ライフサイエンスコーパス: pentose phosphate pathway

1 by the Calvin-Benson-Bassham (CBB) reductive pentose phosphate pathway.

2 metabolism, including several mRNAs from the pentose phosphate pathway.

3 d failed to predict the use of the oxidative pentose phosphate pathway.

4 trate for NADPH generation via the oxidative pentose phosphate pathway.

5 ydrogenase (6-PGDH), the third enzyme of the pentose phosphate pathway.

6 nvolved in starch turnover and the oxidative pentose phosphate pathway.

7 mark of transformed cells, is to support the pentose phosphate pathway.

8 ated flux through the antioxidant-generating pentose phosphate pathway.

9 pgl), which encodes the second enzyme in the pentose phosphate pathway.

10 transport, a glucokinase and enzymes of the pentose phosphate pathway.

11 y between the TGF-beta signaling pathway and pentose phosphate pathway.

12 ed for 4-carbon saccharides arising from the pentose phosphate pathway.

13 -phosphate and d-xylulose 5-phosphate in the pentose phosphate pathway.

14 carbon dioxide assimilation via a reductive pentose phosphate pathway.

15 cycle and its upstream contributors, and the pentose phosphate pathway.

16 e groups comprising either glycolysis or the pentose phosphate pathway.

17 fts from primarily glycolytic to include the pentose phosphate pathway.

18 arboxylic acid (TCA) cycle and an incomplete pentose phosphate pathway.

19 ion of the reduced form of NADPH through the pentose phosphate pathway.

20 e ATP generating roles of glycolysis and the pentose phosphate pathway.

21 eins missing from current annotations of the pentose phosphate pathway.

22 PH and ribose 5-phosphate production via the pentose phosphate pathway.

23 ot the tricarboxylic acid cycle, and not the pentose phosphate pathway.

24 osphogluconolactonase (6Pgl) involved in the pentose phosphate pathway.

25 ogenase and metabolically integrated via the pentose phosphate pathway.

26 lytic-tricarboxylic acid cycle route and the pentose phosphate pathway.

27 ketolase and transaldolase activities of the pentose phosphate pathway.

28 P and NADPH synthesis via glycolysis and the pentose phosphate pathway.

29 the TKL1 gene, encoding transketolase of the pentose phosphate pathway.

30 metabolism in the non-oxidative part of the pentose phosphate pathway.

31 glucose-6-phosphate dehydrogenase or in the pentose phosphate pathway.

32 ne metabolism, glutamate metabolism, and the pentose phosphate pathway.

33 focused on the importance of glycolysis and pentose phosphate pathway.

34 asing dependence upon glutaminolysis and the pentose phosphate pathway.

35 iphosphatase 4 (PFKFB4), drives flux through pentose phosphate pathway.

36 y by glycolysis and to a minor extent by the pentose phosphate pathway.

37 sotope effect is only found in the reductive pentose phosphate pathway.

38 o glycolysis and to the oxidative arm of the pentose phosphate pathway.

39 te dehydrogenase (G6PDH), a regulator of the pentose phosphate pathway.

40 increase in glucose metabolic flux into the pentose phosphate pathway.

41 by high levels of nutrient flux through the pentose phosphate pathway.

42 tributor to cytosolic NADPH is the oxidative pentose phosphate pathway.

43 onance assigned to 6-phosphogluconate in the pentose phosphate pathway.

44 o alterations in glucose metabolized via the pentose phosphate pathway.

45 idation via the tricarboxylic acid cycle and pentose-phosphate pathway.

46 nd is linked through its product Xu5P to the pentose-phosphate pathway.

47 iting enzyme in the nonoxidative part of the pentose-phosphate pathway.

48 ctate even in the presence of oxygen via the pentose-phosphate pathway.

49 drolytic enzymes and also enzymes key to the pentose-phosphate pathway.

50 metabolites through the oxidative arm of the pentose-phosphate pathway.

51 : the Embden-Meyerhof, Entner-Doudoroff, and pentose phosphate pathways.

52 s in both the oxidative and the nonoxidative pentose phosphate pathways.

53 nas, the Entner-Doudoroff, and the reductive pentose phosphate pathways.

