ライフサイエンスコーパス: peptide library

1 valuated by screening a combinatorial Tyr(P) peptide library.

2 from TMEV-infected mice using an overlapping peptide library.

3 through the screening of a combinatorial pY peptide library.

4 inding proteins by screening a combinatorial peptide library.

5 oma cell line, H2009, from a phage-displayed peptide library.

6 eptides were selected from the combinatorial peptide library.

7 natural protein library and a combinatorial peptide library.

8 tro, using a filamentous phage display 7-mer peptide library.

9 isolate peptide mimics from a phage display peptide library.

10 atalyzed digestion of the best pools of each peptide library.

11 man memory T cell response using a synthetic peptide library.

12 rofiled using a positional scanning branched peptide library.

13 et to screen a phage-displayed combinatorial peptide library.

14 er an i.v. administration of a phage display peptide library.

15 ptides were identified using a phage display peptide library.

16 ied using a filamentous bacteriophage random peptide library.

17 dentified from a combinatorial phage display peptide library.

18 e exchange to create a dynamic combinatorial peptide library.

19 pecific peptide ligands from random sequence peptide library.

20 pecificity of mTOR using positional scanning peptide libraries.

21 ion through adenovirus-displayed, semirandom peptide libraries.

22 e sequencing of hit beads from combinatorial peptide libraries.

23 ility for high-throughput screening of (RGD-)peptide libraries.

24 explored using combinatorial chemistry based peptide libraries.

25 solated by screening synthetic combinatorial peptide libraries.

26 tions of phage display selection from 15-mer peptide libraries.

27 apid unambiguous sequencing of combinatorial peptide libraries.

28 nds is usually approached by screening large peptide libraries.

29 ould be desirable to prepare and screen beta-peptide libraries.

30 and H-2K(d) was confirmed using recombinant peptide libraries.

31 acid substitution analogues and nonredundant peptide libraries.

32 15 monoclonal aCL to screen 17 phage-display peptide libraries.

33 sites using the collagen II and III Toolkit peptide libraries.

34 y and binding kinetics of phages, displaying peptide libraries.

35 eening of structurally more diverse bicyclic peptide libraries.

36 atically profiled by screening combinatorial peptide libraries.

37 ts, using recombinant phages encoding random peptide libraries.

38 amenable to the in-cell production of cyclic peptide libraries.

39 MHC alleles was determined using a synthetic peptide library (143 peptides of the core protein of hum

40 A genotype 3a peptide library (616 overlapping peptides spanning open

41 e conducted yeast two-hybrid screens of Brf1 peptide libraries against different TPR-containing Tfc4

42 ting colon cancer, we screened phage display peptide libraries against fresh human colonic adenomas f

43 After screening of the cyclic peptide library against a macromolecular target, the ide

44 Screening of a bicyclic peptide library against tumor necrosis factor-alpha (TNF

45 arallel synthesis of two small, focused beta-peptide libraries allowed us to identify relatively shor

46 The generation of a small peptide library allowed optimization of peptide sequence

47 Oriented peptide library analysis indicated that the BRCT domains

48 ucted fluorogenic and standard combinatorial peptide libraries and analyzed them using fluorescence a

49 tegrates the principles of both the oriented peptide libraries and array technologies.

50 Using combinatorial peptide libraries and B cell lines expressing single HLA

51 such broad-spectrum AMPs from combinatorial peptide libraries and demonstrate that a simple in vitro

52 rculosis and S. coelicolor against synthetic peptide libraries and identified new substrate sequences

53 Here we screened phage-displayed peptide libraries and identified the 13-amino acid linea

54 Phage-displayed peptide libraries and in vitro affinity assays were used

55 positional scanning of biotinylated oriented peptide libraries and insights emerging from those deter

56 ection was developed using bacterial display peptide libraries and multiparameter flow cytometry (MPF

57 asin D and shewasin A using proteome-derived peptide libraries and observed remarkable similarities b

58 The convergence of phage-displayed peptide libraries and recombinant viral vectors launched

59 surface display screening from combinatorial peptide libraries and SPOT peptide array analysis--to el

60 Herein, we use phage-display of naive peptide libraries and synthetic peptides to investigate

61 Using a combinatorial peptide library and a cytotoxic T lymphocyte clone that

62 Here we utilize a peptide library and bioinformatic approach to predict li

63 was mapped by screening the Collagen Toolkit peptide library and by hydrogen/deuterium exchange.

