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1 nhanced binding affinity compared to the p53 peptide.
2 and LMP7 by immunization with a cardiac TnI peptide.
3 e-based nanotransformer and loaded antigenic peptide.
4 tion and secondary nucleation of the Abeta42 peptide.
5 t regulatory sites: Na(+) and the inhibitory peptide.
6 try for strong binders than for low-affinity peptides.
7 A-A, -B, and -C genotypes for all SARS-CoV-2 peptides.
8 rease the prediction accuracy of immunogenic peptides.
9 occur, releasing large numbers of endogenous peptides.
10 is the delineation of the role of individual peptides.
11 omplex class I (MHC I) molecules loaded with peptides.
12 dentification of the first endogenous opioid peptides.
13 o see no increase in GSIS in response to CCK peptides.
14 was performed to identify motifs of binding peptides.
15 fication/quantification of partially labeled peptides.
16 ions (PTMs) affecting single amino acids and peptides.
17 ernal standards to quantify chosen surrogate peptides.
18 of ultra-low concentrations of the Abeta-40 peptides.
19 Exogenously provided competence stimulating peptide 1 (CSP1) failed to modulate the onset kinetics o
23 d (NIR) fluorescence imaging of glucagonlike peptide 1 receptor (GLP-1R)-positive lesions, using the
24 OS in mediating microglial response to Abeta peptide 1-42 (Abeta(42)) stimulation in vitro, in aging-
25 iazolidinediones (glitazones), glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl pepti
27 IGF-1 (recombinant human IGF-1)/BP3 (binding peptide 3) improves lung growth and prevents PH in two a
30 rmal electrophysiology, improves glucose and peptide absorption, diminishes diarrhea and rescues post
32 ions following HCD fragmentation of labeled peptides acquired on Orbitrap platforms at a minimum of
33 ists of opioid receptors to infer endogenous peptide activity, and genetic knockout of opioid peptide
36 o proopiomelanocortin (POMC), agouti-related peptide (AgRP), melanin-concentrating-hormone (MCH) and
39 right properties, for example Antimicrobial peptides (AMPs), can disrupt this protective barrier by
43 t at baseline identifies associations with C-peptide and stratifies subjects for future severity of C
49 satile and selective method to functionalize peptides and proteins through free-radical-mediated dech
50 ter has been the main application of VCD for peptides and proteins, although this is now reinforced b
54 the potential interactions between different peptides and the main anthocyanins from eggplant peels.
55 localized and delocalized motions present in peptides and where they can be found in the electromagne
56 biomarkers (troponins and B-type natriuretic peptide) and cardiac dysfunction for 24-48 h after event
59 This is demonstrated for small molecules, peptides, and proteins up to 66 kDa on three commerciall
62 sal epitope in VP2N which could be used as a peptide antigen to detect FMDV-specific antibodies again
67 ely demonstrate the nature and extent of EPF peptides as non-cell autonomous local signals and provid
69 ospect of future biocompatible devices where peptide assemblies could complex with native and non-nat
73 jor impediment for the design of sustainable peptide-based antibiotics that can be hydrolyzed by wast
77 ese two positions are component parts of the peptide-binding pocket 7 (P7) of the HLA-DR heterodimer,
79 ns involved in bioluminescence, nonribosomal peptide biosynthesis, fatty acid activation, and beta-la
80 kine ligand (CCL) 8 and synthesized a 16-mer peptide (BK1.1) based on this interface region in evasin
81 O-glycosylations on a multiply glycosylated peptide by virtue of enumerating the dehydration scars i
82 rometry responses (signal-to-noise ratio) of peptides by more than 1 order of magnitude on average af
85 N-oxidized using an aspartic acid containing peptide catalyst to afford stable, helically chiral prod
86 We discovered that 2 crustacean cardioactive peptide (CCAP)-expressing neurons in Drosophila adults r
87 opsis and Medicago CEP (C-TERMINALLY ENCODED PEPTIDE)-CEP RECEPTOR signalling controls RSA, the gravi
88 red, small-molecule, calcitonin gene-related peptide (CGRP) receptor antagonist under investigation f
96 an exploratory experiment in mice, a VHH-PTH peptide conjugate showed biological activity, whereas th
97 nsformer-based vaccine, comprising a polymer-peptide conjugate-based nanotransformer and loaded antig
98 Ala(13), Nle(14)]Bn(6-14) (sBB2L) generating peptide conjugates with up to 80 boron atoms per molecul
101 y internalized by U87MG (proportional to the peptide content and abrogated by anti-alpha(v)beta(3)) b
102 tail of keyhole limpet hemocyanin-conjugated peptides corresponding to the AipA, Asp14, and OmpA bind
103 and pathways expressing the stress-sensitive peptide corticotropin-releasing factor (CRF), which has
104 ether tolerizing immunotherapy with a single peptide could control diabetes driven by multiple Ags, w
105 tibodies directed at 58 (15-mer) overlapping peptides, covering the entire sequence of ovomucoid, in
107 onolayers is conjugation to cell-penetrating peptides (CPPs); however, very little is known about the
108 platform yields high-quality MHC-II-binding peptide datasets that can be used to improve the accurac
109 miRNAs may be useful in predicting future C-peptide decline for improved subject stratification in c
111 nical HLA peptides, including an immunogenic peptide derived from an open reading frame downstream of
112 viously designed and synthesized macrocyclic peptides derived from Abeta(17-23) and Abeta(30-36) that
114 uggest that non-canonical tumor-specific HLA peptides derived from annotated non-coding regions could
115 to the resulting ensemble such that averaged peptide-deuteration levels, as predicted by an empirical
119 s delineate how drug HLA-B*57:01 binding and peptide display by antigen presenting cells relate to th
121 panel of variants of the Car9 silica-binding peptide (DSARGFKKPGKR) fused to the C-terminus of superf
122 gen may better engage B cells and designed a peptide encompassing the extracellular domains (ECD) of
124 w cytometry of the five most highly abundant peptides (EP1, -2, -3, -7 or EP9) showed strong binding
125 ilter in shaping the repertoire of presented peptide epitopes and the formation of a hierarchical imm
126 lico techniques, we demonstrate that the two peptides, even if applied individually, transform origin
127 e methods include directly administering the peptides ex vivo (i.e., to excised tissue) or in vivo (i
129 We find that the most potent pore-forming peptides exhibit strong interpeptide interactions, inclu
130 fferents, increasing calcitonin gene-related peptide expression and basal trigeminal nociception.