54 A high flux was found through the oxidative pentose phosphate pathway (19.99 +/- 4.39 micromol d(-1)

55 of the Calvin-Benson-Bassham (CBB) reductive pentose phosphate pathway, a scheme that does not appear

56 C-null strains show indications of oxidative pentose phosphate pathway activation as well as increase

57 on of Nrf2 and the ARE, coupled with reduced pentose phosphate pathway activity and decreased generat

58 Fasting stimulated pentose phosphate pathway activity and metabolism of [U-

59 that CP12 is essential to separate oxidative pentose phosphate pathway activity from Calvin-Benson cy

60 NADPH, a substrate for NOX, and pentose phosphate pathway activity increased with glucos

61 ose uptake, glucose metabolism and oxidative pentose phosphate pathway activity were similarly repres

62 tabolites provides an important biomarker of pentose phosphate pathway activity, triacylglycerol synt

63 sponse in the clinic and of monitoring tumor pentose phosphate pathway activity.

64 nd most abundant sugar in nature, is via the pentose phosphate pathway after a two-step or three-step

65 rovided the first link between the bacterial pentose phosphate pathway and activation of host IFN-bet

66 PDH) controls the flow of carbon through the pentose phosphate pathway and also produces NADPH needed

67 phoribosyl-1-pyrophosphate, a product of the pentose phosphate pathway and an important precursor for

68 cemia by increasing glucose flux through the pentose phosphate pathway and enhancing fatty acid synth

69 fluxes in the pentose phosphate pathway and gluconeogenesis were stabl

70 th a shift in glucose metabolism between the pentose phosphate pathway and glycolysis, (2) interactio

71 between the oxidative steps of the oxidative pentose phosphate pathway and glycolysis.

72 ection against hydrogen peroxide insult in a pentose phosphate pathway and GSH-dependent manner.

73 a fructose-2,6-bisphosphatase, promoting the pentose phosphate pathway and helping to lower intracell

74 lutathione levels through stimulation of the pentose phosphate pathway and identify dehydroascorbate

75 4P is formed exclusively by the nonoxidative pentose phosphate pathway and is not a precursor of arom

76 yrophosphate production by the non-oxidative pentose phosphate pathway and late steps by modulating a

77 nsated by activation of anabolic metabolism (pentose phosphate pathway and lipogenesis) allowing live

78 glutathione biosynthesis or in the oxidative pentose phosphate pathway and other NADPH-producing enzy

79 of genes associated with photosynthesis, the pentose phosphate pathway and primary metabolism, but lo

80 onstrate how reversibility is present in the pentose phosphate pathway and the extents of reversibili

81 ls further showed enhanced activation of the pentose phosphate pathway and the glutathione system, wh

82 se (G6PD) is the rate-limiting enzyme of the pentose phosphate pathway and the principal source of NA

83 is required to divert glucose flux into the pentose phosphate pathway and thereby generate sufficien

84 biosynthetic genes and discrete steps in the pentose phosphate pathway and tricarboxylic acid cycle t

85 The oxidative and nonoxidative pentose phosphate pathways and the ratio between them al

86 nase (G6PD), the rate-limiting enzyme of the pentose phosphate pathway, and by 6-phosphogluconate deh

87 ncluding glycerol oxidation, glycolysis, the pentose phosphate pathway, and carbon sources of stored

88 cluding glycolysis, the oxidative arm of the pentose phosphate pathway, and de novo lipid biosynthesi

89 ses including fatty acid esterification, the pentose phosphate pathway, and gluconeogenesis through t

90 lism, reactive oxygen species clearance, the pentose phosphate pathway, and glutathione homeostasis.

91 f glycolysis, gluconeogenesis, the oxidative pentose phosphate pathway, and glycogen metabolism were

92 ical pathways, such as glycolysis, oxidative pentose phosphate pathway, and glycogen metabolism, were

93 ycolysis, through the oxidative/nonoxidative pentose phosphate pathway, and into the general phenylpr

94 way, nucleotide sugars, intermediates of the pentose phosphate pathway, and lipogenesis, including pr

95 on-photosynthetic one-carbon metabolism, the pentose phosphate pathway, and most or all of the urea c

96 through up-regulation of glucose influx, the pentose phosphate pathway, and NAD salvaging pathways.

97 for the complete non-oxidative phase of the pentose phosphate pathway, and others predicted to media

98 rom erythrose 4-phosphate, generated via the pentose phosphate pathway, and phosphoenolpyruvate.

