ライフサイエンスコーパス: pentanucleotide

1 e sequence, position, and orientation of the pentanucleotide.

2 A probes containing one or two copies of the pentanucleotide.

3 mited to dimer formation on a single pair of pentanucleotides.

4 g T-antigen subunits oriented by core origin pentanucleotides.

5 studies indicate that on the unit made up of pentanucleotide 1 and 3 and the EP assembly unit, the fi

6 EP assembly unit, the first hexamer forms on pentanucleotide 1 and that owing to additional protein-D

7 Pentanucleotides 1 and 3 and the early palindrome (EP) c

8 that T-ag double hexamers prefer to bind to pentanucleotides 1 and 3.

9 Oligomerization on the unit made up of pentanucleotide 2 and 4 and the AT-rich region is initia

10 rmation of the second hexamer takes place on pentanucleotide 2.

11 ome (EP) constitute one assembly unit, while pentanucleotides 2 and 4 and the AT-rich region constitu

12 tions, the second hexamer is able to form on pentanucleotide 3.

13 ion is initiated by assembly of a hexamer on pentanucleotide 4; subsequent formation of the second he

14 Tandem repeats of the pentanucleotide 5'-CCGNN (where N indicates any base) we

15 in the human insulin promoter conform to the pentanucleotide 5'-CTAAT-3' sequence, the Pdx1 responsiv

16 contain (i) one or more copies of the AUUUA pentanucleotide and (ii) a high content of uridylate and

17 e gene ends contain two conserved regions, a pentanucleotide and a tract of uridylate (U) residues, s

18 S3 transcription may relate to the number of pentanucleotides and the cellular proteins that bind to

19 tra have been recorded for tetranucleotides, pentanucleotides, and hexanucleotides.

20 Although two pairs of pentanucleotides are present in the SV40 origin, footpri

21 leotides in the core origin but not to other pentanucleotide arrangements found in ancillary regions

22 We found an expansion of a pentanucleotide (ATTCT) repeat in intron 9 of SCA10 in a

23 consistent with the interpretation that the pentanucleotide AUUUA, rather than the nonamer UUAUUUA(U

24 motif that binds Sp1 protein and an adjacent pentanucleotide (CACGC) that corresponds to the core seq

25 double hexamers formed on "active pairs" of pentanucleotides catalyze a set of previously described

26 However, mutagenesis of the pentanucleotide CCAAT motif or in the presence of urea g

27 hortest substrate sequence was found to be a pentanucleotide containing 5'-CCC flanked on both sides

28 emplated polymerization of 5'-phosphorylated pentanucleotides containing peptide fragments.

29 For the four-pentanucleotide-containing wild-type SV40 core origin, f

30 counts for the heterogeneous distribution of pentanucleotides found in the origins of replication of

31 the middle G/C base pair of the recognition pentanucleotide, GAGGC.

32 s novel mRNP targets a specific guanine-rich pentanucleotide in a region of the beta-globin 3'untrans

33 cing these 45 nucleotides and the stop-start pentanucleotide in between the coding sequences induced

34 the role(s) of the OBDs bound to the site I pentanucleotides in hexamer formation.

35 ag, the origin binding domain can engage the pentanucleotides in site II only if a second region of T

36 Interestingly, the same four pentanucleotides in the core origin are necessary and su

37 iments demonstrate that only two of the four pentanucleotides in the core origin are necessary for T-

38 es binding to the unique arrangement of four pentanucleotides in the core origin but not to other pen

39 Since all four pentanucleotides in the wild-type origin are necessary f

40 eotide deletion downstream of the stop-start pentanucleotide, in addition to disablement of the BM2 i

41 BM2 is expressed from a stop-start pentanucleotide, in which the BM2 initiation codon overl

42 obility shift assay, demonstrating that this pentanucleotide is a core recognition sequence for DAF-3

43 inding, we concluded that the second pair of pentanucleotides is required at a step subsequent to the

44 omoter G-954C and short allele (<11 repeats) pentanucleotide microsatellite polymorphisms, respective

45 unit are 6-15 copies of a tandemly repeated pentanucleotide microsatellite.

