ライフサイエンスコーパス: pentraxin

1 otein Narp (from neuronal activity-regulated pentraxin).

2 Limulus C-reactive protein, the other plasma pentraxin.

3 1-27% identical to those of the large fusion pentraxins.

4 N terminus of all other known horseshoe crab pentraxins.

5 jor IgA receptor, FcalphaRI, as a ligand for pentraxins.

6 une-complex-mediated phagocytosis by soluble pentraxins.

7 Neuronal pentraxin 1 (NP1) is a pro-apoptotic protein induced by

8 Neuronal pentraxin 1 (NP1) was identified as a rat protein that m

9 Here, we investigated the role of neuronal pentraxin 1 (NP1), a member of a newly recognized subfam

10 Neuronal pentraxin 1 (NP1), a protein with exclusive CNS expressi

11 Neuronal pentraxin 1 (NP1), neuronal pentraxin 2 (NP2), and neuro

12 ns of the taipoxin-binding proteins neuronal pentraxin 1 (NP1), neuronal pentraxin 2 (NP2), and taipo

13 el members of the pentraxin family (neuronal pentraxin 1 and 2) that are expressed in the nervous sys

14 the AMPA receptor clustering factor neuronal pentraxin 1 from presynaptic terminals by signaling thro

15 ions, we show that the Id3 and NP1 (neuronal pentraxin 1) genes become transcriptionally active follo

16 Neuronal pentraxin 1 (NP1), neuronal pentraxin 2 (NP2), and neuronal pentraxin receptor (NPR)

17 roteins neuronal pentraxin 1 (NP1), neuronal pentraxin 2 (NP2), and taipoxin-associated calcium-bindi

18 We show here that neuronal pentraxin 2 (NPTX2) is overexpressed specifically in ccR

19 wth factor (2.1-fold, P = .005) and neuronal pentraxin-2 (3.0-fold, P = .029).

20 FX/SR-AI-complex comprises a third protein, pentraxin-2 (PTX2).

21 mation, including increased plasma levels of pentraxin-2 and activated antigen-presenting cells, CD4

22 he fibrocyte inhibitor serum amyloid P (SAP; pentraxin-2) significantly prolonged survival and slowed

23 Heavy chain-Hyaluronan/Pentraxin 3 (HC-HA/PTX3) is a complex purified from huma

24 Because heavy chain-hyaluronic acid/pentraxin 3 (HC-HA/PTX3) purified from human amniotic me

25 t correlated with reduction in persephin and pentraxin 3 (Pearson correlation coefficients = 0.682 an

26 gistic induction of several MMPs, activin A, pentraxin 3 (PTX-3), and IL-8.

27 e pattern-recognition receptor known as long pentraxin 3 (PTX3) has a nonredundant role in antifungal

28 The long pentraxin 3 (PTX3) has been shown to be important in mai

29 Pentraxin 3 (PTX3) is a fluid-phase pattern recognition

30 Pentraxin 3 (PTX3) is a fluid-phase pattern recognition

31 Pentraxin 3 (PTX3) is a multifunctional molecule that pl

32 Pentraxin 3 (PTX3) is a soluble pattern recognition mole

33 The long pentraxin 3 (PTX3) modulates different effector pathways

34 Baseline levels of the long pentraxin 3 (PTX3) was an independent predictor of suppr

35 Pentraxin 3 (PTX3), a prototypic long pentraxin that pla

36 he proteins inter-alpha-inhibitor (IalphaI), pentraxin 3 (PTX3), and TNF-stimulated gene-6 (TSG-6) ha

37 The long pentraxin, pentraxin 3 (PTX3), can play beneficial or detrimental r

38 Pentraxin 3 (PTX3), the prototype of long pentraxins, ha

39 Pentraxin 3 (PTX3), the prototypic long pentraxin, is a

40 of the innate immune system via miR-224 and pentraxin 3 (Ptx3).

41 ed plasma levels of markers of inflammation (pentraxin 3 and C-reactive protein) and endothelial cell

42 nes such as inducible nitric oxide synthase, pentraxin 3 and Id1; resulted in activation of mitogen-a

43 y, we show that soluble HC-HA also contained pentraxin 3 and induced the apoptosis of both formyl-Met

44 nity such as Mincle, dectin-1, dectin-2, and pentraxin 3 are strongly upregulated in DC treated simul

45 y, Jaillon et al. (2014) describe a role for pentraxin 3 molecules in complementing the host's cellul

46 ry factor, insulin-like growth factor 1, and pentraxin 3, 3 predicted targets of miR-29b.

