ライフサイエンスコーパス: peptidase

1 ysis of catalytic specificity of an aspartic peptidase.

2 cteria by over activating the bacterial ClpP peptidase.

3 genesis studies identify LspA as an aspartyl peptidase.

4 e thioester bond, which covalently traps the peptidase.

5 at contains the cleavage site for the signal peptidase.

6 and the function of mitochondrial processing peptidase.

7 , followed by cleavage by the inner membrane peptidase.

8 at is the first member of a new subfamily of peptidases.

9 bstrate profiling technique to define active peptidases.

10 mmensal bacteria requires them to evade host peptidases.

11 -8) is mediated by the activities of several peptidases.

12 lity 2/high-temperature requirement A serine peptidase 1 (ARMS2/HTRA1), complement component 2 (C2),

13 DGF signaling upregulated ubiquitin-specific peptidase 1 (Usp1) to promote the survival of murine pro

14 nonsense mutations in the TPP1 (tripeptidyl peptidase 1), DMD (dystrophin), SMARCAL1 (SWI/SNF-relate

15 lity 2/high-temperature requirement A serine peptidase 1, complement component 2, complement componen

16 heat shock protein 60, Clp protease, and Lon peptidase 1.

17 Here we report that ubiquitin-specific peptidase 10 (USP10) interacts with and stabilizes MSH2.

18 Here we identify ubiquitin-specific peptidase 13 (USP13) as a master regulator that drives o

19 Ubiquitin-specific peptidase 18 (USP18) is a key negative regulator of type

20 ing 1 (SOCS1), SOCS3, and ubiquitin-specific peptidase 18 (USP18).

21 Human kallikrein-related peptidase 2 (KLK2) is a key serine protease in semen liq

22 Free human kallikrein-related peptidase 2 was targeted in prostate cancer xenografts u

23 is specific to free human kallikrein-related peptidase 2, an antigen abundant in malignant prostatic

24 tor of the therapeutic effects of dipeptidyl peptidase 4 (DPP-4) inhibition (vildagliptin) by using t

25 c incretin-based drugs, including dipeptidyl peptidase 4 (DPP-4) inhibitors and glucagon-like peptide

26 s such as the tetraspanin CD9 and dipeptidyl peptidase 4 (DPP4) along with multiple endosomal sorting

27 e coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an entry receptor.

28 e coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an entry receptor.

29 ficient mice receiving background dipeptidyl peptidase 4 (DPP4) inhibitor treatment were characterize

30 However, whether increased dipeptidyl peptidase 4 (DPP4) is involved in the pathogenesis or is

31 Dipeptidyl peptidase 4 (DPP4) is the receptor for cell binding and

32 o the cell surface entry receptor dipeptidyl peptidase 4 (DPP4) occurs via S1(B) We now demonstrate t

33 fruit bat (Artibeus jamaicensis) dipeptidyl peptidase 4 (DPP4) receptor and MERS-CoV replicated effi

34 S-CoV) binds to cellular receptor dipeptidyl peptidase 4 (DPP4) via the spike (S) protein receptor-bi

35 he MERS-CoV cell surface receptor dipeptidyl peptidase 4 (DPP4), and evolutionary mechanisms that may

36 r MERS-CoV has been identified as dipeptidyl peptidase 4 (DPP4), the mouse DPP4 homologue does not al

37 ogether, our results point toward dipeptidyl peptidase 4 (DPP4)-dependent endosomal uptake and subseq

38 Dipeptidyl peptidase 4 (DPP4, CD26), a type II transmembrane ectope

39 novirus transduction of the human dipeptidyl peptidase 4 (hDPP4) receptor and then analyzed the abili

40 this study, we show that ubiquitin-specific peptidase 4 (USP4) interacts directly with and deubiquit

41 e identified as a major source of dipeptidyl peptidase 4 and we also found that skin mast cells and f

42 trial results have suggested that dipeptidyl peptidase 4 inhibitor (DPP4i) use might increase heart f

43 r events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with ty

44 ety of alogliptin, a nonselective dipeptidyl peptidase 4 inhibitor.

