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1 of West Nile virus (WNV) genomic RNA form a penultimate 16-nt small stem-loop (SSL) and an 80-nt ter
4 rtion of Nox2 domains, we show here that the penultimate 22 amino acids of Nox4 are involved in const
6 in gpD is essential for the packaging of the penultimate 8-10 kb (15-20%) of the viral genome; virtua
9 The overhang residues are looped out and the penultimate adenines of the two residues at the top end
10 he presence of a D-methyl substituent on the penultimate alanine residue of the cell wall peptide.
11 as the potential to truncate proteins with a penultimate alanine, proline, or other selective amino a
13 surface of TBP, which in turn positions the penultimate alpha helix of NC2beta to block recognition
17 ase (CF1) is quenched when cysteine 322, the penultimate amino acid of the gamma subunit, is specific
18 structural basis for the contribution of the penultimate amino acid of the peptide ligand to the affi
23 nteractions involving the side chains of the penultimate amino acids of the peptide ligands, whereas
24 tional homodimeric enzyme that catalyzes the penultimate and final steps of de novo purine nucleotide
25 hat are responsible for the catalysis of the penultimate and final steps of the purine de novo synthe
26 lkylamine N-acetyltransferase (AANAT) is the penultimate and key regulatory enzyme in the melatonin b
27 cin and also of L-gulonolactone oxidase, the penultimate and last (also rate-limiting) steps in the s
28 extensive folding cooperativity between the penultimate and terminal base pair, which is independent
29 rmation and cooperativity arises because the penultimate and the ultimate folding transitions in the
30 een N-terminal aspartates and the C-terminal penultimate arginine as well as N-terminal hydrogen-bond
31 substrates and cleaves substrates containing penultimate asparagine, glutamine, isoleucine, leucine,
33 ase encounters an abasic site, we varied the penultimate base pairs (PBs) adjacent to the abasic site
34 he penultimate instar caused a repeat of the penultimate br expression patterns, and the formation of
36 initial endoribonucleolytic cleavage at the penultimate C residue of the tRNA primer yet does not su
37 eactive indolenine C2 oxidation state from a penultimate C21 functionalized Aspidosperma-like pentacy
39 acyl synthase domain in cooperation with the penultimate carboxyl-terminal acyl carrier protein domai
42 leaving enzyme 1 (BACE1) is required for the penultimate cleavage of the amyloid-beta precursor prote
43 position and positioning of the ultimate and penultimate codons of the tmRNA ORF play a crucial role
46 lated by reversible glutathionylation of the penultimate cysteine mediated by growth factor stimulati
48 der multimers (via disulfide bonding between penultimate cysteine residues) resulted in proteins havi
50 pimelate (DAP) moiety of one peptide and the penultimate D-alanine of another peptide or between two
52 rejection of the D-methyl substituent of the penultimate D-alanine residue of the DD-peptidase substr
54 nvolves acyl-transfer chemistry in which the penultimate (D)Ala first acylates the active-site serine
56 e consistent with such an early date for the penultimate deglaciation are either the variability of t
57 of fossil corals, that sea level during the penultimate deglaciation had risen to ~85 meters below t
61 or sediment mixing, the midpoint age for the penultimate deglaciation is determined to be 135 +/- 2.5
64 brupt changes in tropical climate during the penultimate deglaciation, coincident with North Atlantic
67 ic herbicide that inhibits competitively the penultimate enzyme 5-enolpyruvylshikimate 3-phosphate sy
69 lamine N-acetyltransferase (Aanat) mRNA, the penultimate enzyme in melatonin synthesis, and it exhibi
70 is controlled by cAMP through actions on the penultimate enzyme in melatonin synthesis, arylalkylamin
73 l-3-Hydroxyacyl-CoA dehydrogenase (HAD), the penultimate enzyme in the beta-oxidation spiral, reversi
74 e GNAT acetyltransferase superfamily, is the penultimate enzyme in the conversion of serotonin to mel
75 racterized by markedly reduced levels of the penultimate enzyme in the heme biosynthetic pathway, pro
77 lalkylamine N-acetyltransferase (AANAT), the penultimate enzyme in the melatonin pathway (serotonin -
82 underwent alternative splicing, although the penultimate exon deleted variant appeared mainly in cell
83 nucleotides (nt) of exon 22 in mouse and the penultimate exon in both human (exon 21) and mouse (exon