47 tumor necrosis factor-stimulated gene 6, and pentraxin 3, all of which are necessary for normal cumul

48 for the APPs serum amyloid A, complement C3, pentraxin 3, and alpha2-antiplasmin in the liver, despit

49 ater increases in proinflammatory cytokines, pentraxin 3, and inducible nitric oxide synthase transcr

50 binds to the FH ligands C-reactive protein, pentraxin 3, and malondialdehyde epitopes.

51 ze physiological C1q ligands such as IgG and pentraxin 3, and to trigger C1r and C1s activation.

52 n via pattern recognition receptors, such as pentraxin 3, dectin-1, and Toll-like receptors, leads to

53 ive to WT transfectants, including genes for pentraxin 3, granulocyte-macrophage colony-stimulating f

54 on, such as inducible nitric oxide synthase, pentraxin 3, Id1, and scavenger receptor-A.

55 TGF-beta target genes (e.g., adrenomedullin, pentraxin 3, KN motif and ankyrin repeat domains 4, inte

56 CCL3, and CCL20, as well as the opsonin long pentraxin 3, were up-regulated during the first 2 to 6 h

57 We have recently shown that FHR-1 binds to pentraxin 3.

58 Pentraxin-3 (PTX3) analyses of sera from 87 leprosy pati

59 n this context, acute-phase proteins such as Pentraxin-3 (PTX3) are released; however, little is know

60 erleukin (IL)-1beta, IL-6, IL-21, IL-33, and pentraxin-3 (PTX3) concentrations in patients with and w

61 Pentraxin-3 (PTX3) is a member of the pentraxin family o

62 Pentraxin-3 (PTX3) is a multifactorial protein involved

63 Pentraxin-3 (PTX3) is a prototype of the long pentraxin

64 Elevated long pentraxin-3 (PTX3) levels are associated with the develo

65 isoprostanes changed by -3.0% and -9.7%, and pentraxin-3 changed by +50.6% and -11.0% in the placebo

66 to improve upon clinically available tests: pentraxin-3 in giant cell arteritis and Takayasu's arter

67 mong biomarkers to assess clinical activity, pentraxin-3 is perhaps the most promising, but its valid

68 ent HC.HA complexes that are cross-linked by pentraxin-3) and that this occurs via the formation of c

69 ttern recognition receptors, including TLR9, pentraxin-3, and lectin-like oxidized LDL receptor-1, wa

70 e proteins, inter-alpha-inhibitor (IalphaI), pentraxin-3, and TNF-stimulated gene-6 (TSG-6), driving

71 inal proendothelin-1, adjusted P<0.0001, and pentraxin-3, P=0.01) after adjusting for possible confou

72 6), the enzyme that transfers HCs to HA, and pentraxin-3, which further stabilizes the matrix.

73 anes, and 3) inflammation assessed by plasma pentraxin-3.

74 Like immune complex, pentraxin aggregation and opsonization of pathogen resul

75 s of the protomer, and the C terminus of the pentraxin alpha-helix 169-176, particularly Tyr(175).

76 This long pentraxin also failed to bind to products of the interac

77 of GPR56/ADGRG1, an aGPCR with two domains [pentraxin and laminin/neurexin/sex hormonebinding globul

78 ntified the first putative integral membrane pentraxin and named it neuronal pentraxin receptor (NPR)

79 C-reactive protein (CRP) is a unique serum pentraxin and the prototype acute phase reactant.

80 Although conceptually separated, both pentraxins and antibodies are important factors in contr

81 ce suggests a direct link between the innate pentraxins and humoral Fc receptors.

82 nderstanding of the origins and evolution of pentraxins and innate immunity is discussed.

83 st demonstration of heteromultimerization of pentraxins and release of a pentraxin complex by proteol

84 orylethanolamine-agarose, which isolates the pentraxins and separates limulin from the other sialic a

85 l and functional work that bridge the innate pentraxins and the adaptive Fc receptor functions.

86 Pentraxins are a family of ancient innate immune mediato

87 Pentraxins are acute-phase proteins that belong to a fam

88 Mutational and binding studies show that pentraxins are diverse in their binding specificity for

89 Pentraxins are innate pattern recognition molecules whos

90 Pentraxins are major proteins of the innate immune syste

91 cture and the discovery that both prototypic pentraxins are present in Limulus raises the possibility

92 ynaptogenic activity of NP1 by forming mixed pentraxin assemblies.

93 phaRI both in solution and on cells, and the pentraxin binding site on the receptor appears distinct

94 Plasma that was depleted in the pentraxins by passage over phosphorylethanolamine-agaros

95 The pentraxin C-reactive protein (CRP), an innate immune sys

96 o investigate whether FHR-1 binds to another pentraxin, C-reactive protein (CRP), analyze the functio

97 The related pentraxin, C-reactive protein (CRP), is a strong acute-p

98 xin signature" sequence and a characteristic pentraxin calcium-binding domain.