45 nd is critical for the actions of dipeptidyl peptidase 4 inhibitors that enhance GLP-1 levels in pati

46 t match the human sequence in the dipeptidyl peptidase 4 receptor, making mice susceptible to MERS-Co

47 tigen; double immunostaining with dipeptidyl peptidase 4 showed colocalization in scattered pneumocyt

48 Dipeptidyl peptidase 4 was found to be expressed in mast cells in n

49 etry analysis revealed that DPP4 (dipeptidyl peptidase 4) was selectively expressed on the surface of

50 ng oxopeptides toward cleavage by dipeptidyl peptidase 4, the principal regulator of their in vivo st

51 ression of the MERS-CoV receptor, dipeptidyl peptidase 4, was similar in marmosets and macaques.

52 ral cell adhesion molecule L1 and dipeptidyl peptidase 4, were further studied.

53 n mimetic drugs and inhibitors of dipeptidyl peptidase 4, which degrades GLP-1.

54 Acarbose, the dipeptidyl-peptidase 4-inhibitor sitagliptin, the glucagon-like pep

55 derived factor-1-degrading enzyme dipeptidyl peptidase 4.

56 ral cell adhesion molecule L1 and dipeptidyl peptidase 4.

57 Dipeptidyl peptidase-4 (CD26, DPP4) inhibitors are the most widely

58 ceptor agonists and inhibitors of dipeptidyl peptidase-4 (DPP-4) have shown pleiotropic effects on bo

59 group who also had baseline serum dipeptidyl peptidase-4 (DPP-4) higher than the population baseline

60 Linagliptin is a dipeptidyl Peptidase-4 (DPP-4) inhibitor that inhibits the degradat

61 In this regard, dipeptidyl peptidase-4 (DPP-4) inhibitors have recently been report

62 Recent studies concluded that dipeptidyl peptidase-4 (DPP-4) inhibitors provide glycemic control

63 hiazolidinediones, sulfonylureas, dipeptidyl peptidase-4 (DPP-4) inhibitors, and sodium-glucose cotra

64 art failure (hHF) associated with dipeptidyl peptidase-4 (DPP-4) inhibitors, creating uncertainty abo

65 atic degradation by inhibition of dipeptidyl peptidase-4 (DPP-4) promotes glycemic reduction for the

66 P-1 and GLP-2 are both cleaved by dipeptidyl peptidase-4 (DPP-4); hence, inhibition of DPP-4 activity

67 humans and dromedary camels using dipeptidyl peptidase-4 (DPP4) as its receptor.

68 actions, as well as the effect of dipeptidyl peptidase-4 (DPP4) inhibitor on CD in endothelial-pericy

69 The incretin-based therapies, dipeptidyl peptidase-4 (DPP4) inhibitors and glucagon-like peptide-

70 Dipeptidyl peptidase-4 (DPP4) inhibitors used for the treatment of

71 ared the safety and efficacy of a dipeptidyl peptidase-4 inhibitor (sitagliptin) plus basal insulin w

72 iazolidinedione use and increased dipeptidyl peptidase-4 inhibitor use over time (P<0.001).

73 ihyperglycemic medications in the dipeptidyl peptidase-4 inhibitor, glucagon-like peptide-1 receptor

74 6; six trials), intermediate with dipeptidyl peptidase-4 inhibitors (1.25, 1.08-1.45; two trials), an

75 ting the cardiovascular safety of dipeptidyl peptidase-4 inhibitors and some glucagon-like peptide-1

76 e peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors are commonly used for glycemic co

77 tem, GLP-1 receptor agonists, and dipeptidyl peptidase-4 inhibitors for 26 +/- 8 months before underg

78 used in 6.6% of HF patients, and dipeptidyl peptidase-4 inhibitors were used in 5.1%, with trends fo

79 ide [GLP]-1 receptor agonists and dipeptidyl peptidase-4 inhibitors) have proven efficacy for the tre

80 months and once-weekly tablets of dipeptidyl peptidase-4 inhibitors.