131 zyme-instructed self-assembly of a synthetic peptide for trafficking endogenous proteins, this work p
134 driven dissociation because glycan-retaining peptide fragments would not be required for localization
137 Finally, producing antimicrobial/antioxidant peptide from wastes by EDUF fits perfectly with the conc
139 solvents improves digestion, generating more peptides from the rigid beta-barrel regions, without com
140 s review aims to focus on recent advances in peptide-functionalized liposomal formulation techniques
141 iomarkers (N-terminal pro-B-type natriuretic peptide [>40 pg/mL] or troponin T [>0.6 pg/mL]) were rec
142 CANCE STATEMENT The neuropeptide VGF and its peptides have been associated with many metabolic and ne
148 he various segments of the full-length hIAPP peptide; however, only a few have their origin from the
150 since no T cells recognizing any EBV-derived peptide in this common HLA allele have been found thus f
153 esin to facilitate the chemical synthesis of peptides in organic solvent as well as the enzymatic syn
154 re of acetylated/nonacetylated alpha-tubulin peptides in the background of human olfactory neurospher
155 shared and tumor-specific non-canonical HLA peptides, including an immunogenic peptide derived from
159 accurately predicting the affinities of PBD-peptide interactions across multiple protein families.
161 of target protein and employ isotope-labeled peptide internal standards to quantify chosen surrogate
164 cases, the binding between MHC and antigenic peptides is the most selective step in the antigen prese
165 rea under the concentration-time curve for C-peptide level in response to a 4-hour mixed-meal toleran
167 ls (pSILAC), phosphoproteomics, and a unique peptide-level matching strategy, our DeltaSILAC profilin
168 NT-proBNP (N terminal pro B-type natriuretic peptide) levels were examined in multivariable-adjusted
169 (NRG1) is a large (> 60-amino-acid) natural peptide ligand for the ErbB protein family members HER3
170 MBRYO SURROUNDING REGION (ESR)-RELATED (CLE) peptide ligands in connection with their receptors are i
171 des a binding platform for 21 amino acid CIF peptide ligands, which are tyrosine sulfated by the tyro
175 e readily assembles with lipid vesicles into peptide/lipid coaggregates that resemble amyloid fibrils
176 SARS-CoV-2-specific CD8(+) T cells, applying peptide-loaded major histocompatibility complex class I
178 tion of TREM-1 in EV-A71-infected PBMCs with peptide LP17 resulted in decreased levels of pro-inflamm
179 ength numbering), were incorporated into the peptide macrocycles c[Pro(1)-Arg(2)-Phe(3)-Phe(4)-Xaa(5)
180 and panning for antigen-reactive TCRs using peptide major histocompatibility complex binding and cel
181 elective increase in TCR sensitivity to self-peptide MHC in vivo and an enhanced response to weak ago
182 a comprehensive in silico analysis of viral peptide-MHC class I binding affinity across 145 HLA-A, -
183 nalysis presented here can be applied to any peptide-MHC complex of interest with a structural model
184 of peptides and subsequently large bodies of peptide-MHC-II interaction data are key to the solution
187 nd affinity analyses, we designed two cyclic peptide mimics of the TAR-binding beta2-beta3 loop seque
188 Here, we show that constrained 31-residue-peptides ('msR4Ms') designed to mimic the CXCR4-binding
189 on of CeA slices with nociceptin/orphanin FQ peptide (N/OFQ; 500 nM), an endogenous opioid-like pepti
190 interactions of representative amyloidogenic peptides, namely, the 106-126 fragment of prion protein
192 y organized supramolecular polymerization of peptide nanotubes was applied in the assembly of highly
193 broad class of macrocyclic, heavily modified peptide natural products that are unified by the presenc
196 engineered with a novel and highly specific peptide nucleic acid (PNA) as the recognition element.