99 tion of glucose flux between glycolysis, the pentose phosphate pathway, and serine biosynthesis seems

100 ed reduced glucose metabolism in glycolysis, pentose phosphate pathway, and sorbitol pathway, which m

101 r phosphates that constitute glycolysis, the pentose phosphate pathway, and the RNA and DNA backbone,

102 ent decrease in flux through glycolysis, the pentose phosphate pathway, and the tricarboxylic acid (T

103 ioning of glucose carbons into C1/folate and pentose phosphate pathways, and increased tricarboxylic

104 Thus the first two steps of the pentose phosphate pathway are catalysed by a single nove

105 When reactions of the oxidative pentose phosphate pathway are taken into consideration,

106 1 and zwf1 mutants, implicating Sod1 and the pentose phosphate pathway as being critical for maintena

107 ase step, promoting carbon overflow into the pentose phosphate pathway as evidenced by the increased

108 ional view of the Calvin cycle and oxidative pentose phosphate pathway as separate systems, they are

109 s of NADPH reflecting a higher activation of pentose phosphate pathway as this is accompanied with hi

110 nclude up-regulated NADPH production via the pentose phosphate pathway as well as activation of the N

111 etabolic intermediates in the glycolytic and pentose phosphate pathways as well as abnormal mitochond

112 h glycolysis and the oxidative branch of the pentose phosphate pathway, as well as to stimulate de no

113 Results suggested that the deinococcal pentose phosphate pathway augmented the DNA excision rep

114 TORC1 directs increased glucose flux via the pentose phosphate pathway back into glycolysis, thereby

115 an enzyme in the nonoxidative branch of the pentose-phosphate pathway, based on peptide and cDNA iso

116 idative and the nonoxidative branches of the pentose phosphate pathway blocked the stimulation of glu

117 Glycolysis and the pentose phosphate pathway both play a central role in th

118 Its major source is considered to be the pentose phosphate pathway, but cytosolic NADP(+)-depende

119 bolism through the citric acid cycle and the pentose phosphate pathway by 240 and 90%, respectively,

120 er occurs through diverting glucose into the pentose phosphate pathway by ADPr inhibition of glyceral

121 Inhibition of the pentose phosphate pathway by glucose-6-phosphate dehydro

122 Adiponectin also reversed induction of the pentose phosphate pathway by HFD.

123 te of the cells with regard to the oxidative pentose phosphate pathway, Calvin cycle, tricarboxylic a

124 flux through the oxidative reactions of the pentose phosphate pathway can rescue sod1 methionine aux

125 We suggest that reduction of the oxidative pentose phosphate pathway capacity in a nuo mutant is an

126 tration of metabolites of glycolysis and the pentose phosphate pathway, central metabolic players in

127 ne phosphate and fructose-1,6-bisphosphate), pentose phosphate pathway components and Kreb's cycle in

128 non-photosynthetic conditions, the oxidative pentose phosphate pathway contributes to basic metabolis

129 Idn1 act together to shunt glucose into the pentose phosphate pathway, creating an alternative route

130 Further, pentose phosphate pathway deregulation and impaired fatt

131 This pentose phosphate pathway enzyme is NADP-dependent; NADP

132 uiescent mutant 1 (NQM1), a paralogue to the pentose phosphate pathway enzyme transaldolase (TAL1), a

133 croM dehydroascorbate stimulated activity of pentose phosphate pathway enzymes glucose 6-phosphate de

134 3.6% of glycolysis, and three non-oxidative pentose phosphate pathway exchange fluxes were calculate

135 lycolysis, the tricarboxylic acid cycle, the pentose phosphate pathway, fatty acid and nucleotide bio

136 The oxidative pentose phosphate pathway flux was 3.6% of glycolysis, a

137 associated with a corresponding increase in pentose phosphate pathway flux, assessed using (13)C-lab

138 owever, LPS also induced a small decrease in pentose phosphate pathway fluxes and an increase in glut

139 e identified increased citric acid cycle and pentose phosphate pathway fluxes as consistent markers o

140 ol g(-1)h(-1) that was partly caused by high pentose phosphate pathway fluxes.