81 me corin and BNP-degrading enzyme dipeptidyl peptidase-4 were reduced in HF versus normal, perhaps co

82 by producing excessive amounts of Dipeptidyl peptidase-4, a protease that is a target of diabetes the

83 03(+) and CD11b(hi) cDCs, express dipeptidyl peptidase-4/CD26.

84 racellular protease KLK5 (kallikrein-related peptidase 5) is efficient in promoting the infectivity o

85 e cleavage preferences of Kallikrein-related peptidase 7 (KLK7) have previously been delineated using

86 The ubiquitin-specific peptidase 8 (USP8), an endosome-associated deubiquitinat

87 mologues dipeptidyl peptidase IV, dipeptidyl peptidase 9, and prolyl oligopeptidase.

88 tified the deubiquitinase ubiquitin-specific peptidase 9X (USP9X) as an intracellular target, using a

89 Clan CD cysteine peptidases, a structurally related group of peptidases t

90 nts with high-temperature requirement serine peptidase A1 (HtrA1), which is found in the nervous syst

91 ife on Earth, the fundamental details of how peptidases accommodate posttranslational modifications,

92 endo-peptidases act first followed by the successive action o

93 of apoptosis, including apoptosome apoptotic peptidase activating factor 1 (APAF-1).

94 ayed higher alpha-amylase, endoxylanase, and peptidase activities as well as signs of (incipient) pro

95 DA1 peptidase activity also cleaves the deubiquitylase UBP15

96 ficient proteasomes reduced both their basal peptidase activity and the stimulation by ATPgammaS.

97 Sortase-mediated peptidase activity has been reported in vitro, and seven

98 aded because the subcellular distribution of peptidase activity has not been investigated systematica

99 at 37 degrees C) correlate with reduced 20 S peptidase activity in proteasomes purified from cell ext

100 onates were synthesized that inhibit ClpP1P2 peptidase activity in the submicromolar range.

101 le tau was associated with a decrease in the peptidase activity of brain 26S proteasomes, higher leve

102 ion in vitro and in vivo confirming that the peptidase activity of PNT1 is essential for parasite sur

103 We propose that DA1 peptidase activity regulates the duration of cell prolif

104 The resulting lack of nuclear peptidase activity suggests that little, if any, degrada

105 higher affinity and promotes 3-4-fold higher peptidase activity than previous activators.

106 e proteasomes lacking Usp14 had higher basal peptidase activity than WT 26S, and this activity was st

107 lagen degradation, and a potent inhibitor of peptidase activity was identified.

108 hat ClpP1 was responsible for nearly all the peptidase activity, whereas both ClpP1 and ClpP2 contrib

109 other cellular functions in addition to its peptidase activity.

110 oplast transit peptide by stromal processing peptidase, additional processing by unidentified peptida

111 ng alpha-amylase, protease and gamma-carboxy peptidase allowing complete sample preparation within a

112 that beta-lactamases have evolved from a DD-peptidase ancestor.

113 ch are subsequently cleaved by the activated peptidase and destabilized.

114 A streptococci (GAS) Ags, streptococcal C5a peptidase and immunogenic secreted protein.

115 rgely exceeded that of beta-lactones in ClpP peptidase and protease inhibition assays and displayed u

116 entially cleaved by mitochondrial processing peptidase and then by octapeptidyl aminopeptidase 1 (Oct

117 eafloor (8) (mbsf) encode numerous candidate peptidases and carbohydrate-active enzymes ('CAZymes') (

118 They belong to clan CD of cysteine peptidases and contain a well-conserved C-terminal catal

119 radation, secondary metabolism, and secreted peptidases and effectors were drastically reduced.

120 compendium of known and putative Arabidopsis peptidases and inhibitors, and compare the distribution

121 s control as it shows resistance to cellular peptidases and its route of transepithelial transport ha

122 ecules for endothelial nanomedicine includes peptidases and other enzymes, cell adhesion molecules an

123 Pages to show the involvement of peptidases and peptidase inhibitors in biological pathwa

124 Each page shows the peptidases and peptidase inhibitors involved in the path

125 the (near) absence of cysteine and aspartic peptidases and peptidase inhibitors, whereas other pepti

126 The susceptibility to the brush-border peptidases and route of transepithelial transport were o

127 Thus, the active sites of DD-peptidases and serine beta-lactamases are very similar.

128 c data, and used to infer additional plastid peptidases and to generate a coexpression network for 97

129 ramembrane-cleaving protease, signal peptide peptidase, and is required for cell fusion activities.

