ライフサイエンスコーパス: pentosidine

1 rmation of overall free fluorescent AGEs and pentosidine.

2 imidine levels were 10--25 times higher than pentosidine.

3 er than CML levels and 100-fold greater than pentosidine.

4 pecies scavengers decreased the formation of pentosidine.

5 rast to N(epsilon)-(carboxymethyl)lysine and pentosidine.

6 lycoxidation markers carboxymethyllysine and pentosidine.

7 ent decreased free and < 10,000 mol wt bound pentosidine.

8 Neither HD nor PD affected protein-bound pentosidine.

9 ar to the advanced glycosylation end product pentosidine.

10 ociated with 30-32% lower furosine, 9% lower pentosidine, 9-13% lower CML, 24% higher acid-soluble co

11 We have also measured pentosidine, a fluorescent AGE derived from pentose suga

12 We have quantitated pentosidine, a marker of glycoxidative stress in skin co

13 No analysed meat sample showed any traces of pentosidine above the instrumental determination limits.

14 ues within the nucleotide binding domain via pentosidine AGEs.

15 e by AGE-specific polyclonal antibodies, and pentosidine, an acid-stable fluorescent AGE.

16 ious results from our laboratory showed that pentosidine, an advanced glycation product, formed in sk

17 ecific advanced glycation end-products (anti-pentosidine and anti-pyrraline), protein modifications t

18 e sugars, and compared the concentrations of pentosidine and argpyrimidine.

19 related with the levels of renal and cardiac pentosidine and carboxymethyllysine and inversely correl

20 Blocking experiments showed that pentosidine and carboxymethyllysine formation was signif

21 onic renal failure enhances the formation of pentosidine and carboxymethyllysine via Fenton reaction

22 ohistochemical evidence for the formation of pentosidine and CML structures in human Bruch's membrane

23 centrations than the fluorescent cross-links pentosidine and dityrosine, identifying them as major Ma

24 The fact that pentosidine and imidazolysine, formed from ribose and me

25 ollagen glycation (furosine), glycoxidation (pentosidine and N(epsilon)-[carboxymethyl]-lysine [CML])

26 erted similar antiglycative capacity against pentosidine and Nepsilon-carboxyethyl-lysine, although t

27 The renal and cardiac levels of UHP, pentosidine, and carboxymethyllysine in patients with CR

28 mine the carnosine, anserine, homocarnosine, pentosidine, and thiobarbituric acid-reactive substance

29 A polyclonal anti-pentosidine antibody and a monoclonal antibody specific

30 dialysis (PD), yet plasma levels of the AGE pentosidine are significantly lower in PD than in hemodi

31 d AGEs, N(epsilon)-(carboxymethyl)lysine and pentosidine, are glycoxidation products, formed from glu

32 contained a 2-4 x greater content of the AGE pentosidine at all equilibrium time points.

33 However clearance of protein-associated pentosidine by the peritoneal membrane may explain lower

34 Pentosidine concentrations in serum and lens proteins we

35 ases in tissue fluorescence, absorbance, and pentosidine content (P < 0.001 for each comparison) by a

36 active free amine content, molecular weight, pentosidine content, and N-epsilon-carboxymethyl lysine

37 rformance liquid chromatography to determine pentosidine content.

38 (NS) whereas collagen glycation (P < 0.001), pentosidine cross-links (P < 0.001), and collagen fluore

39 Whereas pentosidine cross-links were significantly elevated in c

40 cert with Nepsilon-(carboxymethyl)lysine and pentosidine during glycoxidation of collagen in vitro, a

41 n levels of hemoglobin AGE, or tail collagen pentosidine, fluorescence, and thermal breaking time.

42 etween the accumulation of d-Asp and that of pentosidine for three normal collagenous tissues further

43 our findings, we propose a novel pathway for pentosidine formation on native proteins from glycated p

44 for a tissue-specific glycemic threshold for pentosidine formation, i.e., glycoxidation, in the lens.

45 of early glycation products are involved in pentosidine formation.

46 ere confirmed by lectin binding, and by anti-pentosidine immunoreactivity, an indicator of oxidative

47 tion products carboxymethyl-lysine (CML) and pentosidine, improved functional recovery, and increased

48 Incubation with the glycated gels produced pentosidine in a mixture of N-alpha-acetylarginine + N-a

49 r supports the idea that the accumulation of pentosidine in a particular tissue can, along with the r

50 ohistochemical evaluation showed evidence of pentosidine in Bruch's membrane, choroidal extracellular

51 anced glycation end products (AGEs) (namely, pentosidine in tail collagen and aorta, and Hb-AGE), ami

52 products Nepsilon-(carboxymethyl)lysine and pentosidine increase in skin collagen with age and at an

53 Pentosidine levels analyzed by HPLC also increased in a

54 hs, and both guanidines 1) normalized aortic pentosidine levels and renal collagenase-soluble collage

55 te levels of HbA1 (i.e., 8.0 +/- 0.4%), lens pentosidine levels were normal in this group and were el

56 reased glycated hemoglobin levels and aortic pentosidine levels.

57 /L-Asp ratios showed a good correlation with pentosidine levels.

58 nd that diabetic lens proteins produced more pentosidine on BLP than did aged lens proteins.

59 ns Maillard product 1 (LM-1) (P < 0.001) and pentosidine (P < 0.005) increased significantly with poo

60 ly NC-I and NC-II induced a 50% reduction in pentosidine (P = NS for NC-I; P = 0.035 for NC-II).

61 N(epsilon)-(carboxymethyl)-lysine (CML) and pentosidine (PENT).

62 e that reached approximately 0.17 millimoles pentosidine per mole hydroxyproline in late life (r = 0.

63 Immunoreactivity to pentosidine, pyrraline, and heme oxygenase-1 was seen in

64 0) showed a linear age-dependent increase in pentosidine that reached approximately 0.17 millimoles p

65 Pentosidine was also formed in BLP when incubated with w

66 ents on PD and HD revealed that > 95% of the pentosidine was linked to proteins > 10,000 mol wt; < 1%

67 n-containing gel was incubated with BLP, and pentosidine was measured in the incubation mixtures.

68 ation products carboxymethyllysine (CML) and pentosidine were determined by GC/MS and HPLC, respectiv

69 Mean levels of the AGEs, CML, and pentosidine were markedly elevated in WS and WIS fractio

70 l)lysine, Nepsilon-(carboxyethyl)lysine, and pentosidine were measured with liquid chromatography.