141 Embden-Meyerhof-Parnas, Entner-Doudoroff, or pentose phosphate pathway for glycolytic carbon metaboli

142 no longer required function of the oxidative pentose phosphate pathway for thiamine synthesis were is

143 DNA encoding transaldolase, an enzyme of the pentose-phosphate pathway, from potato (Solanum tuberosu

144 reduced by NADPH generated via the oxidative pentose phosphate pathway, functions as a signal in germ

145 lytic RA T cells diverted glucose toward the pentose phosphate pathway, generated more NADPH, and con

146 nase (G6PD), the rate-limiting enzyme in the pentose phosphate pathway, generates NADPH in a reaction

147 We show that pentose-phosphate-pathway generation of NADPH is critica

148 se, ferredoxin reductase, and enzymes in the pentose phosphate pathway), genes encoding novel metabol

149 nate is prevented by blocks in the oxidative pentose phosphate pathway, gnd (encoding gluconate 6-pho

150 disorders, we focused on the glycolytic and pentose phosphate pathways (GPPPs).

151 Loss of the pentose phosphate pathway had no effect on plaque format

152 d zwf1, which encode the first enzyme in the pentose phosphate pathway, have a more severe growth phe

153 es necessary to reduce NADP by the oxidative pentose phosphate pathway (hexokinase, glucose-6-phospha

154 rains cell proliferation, glycolysis and the pentose phosphate pathway in a catalytic-activity-indepe

155 x from glucose-6-phosphate (G6P) through the pentose phosphate pathway in egg extracts maintains NADP

156 of the Calvin-Benson-Bassham (CBB) reductive pentose phosphate pathway in Rhodobacter capsulatus are

157 of the Calvin-Benson-Bassham (CBB) reductive pentose phosphate pathway in Rhodobacter capsulatus.

158 tion via the Calvin-Benson-Bassham reductive pentose phosphate pathway in Rhodobacter capsulatus.

159 ynthetic pathway and the requirement for the pentose phosphate pathway in thiamine synthesis.

160 Physiological analysis indicated that the pentose-phosphate pathway, in particular, was poisoned b

161 Fru-2,6-BPase), and through promotion of the pentose phosphate pathway, increases NADPH production to

162 te) was associated with perturbations in the pentose phosphate pathway induced initially by colistin

163 ogenase (H6PD) is the initial component of a pentose phosphate pathway inside the endoplasmic reticul

164 the two-step conversion of glucose into the pentose phosphate pathway intermediate 6-phosphogluconat

165 sphate cyclases are enzymes that utilize the pentose phosphate pathway intermediate, sedoheptulose 7-

166 chment of Embden-Meyerhof-Parnas pathway and pentose phosphate pathway intermediates indicated high a

167 ted glucose uptake and metabolism, increased pentose phosphate pathway intermediates, with a complime

168 ase (Tps1) is responsible for regulating the pentose phosphate pathway, intracellular levels of NADPH

169 rangements in the nonoxidative branch of the pentose phosphate pathway involving transaldolase that p

170 The pentose phosphate pathway is a key route of glucose meta

171 The pentose phosphate pathway is a major site of NADPH produ

172 er these conditions, NADPH generation by the pentose phosphate pathway is impaired, but AMPK induces

173 Although the oxidative pentose phosphate pathway is important for tumor growth,

174 establish that the carbon overflow into the pentose phosphate pathway is mainly through its non-oxid

175 ial amounts of NADPH and do so even when the pentose phosphate pathway is operational.

176 The oxidative pentose phosphate pathway is required for function of th

177 ehydrogenase (G6PD), the first enzyme of the pentose phosphate pathway, is the principal intracellula

178 metabolism of glucose from glycolysis to the pentose phosphate pathway, it was hypothesized to have a

179 f cells in 5 mM glucose or inhibition of the pentose phosphate pathway maintained GSSG elevation and

180 Pentose-phosphate-pathway-mediated inhibition of cell de

181 in carbohydrate or hydroxyl acid metabolism, pentose phosphate pathway metabolites, or free fatty aci

182 l developed in this paper and applied to the pentose phosphate pathway not only incorporates reaction

183 products of glycolysis, the Krebs cycle, the pentose phosphate pathway, nucleobases, UDP-sugars, glyc

184 luding glucose and glutamine metabolism, the pentose phosphate pathway, nucleotide and fatty acid bio

185 s to the less efficient Entner-Doudoroff and pentose phosphate pathways on algal-dominated reefs.