46 DNA, we identified discrete regions in each pentanucleotide necessary for normal origin unwinding.

47 propose that spiral assembly is promoted by pentanucleotide pairs arranged in a head-to-tail manner.

48 domain to the SV40 origin requires pairs of pentanucleotide recognition sites separated by approxima

49 10 has been associated with expansion of the pentanucleotide repeat (ATTCT)(n).(AGAAT)(n) from a norm

50 st variation was detected in the number of a pentanucleotide repeat (CAAAA) that controls production

51 We have identified a highly polymorphic pentanucleotide repeat (CCTTT)n within the 5'-putative p

52 n contrast to other expandable repeats, this pentanucleotide repeat does not form stable intra- or in

53 d activation required a TATA box sequence, a pentanucleotide repeat immediately upstream of the TATA

54 It is caused by an expanded ATTCT pentanucleotide repeat in intron 9 of a novel gene, desi

55 a indicate that the new SCA10 intronic ATTCT pentanucleotide repeat in SCA10 patients is unstable and

56 a C protein associated with variation at the pentanucleotide repeat locus.

57 t was completely abolished by changes in the pentanucleotide repeat or adenine string.

58 icant allelic association of a CYP11a 5' UTR pentanucleotide repeat polymorphism with hirsute PCOS su

59 is caused by expansion of an intronic ATTCT pentanucleotide repeat tract.

60 As were constructed containing a 5'-CCGNN-3' pentanucleotide repeat with the Ns varied.

61 zed the allele distribution of a polymorphic pentanucleotide repeat within the 5' upstream promoter r

62 ulated by slipped-strand mispairing across a pentanucleotide repeat, ACAGC, within the 5' end of alxA

63 sex hormone binding globulin (SHBG) gene, a pentanucleotide-repeat polymorphism [(TAAAA)(n)] and a s

64 instabilities) of repeating tri-, tetra- and pentanucleotide repeating sequences associated with a nu

65 by variation in the number of short-sequence pentanucleotide repeats (CAAAA) located immediately down

66 Long tracts of CCG trinucleotide or CCGNN pentanucleotide repeats in DNA have previously been show

67 e ability of differing numbers of (CCTTT)(n) pentanucleotide repeats to induce transcription of the N

68 DNAs containing 76 CCG triplets or 48 CCGNN pentanucleotide repeats were 2.0 +/- 0.2-fold and 2.1 +/

69 ontaining 76 tandem CCG triplets or 48 CCGNN pentanucleotide repeats were methylated with SssI methyl

70 RNA mapped the PTB-binding site to the UCUAA pentanucleotide repeats.

71 er define the oligomerization mechanism, the pentanucleotide requirements for T-ag assembly were inve

72 M.MboIIA methylates the 3' adenine of the pentanucleotide sequence 5'-GAAGA-3'.

73 translated region (L-5' UTR) had neither the pentanucleotide sequence nor homopolymeric sequences, ye

74 f G sequences that are found upstream of the pentanucleotide sequence promoted NSs mRNA termination.

75 probes containing one or more copies of the pentanucleotide sequence TGTCG specifically bound cellul

76 Our studies suggested the importance of a pentanucleotide sequence, CGUCG, for N, NSs, and M mRNA

77 equences, which were located upstream of the pentanucleotide sequence, promoted N and M mRNA terminat

78 ract and eight variably oriented, GAGGC-like pentanucleotide sequences (PS) that serve as LT recognit

79 ral model of the NS5B/RNA complex in which a pentanucleotide single-stranded RNA template occupies a

80 hexamer formation, while particular pairs of pentanucleotides suffice for the assembly of T-ag double

81 Here, we demonstrate that individual pentanucleotides support hexamer formation, while partic

82 In particular, the PE spectra obtained for pentanucleotide tetraanions show evidence for two coexis

83 ubstantial alterations were tolerated in the pentanucleotide UAAUG that contains the ORF A terminatio

84 ing 5 highly sensitive mononucleotides and 2 pentanucleotides was performed.

85 in various [A(5-x)T(x)](4-) and [GT(4)](4-) pentanucleotides, we have established that the second ty

86 ation codon of BM2 protein at the stop-start pentanucleotide were viable and still expressed BM2.

87 Six loci (one tri-, four tetra- and one pentanucleotide) were assembled into a single multiplex