ライフサイエンスコーパス: pentyl

1 o the silica surface from C1 (methyl) to C5 (pentyl).

2 m the aliphatic C-H bonds of a series of 1-Z-pentyl, 1-Z-propyl, and Z-cyclohexyl derivatives and of

3 For example, 12-pentyl-1, 12-dicarba-closo-dodecaborane-1-carboxylic aci

4 entricular M40 with intraperitoneal 3-(3-S-n-pentyl-1,2,5-thiadiazol-4-yl)-1,2,5, 6-tetrahydro-1-meth

5 , and the best-in-class compound, 4-methyl-1-pentyl-1H-benzo[d]imidazol-2-amine, was found to be a pu

6 or 5-chloro-N-(4-(dimethylamino)phenethyl)-3-pentyl-1H-indole-2-carboxamide (11j) was identified.

7 synthesized using (19)F-labeled 2-(5-fluoro-pentyl)-2-methyl malonic acid ((19)F-FPMA) as the labeli

8 dolisation products, 2-butyl-2-octenal and 2-pentyl-2-nonenal, were detected from the interactions be

9 ,6S)-2, 6-dimethyltetrahydro-1(2H)-pyridinyl]pentyl]-2-phenyl-2H-1, 4-benzoxazin-3(4H)-one (1a) as an

10 nalogous dyads based on a zinc 5,10,15-tri(n-pentyl)-20-phenylporphyrin donor show that, for a given

11 ly linked, fixed-distance zinc 5,10,15-tri-n-pentyl-20-phenylporphyrin-NMI-Fe(2)S(2)(CO)(6) donor-acc

12 eries include 5-methoxy-3-(2-methylbenzyl)-7-pentyl-2H-chromen-2-one (19a, PSB-SB-1201), a selective

13 0.022 muM), 5-methoxy-3-(2-methoxybenzyl)-7-pentyl-2H-chromen-2-one (21a, PSB-SB-1202), a dual CB(1)

14 t of coconut and dried figs as 5,6-dihydro-6-pentyl-2H-pyran-2-one (C10 massoia lactone).

15 The new ET primers have 3-(epsilon-carboxy-pentyl)-3'ethyl-5,5'-dimethyloxacarbocyanine (CYA; epsil

16 The 1-pentyl-3-benzoylindole is characterized by the strong in

17 The base peak at m/z 214 in the 1-n-pentyl-3-benzoylindole represents the M-77 cation fragme

18 ,6S)-2, 6-dimethyltetrahydro-1(2H)-pyridinyl]pentyl]-3-oxo-3,4-dihydro-2H- 1,4-benzoxazin-2-yl)-1-ben

19 3-[4-[5-((2S,6R)-2,6-dimethylpiperidin-1-yl)pentyl]-3-oxo-3,4-dihydroquino xolin-2-yl]benzamidine (3

20 Pentyl 4-(N-doxazolidinylcarbonyloxymethyl)phenylcarbama

21 derivative N-(piperidin-1-yl)-5-phenyl-1-(n-pentyl)-4-methyl-1H-pyrazole-3-carboxamid e (AM263).

22 and dynamics of two 40-nm thick films of 4-n-pentyl-4'-cyanobiphenyl (5CB), a nematic liquid crystal,

23 l interface of a nematic material, namely, 4-pentyl-4'-cyanobiphenyl (5CB).

24 for the case of the liquid crystalline oil 4-pentyl-4'-cyanobiphenyl (5CB).

25 entation of a liquid-crystalline film of 4-n-pentyl-4'-cyanobiphenyl was conducted in a new experimen

26 ing energies of benzonitrile, a model for 4'-pentyl-4-biphenylcarbonitrile, and dimethyl methylphosph

27 morphous film of 5,11-bis(3-methoxyphenyl)-6-pentyl-5,11-dihydroindolo[3,2-b]carbazole exceed 10(-3)

28 lly related to cannabinol (6,6,9-trimethyl-3-pentyl-6 H-benzo[ c]chromen-1-ol), a natural constituent

29 analogous sensitivity to the corresponding 1-pentyl-7-aminophenoxazin-3-one substrate 1 used commerci

30 e ligand, 2,4-bis(2,6-diisopropylphenylimido)pentyl; Ad = 1-adamantyl).

31 5 with allyl, cyclopropylmethyl, propyl, or pentyl alcohol catalyzed by K(2)CO(3) afforded O(6)-alky

32 iables (14 compounds), including lactones (6-pentyl-alpha-pyrone, gamma-decalactone, gamma-dodecalact

33 opentyl amidine substituents and DB226 has 3-pentyl amidines.

34 und to carrier proteins via the reducing end pentyl amine linker, to explore their antigenic and immu

35 enient access to chiral alpha-substituted (3-pentyl)amines.