130 f HslV, a double-ring self-compartmentalized peptidase, and one or two AAA+ HslU ring hexamers that h

131 es encoding hemicellulose-degrading enzymes, peptidases, and metabolite transporters were more abunda

132 , plasmin, thrombin, four kallikrein-related peptidases, and several clotting factors.

133 tasis network containing protein chaperones, peptidases, and their substrate recognition factors.

134 Inhibition of aspartic cathepsin D-like peptidases (APDs) has been often discussed as an antipar

135 Trapped peptidases are still active except against very large su

136 n be removed from the transcribed peptide by peptidases, artificial and biomachines working in concer

137 However, many peptidases, as well as their functional connections and

138 ified biallelic variants in the caseinolytic peptidase B homolog (CLPB).

139 CLPB encodes caseinolytic peptidase B homolog ClpB, a member of the AAA+ protein f

140 ate a coexpression network for 97 organellar peptidase baits (1742 genes, making 2544 edges).

141 The prey peptidase becomes covalently attached to the inhibitor,

142 e the hydrolysis of protein peptide bonds by peptidases being a process essential to all life on Eart

143 c assortment of ancestral characters such as peptidases between Trypanosoma and Leishmania, genomic d

144 a deeper understanding of kallikrein-related peptidase biology and pathology.

145 re structural elements with clan CD cysteine peptidases but otherwise structurally differs from the o

146 Here we characterize a ubiquitin-activated peptidase called DA1 that limits the duration of cell pr

147 drolysis of a beta-lactam while that of a DD-peptidase cannot?

148 We found a complement-related peptidase, carboxypeptidase B1 (Cpb1), to be required fo

149 cific subsites immediately adjacent to their peptidase catalytic machinery.

150 notation based on the MEROPS nomenclature of peptidase clans and families, is incorporated into the P

151 ies indicate that deletion of the colibactin peptidase ClbP, a modification introduced to promote acc

152 d its corresponding colibactin by colibactin peptidase ClbP.

153 erted to genotoxic colibactins by colibactin peptidase (ClbP)-mediated cleavage of an N-acyl-d-Asn si

154 are converted to colibactins by a dedicated peptidase, ClbP.

155 (apoM(Q22A)) introduces a functional signal peptidase cleavage site.

156 The AAA+ chaperone ClpC with the peptidase ClpP forms a bacterial protease essential to v

157 The peptidase compendium, including the autophagy and proteo

158 id and mitochondrial peptidases to the total peptidase complement.

159 we now show that the mitochondrial unfoldase-peptidase complex ClpXP associates with the oncoprotein

160 ), SRP receptors, the translocon, the signal peptidase complex, and over 100 other genes with many ot

161 rious protein-translocation machineries, the peptidase-containing ATP-binding cassette transporters (

162 tide receptor (GIPR), caveolin 2 (CAV2), and peptidase D (PEPD) (P-interaction < 0.05).

163 Here, we show that peptidase D (PEPD) binds and suppresses over half of nuc

164 nserved residues in the prodomain and in the peptidase domain of ADAMTS3.

165 Furthermore, the conserved cysteine of the peptidase domain of the Synpcc7942_1133 gene product (du

166 Each PCAT contains two peptidase domains that cleave the secretion signal from

167 LK-nuclease (a RNase) and multiple distinct peptidase domains, which are predicted to carry their to

168 The dipeptidyl peptidase (DPP) 4 family includes four enzymes, DPP4, DP

169 ng kinetics and thermodynamics of dipeptidyl peptidase (DPP)-4 inhibitors (gliptins) were investigate

170 Dipeptidyl peptidase (DPP)-IV inhibitory peptides were purified and

171 ion of an inhibitor of the enzyme dipeptidyl-peptidase (DPP4i), which prevents the cleavage of glucag