64 ughput screening of a phage-displayed random peptide library and classified the cell lines according

65 ha-chymase selects P1 Leu in a combinatorial peptide library and cleaves Ala-Ala-Pro-Leu-4-nitroanili

66 genetic selection, we have screened a random peptide library and identified a group of C-terminal mot

67 d mAb as bait for screening of phage display peptide library and identifying those peptides with rand

68 tope mapping performed by screening a random peptide library and in silico docking modeling suggested

69 rofiled by screening against a combinatorial peptide library and kinetic analysis of individually syn

70 n and from 4 adults with celiac disease to a peptide library and measured T-cell receptor bias.

71 matrix (PSSM) based on results from oriented peptide library and phage display experiments.

72 positional scanning synthetic combinatorial peptide libraries, and biometric data analysis.

73 k with S1 scanning peptides, phage-displayed peptide libraries, and S1 truncation/deletion variants w

74 crine-based screening of large combinatorial peptide libraries, and show that P5 promotes G-protein s

75 fluorescence resonance energy transfer-based peptide library approach in defining the substrate speci

76 ombining a positional scanning combinatorial peptide library approach with a peptide-HLA-I dissociati

77 ssessed in 15 kinases using a new degenerate peptide library approach.

78 Random-sequence peptide libraries are a commonly used tool to identify n

79 Phage-displayed peptide libraries are a powerful tool to identify peptid

80 orced" HDX approach in which MS/MS-confirmed peptide libraries are built via nano or standard ESI wit

81 er of computationally constructed and actual peptide libraries are estimated using this method.

82 Whereas peptide libraries are rich sources of protein-binding mo

83 Hundreds of pools of oriented peptide libraries are synthesized as amino acid scan arr

84 nd intracellular cytokine (ICC) assays using peptide libraries as antigens indicated that a significa

85 Using a small five-member peptide library as a model, we show that by utilizing th

86 mors by in vivo screening of phage-displayed peptide libraries, asking whether they too have distinct

87 Using a positional scanning peptide library assay, we determined the optimal phospho

88 dentified from a combinatorial phage display peptide library assemble preferentially to the edge or p

89 Using a focused peptide library based on a sequence derived from the in

90 ations, we designed a phage-displayed random peptide library based on previous knowledge of structure

91 We constructed a combinatorial peptide library based on the BIV Tat ARM and identified

92 es from a 7776-member rational combinatorial peptide library based on the sequence of the natural por

93 signed a 9,604-member rational combinatorial peptide library based on the structural principles of kn

94 ons, we designed a 3888-member combinatorial peptide library based on the TM domain of Neu (ErbB2) as

95 brane-permeabilizing peptides, we screened a peptide library, based on the archetypal pore-former mel

96 nase substrate specificity using an unbiased peptide library-based approach with direct measurement o

97 g epitope of Bcl-2 could be identified via a peptide library-based membrane assay.

98 A global peptide library-based screening strategy revealed that t

99 ve displayed a 12-amino-acid (12-mer) random peptide library between the H and I sheets of the fiber

100 e not only in competitive immunoscreening of peptide libraries but also as immunogenic carriers of al

101 decreased their degradation and that of the peptide libraries by 30-50%.

