ライフサイエンスコーパス: peptide hormone

1 of ghrelin, a secreted metabolism-regulating peptide hormone.

2 n large part by the N-terminal domain of the peptide hormone.

3 g receptor selectivity in this fast evolving peptide hormone.

4 his region for full agonist activity of this peptide hormone.

5 idates including Neuromedin U, a circulating peptide hormone.

6 e the regulated release of neuropeptides and peptide hormones.

7 the knowledgebase of this critical class of peptide hormones.

8 citonin, and other therapeutically important peptide hormones.

9 ase 1 in response to many growth factors and peptide hormones.

10 endogenously stimulated by moderately large peptide hormones.

11 receptors has been implicated in binding to peptide hormones.

12 AM) catalyzes the COOH-terminal amidation of peptide hormones.

13 nity/protection, sperm-binding proteins, and peptide hormones.

14 ectables and can likely be extended to other peptide hormones.

15 domain, and their signalling is regulated by peptide hormones.

16 py loss-of-function states for the indicated peptide hormones.

17 for developing stabilized analogues of other peptide hormones.

18 Natriuretic peptide hormones, a family of vasoactive peptides with m

19 metabolic products of neurotransmitters and peptide hormones, a novel consequence of the phenomenon

20 coupled receptor that, when activated by the peptide hormone ACTH, stimulates cAMP production and adr

21 In the human adrenal cortex, the peptide hormone adrenocorticotropin (ACTH) directs corti

22 The 52 amino acid peptide hormone adrenomedullin (ADM) plays a major role

23 Here, we report a novel role for the peptide hormone adropin in regulating substrate oxidatio

24 ialized endocrine cells secrete a variety of peptide hormones all along the gastrointestinal (GI) tra

25 teins, typically associated with cleavage of peptide hormones along the secretory pathway.

26 To develop novel proteolysis-resistant peptide hormone analogs, we utilize a strategy that reli

27 Gastrin is a peptide hormone and an important factor in determining t

28 ence of HID-1 results in specific defects in peptide hormone and monoamine storage and regulated secr

29 Hepcidin is a liver-derived peptide hormone and the master regulator of systemic iro

30 This enzyme is able to activate/inactivate peptide hormones and could be involved in a cascade of e

31 of G protein-coupled receptors (GPCRs) bind peptide hormones and have causal roles in many diseases,

32 , inhibition of inflammation, the release of peptide hormones and modulation of fever.

33 Biosynthesis of most peptide hormones and neuropeptides requires proteolytic

34 that most proteins participate in producing peptide hormones and neurotransmitters, enzymes, and the

35 en the importance of insulin and its related peptide hormones and previous studies of glycosylated in

36 Peptide hormones and their cognate receptors belonging t

37 Peptide hormones and their receptors are widespread in m

38 ing a TIR domain-containing protein, a plant peptide hormone, and many OLIGO PEPTIDE TRANSPORTER gene

39 in catecholamine neurotransmitters, amidated peptide hormones, and collagen biosynthetic pathways.

40 a rich source of bioactive molecules such as peptides, hormones, and neurotransmitters, but relativel

41 We report that overproduction of the peptide hormone Angiotensin II (AngII) in tumor-bearing

42 matic activity is responsible for processing peptide hormones angiotensin III and IV.

43 ), cytokinin (CK), brassinosteroids (BR) and peptide hormones are also implicated in plant defence si

44 Peptide hormones are attractive as injectable therapeuti

45 CLE peptide hormones are critical regulators of many cell pr

46 Peptide hormones are implicated in many important aspect

47 Peptide hormones are key physiological regulators, and m

48 Peptide hormones are powerful regulators of various biol

49 Neurotransmitters and peptide hormones are secreted by regulated vesicle exocy

50 Neuropeptides and peptide hormones are stored in the amyloid state in dens

51 he previously held paradigm that steroid and peptide hormones are the primary regulators of mammary g

52 Many neuropeptides and peptide hormones are very similar to antimicrobial pepti

53 -related increases in circulating ghrelin, a peptide hormone, are necessary and sufficient for stress

54 processing of proglucagon yields three major peptide hormones as follows: glucagon in the alpha cells

55 polypeptide (IAPP or amylin) is a 37-residue peptide hormone associated with glucose metabolism that

56 levels of brain natriuretic peptide (BNP, a peptide hormone associated with left ventricular systoli

57 ulating the secretion of the cardiac-derived peptide hormone, atrial natriuretic peptide.