172 Like the closely related dipeptidyl peptidase DPPIV, the extracellular domain of FAP can be

173 terization of the dual function macrocyclase-peptidase enzyme involved in the biosynthesis of the hig

174 nal anchors, whose cleavage via the prepilin peptidase, essential for pilin membrane extraction and a

175 ases and peptidase inhibitors, whereas other peptidase families were exclusively organellar; reasons

176 and they comprise the largest of all of the peptidase families, their dynamic motions remain obscure

177 discovered that PGM48 is a member of the M48 peptidase family with PGM48 homologs, forming a clade (M

178 The visceral peptidase from farmed giant catfish could be an alternat

179 The peptidase from the viscera of farmed giant catfish was u

180 and a detailed framework for studies on C11 peptidases from other phylogenetic kingdoms.

181 We find residual carboxy- and endo-peptidase gamma-secretase activities, similar to the for

182 CFEs were suitable sources of peptidases, glutamate dehydrogenase and cystathionine ga

183 efects in PMPCA and mitochondrial processing peptidase have been described in association with a dise

184 We report here that host range restriction peptidase (hrrP), a gene found on one of these plasmids,

185 Signal peptidase I (SpI) cleavage sites were found in 463 of th

186 sttranslational processing requires a signal peptidase II (LspA) that removes the signal peptide.

187 he signal sequence is then cleaved by signal peptidase II (LspA) to give an N-terminal S-diacylglycer

188 in signal peptide recognition site of signal peptidase II (SpII).

189 omozygous frameshift mutation in tripeptidyl peptidase II (TPP2) abolishing protein expression.

190 Tripeptidyl peptidase II (TPPII) is a eukaryotic protease acting dow

191 cence arising from deficiency in tripeptidyl peptidase II (TPPII).

192 f cells producing native OPH with the signal peptidase II inhibitor globomycin resulted in accumulati

193 ffective at visualizing B1R-positive tumors, peptidase inhibition with phosphoramidon greatly enhance

194 previously reported that secretory leukocyte peptidase inhibitor (SLPI) is regulated by the AR in a l

195 We found that four splice variants of the peptidase inhibitor 16 (PI16) mRNA are among the most hi

196 kines (IL-12p40, IL-13, IL-22, CCL17, CCL18, peptidase inhibitor 3 [PI3]/elafin, and S100As) showed c

197 imicrobials (IL-17A, IL-19, CCL20, LL37, and peptidase inhibitor 3/elafin), TH9/IL-9, IL-33, and inna

198 Missense mutations in the serine peptidase inhibitor Kazal type 5 (SPINK5) skin barrier g

199 In this study, we identified SPINT2 (serine peptidase inhibitor Kunitz type 2), a proteolytic inhibi

200 Cela1 was covalently bound to serpin peptidase inhibitor, clade A, member 1, resulting in a h

201 mutations were found in the SERPINF1 (Serpin Peptidase Inhibitor, Clade F) gene which encodes PEDF (p

202 8 (MTRNRL8), interleukin-8 (IL8), and serpin peptidase inhibitor, clade H (SERPINH1) and chemokine li

203 ly 180-kDa multidomain membrane-anchored pan-peptidase inhibitor, which is cleaved by host endopeptid

204 along with the known substrate cleavages and peptidase-inhibitor interactions, and a link to the KEGG

205 ses and identified IL-1 cytokines and serine peptidase inhibitors as the most dysregulated esophagus-

206 es to show the involvement of peptidases and peptidase inhibitors in biological pathways have been cr

207 Each page shows the peptidases and peptidase inhibitors involved in the pathway, along with

208 ence of cysteine and aspartic peptidases and peptidase inhibitors, whereas other peptidase families w

209 a mechanism that was partially prevented by peptidase inhibitors.

210 ch are hydrolyzed by the asparagine-specific peptidase into the active component amicoumacin A.