36 o-1-[[4-(4-pyridinyl)-1-piperazinyl]carbonyl]pentyl]amino]-1-[ (3,5-dibromo-4-hydroxyphenyl)methyl]-2

37 o-l-[[4-(4-pyridinyl)-l-piperazinyl]carbonyl]pentyl]amino]-1-[(3,5-d ibromo-4-hydroxyphenyl)methyl]-2

38 ipophilic) and 3-fold more potent than the 1-pentyl analog (less lipophilic), indicating that, in add

39 With 1-pentyl and 1-propyl derivatives, alpha-CH2 activation to

40 -A 2B 2- or cis-A 2BC-porphyrins wherein A = pentyl and B/C = pyridyl ( o-, m-, p-).

41 R)H, where R = methyl, ethyl, propyl, butyl, pentyl, and hexyl, to generate RH and Tp'Rh(L)(C(6)D(5))

42 ing substituents (methyl, ethyl, n-propyl, n-pentyl, and phenyl) at the C-1 position of the cocaine t

43 xylate anion does not afford 1-bicyclo[1.1.1]pentyl anion as previously assumed.

44 A 1-bicyclo[1.1.1]pentyl anion was prepared nevertheless via the fluoride-

45 , or five methylene units (propyl, butyl, or pentyl) at C-5 were prepared and tested as reporter prob

46 biphenyl (5CB) and 4'-(3,4-difluor-phenyl)-4-pentyl-bicylohexyl (5CF) molecules partitioning into a d

47 In this system, 4-cyano-4'-pentyl biphenyl (5CB) was doped with a sulfur- and nitro

48 ngeners of pentamidine in which the flexible pentyl bridge of pentamidine was replaced by trans-1,2-b

49 Simple butyl and pentyl, but not ethyl, carbamate prodrugs inhibited the

50 yl-butyl-carbamate (34) and 2-ethyl-3-methyl-pentyl-carbamate (38) also exhibited potent activity in

51 form [(PNP)Ti(eta(2)-H2C horizontal lineCH(n)Pentyl)(CH2(t)Bu)] (6) and [(PNP)Ti(eta(2)-H2C horizonta

52 changing the length and branching of the end pentyl chain (C5H11) of anandamide (AN), various analogs

53 Like the THCs, the branching of the end pentyl chain in AN (1e-h) increased potency both in in v

54 It was shown that the SAR of the end pentyl chain in AN is very similar to that of THCs.

55 f the methyl group than the methylene of the pentyl chain, in excellent agreement with the previous e

56 ic activators of PKCepsilon, such as 8-(2-(2-pentyl-cyclopropylmethyl)-cyclopropyl)-octanoic acid met

57 cond group consists of alpha-butyl and alpha-pentyl dibenzyl ketones that yield equimolar amounts of

58 d enol ether chain with a maximum ee for the pentyl enol ether.

59 entenes occurs at a slower rate and leads to pentyl ester covalently bound to the surface.

60 e(2)NN](-) = 2,4-bis(2,6-dimethylphenylimido)pentyl} gives {[Me(2)NN]Ni}(2)(mu-eta(2):eta(2)-ONAr) (1

61 ompared to its tert-butyl analogue, the tert-pentyl group has been found to improve enantioselectivit

62 In particular, the tert-pentyl group of this ligand was systematically replaced

63 a derivative of this analogue lacking the n-pentyl group was produced, consistent with a RedG cataly

64 the p-anisyl group of 1 was replaced by an n-pentyl group, the resultant antagonist 3 exhibited subst

65 tert-Pentyl groups are recognized to be highly effective ster

66 ed orientations of its phosphonic acid and 3-pentyl groups in the NA active site as inferred from the

67 rent from that of a porphyrin bearing linear pentyl groups.

68 enylethyne linker and bear swallowtail (or n-pentyl) groups at the nonlinking meso positions.

69 e labile hydrocarbon in Tp'Rh(CNneopentyl)(n-pentyl)H or Tp'Rh(CNneopentyl)(CH3)H.

70 The synthetic compounds contained pentyl, hexyl, or hexanoyl and octyl lipid chains at the

71 hyldesferrithiocin, N-[5-(acetylhydroxyamino)pentyl]hydroxamate (3); desmethyldesferrithiocin, N-benz

72 ro-3-(1'-2"-R-hydroxy-3'N-(5-amino-1-carboxy pentyl)iminodiacetic acid)propyl ether (DHGN).

73 -ethyl) or potent opioid agonist activity (N-pentyl) in morphinan-like ligands which interact with th

74 or four alkyl groups (ethyl, propyl, butyl, pentyl), in which case microwave irradiation was used fo

75 ed by FTIR spectroscopy for methyl through n-pentyl isocyanide bound to a series of 20 different dist

76 Dendrimers constituted with n-pentyl linker were found to afford higher solubilities o

77 [3H-4,5-pentyl]MNAN and [3H-2,3-pentyl]-MNAN were synthesized, p

78 [3H-4,5-pentyl]MNAN and [3H-2,3-pentyl]-MNAN were synthesized, purified, and incubated w

79 connect the branch junctures from ethyl to n-pentyl moiety (C(2)G3-C(5)G3).

