupanic pentacyclic triterpenoids found in apple peel were studi

127 Structurally related pentacyclic triterpenoids methyl 2-cyano-3,12-dioxoolean

128 Sedimentary hopanes are pentacyclic triterpenoids that serve as biomarker proxie

129 l one-pot transformation of dialdehyde 24 to pentacyclic unsaturated amine 25.