211 ing organ growth in Arabidopsis thaliana The peptidase is activated by two RING E3 ligases, Big Broth

212 ensin converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) inhibitory and oxygen radical abso

213 Nine novel dipeptidyl peptidase IV (DPP-IV) inhibitory peptides (FLQY, FQLGASP

214 s used to optimise the release of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides during hydroly

215 ficant effect of pH regulation on dipeptidyl peptidase IV (DPP-IV) properties.

216 y and histochemical estimation of dipeptidyl-peptidase IV enzyme activity of donor cells in the negat

217 ony stimulating factor (G-CSF), a dipeptidyl peptidase IV inhibitor (DPP-4i), and a proton pump inhib

218 not inhibit close FAP homologues dipeptidyl peptidase IV, dipeptidyl peptidase 9, and prolyl oligope

219 e and senescent rats deficient in dipeptidyl-peptidase IV.

220 e (37.8%), alpha-amylase (35.6%), dipeptidyl peptidase-IV (34.4%), reactive oxygen species (81.6%), a

221 riety of bioactivities, including dipeptidyl peptidase-IV (DPP-IV) and angiotensin converting enzyme

222 t because of rapid degradation by dipeptidyl peptidase-IV (DPP-IV) and renal clearance.

223 short due to rapid degradation by dipeptidyl peptidase-IV (DPP-IV) and renal clearance.

224 ionate increased DBS, enhanced by dipeptidyl peptidase-IV (DPPIV) inhibition, at the same time as inc

225 d source of natural inhibitors of dipeptidyl peptidase-IV and prolyl endopeptidase and could potentia

226 d clinical variants, for example, dipeptidyl peptidase-IV inhibitor-associated noninflammatory bullou

227 astomyces dermatitidis elaborates dipeptidyl-peptidase IVA (DppIVA), a close mimic of the mammalian e

228 Kallikrein-related peptidases (KLKs) are a group of serine proteases widely

229 ne proteases known as the kallikrein-related peptidases (KLKs).

230 Subsequently, peptidase-laden ECAM is shed from the membrane and may d

231 nst a hepatic surface protein, leucine amino peptidase (LAP).

232 by the intramembrane protease signal peptide peptidase-like (SPPL)2a, a process critical for B cell d

233 nd the intramembrane protease signal peptide peptidase-like 2a (SPPL2a).

234 rough proteolytic cleavage by signal peptide peptidase-like 2a.

235 Signal peptide peptidase-like 3 (SPPL3) is a poorly characterized endop

236 e III is further processed by signal peptide peptidase-like proteases SPPL2a and SPPL2b.

237 interacting proteins (KChIPs) and dipeptidyl peptidase-like proteins (DPPLs).

238 nteracting proteins (KChIPs), and dipeptidyl peptidase-like proteins (DPPLs).

239 TD and deletion of porU, a C-terminal signal peptidase linked to T9SS-mediated secretion.

240 Deleting the lipoprotein signal peptidase (lsp) gene in Streptomyces coelicolor results

241 Here, we identify a secreted enzyme, peptidase M20 domain containing 1 (PM20D1), that is enri

242 rst followed by the successive action of exo-peptidases (mainly, tri- and di-peptidylpeptidases, amin

243 n internal cleavage by the matrix processing peptidase MPP, and in this respect, it differs from all

244 However, a more widely expressed islet peptidase, neprilysin, degrades angiotensin-(1-7) into s

245 des a systematic insight into the organellar peptidase network in Arabidopsis thaliana We present a c

246 idase, additional processing by unidentified peptidases occurs to avoid unstable or otherwise unfavor

247 Cruzipain, the main papain-like cysteine peptidase of T. cruzi, is an important virulence factor

248 Peptidases of the a-disintegrin and metalloproteinase (A

249 se) that has sequence similarity to cysteine peptidases of the papain and calpain families.

250 oramidon were used to evaluate the impact of peptidases on tumor visualization.

251 s of membrane proteins are cleaved by signal peptidase once the nascent proteins reach the endoplasmi

252 Among the 480 genes coding for protease/peptidases, only four were found enriched in cortical in

253 Nevertheless, we did not detect any YbAnbu peptidase or amidase activity.

254 te physiological influence of manipulating a peptidase or an inhibitor cannot be always predicted, si

255 s by modulating the expression of some other peptidases or their inhibitors.