102 d ribosome display (RD) with the analysis of peptide libraries by next generation sequencing (NGS) of

103 Peptide mimics isolated from phage display peptide libraries by panning with self-tumor-associated

104 The development of peptide libraries by site-selective modification of a fe

105 quence was previously isolated from a random peptide library by binding to growth hormone binding pro

106 A systematic screening of a Pex5 peptide library by ligand blot analysis revealed a novel

107 We recently demonstrated that phage peptide libraries can be an excellent source of immunore

108 ts indicate that virus-displayed, semirandom peptide libraries can be used to optimize targeting infe

109 motifs selected in vivo from a combinatorial peptide library can cross the BBB under normal and patho

110 The cyclic peptide library can potentially be of any size and the p

111 icrofluidic device to screen a combinatorial peptide library composed of 5 x 108 members displayed on

112 specificity of 3Clpro using fully degenerate peptide libraries consisting of all 160,000 possible nat

113 protein interactions of FXI, a large random peptide library consisting of 10(6) to 10(7) peptides wa

114 Our peptide library consists of a novel series of cyclic alp

115 ntral to this process is the idea that small peptide libraries contain sequences that will bind to in

116 nitially identified from combinatorial phage peptide libraries, contain the sequence YPYF(I/L)P(L/I)

117 cetylase sequence specificity using oriented peptide libraries containing acetylated lysine.

118 synthesize and screen one-bead-one-compound peptide libraries containing free C-termini.

119 ter enzyme selectivity can be achieved using peptide libraries containing unnatural amino acids such

120 ike ligands from an mRNA-display macrocyclic peptide library containing >10(12) members.

121 A pY peptide library containing completely randomized residue

122 AMPs, including SMAP-29 and hRNase 7, from a peptide library containing crude mammalian cell lysates.

123 An inverted peptide library containing five random residues (theoret

124 A combinatorial peptide library containing four random residues at the N

125 obes, a feature that we show to be rare in a peptide library containing many members with species-spe

126 A 16,384-member rational combinatorial peptide library, containing peptides of 9-15 amino acids

127 We demonstrate here that composition-space peptide libraries coupled with function-based high-throu

128 ve alphaMI-domain binding sites, we screened peptide libraries covering the complete sequences of the

129 We developed an in vivo peptide library covering substrates of the ER Hsp70 syst

130 On the basis of matrices derived from the peptide library data, we identified and then confirmed t

131 recognition specificity using substitutional peptide libraries demonstrated that the alphaMI-domain b

132 by folding HLA-E in vitro in the presence of peptide libraries derived from a nonameric leader peptid

133 with Reptin was localized using overlapping peptide libraries derived from the AGR2 protein sequence

134 internal agonist, we systematically screened peptide libraries derived from the ectodomain for agonis

135 Analysis of a synthetic peptide library derived from LL-37 showed that antimicro

136 With the use of a peptide library derived from Sema3F, C-1 residues that p

137 We demonstrate the approach using a peptide library derived from the Escherichia coli proteo

138 by comparison of in vitro phosphorylation of peptide libraries differing by a single residue at that

139 ay of specific epitopes but are incapable of peptide library display and affinity selection.

140 Pools of disulfide-constrained random peptide libraries displayed on phage were selected for b

141 inhibitors through selection of constrained peptide libraries displayed on phage.

142 An improved binary tag system for encoding peptide libraries during synthesis was designed to facil

143 First, using overlapping peptide libraries encompassing the entire translated seq

144 ith the optimal binding motifs determined by peptide library experiments, as well as other experiment

145 By screening a combinatorial peptide library, followed by structure-activity relation

146 ariable cysteine-constrained phage-displayed peptide libraries for factor H-binding peptides.

147 itionally relied upon testing of overlapping peptide libraries for their reactivity with T cells in v

148 A searchable modified peptide library for Arabidopsis is available online at h

149 We screened a peptide library for mutations in SDF-1 that provide resi

150 We screened a phage-displayed peptide library for peptides that home to wounds in mice

151 this new system to screen a capsid-displayed peptide library for retargeted viral infection.