198 the zein gene from maize using pyrrolidinyl peptide nucleic acid (PNA) immobilized on a magnetic sol
199 lysis, we identified six fractions with high peptide number and uniqueness that can account for 80% o
200 suggest that on reaching the cytoplasm, the peptide occupies its binding site prior to the transitio
203 the form of a collection of conserved short peptides) of each subfamily, and thus were further used
205 akes use of a reactive linker to form cyclic peptides on the phage surface while simultaneously intro
206 ed the presence of only two short allergenic peptides on the surface of CpCP3, which was highly susce
207 olymer augments the efficacy of an oncolytic peptide (OP; KKWWKKWDipK) for immunotherapy by exploitin
208 ry input for the server consists of a set of peptides or proteins, optionally with PTM sites, and the
212 hibitor 3 (PI3), a gene in the antimicrobial peptide pathway and known to be involved in antimicrobia
213 y useful to increase the number of annotated peptide peaks with their corresponding amino acid sequen
214 iquitylation sites from as little as 500 mug peptide per sample from cells or tissue in a TMT10plex i
215 e observations demonstrate that our designed peptides perturb TJs in human lung as well as human and
217 and purification were tested and the tryptic peptide pools were analysed by untargeted high resolutio
219 e a scan mode that samples up to 100% of the peptide precursor ion current in m/z and mobility window
224 ng factor (PDF), a neuromodulatory signaling peptide produced only by circadian clock circuit neurons
229 been used especially in chemical biology for peptide/protein synthesis, posttranslational modificatio
231 Here, we describe a methodology for targeted peptide quantification using a trapped ion mobility quad
232 inimum inhibitory concentration (MIC) of the peptide ranged from 80 mug/ml for X. citri to 600 mug/ml
233 at the soluble, nonfibrillizing Abeta (1-30) peptide recapitulates full-length Abeta stereoselective
239 ydrides, for the synthesis of peptidyl-RNAs, peptides, RNA oligomers and primordial phospholipids.
240 ogical fit ensures that CDR3beta reaches the peptide's featured C-terminal segment for pMHC sampling,
241 believed to be activated by a lipid-sensing peptide(s) in the ER that can cluster PM-derived cholest
246 we have investigated the effect of a shorter peptide sequence derived from Cpn 60.1, named IRL201104,
253 y inactive mutant in vivo (based on in vitro peptide studies) actually retains substantial H3K4 demet
256 and also requires the presence of activator peptides, such as benzoyl-leucyl-leucine (Bz-LL), for fu
257 ing regardless of the presence of the leader peptide, suggesting that although the PEP domain serves
258 rganic solvents commonly used in polymer and peptide synthesis results in the alteration of DNA helic
260 l disruption of the plasma membrane once the peptide targets specific phospholipids found on the cyto
262 oassembly process of PAP(248-286), a seminal peptide that displays both amyloid-forming and antimicro
263 rgeting approach is based on pHLIP, a unique peptide that selectively targets tumors in vivo by ancho
265 function characterization, we present simple peptides that bind alpha-cobratoxin (alpha-Cbtx) and pre
268 on resonance, we identified parasite-derived peptides that have the sequence-specific ability to incr
269 e the development of novel anti-inflammatory peptides that therapeutically target the chemokine netwo
270 s and correctly identified >75% of HLA-bound peptides that were observed experimentally in 11 patient
271 h as specificity for aggregated forms of the peptide, the ability to distinguish polymorphic aggregat
272 udies were initially limited to simple model peptides, the past decade has seen a dramatic advancemen
273 he coating facilitated the mass transport of peptides through the PAN layer, thus enabling extraction
274 ontaining and UV-reduced cysteine-containing peptides to be identified by a nontargeted database sear
276 cs made by phospholipids and amphipathic 18A peptides to mediate the formation of supported phospholi
277 we study adhesion of Lys and DOPA-containing peptides to organic and inorganic substrates using singl
278 oemission spectroscopies, bonding of the two peptides to TiO(2) surfaces (either nanostructured or si
282 detection and identification of cross-linked peptides using multistage mass spectrometry (MS(n)).
283 ated as the separation media for analysis of peptides using supercritical fluid chromatography-mass s
285 CD8 T cells against the immunodominant TMEV peptide VP2(121-130) Loss of H-2D(b) on CD11c(+) APCs mi
287 noted that these 1:1 alpha/Sulfono-gamma-AA peptides were completely resistant to proteolytic degrad
291 unds, representative of mono- and disulfated peptides, were used to compare the enrichment capabiliti
292 identified 53 differentially phosphorylated peptides when comparing low responders with high respond
293 n of the Toll pathway-mediated antimicrobial peptides when the flies were challenged with Gram-positi
294 ts, a class of Bronsted basic guanidinylated peptides, which catalyze an efficient atroposelective ch
295 thod in the case of the amyloid beta (Abeta) peptide, whose oligomers are associated with Alzheimer's
298 omeostatic control, and express insulin-like peptides with well-established roles in regulating food