58 , they do not differentiate to express their peptide hormone battery, nor do they project an axon via

59 IAPP, a 37 amino-acid peptide hormone belonging to the calcitonin family, is a

60 6 amino acids with two functional domains, a peptide hormone-binding domain and a G-protein-coupled r

61 re all members of the insulin superfamily of peptide hormones but bind to several distinct classes of

62 way, allows for high-affinity sensing of the peptide hormone by binding to an Arg-His-Asn motif in ID

63 The peptide hormone calcitonin is intimately connected with

64 The peptide hormone calcitonin, which inhibits osteoclast fu

65 olysis-resistant variants of other important peptide hormones can also be found using this strategy t

66 rids (phybrids) comprising covalently linked peptide hormones can leverage independent biological pat

67 d extracellular loop of the receptor for the peptide hormone, cholecystokinin.

68 Ghrelin, a peripherally produced peptide hormone, circulates at high concentrations durin

69 ation of islet amyloid polypeptide (IAPP), a peptide hormone co-synthesized and co-stored with insuli

70 Calcitonin is a peptide hormone consisting of 32 amino acid residues and

71 and the complicated topology of this 51-mer peptide hormone consisting of two chains and three disul

72 ike peptide 5 (INSL5) is a complex two-chain peptide hormone constrained by three disulfide bonds in

73 Hepcidin is a tightly folded 25-residue peptide hormone containing four disulfide bonds, which h

74 Islet amyloid polypeptide (IAPP) is a peptide hormone cosecreted with insulin by pancreatic be

75 ssue by determining the mechanism by which a peptide hormone, crustacean cardioactive peptide (CCAP),

76 ting to the VTA were suppressed by leptin, a peptide hormone derived from adipocytes that signals per

77 that parathyroid hormone-related peptide, a peptide hormone derived from normal and tumor cells that

78 hytosulfokines (PSKs) are secreted, sulfated peptide hormones derived from larger prepropeptide precu

79 r, they provide evidence that the endogenous peptide hormone does not function as an activator per se

80 r numbers of known bioactive peptides (e.g., peptide hormones) during the analysis of gut samples, su

81 rine cells, including those that secrete the peptide hormones (e.g., ghrelin and glucagon-like peptid

82 mplex actions and interactions among several peptide hormones: ecdysis triggering hormone (ETH), eclo

83 he ECD scaffold and the helical structure of peptide hormones emphasizes this hot dog model as a gene

84 inducible and ABA/sugar-repressible putative peptide hormone encoded by GASA6 was severely repressed

85 Adropin is a peptide hormone encoded by the Energy Homeostasis Associ

86 cades of research have demonstrated that the peptide hormone endothelin-1 (ET-1) plays multiple, comp

87 interaction, with the amino terminus of the peptide hormone extended toward the transmembrane helix

88 Evolution often diversifies a peptide hormone family into multiple subfamilies, which

89 The corticotropin-releasing factor (CRF) peptide hormone family members coordinate endocrine, beh

90 Peptide hormone fibroblast growth factor-21 (FGF21) has

91 cytosis of neurotransmitter from neurons and peptide hormones from endocrine cells.

92 ription 3 (Stat3) transduces signals of many peptide hormones from the cell surface to the nucleus an

93 Recently, peptide hormones from the nervous system have been shown

94 d to developing therapeutics targeting other peptide hormone G protein-coupled receptors.

95 The peptide hormone gastrin exerts a suppressive effect on a

96 site is shared by the human gastrointestinal peptide hormones gastrin and cholecystokinin.

97 The peptide hormone ghrelin acts in the central nervous syst

98 The peptide hormone ghrelin is important for both homeostati

99 The peptide hormone ghrelin is the endogenous ligand for the

100 The peptide hormone ghrelin is the only known protein modifi

101 The gastrointestinal peptide hormone ghrelin stimulates appetite in rodents a

102 This interaction links the orexigenic peptide hormone ghrelin to lipid transport and metabolis

103 n octanoyl group to the appetite-stimulating peptide hormone ghrelin, potentially preventing obesity.