152 In this study, we used random peptide libraries from 7- to 13-mers and studied binding

153 Profiling its specificity with peptide libraries from Escherichia coli revealed a prefe

154 t will also allow the construction of random peptide libraries from which specific binding activities

155 d a method for estimating the diversity of a peptide library from the sequences of a limited number o

156 ocks in the ribosomal synthesis of unnatural peptide libraries, from which functional, NRP-like molec

157 Capsid-displayed adenoviral peptide libraries have been a significant, yet unfeasibl

158 Peptides identified from combinatorial peptide libraries have been shown to bind to a variety o

159 Random bacteriophage (phage) display peptide libraries have traditionally been used for the s

160 Screening of the peptide library identified a lead substrate specifically

161 In addition, screening a combinatorial peptide library identified select amino acid substitutio

162 further expand the utility of combinatorial peptide libraries in biomedical research.

163 We discuss the contribution of phage display peptide libraries in determining dominant B-cell epitope

164 Direct screening of combinatorial peptide libraries in patients may allow the identificati

165 od for the rapid generation of combinatorial peptide libraries in sufficient purity to assay the prod

166 to synthesis and screening of combinatorial peptide libraries in the future.

167 Here, by selecting combinatorial random peptide libraries in tumor-bearing mice, we uncovered a

168 ypothesis that methods focusing on screening peptide libraries in vitro for members with the appropri

169 Here we screened a peptide library in cancer patients to uncover ligand-rec

170 Here we screen a combinatorial peptide library in mice and characterize a peptide (with

171 Screening of a combinatorial peptide library in positional scanning format led to the

172 was used to isolate mimotopes from a 12-mer peptide library in successive selection rounds.

173 ecapeptide positional scanning combinatorial peptide libraries indicated a preference for basic resid

174 one-bead, one-compound (OBOC) combinatorial peptide libraries is routinely carried out with the pept

175 Affinity selection of phage display peptide libraries is routinely used for isolating peptid

176 through screening and analysis of synthetic peptide libraries, ligand 1 has 7500-fold improved affin

177 d viremic KTR were stimulated using BK virus peptide libraries loaded or not on monocytes-derived den

178 rtoires were determined by identifying bound peptide library members for each specimen using cell sor

179 hod for the sequence determination of cyclic peptide library members has been developed.

180 we report the development of a combinatorial peptide library method for systematically profiling the

181 Here we describe a combinatorial peptide library method that allows rapid generation of p

182 tinct target sequences, we used a degenerate peptide library method to comprehensively characterize t

183 Several peptide library methods have been developed and widely u

184 d the degradation of proteasome products and peptide libraries nearly completely.

185 display, enabling the synthesis of unnatural peptide libraries of 10(14) unique members for the in vi

186 This report demonstrates that peptide libraries of defined character can serve as a re

187 e previously been delineated using synthetic peptide libraries of fixed length, or single protein cha

188 Recombinant FAP cleavage of peptide libraries of short amino acid sequences surround

189 In brief, phage-encoded combinatorial peptide libraries of the format X(m)CX(n)CX(o)CX(p) are

190 ribe a method for the biosynthesis of cyclic peptide libraries of up to 10(8) members in Escherichia

191 pproach that utilises human proteome-derived peptide libraries of varying length, termed Proteomic Id

192 and robust cyclization procedure to screen a peptide library of >10(13) different sequences and isola

193 A 5-mer OBOC peptide library of 104,907 unique sequences was construc

194 We first established a comprehensive peptide library of allergens from various commercial ext

195 expand the testable sequence space within a peptide library of approximately 100 members for CDK1, C

196 njugated alphaDEC205 with a linker-optimized peptide library of known CD8 T-cell epitopes from the mo

197 A peptide library of topographically segregated encoded re

198 his goal, we biopanned three phage-displayed peptide libraries on a series of well-defined human non-

199 struction of high-complexity random sequence peptide libraries on MS2 VLPs and that allow control of

200 Here, phage-peptide library panning coupled with screening using nex

201 We use two distinct modified peptide-library platforms (beads and glass slides) to de

202 In vitro selection of chemically modified peptide libraries presented on phage, while a powerful t

203 uration through the screening of macrocyclic peptide libraries produced in E. coli cells.

