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1 of the monomers contributes unequally to the pentameric (2:1:1:1) complex of Rho dimer and Gt heterot
3 xpression in Xenopus oocytes of concatenated pentameric (alpha7)5-, (alpha7)4(beta2)1-, and (alpha7)3
5 metry with the capsid protein organized into pentameric and hexameric clusters that interact via prom
8 nge its own structure in response but remain pentameric, and then bind to pathogenic proteins deposit
10 or capsid protein virus protein 1 (VP1), and pentameric arrangement of VP1 monomers results in the fo
12 e-II PKA-AKAP18gamma complexes reveal hetero-pentameric assemblies that adopt a range of flexible tri
14 nally identified subunit LvgA, and that this pentameric assembly binds Legionella effector proteins.
15 e external scaffolding protein D organize 12 pentameric assembly intermediates into procapsids, a rea
16 ffolding protein B mediates the formation of pentameric assembly intermediates, whereas the external
17 However, monomers are incorporated into 12 pentameric assembly intermediates, which become the caps
20 mutation increases the stability of the PLN pentameric assembly via disulfide bridge formation, prev
29 ich is composed of a cytotoxic A subunit and pentameric B subunits that bind globotriaosylceramide on
31 econstructions, supporting the presence of a pentameric, but not hexameric, pRNA ring in the context
32 relevance of the dissociation of circulating pentameric C-reactive protein (pCRP) to its monomeric su
33 n, concanavalin A, and pyruvate kinase), and pentameric (C-reactive protein) complexes, ranging in si
35 the genome by displacing one or more of the pentameric capsomers may be the result of a low-pH envir
39 scL when the majority of the subunits of the pentameric channel contain the fluorescent mEos3.2 prote
40 s isoflurane and propofol of the prokaryotic pentameric channel GLIC is investigated by molecular sim
41 Although the precise biological role of this pentameric channel is still unknown, this report is neve
44 n brain, mediating its actions chiefly via a pentameric chloride ion channel, the GABAA receptor.
45 ing DNA clamps, which are loaded onto DNA by pentameric clamp loader complexes belonging to the AAA+
46 onformation is ideal for encapsulating small pentameric clusters, either a water molecule or a fluori
49 GP129, which encodes a subunit of the GPCMV pentameric complex (PC) believed to govern viral entry i
50 ion of the genome encoding components of the pentameric complex (PC), in particular homologs of human
51 ressed and purified soluble gH/gL/pUL128-131 pentameric complex and gH/gL from Chinese hamster ovary
52 lasmic reticulum, is a membrane-bound hetero-pentameric complex consisting of Gpi8, Gpi16, Gaa1, Gpi1
53 -strain-like strains of CMV, which display a pentameric complex consisting of the viral glycoproteins
54 he necessity to monitor the integrity of the pentameric complex during the vaccine manufacturing proc
55 efective human cytomegalovirus with restored pentameric complex glycoprotein H (gH)/gL/pUL128-131 for
57 light the importance of the gH/gL/pUL128-131 pentameric complex in HCMV vaccine design and emphasize
58 accine candidate but the glycoprotein H (gH) pentameric complex is now recognized as the major target
60 Thus, inclusion of epitopes derived from the pentameric complex may provide enhanced efficacy by indu
62 the dominant virus-neutralizing antigen-the pentameric complex of glycoprotein H (gH), gL, and pUL12
63 and together with the gH/gL/UL128/130/131 a pentameric complex permits infection of epithelial, endo
64 ct with the epitopes of the gH/gL/pUL128-131 pentameric complex resulting in viral neutralization, we
67 eplication-defective virus with the restored pentameric complex, rhesus macaques can develop broadly
69 domain of Arno can also associate to form a pentameric complex, which suggests that the uncompetitiv
78 in a sequential manner, with tetrameric and pentameric complexes forming as intermediate states lead
79 ated ion channel family, neuronal nAChRs are pentameric, composed of various permutations of alpha (a
82 s of alpha4 and beta2 subunits and establish pentameric concatemers as a means to delineate interacti
83 p16 of varphi29 was previously reported as a pentameric configuration by cryo-electron microscopy (cr
84 eta2 subunits expressed with free alpha5 and pentameric constructs incorporating a single copy of alp
89 tro exposure of normal neutrophils to native pentameric CRP led to a dose- and time-dependent loss of
96 the activation, blockade, and regulation of pentameric Cys-loop ion channels at the atomic level.