186 resented that intermediates of the oxidative pentose phosphate pathway (OPPP) are channeled from one

187 showing that HEXOKINASE1-mediated oxidative pentose phosphate pathway (OPPP) metabolism is required

188 The oxidative pentose phosphate pathway (OPPP) provides plants with im

189 tion network of glycolysis and the oxidative pentose phosphate pathway (OPPP).

190 e in the flux of the oxidative branch of the pentose phosphate pathway (ox-PPP) in response to the PD

191 that inhibition of the oxidative arm of the pentose phosphate pathway (oxPPP) is required for antima

192 a dependence on the oxidative branch of the pentose phosphate pathway (oxPPP), and oxPPP inhibition

193 The pentose phosphate pathway plays several key roles in met

194 abolites revealed a reduction in glycolysis, pentose phosphate pathway, polyamines and nucleotides, b

195 genation elevates glycolytic flux and lowers pentose phosphate pathway (PPP) activity in mammalian er

196 A sudden increase in pentose phosphate pathway (PPP) activity, the fastest kn

197 dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway (PPP) and plays an essential r

198 R-ABL-ERK signaling in H929 cells drives the pentose phosphate pathway (PPP) and RNA biosynthesis, wh

199 two cytosolic NADPH-producing pathways, the pentose phosphate pathway (PPP) and the NADP-dependent m

200 ADP(+)/NADPH ratio controls flux through the pentose phosphate pathway (PPP) and the polyol pathway,

201 and miR-206 to direct carbon flux toward the pentose phosphate pathway (PPP) and the tricarboxylic ac

202 d and carbohydrate metabolites, particularly pentose phosphate pathway (PPP) and tricarboxylic acid (

203 cent case reports suggest a link between the pentose phosphate pathway (PPP) enzyme transaldolase (TA

204 NAD(P+)-requiring processes, especially the pentose phosphate pathway (PPP) enzyme, 6-phosphoglucona

205 y mediating fluxes through glycolysis or the pentose phosphate pathway (PPP) in an oxidative stress-d

206 increased glucose flux through the oxidative pentose phosphate pathway (PPP) in erythrocytes.

207 The oxidative pentose phosphate pathway (PPP) is crucial for cancer ce

208 emonstrate that a metabolic shift toward the pentose phosphate pathway (PPP) is necessary for NET rel

209 Here we add the pentose phosphate pathway (PPP) of T. brucei to the glyc

210 The pentose phosphate pathway (PPP) plays a critical role in

211 of the reversible nonoxidative branch of the pentose phosphate pathway (PPP) that is responsible for

212 on increases the flux of glucose through the pentose phosphate pathway (PPP) to increase nucleotide p

213 -phosphogluconate dehydrogenase (PGD) in the pentose phosphate pathway (PPP) were found to be the NAD

214 6PD) is the first, rate-limiting step in the pentose phosphate pathway (PPP), a key metabolic pathway

215 The pentose phosphate pathway (PPP), metabolism in the citri

216 revealed that metabolites in the glycolysis, pentose phosphate pathway (PPP), pyrimidine biosynthesis

217 potential by shunting nectar glucose to the pentose phosphate pathway (PPP), resulting in a reductio

218 re regulated by the supply of NADPH from the pentose phosphate pathway (PPP), the effect of transaldo

219 the supply of reducing equivalents from the pentose phosphate pathway (PPP), we studied the impact o

220 sphogluconate dehydrogenase in the oxidative pentose phosphate pathway (PPP), while 2-PG activates 3-

221 e metabolism and increased NADPH levels in a pentose phosphate pathway (PPP)-dependent manner.

222 of ribose, leading us to hypothesize that a pentose phosphate pathway (PPP)-responsive regulator med

223 cts carbon flux from the Calvin cycle to the pentose phosphate pathway (PPP).

224 s an anti-oxidant response by regulating the pentose phosphate pathway (PPP).

225 ylic acid cycle and the oxidative arm of the pentose phosphate pathway (PPP).

226 cose flux towards glycolysis relative to the pentose phosphate pathway (PPP).

227 lase (TKT), a key enzyme of the nonoxidative pentose phosphate pathway (PPP).

228 with H2O2 rapidly induces glycolysis and the pentose phosphate pathway (PPP).