204 of immunoprecipitation/mass spectrometry and peptide library profiling, we identified the eukaryotic

205 -I collagen as well as kinetic studies using peptide libraries randomized at P1 and P1', showed very

206 Combinatorial peptide libraries ranging in length between 9 and 12 ami

207 In this report, we screened a peptide library representing the SARS-CoV S protein sequ

208 pitope mapping with a phage-displayed random peptide library revealed that one of these mAbs (2A5) co

209 fluorescence resonance energy transfer-based peptide library revealed that the I144A, I144C, and I144

210 Epitope mapping, using a phage display peptide library, revealed that cAb29 binds the 2alpha(1)

211 Previously, a phage display peptide library screen identified SM1, a peptide that bi

212 Here we describe a peptide library screen to identify sequence requirements

213 An iterative mixture-based random doedecamer peptide library screen with Edman sequencing of MMP-20 c

214 ing kinase phosphorylation motifs than older peptide library screening approaches based on Edman sequ

215 We performed combinatorial peptide library screening in vivo on a novel human prost

216 this reaction, we have used a combinatorial peptide library screening platform as a method to explor

217 We used combinatorial peptide library screening to design an optimal peptide s

218 Finally, we used combinatorial peptide library screening to determine that PASK prefers

219 rected mutagenesis, pegylation of molecules, peptide library screening, and gene transfer) have resul

220 ifs through integration of bacterial display peptide library screening, next-generation sequencing (N

221 Through peptide library screening, we identified ADAMTS-like pro

222 ion site sequence, which we verified through peptide library screening.

223 this study demonstrate that phage-displayed peptide library screens on lipid membranes result in the

224 peaklists accommodating, in MS/MS-confirmed peptide library searches, ambiguous mass-hits to non-tar

225 dria, and that an internalizing-phage random peptide library selects for peptide motifs that localize

226 roof of concept, we produced phage-displayed peptide libraries Ser-[X]4-Gly-Gly-Gly, with Gly and Ser

227 Experiments with random-sequence peptide libraries show the single-chain dimer to be high

228 y diverse T cells specific for CMV lysate or peptide libraries spanning pp65 and immediate early (IE)

229 By screening peptide libraries spanning the sequence of the alphaIIb

230 Using an overlapping peptide library spanning each of the RSV-derived protein

231 pectrometry and screening of a 413,611 human peptide library spanning the entire human proteome ident

232 Using a peptide library spanning the entire LMP2 sequence, 25 CT

233 icial antigen-presenting cells loaded with a peptide library spanning the entire PRAME protein and co

234 Using a peptide library spanning the entire sequence of the hexo

235 nse, using for the first time an overlapping peptide library spanning the entire viral genome.

236 horylation sequence reported previously from peptide library studies.

237 re investigated by positional scanning using peptide libraries that substituted its leucine core with

238 iously identified ligands from combinatorial peptide libraries that target tumor vasculature after in

239 echnology was demonstrated for two synthetic peptide libraries that were used to screen and optimize

240 Kv1.3 channel blockers from a natural venom peptide library that was formatted for autocrine-based s

241 de novo sequencing followed by a search in a peptide library that we created.

242 A peptide library (that was displayed on phage) was positi

243 y to specify the amino acid frequency in the peptide library; these frequencies often differ signific

244 Here, we screened degenerate peptide libraries to deduce the optimal ULK1 substrate m

245 We have used peptide libraries to determine the optimal substrate seq

246 rface biomarkers, emphasizing the utility of peptide libraries to probe the surface of a cell.

247 Here we use assembly assays with peptide libraries to show that high-expressing B15 class

248 en developed to screen one-bead-one-compound peptide libraries to systematically profile the sequence

249 enesis, homology modeling, and assays with a peptide library to characterize the structural determina

250 four rAbs to probe a random phage-displayed peptide library to determine if epitopes within the MV n

251 gonal high-throughput screen of an iterative peptide library to identify peptide sequences that have

252 sisted iterative screening applied to random peptide libraries unveiled a novel and atypical recognit

253 es, we screened computationally designed BH3 peptide libraries using bacterial surface display to ide

254 erties were identified from a Zealand Pharma peptide library using pharmaceutical profiling, establis

255 0-1) substrates, were selected from a random peptide library using the phage display technique.