84 ed to pursue direct Sanger sequencing of the penultimate exon of DVL1 and its paralogs DVL2 and DVL3
85 racterized by being uniformly located in the penultimate exon of DVL1 and resulting in a -1 frameshif
87 nse variant (c.2737C>T [p.Arg913Ter]) in the penultimate exon of ZSWIM6 who have severe-profound inte
88 All mutations were located in the last or penultimate exon, suggesting escape from nonsense-mediat
89 5-azacytidine inhibited the deletion of the penultimate exon, whereas two indolocarbazole-derived in
90 o truncating PPM1D mutations in the last and penultimate exons cause syndromic ID, which provides add
91 re termination codons within the terminal or penultimate exons that are not subject to nonsense-media
93 -methylglucuronate moiety linked to a xylose penultimate from the reducing terminal xylose and some n
94 ade by the glycosidic oxygen and 4-OH of the penultimate galactose, that is complementary to the hydr
95 e human enzyme cleaves both the ultimate and penultimate gamma-linkages of methotrexate polyglutamate
96 ch age control has been lacking for even the penultimate glacial termination (T-II), which culminated
97 nd eMed hydrographic variability through the penultimate glacial termination (TII) and last interglac
98 a sedimentary archive from the lake over the penultimate glacial-interglacial transition (MIS 6-5) an
100 , reversible tyrosination and removal of the penultimate glutamate from alpha-tubulin, and phosphoryl
103 s cotranslationally via an amide bond to the penultimate glycine residue within the canonical motif (
104 on and enhanced methane emissions during the penultimate Heinrich event, the Bolling and Allerod inte
105 that include the extended loop prior to the penultimate helix, the extended Omega-loop, and a beta-h
108 e intein N-terminus and the conserved intein penultimate His are absent in the KlbA family of inteins
109 arose by mutation from ancestors in which a penultimate His facilitated splicing, (ii) that loss of
115 However, substitution of an alanine for the penultimate histidine residue, with either asparagine or
116 h can cleave methionine from substrates with penultimate histidine, asparagine, glutamine, leucine, m
119 1348 The Carboniferous, the time of Earth's penultimate icehouse and widespread coal formation, was
121 ive isoforms are weakly expressed during the penultimate instar and highly expressed during the prepu
122 prene, a juvenile hormone analog, during the penultimate instar caused a repeat of the penultimate br
123 engineering substitutions at both the +1 and penultimate intein positions, we have further characteri
126 h-latitude stadials and interstadials of the penultimate interglacial and the last deglaciation.
128 ting groups were removed by treatment of the penultimate intermediate 65 with TAS-F (tris(dimethylami
129 l fluoride 3, and the global desilylation of penultimate intermediate 77 mediated by in situ generate
132 transfer of this acyl moiety by CouN7 to the penultimate intermediate in coumermycin A1 assembly comp
133 H(2) bound to FeMo-co and corresponds to the penultimate intermediate of N(2) hydrogenation, the stat
134 d the utility of functionalized boronates as penultimate intermediates in the synthesis of diverse co
136 ng read the paper by Oikarinen et al. in the penultimate issue of Insights into Imaging, the author d
139 ucylblasticidin S (LBS) was suggested as the penultimate metabolite with 20-fold less inhibitory acti
140 thermore, we show that a substitution in the penultimate MftA Val-29 position causes the accumulation
142 toward styrene is greatly improved when the penultimate monomer on the growing polymer chain is styr
143 lactose, which is the most commonly observed penultimate monosaccharide to SA, may mediate AAV9 trans
144 nd various small amino acids residues at the penultimate N-terminal position were prepared via solid-
149 cate that side chains that interact with the penultimate nucleotide (Q419, N420, and Y423) are import
150 erminants that allows the positioning of the penultimate nucleotide at the polymerization active site
155 e relative importance of sialic acid and the penultimate oligosaccharide sequence on binding affinity
158 olpyruvate synthase intein improved when its penultimate Phe was changed to His, but splicing of the
159 Bn-related agonists, with the presence of a penultimate phenylalanine being critical for high-affini
161 of gene 5 protein, and an oxygen atom on the penultimate phosphate diester of the primer strand.