102 tilage oligomeric matrix protein (COMP) is a pentameric extracellular protein expressed in cartilage
103 could select Mg(2+) over Ca(2+), a bilayered pentameric filter lined with a ring of amides and a ring
105 f intact FMDV particles (146 S; 8200 kDa) or pentameric FMDV coat protein aggregates (12 S; 282 kDa)
106 hotoinduced conformational transition of the pentameric foldamer 105 is reflected in distinct spectra
107 e show that monomeric CRP (mCRP) but not the pentameric form (pCRP) upregulates IL-8 and CCL2 levels
115 upport a unique vaccine concept based on the pentameric gH complex, we established a panel of 45 mono
116 as dependent on high-level expression of the pentameric gH/gL/gpUL128-131A complex, a feature of WT b
117 artilage oligomeric matrix protein (COMP), a pentameric glycoprotein found in cartilage, tendon, liga
119 ELISA-based ligand binding assays, purified pentameric H2O2-treated CRP bound to a number of immobil
122 olecular assembly binds multivalently to the pentameric human C-reactive protein, a biomolecule impli
128 y of, the wild-type alpha7nAChR ligand-gated pentameric ion channel, the findings point to the existe
130 ranslocated across cellular membranes by the pentameric ion channel/transporter FocA that, together w
131 three components: dodecameric portal (gp20), pentameric large terminase motor (gp17), and 11- or 12-m
132 ype A receptor (GABA(A)R) is a member of the pentameric ligand gated ion channel (pLGIC) family that
138 nding to the bacterial Gloeobacter violaceus pentameric ligand-gated ion channel (GLIC), a structural
139 tures of the bacterial Gloeobacter violaceus pentameric ligand-gated ion channel (GLIC), which is sen
140 IC), a proton-gated prokaryotic homologue of pentameric ligand-gated ion channel (LGIC) from G. viola
141 ructure of GLIC, a prokaryotic member of the pentameric ligand-gated ion channel (pLGIC) family, prov
145 -electron microscopy Torpedo model; the only pentameric ligand-gated ion channel imaged in a native l
154 -derived structure of full-length eukaryotic pentameric ligand-gated ion channels (pLGICs) is still l
155 itter-gated ion channels, the superfamily of pentameric ligand-gated ion channels (pLGICs) is unique
168 w insights into the signalling mechanisms of pentameric ligand-gated ion channels and enhance current
169 ne receptor (nAChR) belongs to the family of pentameric ligand-gated ion channels and is involved in
170 e receptors (nAChRs) belong to the family of pentameric ligand-gated ion channels and mediate fast ex
171 r this loop, which is vestigial in bacterial pentameric ligand-gated ion channels and was largely rem
172 tational approaches, we show that eukaryotic pentameric ligand-gated ion channels are characterized b
176 igand binding at the extracellular domain of pentameric ligand-gated ion channels initiates a relay o
178 receptor (nAChR) belongs to a superfamily of pentameric ligand-gated ion channels involved in many ph
180 he M3-M4 linker but also the M1-M2 linker of pentameric ligand-gated ion channels modulates function
183 obutyric acid type A (GABA(A)) receptors are pentameric ligand-gated ion channels that mediate fast i
184 ns with M1/M3 to reduce the sensitivities of pentameric ligand-gated ion channels to their surroundin
186 with other members of the Cys-loop family of pentameric ligand-gated ion channels, 5-hydroxytryptamin
187 e maturation and function of the prokaryotic pentameric ligand-gated ion channels, GLIC and ELIC, was
189 Although numerous studies have focused on pentameric ligand-gated ion channels, the details of ane
200 -nitrite transporters) form a superfamily of pentameric membrane channels that translocate monovalent
201 ome the founding father of a broad family of pentameric membrane receptors, paving the way for their
204 r crystal structure at 3.5 A resolution of a pentameric MscL from Mycobacterium tuberculosis represen
207 in is a histone chaperone that consists of a pentameric N-terminal domain and an unstructured C-termi
208 cotinic acetylcholine receptors (nAChRs) are pentameric, neurotransmitter-gated ion channels responsi
210 receptor subunit, an "accessory" subunit of pentameric nicotinic receptors, that has been shown to p
211 pose a new family of proteins that share the pentameric nucleoplasmin-like NPL domain and are found i
212 he acetylcholine binding protein (AChBP) are pentameric oligomers in which binding sites for nicotini
213 hesis of an azide functionalized fluorescent pentameric oligothiophene that can be utilized as a liga
214 2) had a high propensity to form paranuclei (pentameric or hexameric) structures that could self-asso
215 ng platform for RTA on the ribosome and that pentameric organization of the stalk accelerates recruit
218 eractions between the trimeric fiber and the pentameric penton base are mediated by a hydrophobic rin
219 structure and its mode of attachment to the pentameric penton base by using an integrative approach
220 tcomes correlate with the requirement of the pentameric penton base to simultaneously bind several in
223 denine recognition and ATP hydrolysis in the pentameric phage T4 large "terminase" (gp17) motor.