256 nd BT2) were selected from a phage-displayed peptide library via binding to tetragonal BaTiO3 powder.

257 When the peptide library VVWXTA (where X represents all 20 common

258 degradation in the extracts and that of the peptide libraries was completely blocked by o-phenanthro

259 The bead-based peptide library was composed of the general sequence H(2

260 First, a human anti-peptide library was constructed by diversifying a scaffo

261 A random peptide library was expressed on the surface of a mammal

262 A yeast-displayed cystine-knot peptide library was generated by substituting a six amin

263 A phosphotyrosyl (pY) peptide library was screened against the SH2 domains, an

264 A combinatorial phosphotyrosyl (pY) peptide library was screened to determine the amino acid

265 This peptide library was subsequently used to evolve an inhib

266 In this work, a cyclic peptide library was synthesized and screened against the

267 performed using high-resolution MS, and the peptide library was then used to identify prototypic and

268 An acetyl-histone peptide library was used to determine the thermodynamic

269 Next, the generated peptide library was used to develop a targeted proteomic

270 A peptide library was used to map the binding site and def

271 nel of single-substitution analogs and large peptide libraries, we derived novel detailed binding mot

272 Using peptide libraries, we determined if this frequently iden

273 Using peptide libraries, we found that in PTN the alphaMI doma

274 Using combinatorial peptide libraries, we functionally measured broad T-cell

275 By screening HMGB1 peptide libraries, we identified a tetramer (FSSE, desig

276 Probing phage-displayed peptide libraries, we identified and characterized mimet

277 tility in genetically encoded, combinatorial peptide libraries, we report a simple and robust method

278 Using phage display peptide libraries, we screened for ligands that bound to

279 Using a phage-displayed peptide library, we determined that 24B11 binds an epito

280 sing dendritic cells pulsed with a cyclin-A1 peptide library, we generated T cells against several cy

281 Using a combinatorial peptide library, we identified a consensus binding seque

282 mia cells with a combinatorial phage display peptide library, we isolated a peptide motif, sequence P

283 Six constrained peptide libraries were constructed and selected against

284 nship (SAR) study, two highly focused cyclic peptide libraries were further designed, synthesized, an

285 Bacterial cell-displayed peptide libraries were quantitatively screened for binde

286 The FAIMS approach identified 35% of the peptide library, whereas LC-MS/MS alone identified 8% an

287 e reactivity of these compounds with a model peptide library, which collectively contained all 20 nat

288 By scanning synthetic combinatorial peptide libraries with each enzyme, we compared the pref

289 Preparation of support-bound combinatorial peptide libraries with free C-termini has been challengi

290 Panning of phage display peptide libraries with mAb 763.74 and mAb GH786 resulted

291 long natural protein and short combinatorial peptide libraries with much higher complexities.

292 By screening a 13-mer peptide library with a diversity of 10(8), we have ident

293 using a one-bead, one-compound (OBOC) acetyl-peptide library with a quantum dot tagging strategy and

294 t mimic the LOS by screening a phage-display peptide library with a rabbit Ab specific for NTHi LOS.

295 trate consensus, we screened a combinatorial peptide library with active MRK.

296 motope of GD2, isolated from a phage display peptide library with anti-GD2 mAb 14G2a, induces MHC cla

297 ular mimicry was sought by screening a phage peptide library with anti-GPIIIa49-66 antibody as bait f

298 med an external correction using a synthetic peptide library with known peptide relative abundance.

299 Screening of the X(15) phage display peptide library with the anti-GD2 monoclonal antibody (m

300 We screened a random peptide library within the receptor-binding domain of a