99 In many ways, pentraxins can be regarded as innate antibodies.

100 ltimerization of pentraxins and release of a pentraxin complex by proteolysis.

101 eport that native Narp in brain is part of a pentraxin complex that includes NP1.

102 mic NPCD isoforms are composed of a neuronal pentraxin domain (formerly thought exclusively extracell

103 ciation of Kv4.2 with a protein containing a pentraxin domain (PPTX).

104 mGluR1/5), TACE cleaves NPR and releases the pentraxin domain from its N-terminal transmembrane domai

105 this peptide and a conserved portion of the pentraxin domain that is involved in the homo- and heter

106 s, while their closely homologous C-terminal pentraxin domains mediate association with AMPA-type glu

107 immune system (e.g., complement C1q and C3, pentraxins, Dscam), members of the major histocompatibil

108 early gene Narp (neuronal activity-regulated pentraxin) encodes a secreted synaptic protein that can

109 Because members of the collectin and pentraxin families of serum proteins bind to blebs on ap

110 e previously identified novel members of the pentraxin family (neuronal pentraxin 1 and 2) that are e

111 Pentraxin-3 (PTX3) is a member of the pentraxin family of innate immune regulators, which incl

112 serum amyloid P component are members of the pentraxin family of oligomeric serum proteins which has

113 C-reactive protein (CRP) is a member of the pentraxin family of proteins and an acute phase reactant

114 lectins is limulin, which is a member of the pentraxin family of proteins and is found in the plasma

115 amyloid P component (SAP) is a member of the pentraxin family of proteins.

116 normal serum components which belong to the pentraxin family of proteins.

117 equence indicates homology to members of the pentraxin family of secreted lectins that include C-reac

118 non-fibrillar glycoprotein belonging to the pentraxin family of the innate immune system.

119 More recently, members of the pentraxin family were found to interact with cell-surfac

120 SAP, a member of the pentraxin family, binds to Fcgamma receptors and modifie

121 ysis shows that PPTX is a member of the long pentraxin family, is 53% identical to mouse PTX3, and ha

122 P), a member of the evolutionarily conserved pentraxin family, is a normal component of a number of b

123 Serum amyloid P (SAP) is a member of the pentraxin family.

124 consistent with the lectin properties of the pentraxin family.

125 ctin structure to be determined, reveals the pentraxin fold and a novel doubly stacked octameric ring

126 The serum-amyloid-P-component-like pentraxin from Limulus polyphemus, a recently discovered

127 entraxin-3 (PTX3) is a prototype of the long pentraxin group.

128 An invertebrate SAP-like pentraxin has not previously been identified and it has

129 Pentraxin 3 (PTX3), the prototype of long pentraxins, has been described to be associated with end

130 ning 35 calcium exchanger beta repeats and a pentraxin homology domain.

131 Promoter hypermethylation of neuronal pentraxin II (NPTX2), a risky methylated gene, was confi

132 Nptx2 encodes neuronal pentraxin II (or neuronal activity-regulated pentraxin,

133 yloid P component (SAP), two major classical pentraxins in humans, are soluble pattern recognition mo

134 broader role than complement activation for pentraxins in immunity.

135 to activate FcalphaRI defines a function for pentraxins in inflammatory responses involving neutrophi

136 ct the localization and function of neuronal pentraxins in neuronal uptake or synapse formation and r

137 esults establish antibody-like functions for pentraxins in the FcgammaR pathway, suggest an evolution

138 ber of a newly recognized subfamily of "long pentraxins," in the HI injury cascade.

139 The classical pentraxins include serum amyloid P component (SAP) and C

140 ular, high-sensitivity C-reactive protein, a pentraxin innate immune recognition molecule and classic

141 Narp (neuronal activity-regulated pentraxin) is a secreted immediate-early gene (IEG) regu

142 Pentraxin 3 (PTX3), the prototypic long pentraxin, is a soluble pattern recognition receptor inv

143 previously unidentified domain that we term Pentraxin/Laminin/neurexin/sex-hormone-binding-globulin-

144 iencies of the classical pathway and certain pentraxins lead to impaired handling of apoptotic cells

145 The serum amyloid P component (SAP)-like pentraxin Limulus polyphemus SAP is a recently discovere

146 The use of FcgammaR by the pentraxins links innate and adaptive immunity and may ha

147 tory leukoprotease inhibitor (SLPI), elafin, pentraxin, LL-37, alpha-defensins and beta-defensin-2, a

148 a1 and alpha4beta1 integrins, the N-terminal pentraxin module of thrombospondin-1 is a ligand for alp

149 and is derived from a similar position in a pentraxin module.