225 attached, regardless of their position, the pentameric phenylenevinylenes are well water-soluble.
226 aluation of three novel aldehyde-substituted pentameric phenylenevinylenes carrying branched oligo(et
227 Here, we report the T-state structure of pentameric PLN solved by a hybrid solution and solid-sta
230 ng this model into a cryo-EM map generated a pentameric pRNA structure; five helices projecting from
231 ructures of tetrameric (cinnamtannin A2) and pentameric procyanidins (cinnamtannin A3) were elucidate
232 he isolation and semisynthesis of dimeric to pentameric procyanidins from T. cacao by countercurrent
233 meric B2 and B5, trimeric C1, tetrameric and pentameric procyanidins, were isolated from unroasted co
234 the spatial arrangement of the hexameric and pentameric protein capsomers in the growing shell during
240 housands of subunits including hexameric and pentameric proteins that form a shell to encapsulate the
241 ype I restriction enzymes (REases) are large pentameric proteins with separate restriction (R), methy
242 of the amino acid sequence of AgSF1 reveals pentameric QPGSG iterations that are similar to conserve
243 esolution structures of other members of the pentameric receptor superfamily provide touchstones for
248 binding behavior and substrate affinity to a pentameric recognition protein (C-reactive protein, CRP)
250 arly, the central thymine nucleotide of both pentameric repeats was essential for efficient toxT acti
252 -referential contigs predominantly contained pentameric repeats, especially two motifs: AATGG and GTG
253 catemer recognized by TerS, assembles into a pentameric ring motor on the prohead's portal vertex and
259 in of the capsid protein forms hexameric and pentameric rings, while C-terminal domain homodimers con
261 engrafting the V1V2 domain into trimeric and pentameric scaffolds in structurally constrained conform
263 quence consisting of inverted repeats of the pentameric sequence nGAAn, known as heat shock elements
266 ompared the interaction of RTA with the full pentameric stalk complex containing two pairs of P1/P2 p
267 specificity of CRP in its acidic pH-induced pentameric state has implications for toxic conditions i
268 uracy of this approach by characterising the pentameric state of phospholamban, a key player in the r
269 iation' state into a catalytically competent pentameric state, is accompanied by substantial domain r
271 d beta2 subunits assemble in two predominant pentameric stoichiometries, which differ in their sensit
275 these receptors do not form their functional pentameric structure in cell lines, and mechanisms that
276 ma by determining which residues support the pentameric structure in the presence or absence of Mg(2+
277 acidosis or other possible modifiers of the pentameric structure of CRP at the sites of inflammation
278 c pH did not monomerize CRP but modified the pentameric structure, as determined by gel filtration, 1
281 -fold homodecamer of two head-to-head facing pentameric subunits, harboring 10 active sites at the in
282 ay dead end or at best served for storage of pentameric subunits, which was later shown to be unlikel
285 the procapsid conclusively demonstrates the pentameric symmetry of the pRNA and illuminates the rela
286 by mass spectrometry revealed that a hetero-pentameric tau3-delta-delta' Bacillus subtilis clamp-loa
288 f different proteins that form hexameric and pentameric tiles, which interact to allow the formation
290 ture that has 42 turret-like projections: 12 pentameric turrets positioned on the icosahedral 5-fold
291 shape consistent with an arrangement of two pentameric units connected by an interstitial dimer.
294 jacent capsomers affect the positions of the pentameric vertices, resulting in different triangulatio
295 2-subunit portal situated beneath one of the pentameric vertices, thus removing uncertainty over the
296 minant SIMs in a SIM cluster often contain a pentameric VIDLT ((V/I/L/F/Y)(V/I)DLT) core sequence tha
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