ライフサイエンスコーパス: peptide motif

1 event blocks ADAP-SH3c domain binding to the peptide motif.

2 eins are known to be mediated by a conserved peptide motif.

3 has defined the binding pocket for the LXCXE peptide motif.

4 host macrophages with its ELR (Glu-Leu-Arg) peptide motif.

5 ind ligands containing the Arg-Gly-Asp (RGD) peptide motif.

6 l antigen sensitivity and recognize the same peptide motif.

7 d peptides containing an appropriate HLA-B35 peptide motif.

8 a variety of interactions and bind distinct peptide motifs.

9 by the activators' short acidic-hydrophobic peptide motifs.

10 n components through their carboxyl-terminal peptide motifs.

11 been found which recognize specific internal peptide motifs.

12 ined by a common fold and a set of conserved peptide motifs.

13 us A (PVA) proteinases that cleave different peptide motifs.

14 redicted by encoded transmembrane and leader peptide motifs.

15 GXM), is highly protective and binds several peptide motifs.

16 SH3 domains interact with proline-rich peptide motifs.

17 ide interaction does not utilise established peptide motifs.

18 be segregated into four groups according to peptide motifs.

19 tal anionic groups linked by self-assembling peptide motifs.

20 formed between structured domains and short peptide motifs.

21 compact interaction modules, referred to as peptide motifs.

22 dular domains each interacting with multiple peptide motifs.

23 evolutionary conservation of Vg-proteotypic peptide motifs.

24 ons, were found to share largely overlapping peptide motifs.

25 responsible for their emergence from simple peptide motifs.

26 t the CRD and guide selection of synergistic peptide motifs adjacent to the CRD.

27 The two distinct peptide motifs adopt markedly different bound conformati

28 Asp(330) exposed a novel p10 NH(2)-terminal peptide motif (AISS) that retained the ability to mediat

29 h foldable sequence-space between the simple peptide motif and extant protein fold is demonstrated.

30 es the utility of the approach to predicting peptide motifs and individual residues important for the

31 the potential utility of myriad other short peptide motifs and provide a blueprint for therapeutic a

32 By analyzing selected cell-homing peptide motifs and their NCI-60 recognition patterns, we

33 novel leucine-rich sequence or an undefined peptide motif, and both appear to act through CRM1-indep

34 et binds E2F, the A/B pocket binds the LXCXE peptide motif, and the C pocket binds the nuclear c-Abl

35 re screened for H-2b allele-specific class I peptide motifs, and four peptides (PA11, PA12, PA13, and

36 The same peptide motifs are contained in pathogenic microorganism

37 These peptide motifs are not only conserved among the TCF fami

38 While this staggering number suggests that peptide motifs are numerous and the most understudied fu

39 ent work demonstrates that chromatin-derived peptide motifs are portable and in some cases can be cus

40 ich contain COOH-terminal PDZ domain binding peptide motifs, are found colocalized at high density at

41 Arginine-rich peptide motifs (ARMs) capable of binding unique RNA stru

42 ubstitutions defined the critical amino acid peptide motif as RRKQXK-PXXF.

43 of the discovery of phosphoserine/threonine peptide motifs as binding targets of the polo box domain

44 - blocking peptides yielded phage with a new peptide motif (Asn-Pro-Phe) that also bound specifically

45 owth regulators able to bind both glycan and peptide motifs at intra- and extracellular sites.

46 The crystal structure of this peptide motif bound to vinculin D1 shows that the two he

47 tapeptides, based on our previously reported peptide motif c(-phg-isoDGR-X-), in which high activity

48 ains three copies of a conserved DNA-binding peptide motif called the 'AT-hook' that preferentially b

49 orylation site but also by binding to linear-peptide motifs called docking sites.

50 and computational analysis, that a truncated peptide motif can engage the two anomers of an isolated

51 Surprisingly small peptide motifs can confer critical biological functions.

52 s utilized to successfully identify a simple peptide motif capable of recapitulating, via gene duplic

53 lpha-helical coiled-coil to generate modular peptide motifs capable of assembling into metalloporphyr

54 o the DNA template by interacting with short peptide motifs conserved in a variety of sequence-specif

55 The results showed that: (a) minimal signal peptide motifs consisting of charged N, hydrophobic H, a

56 II beta-turn that serves to place the entire peptide motif, consisting of ThrP5, ProP6, TrpP8, MetP9

57 hanistic models that describe how reiterated peptide motifs could synergistically effect transcriptio

58 A peptide motif [CS][CS]-x(0,2)-G-x(1)-C-x(2,3)-S-x(3)-L f

59 evidenced by their requirement for specific peptide motifs, cytoskeletal elements, and motor protein

60 Here we show that a phosphorylated peptide motif derived from human papillomavirus 8 (HPV-8

61 in a shallow groove formed by the conserved peptide motif E ... H ... SXWY ... G, with additional st

62 mbrane-associated adaptors, which have short peptide motifs, either the clathrin-box (CBM) and/or the

63 dia proteins and tagged them with a multiple peptide motif element called F8M4.