150 secretion of the neuronal activity-regulated pentraxin (Narp) by hippocampal axons is restricted to c

151 Neuronal activity regulated pentraxin (Narp) has been implicated in the aggregation

152 Neuronal activity regulated pentraxin (Narp) is a secreted neuronal product which cl

153 diate early gene neuronal activity-regulated pentraxin (NARP) is an alpha-amino-3-hydroxy-5-methyl-4-

154 ic strength, the neuronal activity-regulated pentraxin (Narp), and glutamate decarboxylase (GAD65).

155 pentraxin II (or neuronal activity-regulated pentraxin, Narp), which is involved in the clustering of

156 distinguishes it as the first serum-related pentraxin not expressed in the liver.

157 ere, we report that a member of the neuronal pentraxin (NP) family, neuronal pentraxin receptor (NPR)

158 over, we show that axonally derived neuronal pentraxins NP1 and NPR are required for GluR4 recruitmen

159 We hypothesized that neuronal pentraxin (NP1), a proapoptotic protein induced by low n

160 Neuronal pentraxins (NPs) are hypothesized to play important role

161 Neuronal pentraxins (NPs) define a family of proteins that are ho

162 Neuronal pentraxins (NPTX) and their corresponding receptors (NPT

163 imulus C-reactive protein, the most abundant pentraxin of the plasma.

164 anisms that parallel the known role of short pentraxins outside the CNS.

165 The long pentraxin, pentraxin 3 (PTX3), can play beneficial or de

166 Human serum amyloid P component, a pentraxin protein that is very closely related to CRP, s

167 ng concentrations of the constitutive plasma pentraxin protein, serum amyloid P component (SAP), in s

168 Relative deficiency of pentraxin proteins is implicated in the pathogenesis of

169 strate the existence of a separate family of pentraxin proteins that are expressed in the human brain

170 cavenger receptor cysteine rich (SRCR); (ii) pentraxin (PTX); (iii) polycystine-1, lipoxygenase, alph

171 aeruginosa strain and treated with the long pentraxin PTX3.

172 1), neuronal pentraxin 2 (NP2), and neuronal pentraxin receptor (NPR) are members of a new family of

173 the neuronal pentraxin (NP) family, neuronal pentraxin receptor (NPR), undergoes regulated cleavage b

174 ral membrane pentraxin and named it neuronal pentraxin receptor (NPR).

175 Specifically, both human and mouse pentraxins recognize major forms of Fc receptors in solu

176 We have proposed that these three neuronal pentraxins represent a novel neuronal uptake pathway tha

177 ere we describe the structural mechanism for pentraxin's binding to FcgammaR and its functional activ

178 id sequence, the first invertebrate SAP-like pentraxin sequence, have been determined.

179 presented here and the known horseshoe crab pentraxin sequences, suggest that adaptation and refinem

180 studies demonstrated that PTX3 and the short pentraxin serum amyloid P express sialic acids that are

181 The pentraxins, serum amyloid P component (SAP) and C-reacti

182 Regions of homology include an 8 amino acid "pentraxin signature" sequence and a characteristic pentr

183 RNAi knockdown and knockout of the neuronal pentraxins significantly decreases GluR4 targeting to sy

184 om Limulus polyphemus, a recently discovered pentraxin species and important effector protein of the

185 nding to phosphocholine, is established as a pentraxin species distinct from all other known horsesho

186 hemus SAP is a recently discovered, distinct pentraxin species, of known structure, which does not bi

187 entified a calcium-dependent lectin from the pentraxin superfamily in the egg jelly coat from the Sou

188 Pentraxin 3 (PTX3), a prototypic long pentraxin that plays a non-redundant role in innate immu

189 distinct from all other known horseshoe crab pentraxins that exist in many variant forms sharing a hi

190 vities have been attributed to SAP and other pentraxins, their biological functions remain unclear.

191 Pentraxin then accumulates AMPA receptors on the postsyn

192 Pentraxin three, a regulator of innate immunity and neur

193 A possible role of pentraxins to maintain extracellular proteostasis is dis

194 e role of these receptors in phagocytosis by pentraxins using zymosan as a ligand.

195 el class of protein, which we named neuronal pentraxin with chromo domain (NPCD), as a PTPRO-interact

196 This novel protein, NPCD (Neuronal Pentraxin with Chromo Domain), has multiple cytoplasmic

197 Phylogenetic analysis clusters Limulus SAP pentraxin with the horseshoe crab C-reactive proteins (C

198 ium-binding site is similar to that in human pentraxins, with two calcium ions bound in each subunit.