104 d behavior was dependent on signaling by the peptide hormone ghrelin.

105 The peptide hormone glucagon-like peptide-1 (GLP-1) enhances

106 Peptide hormones governing many developmental processes

107 mor-homing peptides, antimicrobial peptides, peptide hormones, growth factors and matrix metalloprote

108 Complementary surfaces are buried when peptide hormones, growth factors, or cytokines bind and

109 crude ETEC filtrates, purified STa, and the peptide hormone guanylin.

110 Motilin, a peptide hormone has a direct excitatory effect on circul

111 Ghrelin, a gastric peptide hormone, has been reported to regulate growth ho

112 Hepcidin, an antimicrobial-like peptide hormone, has emerged as the master regulator of

113 PCRs), cell-surface proteins that respond to peptide hormones, has been restricted to the amino-termi

114 herapeutic properties of recombinant relaxin peptide hormone have been investigated in several diseas

115 The peptide hormone hepcidin (Hepc) limits iron uptake from

116 entral role is related to the secretion of a peptide hormone hepcidin by hepatocytes.

117 The hepatic peptide hormone hepcidin controls the duodenal absorptio

118 A major focus is on the regulation of the peptide hormone hepcidin during the inflammatory respons

119 The peptide hormone hepcidin inhibits FPN as part of a homeo

120 The hepatic peptide hormone hepcidin is considered the central regul

121 The hepatic peptide hormone hepcidin is the principal regulator of i

122 The peptide hormone hepcidin is the principal regulator of s

123 Levels of the peptide hormone hepcidin negatively correlate with syste

124 The peptide hormone hepcidin regulates iron metabolism in re

125 The peptide hormone hepcidin regulates iron metabolism, and

126 The peptide hormone hepcidin regulates mammalian iron homeos

127 Treatment of cells with the peptide hormone hepcidin, a systemic regulator of iron m

128 emic iron balance is controlled by the liver peptide hormone hepcidin, which is transcriptionally reg

129 signaling induces hepatic expression of the peptide hormone hepcidin.

130 iron exporter ferroportin and its regulatory peptide hormone hepcidin.

131 omeostasis is regulated by the liver-derived peptide hormone, hepcidin.

132 The peptide hormone human relaxin-2 (H2-RLX) has emerged as

133 epeat receptor kinase (LRR-RK) HAESA and the peptide hormone IDA.

134 ADM), and amylin belong to a unique group of peptide hormones important for homeostasis in diverse ti

135 Hepcidin is the key peptide hormone in iron homeostasis, and is secreted pre

136 urther support the concept of C-peptide as a peptide hormone in its own right and suggest a potential

137 ly conserved sequences, we predicted another peptide hormone in pro-somatostatin and named it neurono

138 trol and prolong the bioactivity of a native peptide hormone in vivo.

139 ic enzyme for the production of POMC-derived peptide hormones in secretory vesicles.

140 ction of ACTH, beta-endorphin, and alpha-MSH peptide hormones in the regulated secretory pathway.

141 mice that have defects in the production of peptide hormones, in the function of cell membrane recep

142 ropin releasing factor (CRF)/urocortin (Ucn) peptide hormones include four structurally similar pepti

143 Several peptide hormones including bradykinin and angiotensin I

144 NE cells express a variety of peptide hormones, including the bombesin (BBS)-like pept

145 ptors that are activated by neurohypophysial peptide hormones, including vasopressin (AVP).

146 embers of the oxytocin/vasopressin family of peptide hormones induce in Hirudo verbana a sequence of

147 Peptide hormones, initially identified in the periphery

148 ptide binding in which the C terminus of the peptide hormone interacts almost exclusively with the N-

149 served that a major portion of both of these peptide hormones interacts with the phospholipid head gr

150 Hepcidin-25 is a peptide hormone involved in iron absorption and homeosta

151 Ghrelin is a peptide hormone involved in regulation of appetite, gluc

152 rs (GPCRs) respond to paracrine or endocrine peptide hormones involved in control of bone homeostasis

153 nt techniques to determine specific forms of peptide hormones involved in physiologic processes; inve

154 The action of a variety of peptide hormones is critical for proper growth and diffe

155 in the concentration of functionally related peptide hormones is critical to understanding the etiolo