164 cent transcript stimulates hydrolysis of the penultimate phosphodiester bond by providing active grou
165 n is through the association of Shc with the penultimate phosphotyrosine within the TPO receptor, Mpl
166 ratified by ancestry, time to progression on penultimate platinum, and response to most recent platin
167 status, progression-free interval after the penultimate platinum-based regimen, and best response to
168 system, stratified by time to progression on penultimate platinum-based regimen, response to the most
169 Placing the C-terminal phenylalanine in the penultimate position also results in loss of function.
170 eaves selected amino acids at the N-terminal penultimate position and has the potential to alter the
172 elenocysteine residue that is located in the penultimate position at the carboxyl terminus and which
173 rtant, and the charged residue (R227) in the penultimate position in the mouse hepatitis coronavirus
174 strictly conserved cysteine (Cys111) at the penultimate position in the sequence forms an intramolec
178 terminal position or, alternatively, in the penultimate position with galactose in the terminal posi
181 nd serves multiple functions in cleaving the penultimate positioned prolyl bonds at the NH(2) terminu
182 ion of two residues (Glu-145 and Ser-146) at penultimate positions in this chain rescued dimer format
183 an additional step beyond production of the penultimate precursor GA9 mediated by the homologous ope
184 uced by methylseleninic acid (MSeA), a novel penultimate precursor of the putative critical anticance
186 efficient large-scale synthesis of acid 1, a penultimate precursor to the HCV NS5A inhibitor BMS-9860
187 r/Phe is positioned between the terminal and penultimate primer bases and (b) the phenolic OH group i
190 tion of 6, 7-dimethyl-8-ribityllumazine, the penultimate product in the synthesis of riboflavin.
194 gradation, the present results indicate that penultimate proline residues also are an important means
195 of a neuropeptide database that illustrates penultimate proline residues are frequently found in neu
196 ugh it is commonly proposed that the role of penultimate proline residues is to protect peptides from
197 ere performed on two model peptides in which penultimate proline residues were known to be important
198 e second position from the N-terminus (i.e., penultimate proline) frequently adopt multiple conformat
200 roteins with substitutions in the N-terminal penultimate residue as well as deletion of the CP "gate"
201 e removal of the initiator methionine if the penultimate residue has a small radius of gyration (glyc
203 n bound to nucleosomes, and suggest that the penultimate residue in the CTD (K195) is juxtaposed betw
204 Here, we have examined mutations at the penultimate residue of eIF1, G107, that produce Sui(-) p
206 rries a single amino acid replacement at the penultimate residue of the C-terminus, indicating the C-
207 problems posed by larger substituents on the penultimate residue of the peptide, and in particular by
209 ump by lysophospholipids did not involve the penultimate residue, Thr-947, which is known to be phosp
214 ift from thoracic-like to lumbar-like at the penultimate rib-bearing level, rather than the ultimate
215 ty is strictly dependent on the 2'-OH of the penultimate ribose, it is indifferent to a 2'-OH versus
219 the most recent sample before diagnosis, the penultimate sample before diagnosis, and the oldest samp
220 ibition was due to a Michael addition of the penultimate selenocysteine residue of TrxRs to the QMs.
221 e been identified in mammals: both contain a penultimate selenocysteine residue that is essential for
223 pite the presence of an N-terminal Ala and a penultimate Ser, the KlbA inteins splice efficiently usi
224 ns, using an appropriately modified powerful penultimate single-step vindoline-catharanthine coupling
226 s also stabilize the "barbell shapes" of the penultimate stage in platelet production, because additi
227 feature of normal development, including the penultimate stage of anther development, leading to dehi
230 isk of in situ breast cancer, the postulated penultimate stage preceding invasive breast cancer.