229 ediates into the hexosamine biosynthesis and pentose phosphate pathways (PPP).

230 ynthesized endogenously from glucose via the pentose-phosphate pathway (PPP) in stable isotope-assist

231 The apparent connection between Sod1 and the pentose phosphate pathway prompted an investigation of m

232 nase (G6PD), the key enzyme of the oxidative pentose phosphate pathway, provides reducing equivalents

233 rate metabolism (glycolysis/gluconeogenesis, pentose phosphate pathway, pyruvate metabolism), proteas

234 ation of glyceraldehyde-3-phosphate into the pentose phosphate pathway; radC, which encodes a RecG-li

235 ion and may enhance glucose turnover via the pentose phosphate pathway rather than through glycolysis

236 demonstrates an essential role of oxidative pentose-phosphate pathway reactions in peroxisomes, like

237 as the first and rate-limiting enzyme in the pentose phosphate pathway, responsible for the generatio

238 lycine into the cytosol is observed; (b) the pentose phosphate pathways serve for biosynthesis only,

239 rnative route for directing glucose into the pentose phosphate pathway that bypasses hexokinase and t

240 utant has reduced flux through the oxidative pentose phosphate pathway that may contribute to, but is

241 otransposition, apoptosis, and the oxidative pentose phosphate pathway that these genes are involved

242 but instead of increasing the glycolysis and pentose phosphate pathway, the glucose is shunted throug

243 While NQM1 appears not to function in the pentose phosphate pathway, the interplay of NQM1 with VH

244 ently in clinical trials, on glycolysis, the pentose phosphate pathway, the tricarboxylic acid (TCA)

245 vity and redirected glucose flux through the pentose phosphate pathway, thereby conferring a selectiv

246 UDP-glucose; an alternative to the textbook pentose-phosphate pathway therefore predominates in plan

247 nt is NADPH, which is mainly produced by the pentose phosphate pathway through the actions of glucose

248 ert energy production from glycolysis to the pentose phosphate pathway to generate NADPH.

249 tes shunting of glucose-6-phosphate into the pentose phosphate pathway to generate reduced glutathion

250 hosphate is then converted by enzymes of the pentose phosphate pathway to glyceraldehyde 3-phosphate

251 ydrogenase, the TCA cycle, and the oxidative pentose phosphate pathway to obtain NADPH.

252 ,6-bisphosphatase, potentially promoting the pentose phosphate pathway to produce NADPH for antioxida

253 nverted by known enzymes of the nonoxidative pentose phosphate pathway to ribose-5-phosphate.

254 ferentially metabolized via the nonoxidative pentose phosphate pathway to synthesize nucleic acids an

255 erating in a gluconeogenic fashion), and the pentose phosphate pathways to form an unforeseen metabol

256 stressed cells protected Rpe and enabled the pentose-phosphate pathway to retain function.

257 ase in TIGAR expression, which regulates the pentose phosphate pathway, treatment with the MUC1-C inh

258 pression of lipogenesis, glycolysis, and the pentose phosphate pathway triggered a strong growth rest

259 showed that: (i) flux through the oxidative pentose phosphate pathway varied independently of the re

260 Activation of the pentose phosphate pathway was identified from the list o

261 and ribulose 5-phosphate 3-epimerase) in the pentose phosphate pathway were overexpressed, and a gera

262 nitrate assimilation, energy metabolism, and pentose-phosphate pathway were most affected.

263 ologs, RpiRc is a potential regulator of the pentose phosphate pathway, which also regulates RNAIII l

264 a methionine auxotrophy was dependent on the pentose phosphate pathway, which is a major source of NA

265 Transaldolase (TAL) is a key enzyme of the pentose phosphate pathway, which is responsible for gene

266 amental routes, glycolysis and the oxidative pentose phosphate pathway, which produces NADPH and the

267 th was potentiated by its suppression of the pentose phosphate pathway, which resulted in inhibition

268 xylic acid (TCA) cycle intermediates and the pentose phosphate pathway, which results in increased gl

269 hat a concerted preemptive activation of the pentose phosphate pathway, which targets both mRNA trans

270 produce NADPH from glucose is the oxidative pentose phosphate pathway, with malic enzyme sometimes a

271 nerated by metabolism of glucose through the pentose phosphate pathway, would have an anticonvulsant