156 However, the remodelling capacity of these peptide hormones is difficult to study in chronic settin

157 Hepcidin, a peptide hormone, is a key regulator in mammalian iron ho

158 The 37-residue peptide hormone islet amyloid polypeptide (IAPP) plays a

159 Calcitonin is a 32-residue peptide hormone known for its hypocalcemic effect and it

160 s system cells but does not co-localize with peptide hormones known to elicit molting behavior, sugge

161 isting variation in a subfamily of plant CLE peptide hormones leads to a synthetic bifunctional pepti

162 on of the receptor for the adipocyte-derived peptide hormone leptin (OB-R) is a characteristic featur

163 For both D. ocoee and E. guttolineata, peptide hormone-like transcripts occur at high frequency

164 Hepcidin, a peptide hormone made in the liver, is the principal regu

165 In contrast to animals, data for plant peptide hormone maturation are scarce and the specificit

166 l electron transport, iron mobilization, and peptide hormone maturation.

167 l electron transport, iron mobilization, and peptide hormone maturation.

168 by the discovery of hepcidin, the main serum peptide hormone negative regulator of body iron.

169 tegrated to obtain a structural model of the peptide hormone neuropeptide Y (NPY) bound to its human

170 sults support the hypothesis that packing of peptide hormones/neuropeptides in dense-core vesicles do

171 quence of OCN predicts that, like many other peptide hormones, OCN is first synthesized as a prohormo

172 stimulating factor (G-CSF) is an endogenous peptide hormone of the hematopoietic system that has bee

173 stimulating factor (G-CSF) is an endogenous peptide hormone of the hematopoietic system that has ent

174 7) [Ang-(1-7)] is an endogenous 7-amino acid peptide hormone of the renin-angiotensin system that has

175 hrough modulating the actions of circulating peptide hormones on the brain.

176 In particular, the peptide hormone osteocalcin, which is made by bone and f

177 Two peptide hormones, oxytocin and vasopressin, are also ass

178 zes recent progress on the identification of peptide hormones participating in the pathophysiology of

179 eoblasts that inactivates an uncharacterized peptide hormone, phosphatonin, which suppresses bone min

180 Here, we describe a growth-promoting peptide hormone, phytosulfokine (PSK), as attenuating PT

181 Glucagon, a 29-residue peptide hormone, plays an important role in glucose home

182 es involved in the proteolytic maturation of peptide hormone precursors and are implicated in a varie

183 proteolytic maturation of a large number of peptide hormone precursors.

184 roles in the maturation of neuropeptides and peptide hormone precursors.

185 ical processes, including tissue remodeling, peptide hormone processing, and cancer.

186 Prolactin is a peptide hormone produced by the anterior pituitary gland

187 Relaxin, a peptide hormone produced during pregnancy, is involved i

188 mation requires hepcidin, an iron regulatory peptide hormone produced in the liver, but the inflammat

189 Inhibin is a heterodimeric peptide hormone produced in the ovary that antagonizes a

190 Ghrelin, an octanoylated peptide hormone produced in the stomach, rises dramatica

191 Leptin, a peptide hormone produced primarily by the adipocytes, is

192 ology and mass spectrometry, we identified a peptide hormone product of the gastrin gene (glycine-ext

193 Batterham et al. report that the gut peptide hormone PYY3-36 decreases food intake and body-w

194 evolutionary lineage of the neurohypophysial peptide hormone receptor family of G-protein coupled rec

195 a and represent the best refined models of a peptide hormone receptor in this important family.

196 search for small-molecule drugs that act at peptide hormone receptors has resulted in the identifica

197 iverse plant peptides, suggesting that plant peptide hormone receptors may share a common ligand bind

198 anistic link between increased expression of peptide hormone receptors, such as GRP-R, and proangioge

199 ptor (GIPR), are three metabolically related peptide hormone receptors.

200 n agonist at three key metabolically-related peptide hormone receptors: glucagon-like peptide-1 (GLP-

201 sponsible of the degradation of the incretin peptide hormones regulating blood glucose levels.

202 Parathyroid hormone (PTH) is an important peptide hormone regulator of bone formation and osteobla

203 ation using short-term administration of the peptide hormone relaxin (RLN).

