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   1 hic secreted APPalpha (sAPPalpha) and the P3 peptide fragment.                                       
     2  expression of a betaarr1 C-terminal-derived peptide fragment.                                       
     3 in the hydrolysis of polypeptides into small peptide fragments.                                      
     4 e of proIAPP in detail by analyzing a set of peptide fragments.                                      
     5 ent for intact proteins rather than degraded peptide fragments.                                      
     6 uently requires proteolysis of proteins into peptide fragments.                                      
     7 ire processing of native proteins into short peptide fragments.                                      
     8 hat is based on the coupling of glycopeptide/peptide fragments.                                      
     9 as obtained through N-terminal sequencing of peptide fragments.                                      
    10 hod for the total synthesis of proteins from peptide fragments.                                      
    11 d comparative mass spectrometric analysis of peptide fragments.                                      
    12  leading to the formation of Abeta and Abeta peptide fragments.                                      
    13 ell as circulating N-terminal and C-terminal peptide fragments.                                      
    14 ave studied the characteristics of these two peptide fragments.                                      
    15 half by mapping the photocovalently modified peptide fragments.                                      
    16 ed to completely prevent generation of small peptide fragments.                                      
    17 '-phosphorylated pentanucleotides containing peptide fragments.                                      
    18 ased upon single-stranded DNA scaffolding of peptide fragments.                                      
    19 only a few structures of oligomers formed by peptide fragments.                                      
    20 ro, staphopain B degraded LL-37 into shorter peptide fragments.                                      
    21 e semisynthesis via the chemical ligation of peptide fragments.                                      
    22 ti-apoptotic N1 and the scrapie-resistant C1 peptide fragments.                                      
    23 hat generate the pathogenic or nonpathogenic peptide fragments.                                      
    24  where it cleaves food proteins into smaller peptide fragments.                                      
    25 ation may prevent the formation of cytotoxic peptide fragments.                                      
    26 erform native chemical ligation (NCL) of two peptide fragments.                                      
    27 nize the organismal origin of unknown DNA or peptide fragments.                                      
    28 bn-N) and the TRAP (tyrosine-rich amelogenin peptide) fragments.                                     
  
  
  
  
    33     Synthesis and coupling of the individual peptide fragments [34 + 35 --> 51] followed by macrocycl
    34 Preabsorption of the antiserum with metastin peptide fragment (45-54)-NH2 (1 microg/ml) resulted in n
    35 um directed against the synthetic C-terminal peptide fragment (47-73), irBC was detected in the mouse
    36 sing amino acid sequences derived from Csp24 peptide fragments, a full-length cDNA was cloned and sho
    37 d chromatography fraction revealed two alpha-peptide fragments (alpha128-alpha139) and a heme moiety 
  
    39 esulted in the cleavage of the MB containing peptide fragment and caused a decrease in electrical sig
  
    41 d PKC-stimulated phosphorylation of the same peptide fragments and comigration of PKC-stimulated phos
  
    43 corresponding to the carbohydrate-containing peptide fragments and large and small trypsin fragments 
    44 with MALDI-TOF mass spectrometry analysis of peptide fragments and peptide microsequencing, indicates
  
    46 sequence patterns, distinct from non-binding peptide fragments, and multi-millions of binding and non
    47 -expressed T-cell receptors (TCRs) recognize peptide fragments (antigens) of pathogens bound to major
    48 h analyses typically assume that a protein's peptide fragments are observed with equal likelihood, on
  
    50 -isotope tags and fragmented, and the tagged peptide fragments are separated by liquid chromatography
    51 s in the fluorescence intensity of a labeled peptide fragment as well as a decrease in solution pH as
  
  
    54  mechanisms by which beta-amyloid (Abeta), a peptide fragment believed to contribute to Alzheimer's d
  
    56 ld SPI forms large ions identified as common peptide fragments bound to either Fmoc or the surface li
    57  effective in preliminary searches for C-PTH peptide fragments, but the use of high laser power limit
  
  
  
    61 vealed that the CB1 C-terminal juxtamembrane peptide fragment CB1-(401-417) can directly activate the
    62 nhardtii caltractin (CRC-C) and a 19 residue peptide fragment comprising the putative cdc31p-binding 
    63 ctional characteristics of template-directed peptide fragment condensation reactions in neutral aqueo
    64 offer the promise of using this chemistry in peptide fragment condensations to produce modified pepti
  
  
    67  receptor, while [ (125)I]IAC44 was found in peptide fragments consistent with labeling of both SBDLI
  
  
    70  in its amino acid sequence and that a TcSSS peptide fragment containing a sequence homologous to a b
    71  and RGS16 incorporated [3H]palmitate into a peptide fragment containing Cys-98, a highly conserved c
  
  
    74 o signal, whereas the enzymatically produced peptide fragment containing the above sequence showed th
    75 the label was recovered in the COOH-terminal peptide fragment containing the engineered cysteine.    
  