256 ome contains several genes encoding cysteine peptidases other than gingipains.

257 an increase in the level of the neprilysin 1 peptidase overcomes memory deficits induced by amyloid p

258 eous process but is governed by a standalone peptidase PepN, which hydrolyzes LBS in a pH-sensitive w

259 Here, we show that the only PG-localized peptidase PGM48 positively regulates leaf senescence.

260 ucial for enzymatic activity of the prepilin peptidase PilD and (iii) that pilin subunits with a C-te

261 The structure of a C11 peptidase PmC11 from the gut bacterium, Parabacteroides

262 le amino acids from mitochondrial processing peptidase-processed proteins.

263 This insight builds upon the paradigm of how peptidases recognize substrates and provides a molecular

264 ed soluble or membrane-anchored multimodular peptidases regularly found in several paralogous copies

265 ctions, in addition to enzyme inhibitors and peptidase regulators.

266 hibitors of mosquito peptidyl dipeptidase, a peptidase related to mammalian angiotensin-converting en

267 vator) is a serine protease belonging to the peptidase S1 family.

268 nherited and caused by the inability of SUMO peptidase sentrin/SUMO-specific protease 2 (SENP2) to de

269 In a milk-clotting assay, this peptidase showed maximal milk clotting activity at 60-65

270 The three peptidases showed selectivity for different glycans, rev

271 Type I signal peptidase (SPase I) is an integral membrane Ser/Lys prot

272 steine residue at the junction of the signal peptidase (Spase) cleavage site along with a well conser

273 The signal peptide peptidase (SPP)-related intramembrane aspartyl proteases

274 e describe a general approach for predicting peptidase substrates de novo using protein structure mod

275 metalloprotease HrrP (host range restriction peptidase), suggesting that disulfide bond formation may

276 PmC11 is a monomeric cysteine peptidase that comprises an extended caspase-like alpha/

277 ata provide evidence that PNT1 is a cysteine peptidase that is required exclusively for maintenance o

278 of a bacterial calpain, a calcium-responsive peptidase that may generate substrates required for the

279 References 912 Subtilases (SBTs) are serine peptidases that are found in all three domains of life.

280 tatins are reversible inhibitors of cysteine peptidases that are found naturally in plants.

281 of beta-lactam antibiotics are bacterial DD-peptidases that catalyze the final steps of peptidoglyca

282 peptidases, a structurally related group of peptidases that include mammalian caspases, exhibit a wi

283 further insight into this group of bacterial peptidases that likely represent ancestral versions of m

284 he alpha subunit of mitochondrial processing peptidase, the primary enzyme responsible for the matura

285 In the presence of the peptidase, the reactive intermediates are converted to a

286 is an integrated source of information about peptidases, their substrates and inhibitors, which are o

287 e other well-characterized groups of clan CD peptidases, there are no high-resolution structures of s

288 while, some rhizobial strains have evolved a peptidase to specifically degrade these antimicrobial pe

289 aborate with the self-compartmentalized ClpP peptidase to unfold and degrade specific proteins in bac

290 teins can also be isolated and hydrolysed by peptidases to produce hydrolysates.

291 he distribution of plastid and mitochondrial peptidases to the total peptidase complement.

292 ynpcc7942_1133 gene product (dubbed PteB for peptidase transporter essential for biofilm) is crucial

293 Peptides generated by the action of peptidases upon cheese proteins were separated by revers

294 We identified ubiquitin-specific peptidase (Usp) 12 and Usp46, which had not been previou

295 es in the level of expression of several C1A peptidases were also detected.

296 f the transcripts encoding putative secreted peptidases were assigned to lineages (7,13,14) of uncult

297 s showed that the gene encoding pyroglutamyl peptidase, which removes N-terminal OP residues, cluster

298 LPVPQK and BCM 5 were hydrolyzed by cellular peptidases while bradykinin was found intact.

299 s lspB, a gene encoding a lipoprotein signal peptidase whose expression appears detrimental for infec

300 Our results revealed an aspartic peptidase with molecular mass approximately 38kDa, maxim