204 The peptide hormone relaxin is showing potential as a treatm

205 recombinant form of the naturally occurring peptide hormone relaxin-2, is a pleiotropic vasodilating

206 The ovarian peptide hormone, relaxin, circulates during pregnancy, c

207 eyond the widely accepted role of regulating peptide hormone release from enteroendocrine cells in th

208 nce resulting from changes in sensitivity of peptide hormone release.

209 Angiotensin II (AngII), a peptide hormone released by adipocytes, can be cataboliz

210 Secretin is a peptide hormone released from the duodenum to stimulate

211 d (acoustic) extraction of insulin and other peptide hormones released from freshly prepared islets,

212 edullin (Adm, gene; AM, protein)-a mitogenic peptide hormone required for normal cardiovascular devel

213 as a regulator connecting sugar, ABA, GA and peptide hormone responses.

214 at subtle changes in the native structure of peptide hormone(s) could alter its conformational dynami

215 ere we investigate GAG interactions with the peptide hormone salmon calcitonin (sCT).

216 Leptin is a peptide hormone secreted by adipose tissue and regulates

217 lin is a 28 amino acid, appetite-stimulating peptide hormone secreted by the food-deprived stomach.

218 Hepcidin is a peptide hormone secreted by the liver in response to iro

219 Hepcidin is a peptide hormone secreted by the liver that plays a centr

220 mic iron balance is regulated by hepcidin, a peptide hormone secreted by the liver.

221 Ghrelin is an endogenous peptide hormone secreted primarily by the stomach and is

222 Ghrelin is an orexigenic gastric peptide hormone secreted when caloric intake is limited.

223 gulates the expression of genes encoding the peptide hormones secreted by each cell type, including t

224 The gastrointestinal peptide hormone, secretin (SCT) that binds to secretin r

225 rantee continuous availability and function, peptide hormone secretion must be tightly coupled to its

226 ein expressed in cells with stimulus-coupled peptide hormone secretion, including pancreatic beta cel

227 These synthetic peptide hormones share the overall structure of GLP-1 an

228 to study the mechanisms by which steroid and peptide hormone signaling control gene expression.

229 been implicated as a downstream effector of peptide hormone signaling during urogenital ridge develo

230 aling pathways, multiple growth factors, and peptide hormone signaling systems, and genes involved in

231 The endocrine system mediates long-range peptide hormone signaling to broadcast changes in metabo

232 egation and fibril reversibility of a cyclic peptide hormone somatostatin (SST)-14 using various tech

233 imide bridge, and this is illustrated on the peptide hormone somatostatin.

234 udies define mechanisms for gastrointestinal peptide hormone stimulation of glucose uptake.

235 Heart muscle cells produce peptide hormones such as natriuretic peptides.

236 PC2), an enzyme involved in the synthesis of peptide hormones, such as glucagon and proopiomelanocort

237 mammals, the production of insulin and other peptide hormones, such as the islet amyloid polypeptide

238 utocrine feedback mechanism in regulation of peptide hormone synthesis.

239 tropin-releasing hormone (GnRH) is a trophic peptide hormone synthesized by hypothalamic neurons and

240 have decreased urinary levels of hepcidin, a peptide hormone that binds to the cellular iron exporter

241 -Fc(mIgG)-Leptin, a bifunctional therapeutic peptide hormone that combines the glucagon-like peptide

242 e peptide 1 (GLP-1) is a 30 or 31 amino acid peptide hormone that contributes to the physiological re

243 Hepcidin, a peptide hormone that decreases intestinal iron absorptio

244 Hepcidin is a peptide hormone that functions as a key regulator of mam

245 Cholecystokinin (CCK) is a peptide hormone that induces bile release into the intes

246 al peptide (Hamp) is a hepatic defensin-like peptide hormone that inhibits duodenal iron absorption a

247 Somatostatin (SS) is a peptide hormone that inhibits insulin secretion in beta-

248 ation factor 1 (AtRALF1) is a small secreted peptide hormone that inhibits root growth by repressing

249 Ghrelin (Grln) is a peptide hormone that is predominantly produced in the st

250 Ghrelin is a 28-residue peptide hormone that is principally released from the st

251 Glucagon-like peptide 1 (GLP-1) is a peptide hormone that is released from the gut in respons

252 l natriuretic peptide (ANP) is an endogenous peptide hormone that is synthesized and secreted by the