  
    78 718 and 1831, corresponding to the unlabeled peptide fragments containing the active site Tyr411 resi
    79 fibrils are built by modifying the synthetic peptide fragment corresponding to residues 105-115 of th
  
    81 natured F30H-G(B1) is more extensive than in peptide fragments corresponding to the beta1-beta2, alph
    82 d anti-hinge antibodies were generated using peptide fragments corresponding to the endostatin region
    83 tion of vectors that drive the expression of peptide fragments corresponding to their binding domains
    84 cortactin Src homology 3 (SH3) domain with a peptide fragment derived from a cDNA encoding a region o
  
    86 tal surface with REDOR NMR show that, in the peptide fragment derived from the N-terminal 15 amino ac
  
    88 f high-resolution structures of CaM bound to peptide fragments derived from ion channels, there is no
  
  
    91 ancing activity parallels the degradation of peptide fragments derived from the semenogelins (SEMs), 
    92 the Ru label, whereas binding of the cleaved peptide fragment devoid of Ru label reduced the ECL sign
  
  
    95 measure the molecular weights of the tryptic peptide fragments (e.g., peptide mass mapping) and parti
    96  rabbit antiserum raised against a synthetic peptide fragment encoding the unique C terminus revealed
    97 ing the Rosetta fragment picker for accurate peptide fragment ensemble generation, the PIPER docking 
    98 uence patterns between intra-protein binding peptide fragments exist, they can be extracted using a d
    99 vity to Scl-70 and 8 overlapping recombinant peptide fragments (F1-F8) that span the human topo I mol
   100 the peptide mass fingerprint (MALDI-TOF) and peptide fragment fingerprinting (MALDI LIFT-TOF/TOF) spe
  
  
   103 on these regions, we focused on an antigenic peptide fragment from a disulfide bridge-bounded region 
  
  
   106 anic molecule (fluorescein), a 12 amino acid peptide fragment from the C-terminus of beta-catenin, th
  
  
   109 xpensive methodology to generate fluorescent peptide fragments from a parent sequence with diverse ch
   110 nd multi-millions of binding and non-binding peptide fragments from currently available protein X-ray
   111 tration calorimetry to investigate synthetic peptide fragments from different domains of the full-len
  
  
  
  
  
   117 vations by examining a series of overlapping peptide fragments from the human and rodent sequences.  
  
  
   120 proteins and/or an LC-MS analysis of tryptic peptide fragments generated after the oxidation reaction
  
   122 taL-crystallin was higher in the presence of peptide fragments generated from oxidized and trypsin-di
  
  
   125 erefore been necessary, for instance, on the peptide fragment GNNQQNY7-13 of yeast prion protein Sup3
  
   127 l crystal structures of skeletal muscle RyR1 peptide fragments have been solved, but these cover less
  
  
   130 with CD and 1D NMR studies of the 21-residue peptide fragment (HP21) derived from HP36 have shown tha
   131 s work, for the first time, four human C-PTH peptide fragments, hPTH(34-84), hPTH(37-84), hPTH(38-84)
  
  
   134 oth cell types, and amino acid sequencing of peptide fragments identified the same protein, histone H
   135  antibodies against GB-generated centromeric peptide fragments identify a distinct clinical subset.  
   136 hat inhibit the recruitment of a coactivator peptide fragment in in vitro biochemical assays (IC(50) 
  
   138 signature for identifying inhibitor-modified peptide fragments in complex mass spectrometry data.    
  
  
   141 , we identified over one dozen APP-generated peptide fragments in wild-type yeast (PRE1PRE2) and over
  
   143 on program, it was observed that some cyclic peptides fragmented in unexpected ways resulting in the 
   144 eave chromogranin A into biologically active peptide fragments, including catestatin, which inhibits 
  
   146 ry/mass spectrometry analysis on the tryptic peptide fragments indicates that the 3-fluorosialyl moie
   147  reached by using only seven short synthetic peptide fragments, instead of the 155 non-overlapping 15
  
   149 ecursors, presentation requires transport of peptide fragments into the ER, but the nature of the cyt
   150 site-specific integration of amino acids and peptide fragments into the homodetic cyclic peptide arch
  
   152 ed by a diagnostic mass shift in one or more peptide fragment ions (for example, phosphorylation).   
  