64 Peptide motifs embedded within intrinsically disordered

65 ucture drives Grp94 recognition, rather than peptide motifs exposed by unfolded protein.

66 The LXCXE peptide motif facilitates interaction between the RB tum

67 Most PDZ domains recognize specific peptide motifs followed by a required COOH-terminus.

68 To identify peptide motifs for FAP-selective inhibitor design, we us

69 enced the erg6 cDNA, identified the putative peptide motifs for the sterol and SAM binding sites in t

70 tructure of human Pds5B bound to a conserved peptide motif found in both Wapl and Sororin.

71 terminal half of which contains a mixture of peptide motifs found in alpha-, beta-, and gamma-tubulin

72 (KLC(TPR)), they can recognize short linear peptide motifs found in many cargo proteins characterize

73 its kinesin-1 interactions with short linear peptide motifs found in organelle-specific cargo adaptor

74 Adaptor protein interaction with specific peptide motifs found within the intracellular, carboxyl

75 his study shows that a short linear EEIWVLRK peptide motif from Caskin1 is necessary and sufficient f

76 The data suggest that peptide motifs from at least three regions of the N-term

77 The selection of distinct peptide motifs from identical libraries confirmed that m

78 crystallography, we show that FxDxF and WVxF peptide motifs from synaptojanin bind to distinct subdom

79 neutrophil-binding phage displaying a novel peptide motif, GPNLTGRW.

80 sin comprises two phylogenetically conserved peptide motifs, [GS]LFXG[ML]X[LV] and S[AV]F[SA]FLN, wit

81 A peptide motif, GXXX(D/E)(R/K)XG(R/K)(R/K), has been cons

82 activity, and a synthetic acidic-hydrophobic peptide motif had large-scale chromatin decondensation a

83 These essential peptide motifs have now been shown to function by access

84 age displaying trinitrotoluene (TNT)-binding peptide motifs identified from a phage display selective

85 AuNCs toward S. aureus and MRSA, the binding peptide motifs identified from HSA-AuNCs were characteri

86 ecific mutants, we identified a novel, short peptide motif immediately C-terminal to the signal seque

87 Although a short conserved peptide motif in Sall1 is sufficient to recruit NuRD, it

88 We demonstrate here that a peptide motif in the C terminus of the HTLV-1 nucleocaps

89 substitution mutants, we identified a short peptide motif in the cytoplasmic C-terminal region of EA

90 ated that this domain binds to both the NPXY peptide motif in the lipoprotein receptor tails as well

91 with clathrin through one or two copies of a peptide motif in the p6 domain of Gag that resembles the

92 (HIV-1) and other retroviruses harbor short peptide motifs in Gag that promote the release of infect

93 well established that retroviruses use short peptide motifs in Gag, known as late domains, to usurp c

94 the IRS proteins may ordinarily bind acidic peptide motifs in membrane proteins or other acidic memb

95 The presence of related peptide motifs in other transcription factors indicates

96 sion that involves competition between short peptide motifs in repressor and activator proteins for i

97 DZ domains accomplish by binding to specific peptide motifs in target proteins.

98 Mutational disruption of each of five LXXLL peptide motifs in the beta-catenin armadillo repeats did

99 lved in endosomal protein sorting, and short peptide motifs in the HIV-1 Gag late domain and Ebola vi

100 t there might be over a million instances of peptide motifs in the human proteome.

101 to known Stat3-binding phosphotyrosine (pY) peptide motifs, including those of the epidermal growth

102 r for E2F-responsive elements, and an RGD-4C peptide motif inserted into the adenoviral fiber to enha

103 ficile by the sortase SrtB and that an SPKTG peptide motif is involved in the transpeptidation reacti

104 Interestingly, this peptide motif is sequestered within the known ASF1-H3-H4

105 Single peptide motifs joined by a flexible amino acid linker in

106 iral structural protein, Gag, contains small peptide motifs known as late domains that promote effici

107 proteins containing the abundant endothelial peptide motifs led to a nearly 100-fold increase of surf

108 We evaluated several cyclic peptide motifs linked by ester bonds between the P2 and

109 ) of NHERF specifically binds to an internal peptide motif located within the COOH-terminal regulator

110 tudies reveal that multiple degenerate short peptide motifs located within the RGG domain of Npl3p se

111 L epitope prediction that relies on dominant peptide motifs may not always identify the correct epito

112 ve identified a short evolutionary conserved peptide motif named SADH motif (SCRIB ABLIMs DMTN Homolo

113 xport can be determined by positively acting peptide motifs, namely, NESs, and suggest that Rev prote

114 Similarly, this same synthetic peptide motif of HIP could block about 50% of [3H]HP bin

115 to a heparan sulfate (HS)-binding synthetic peptide motif of HIP in a HP-inhibitable fashion.

116 control by binding the C-terminal (M/I)EEVD peptide motif of Hsp/c70(90) with its N-terminal tetratr

117 e neuropilin-binding RXXK tissue-penetration peptide motif of iRGD.