253 Fibroblast growth factor 21 (FGF21) is a peptide hormone that is synthesized by several organs an

254 Relaxin is a peptide hormone that mediates antifibrotic effects throu

255 tropin-releasing hormone (GnRH) is a trophic peptide hormone that modulates reproductive function and

256 Hepcidin is a peptide hormone that negatively regulates iron egress fr

257 Angiotensin II, a small peptide hormone that plays key roles in the regulation o

258 Hepcidin is a peptide hormone that regulates iron homeostasis and acts

259 Hepcidin is a peptide hormone that regulates iron homeostasis and acts

260 Uroguanylin is a peptide hormone that regulates sodium excretion by the k

261 e intestine secrete cholecystokinin (CCK), a peptide hormone that stimulates digestion of fat and pro

262 Ghrelin is a peptide hormone that stimulates growth hormone (GH) rele

263 n of this strategy to oxyntomodulin (OXM), a peptide hormone that stimulates insulin secretion from i

264 ich is processed to ghrelin, an octanoylated peptide hormone that stimulates release of growth hormon

265 Ghrelin is a gastric peptide hormone that stimulates weight gain in vertebrat

266 Angiotensin II (Ang II) is a peptide hormone that, like many cytokines, acts as a pro

267 The protein and peptide hormones that control these physiological parame

268 o proteolytically process a diverse suite of peptide hormones that coordinate larval and pupal growth

269 ve successfully identified other steroid and peptide hormones that impact on mammary gland developmen

270 thesis coupling for glucagon, one of several peptide hormones that increase blood glucose levels.

271 This variation is mediated by steroid and peptide hormones that influence ion currents through cha

272 quences homologous to other classes of plant peptide hormones that may be utilized by these pests.

273 is that AMON acts to proteolytically process peptide hormones that regulate hatching, larval growth,

274 Hepcidin-25 is a peptide-hormone that has been proposed as the key biomar

275 e main amyloidogenic region from the insulin peptide hormone, the LVEALYL heptapeptide.

276 cardioactive peptide (CCAP) neurons and the peptide hormones they secrete are critical for ecdysis;

277 ue role as the sole blood glucose-decreasing peptide hormone, this coupling is considered an exceptio

278 the first to report DOPA cross-linking of a peptide hormone to a GPCR and the first to identify a re

279 nd imipramine pamoate (Tofranil-PM); and the peptide hormones triptorelin pamoate (Trelstar) and octr

280 The peptide hormone Urocortin 3 (Ucn 3) is abundantly and ex

281 The peptide hormone urocortin3 (Ucn3) is abundantly expresse

282 Although the circulating level of peptide hormone urotensin II (UII) and kidney tissue exp

283 Neuropeptides are peptide hormones used as chemical signals by the neuroen

284 chanism that accounts for the ability of the peptide hormone vasopressin to regulate water excretion

285 urons (MNC) which synthesize and release the peptide hormones vasopressin and oxytocin.

286 ocrine tissues secrete neurotransmitters and peptide hormones via large dense-core vesicles (LDCVs).

287 aracterize conformational changes induced by peptide hormones, we investigated interactions of the cl

288 interactions at the N-terminal domain of the peptide hormone were manifested by suppressed cAMP gener

289 Several peptide hormones were recently suggested to be stored as

290 IAPP is a 37-residue peptide hormone which forms amyloid fibers in individual

291 Secretin is a 27-residue peptide hormone with a diffuse pharmacophoric domain tha

292 Apelin is an important mammalian peptide hormone with a range of physiological roles, esp

293 recombinant human relaxin-2, is a vasoactive peptide hormone with many biological and haemodynamic ef

294 Adrenomedullin (AM) is a peptide hormone with numerous effects in the vascular sy

295 Fibroblast growth factor 21 (FGF21), a peptide hormone with pleiotropic effects on carbohydrate

296 iuretic peptides (NPs) are cyclic vasoactive peptide hormones with high therapeutic potential.

297 Thus, two peptide hormones with opposing action in weight regulati

298 vous system, equipped with neuropeptides and peptide hormones with potent antimicrobial properties, m

299 The storage of protein/peptide hormones within subcellular compartments and sub

300 A nonradioactive label for peptide hormones would be useful for pharmacokinetic stu