231 downstream sequence or DS) with the 16S rRNA penultimate stem (anti-DS or ADS region) enhances protei
232 ptidyl (P) site, the functional relay of the penultimate stem helix of SSU rRNA, and other structures
233 functional relay is centered around the long penultimate stem of 16S rRNA at the subunit interface, i
234 ty between the DB sequences and the 16S rRNA penultimate stem resulted in increased protein accumulat
236 droxyl of a tetracycline intermediate in the penultimate step during biosynthesis of the anticancer n
238 ssential hexameric enzyme that catalyzes the penultimate step in coenzyme A (CoA) biosynthesis and is
239 ine adenylyltransferase (PPAT) catalyzes the penultimate step in coenzyme A (CoA) biosynthesis: the r
242 acylglycerol to diacylglycerol, which is the penultimate step in one pathway for triacylglycerol synt
243 rly, glycerol 3-phosphate, necessary for the penultimate step in phosphatidylglycerol production, dec
245 to L-histidinol and inorganic phosphate, the penultimate step in the biosynthesis of L-histidine.
246 sferase (GNAT) superfamily and catalyzes the penultimate step in the biosynthesis of melatonin; a lar
247 e compelling evidence that AsbA performs the penultimate step in the biosynthesis of petrobactin, inv
251 ndent O-methyltransferase that catalyzes the penultimate step in the biosynthesis of the aminocoumari
252 e phenoxazinone synthase (PHS) catalyzes the penultimate step in the biosynthesis of the antibiotic a
254 A ribosyltransferase-isomerase catalyzes the penultimate step in the biosynthesis of the hypermodifie
255 ine adenylyltransferase (PPAT) catalyzes the penultimate step in the coenzyme A (CoA) biosynthetic pa
256 adenylyltransferase (PPAT) regulates the key penultimate step in the essential coenzyme A (CoA) biosy
257 ependent aminotransferase that catalyzes the penultimate step in the production of dTDP-Quip3NAc.
259 se in Saccharomyces cerevisiae catalyzes the penultimate step in the synthesis of triacylglycerol (i.
260 hosphatidate phosphatase (PAP) catalyzes the penultimate step in the synthesis of triacylglycerol and
261 osphatidate phosphatase, which catalyzes the penultimate step in the synthesis of triacylglycerol and
262 ylacetoacetate to fumarylacetoacetate is the penultimate step in the tyrosine/phenylalanine catabolic
263 phosphatidate phosphatase that catalyzes the penultimate step in triacylglycerol synthesis and plays
264 oded phosphatidate phosphatase catalyzes the penultimate step in triacylglycerol synthesis, and the d
267 oposed Plm biosynthetic pathway in which the penultimate step is hydroxylation of the cyclohexanecarb
268 rom shikimic acid via a pathway in which the penultimate step is the isomerization of 2-cyclohexenylc
270 s adduct resembles the intermediate from the penultimate step of the carboligation reaction between b
271 de transformylase isozymes that catalyze the penultimate step of the de novo purine biosynthesis path
272 olase) and is responsible for catalyzing the penultimate step of the de novo purine biosynthetic path
274 methyl-but-2-enyl diphosphate (HMBPP) in the penultimate step of the methyl-erythritol phosphate (MEP
276 e-3-phosphate synthase (EPSPS) catalyzes the penultimate step of the shikimate pathway and is the tar
278 c acid phosphatase (PAP) responsible for the penultimate step of triglyceride synthesis and dephospho
279 (DTBS) catalyze the antepenultimate and the penultimate steps, respectively, of biotin synthesis.
281 terminal alpha-2,3-linked sialic acid or the penultimate sugar (galactose) destroyed the ability of t
283 eomycins (PLMs) are BLM analogs in which the penultimate thiazolium ring of the bithiazole tail is re
284 ows the importance of phosphorylation of the penultimate Threonine (ERalpha-T(594)) for high-affinity
285 d the requirement for phosphorylation of the penultimate threonine, which is found in most members of
291 ls of TRAP family members harbor a conserved penultimate tryptophan, which is essential for aldolase
292 bands suggest conformational shifts for the penultimate Tyralpha140 on the F helix, the "switch" reg
293 n the significance of phosphorylation of the penultimate tyrosine for maintenance and processing of t
294 it binding pocket residues in HifB or at the penultimate tyrosine in HifA abolished formation of HifB
296 Phosphorylation of p97's highly conserved penultimate tyrosine residue, which is the main phosphor
297 In the case of the PAN and 19S activators, a penultimate tyrosine/phenylalanine residue contacts the
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