ライフサイエンスコーパス: peptide deformylase

1 at least a modest success with inhibitors of peptide deformylase.

2 incomplete N-formyl-methionine processing by peptide deformylase.

3 s of the essential prokaryotic gene encoding peptide deformylase.

4 ctrophotometric assay has been developed for peptide deformylase.

5 atically examine the sequence specificity of peptide deformylase.

6 oup of the nascent polypeptide is removed by peptide deformylase.

7 and sensitive method for kinetic studies of peptide deformylase.

8 as potent, time-dependent inhibitors of the peptide deformylase.

9 tion of the zinc containing Escherichia coli peptide deformylase.

10 encoding the processed forms of Arabidopsis peptide deformylase 1 and 2 (pAtDEF1 and 2, respectively

11 , was effective in vitro against Arabidopsis peptide deformylase 1 and 2 activity, respectively.

12 Peptide deformylase activity was thought to be limited t

13 mbinant Arabidopsis peptide deformylases had peptide deformylase activity with unique kinetic paramet

14 on in the culture medium, thereby inhibiting peptide deformylase activity.

15 -terminal formyl group is usually removed by peptide deformylase, an enzymatic activity requiring iro

16 rial agents that are inhibitors of bacterial peptide deformylase and UDP-3-O-(R-3-hydroxymyristoyl)-N

17 found in the active site of all eubacterial peptide deformylases, and N-terminal extensions identifi

18 minus, there has been increasing interest in peptide deformylase as a potential target for antibacter

19 alt and the zinc containing Escherichia coli peptide deformylase bound to the transition-state analog

20 In addition, active peptide deformylase can be reconstituted in vitro from t

21 Peptide deformylase catalyzes the removal of the N-formy

22 Peptide deformylase catalyzes the removal of the N-termi

23 espite being a broad-specificity enzyme, the peptide deformylase deformylates different peptides at d

24 Peptide deformylase (EC 3.5.1.31) catalyzes the removal

25 The purified iron-enriched form of S. aureus peptide deformylase enzyme retained high activity over m

26 In addition, the selectivity of peptide deformylase for the N-formyl over the N-acetyl g

27 As an example, recombinant peptide deformylase from Bacillus subtilis was overexpre

28 and found to be excellent substrates of the peptide deformylase from Escherichia coli (k(cat)/K(M) =

29 eversible inhibitors of purified recombinant peptide deformylase from Escherichia coli and Bacillus s

30 e pH optimum and the catalytic activity of a peptide deformylase from Escherichia coli.

31 Both recombinant Arabidopsis peptide deformylases had peptide deformylase activity wi

32 The first crystal structure of Class II peptide deformylase has been determined.

33 A continuous assay for peptide deformylase has been developed using a formylate

34 ural product Sch 382583 (1), an inhibitor of peptide deformylase, has been synthesized in 16 steps fr

35 er, purification and characterization of the peptide deformylase have remained a major challenge beca

36 We describe here a new human peptide deformylase (Homo sapiens PDF, or HsPDF) that is

37 The human homolog of peptide deformylase (HsPDF) resides in the mitochondria,

38 The results suggest an essential role for peptide deformylase in protein processing in all plant p

39 GSK1322322 is a novel peptide deformylase inhibitor in the early phase of deve

40 peptide antibiotics, a glycylcycline, and a peptide deformylase inhibitor, a member of a new antibac

41 that treatment of Escherichia coli with the peptide deformylase inhibitor, actinonin, results in the

42 Actinonin, a specific peptide deformylase inhibitor, was effective in vitro ag

43 her novel quinolones that have high potency, peptide deformylase inhibitors, and new lincosamide, oxa

44 ich may play a role in the design of general peptide deformylase inhibitors.

45 Peptide deformylase is an essential Fe2+ metalloenzyme t

46 These results suggest that peptide deformylase is the likely molecular target respo

47 tituted recombinant form of Escherichia coli peptide deformylase (PDF(Ec)) via isothermal titration m

48 Peptide deformylase (PDF) catalyzes the hydrolytic remov

49 Peptide deformylase (PDF) catalyzes the hydrolytic remov

50 Peptide deformylase (PDF) catalyzes the removal of the N

51 Peptide deformylase (PDF) catalyzes the subsequent remov

52 Peptide deformylase (PDF) has been identified as a promi

53 Peptide deformylase (PDF) has received considerable atte

54 Peptide deformylase (PDF) is among the few antibacterial

55 Peptide deformylase (PDF) is an enzyme that is responsib

56 Peptide deformylase (PDF) is essential in prokaryotes an

57 e presumable promoter region of the gene for peptide deformylase (PDF), a metal-dependent enzyme that

58 the N-terminal Met residue of the peptide by peptide deformylase (PDF).

59 Peptide deformylase proteins (PDFs) participate in the N

60 Removal of the formyl group by a peptide deformylase renders the dipeptide product, which

61 modium falciparum, a complete picture of the peptide deformylase structure and function relationship

62 er in their protein biosynthetic mechanisms, peptide deformylase, the bacterial enzyme responsible fo

63 he design of effective antibiotics targeting peptide deformylase, the structures of the protein-inhib

64 Indeed, three sample mononuclear enzymes, peptide deformylase, threonine dehydrogenase, and cytosi

65 he assessment of the catalytic properties of peptide deformylase using a series of synthetic N-formyl

66 A macrocyclic, peptidomimetic inhibitor of peptide deformylase was designed by covalently cross-lin

67 porter protein expressed in a strain lacking peptide deformylase was shown to retain the formyl group