  
   155 aining reagents for shifting mass defects of peptide fragment ions was systematically investigated, t
   156    The ASA method successfully distinguishes peptide fragment ions with and without an FIMDL group an
  
   158 ctra included singly protonated peptide ion, peptide fragment ions, and peaks characteristic of the s
   159 dentification of these separated proteins or peptide fragments is typically achieved by mass spectrom
  
   161 ce with the mixed GAG glycosylation of agrin peptide fragments, it was found that recombinant and in 
   162 e (TDP1) is a DNA repair enzyme that removes peptide fragments linked through tyrosine to the 3' end 
   163  type glycopeptide fraction revealed Asn-732 peptide fragments linked to the sulfoquinovose-containin
   164  that exist in vertebrates, presenting small peptide fragments, lipid molecules, or small molecule me
  
   166  for DnaK, examined via a short 13-mer apoMb peptide fragment matching the binding site sequence, dis
   167 f spermatogenesis suggests that this laminin peptide fragment may serve as a contraceptive in male ra
  
   169 inally, intracellular application of the MIF peptide fragment MIF-(50-65), which harbors the thiol ox
   170 he biotinylated peptides and analysis of the peptide fragment mixture by nanospray liquid chromatogra
   171 sis of the pepsin-induced fibrils implicates peptide fragments (named H) consisting of the 13 or 15 N
  
  
   174 gen-associated molecular patterns, including peptide fragment of bacterial flagellin (flg22) or trans
  
   176 Using in vitro systems, we have identified a peptide fragment of gankyrin, 176LHLACDEERN185, which is
  
   178 reatment of MeCP2 mutant mice with an active peptide fragment of Insulin-like Growth Factor 1 (IGF-1)
   179 as reinhardtii centrin for calcium and for a peptide fragment of Kar1p using CD, fluorescence, and NM
   180 that the binding mode and stoichiometry of a peptide fragment of NDR (NDR(62-87)) is the same as for 
   181 location of PPAR-gamma is blocked by a short peptide fragment of NOC that inhibits its physical inter
  
   183 I), an amyloid fibril formed from a cationic peptide fragment of prostatic acidic phosphatase (PAP), 
  
  
   186 we report the high-resolution structure of a peptide fragment of the amyloidogenic protein transthyre
  
  
  
  
  
  
   193 assessed whether administration of a soluble peptide fragment of the NgR (sNgR) that binds to and blo
  
   195 myloid fibrils formed from a self-assembling peptide fragment of the protein prostatic acid phosphata
  
  
   198 d VEGF-A binding in the NRP1 b1 domain and a peptide fragment of VEGF-A was shown to bind at the same
  
   200  of DCs to internalize, degrade, and express peptide fragments of antigenic proteins on their surface
   201 s were substantially inhibited by N-terminal peptide fragments of Anxa2 or anti-Anxa2 antibodies.    
  
   203 uence curvature sensing and explores whether peptide fragments of even shorter length can function as
  
  
  
  
   208 pansion, followed by exposure to overlapping peptide fragments of PE38 and an IL-2 ELISpot assay to m
   209 cyte Antigen (HLA) Class I molecules bind to peptide fragments of proteins degraded inside the cell a
   210 ificant reactions of the monochloramine with peptide fragments of proteins that are associated with c
   211 gators have therefore preferred to work with peptide fragments of PrP, suggesting that these peptides
  
   213 betic (NOD) mice, repeated administration of peptide fragments of target antigens in incomplete Freun
   214 sequencing of two cyanogen bromide-generated peptide fragments of the 43-kDa trans-factor revealed co
   215  ionization mass spectrometry identified two peptide fragments of the alphaB crystallin Walker-B moti
  
   217   Previous studies have shown that synthetic peptide fragments of the PrP sequence corresponding to r
  
  
   220 the modified ubiquitin and isomeric glycated peptides (fragments of bovine serum albumin (BSA)).     
  
   222 on, expression of a dominant negative mutant peptide fragment or injection of a function-blocking ant
   223  allows the controlled production of typical peptide fragments or elemental reporter ions informing a
   224 gamma-chains of fibrin and the appearance of peptide fragments over time were assessed by polyacrylam
   225 he CD8(+) T-cell surface interact with short peptide fragments (p) bound to MHC class I molecules (pM
  
  
  
   229   Full-length and conserved C-terminal delta peptide fragments permeabilize the plasma membranes of n
  
  
   232 udy, we provide evidence that the C-terminal peptide fragment produced by caspase cleavage inhibits t
   233   Low molecular weight protamine (LMWP) is a peptide fragment produced in our laboratory from enzymat
  
  
   236 scopic and mass spectrometric studies of the peptide fragments resulting from tryptic digestion of Ka
   237 nce liquid chromatographic separation of the peptide fragments resulting from tryptic digestion of re
   238 and structure of microbial communities using peptide fragment sequences extracted from metagenomic se
  