80 4S)-[4-amino-5-[2-(2-aminoethyl)phenylamino]-pentyl]-N'-nitroguanidine (17) (K(i) = 50 nM), which als

81 itors, (4S)-N-{4-amino-5-[(2-aminoethylamino]pentyl}-N'-nitroguanidine (1) and 4-N-(Nomega-nitro-l-ar

82 sq)2 (3, X = Cl, Br, I; disq- = N,N'-bis(neo-pentyl)-ortho-diiminosemiquinonate) in which each redox-

83 omplex, [Zr(pda)2]n (1, pda2- = N,N'-bis(neo-pentyl)-ortho-phenylenediamide, n = 1 or 2), prepared by

84 ers contain one or two thermolabile, 4-oxo-1-pentyl (OXP) phosphotriester (PTE) modification groups a

85 ydroxy-4- methyl-1-oxo-2-[(1-oxopropyl)amino]pentyl]oxy]-L-leucyl-N,O-dimethyl-,(7-->1)-lac tone (9CI

86 Pentyl PABC-Doxaz (PPD) is a Doxaz carbamate prodrug tha

87 Pentyl PABC-Doxaz (PPD) is a prodrug of Doxaz that is ac

88 primers with one or two thermolabile 4-oxo-1-pentyl phosphotriester modifications in improving multip

89 sisting of four zinc 5-phenyl-10,15,20-tri(n-pentyl)porphyrins (Z3PN) attached to the 1,7,N,N'-positi

90 ligand design led to the identification of 3-pentyl-quinoline-2-amine as a novel, human TLR8-specific

91 ron affinity of 3-tert-butyl-1-bicyclo[1.1.1]pentyl radical (14.8 plus minus 3.2 kcal/mol) was measur

92 intensity at 1681 cm(-1) in the 1-benzoyl-3-pentyl regioisomer.

93 ionships regarding the highly functionalized pentyl side chain attached at C-3 of mithramycin (MTM),

94 of the MTM biosynthesis, a keto group of the pentyl side chain is reduced to a secondary alcohol, and

95 to bind to the DNA, alteration of the MTM 3-pentyl side chain led to a compound (mithramycin SK) wit

96 9-THC, (3) the five terminal carbons and the pentyl side chain of delta9-THC, and (4) the polyolefin

97 r cleavage reactions of the initially formed pentyl side chain with a reactive beta-dicarbonyl functi

98 ially, highlighting that the position of the pentyl substituent can be varied while maintaining detec

99 For example, the 2-pentyl substituted aminophenoxazin-3-one 22b performed w

100 se inhibitors that comprise rare N-hydroxy-2-pentyl-succinamic acid warheads.

101 lane via synthesis of N,N'-bis(bicyclo[1.1.1]pentyl)sulfamide and azoxybicyclo[1.1.1]pentane.

102 n, there is an increasing preference for the pentyl tail of Delta(8)-THC to bend toward the tricyclic

103 s possessing bulky N-substituents (e.g., neo-pentyl, tert-butyl, etc.) were stable in the solid-state

104 activity occurring for the butyl (TLR-7) and pentyl (TLR-8) derivatives.

105 contrast, no enhancement in potency for the pentyl to DMH side chain exchange was seen in the mouse

106 2-(3-(1-carboxy-5-(4-(211)At-astatobenzamido)pentyl)ureido)-pentanedioic acid ((211)At- 6: ) was synt

107 ((S)-1-carboxy-5-((4-(123)I-iodobenzyl)amino)pentyl)ureido)pentanedioic acid, (123)I-MIP-1072, target

108 (S)-2-(3-((S)-1-carboxy-5-(4-iodobenzylamino)pentyl)ureido)pentanedioic acid, and MIP-1095, (S)-2-(3-

109 2-(3-((S)-1carboxy-5-(3-(4-iodophenyl)ureido)pentyl)ureido)pentanedioic acid, were selected for furth

110 rsatile intermediate 2-[3-(5-amino-1-carboxy-pentyl)-ureido]-pentanedioic acid (Lys-C(O)-Glu), which

111 [(5-[(125)I]iodo-pyridine-3-carbonyl)-amino]-pentyl]-ureido)-pe ntanedioic acid ([(125)I]8) in 65-80%

112 [3-[1-carboxy-5-(4-(125)I-iodo-benzoylamino)-pentyl]-ureido]-pentanedioic acid ((125)I-DCIBzL) was sy

113 3-[1-carboxy-5-(4-[(125)I]iodo-benzoylamino)-pentyl]-ureido]-pentanedioic acid ([(125)I]3), 2-[3-[1-c

114 -[1-carboxy-5-(4-[(18)F]fluoro-benzoylamino)-pentyl]-ureido]-pentanedioic acid ([(18)F]6), and 2-(3-[

115 [(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-p entanedioic acid) and more recently (1

116 oxy-5-[(6-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-pentaned ioic acid (DCFPyL), PSMA-617, P

117 9 emu g(-1)), which can effectively catalyze pentyl valerate esterification and be easily separated b