   240 em, it is generally assumed that angiotensin peptide fragments shorter than angiotensins II and III, 
   241 ts on the full alphatalpha motif and its two peptide fragments show that interhelical tertiary contac
   242 ons followed by MALDI-TOF MS analysis of the peptide fragments showed these 47 kDa species to be CRP 
  
   244 e species include full-length SOD1 proteins, peptide fragments, stable oligomers and ubiquitinated en
   245 ) NMR study of the fibrils formed by a small peptide fragment, structural details of beta(2)m fibrils
   246  cross-linking and co-immunoprecipitation of peptide fragments suggested an inter-subunit N- and C-te
   247 tive did not identify any covalently labeled peptide fragments, suggesting that the phenylazido side 
   248 ansfected HEK-293 cells revealed that a CFTR peptide fragment that binds AMPK (CFTR-1420-57) disrupte
   249 an be used as a template to design a minimal peptide fragment that can be used as a drug against Rho-
  
   251 e the solution structure of the Abeta(21-30) peptide fragment that may be relevant for understanding 
  
   253 otease digestion of the complex, generated a peptide fragment that was bound to the SG promoter.     
   254 ides/proteins such as protamine into smaller peptide fragments that are not detected by the sensing f
   255 ty of SagA is required and generates muramyl-peptide fragments that are sufficient to protect C. eleg
   256 oach involves the digestion of proteins into peptide fragments that can be detected and sequenced wit
   257 radation, inflammation and invasion liberate peptide fragments that can subsequently interact with ce
   258 th or without CKI-alpha depletion identified peptide fragments that corresponded to the region locate
   259 osurvival signaling or generate proapoptotic peptide fragments that help to execute the death program
  
   261 arboxyl-terminal parathyroid hormone (C-PTH) peptide fragments that may be present at only picomolar 
   262 acquisition of approximately 100 overlapping peptide fragments that redundantly cover the 243-residue
   263  that barnase can be split into two inactive peptide fragments, that when co-expressed can complement
   264  the C-terminal acyl donor and using smaller peptide fragments, the Cys(29)-Gly(77) glycopeptide doma
   265  derived from automatic Edman degradation of peptide fragments, the SmCI sequence was fully character
   266   Alanine ligation was used to assemble four peptide fragments, themselves prepared by solid phase pe
   267  are generally characterized through tryptic peptide fragments, this paper reports a method for the i
   268 ies via the deactivation of the SrtA-excised peptide fragment through diketopiperazine (DKP) formatio
   269 ble to effectively stabilize the problematic peptide fragment through the attachment of cleavable arg
   270  used to probe the intrinsic fluorescence of peptide fragments through "deep-UV" excitation of aromat
   271 omochiral products from a racemic mixture of peptide fragments through a chiroselective autocatalytic
   272  acyl-enzyme intermediate linking one of the peptide fragment to a catalytic subunit of the proteasom
   273  MyBP-C (cMyBP-C), we added human N-terminal peptide fragments to human and rodent skinned ventricula
  
   275 ex with the human receptor and a coactivator peptide fragment using x-ray crystallography at 1.9-A re
  
  
   278  increase in the relative intensities of the peptide fragments was achieved, which led to the identif
  
   280 aterial throughput and convergency, the five peptide fragments were assembled into the native ATAD2 b
   281 ch protein digest and the number of detected peptide fragments were compared with conventional MALDI 
   282 the peptide bonds of BSA were hydrolyzed and peptide fragments were desorbed from the surface of gold
  
  
  
   286 ll-length Gag-p24 protein, and the resulting peptide fragments were identified by mass spectrometry. 
   287 ng MALDI-TOF MS, and 102 out of 153 possible peptide fragments were identified giving a sequence cove
   288 digested with chymotrypsin, and the modified peptide fragments were isolated and characterized as 6-h
  
   290 ed caspase-3 in vitro, 13- and 17-kDa capsid peptide fragments were observed and were predicted by al
   291 th trypsin and endoproteinase Asp-N, and the peptide fragments were purified by high performance liqu
   292 le GFAP- and MBP-immunoreactive proteins and peptide fragments were seen, and many of them were also 
  
   294 istinct proteasomal degradation patterns and peptide fragments were unique to either mature DC or act
  
   296 ) is a naturally occurring 40- or 42-residue peptide fragment with a primary role in Alzheimer's dise
   297 a recombinantly produced PIKfyve FYVE domain peptide fragment with PtdIns 3-P-containing liposomes th
  
   299 omic sequence collections revealed groups of peptide fragments with a relatively high abundance and n
  
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