118 d this by analyzing the function of the ;QA' peptide motif of the Hox protein Ultrabithorax (Ubx), a

119 Two copies of a mutant peptide motif of VP16 (viral protein 16) possess large-s

120 Three peptide motifs of cMyBPC were identified as the potentia

121 ibodies in human sera that recognize allelic peptide motifs of distinct parasite types.

122 Peptide motifs of HLA-C unveil anchors in position 2 or

123 approach was developed in order to identify peptide motifs of interest based on clustering and contr

124 a tool to elucidate the specific function of peptide motifs of proteins.

125 , SM proteins bind the N-terminal peptide (N-peptide) motif of the SNARE subunit syntaxin, but the fu

126 ferred to a protein by the presentation of a peptide motif on a surface loop.

127 nt (PIF) pocket--is engaged by an activating peptide motif on downstream substrate kinases (PIFtides)

128 recycling in a manner that is dependent on a peptide motif on the cytoplasmic domain.

129 xes through their ability to recognize short peptide motifs on other proteins.

130 hereby MDM2 binding to at least two distinct peptide motifs on p53 promotes ubiquitination.

131 nique for selectively recognizing glycan and peptide motifs on the surface of red blood cells.

132 ittle is known about the functional domains, peptide motifs, or residues of any Vif protein.

133 nhances the subsequent binding of additional peptide motifs; or 3) a high-affinity interaction betwee

134 ernative way to obtain the whole class I MHC peptide motif, particularly when a specific antibody is

135 sequence, yet a lysine-rich 12-14-amino acid peptide motif (pentalysine cluster), which is conserved

136 dditive contributions of activity-regulating peptide motifs play important roles in moderating the ph

137 Here we show that a repeated peptide motif present in both SMRT and NCoR is sufficien

138 aromyces cerevisiae gene YRB1 and contains a peptide motif present in several proteins found within t

139 Tyrosine 204 resides in a peptide motif previously thought to be involved in AdoMe

140 IV from the plasma membrane requires a small peptide motif, Pro-Thr/Ser-Ala-Pro (PTAP), located near

141 at sequence-dependent glycosylation of small peptide motifs results in glycomodules.

142 Here we observed the presence of a tri-peptide motif, RGD, in domain 6 of the human CDH17 seque

143 s transmembrane domain(s) or signal sequence peptide motif(s) suggests that Tub is an intracellular p

144 tides having a motif almost identical to the peptide motif selected by 2H1.

145 We used in vivo phage display to isolate a peptide motif (sequence CKGGRAKDC) that homes to white f

146 phage display peptide library, we isolated a peptide motif, sequence Phe-Phe/Tyr-Any-Leu-Arg-Ser (F(F

147 Natural biopolymers, such as peptide motif sequences, can be used as a template to di

148 synergistically effect transcription: 1) the peptide motifs simultaneously bind to quasi-identical si

149 haracterized and revealed a highly conserved peptide motif sufficient to inhibit TCR-mediated signali

150 A conserved peptide motif, T1, within the DT transmembrane helix 1 m

151 nts were performed to compare the avidity of peptide motifs, tandemly repeated two or four times, and

152 epressors, which bind to TLX via a conserved peptide motif termed the Atro box.

153 AAVP-TNF particles displaying the octreotide peptide motif (termed Oct-AAVP-TNF) were confirmed in vi

154 eractions through the binding of a conserved peptide motif, termed PAM2.

155 analysis of the features of this turn-helix peptide motif that are necessary for IGFBP-1 binding and

156 Moreover, this work uncovers a new peptide motif that binds to and inhibits intracellular a

157 Zalpha is a peptide motif that binds to Z-DNA with high affinity.

158 esulfonamides and that also includes the RGD peptide motif that can bind to cell-surface integrin adh

159 two zinc fingers (ZFs) consisting of a CCHC peptide motif that coordinates Zn(II).

160 oteins, possesses a well-characterized LXCXE peptide motif that interacts with the pocket domain of p

161 p codons on full-length mRNA using a nascent peptide motif that interferes with translation terminati

162 nds tightly to Vps45p via a short N-terminal peptide motif that is absent in Pep12p.

163 Thus, SurA recognizes a peptide motif that is characteristic of integral outer m

164 The eib sequences predict a C-terminal peptide motif that is characteristic of outer membrane p

165 ce analysis shows that P267 is embedded in a peptide motif that is conserved among the Trm5 family, b

166 These catalysts are based on a DXaa-DXaa peptide motif that is known to target the teicoplanin st

167 amino acid residues and a minimal fusogenic peptide motif that is necessary for promoting cell-cell

168 In addition, we have identified a conserved peptide motif that is required for this interaction.

169 d by a tripeptide in the V2 loop of gp120, a peptide motif that mimics structures presented by the na

170 Recent studies identified a short peptide motif that serves as a docking site for cyclin/c

171 mals, like pathogenic bacteria, have evolved peptide motifs that allosterically activate N-WASP, lead

172 ymes of halophilic organisms contain unusual peptide motifs that are absent from their mesophilic cou

173 activator subdomains and acidic-hydrophobic peptide motifs that are responsible for transcriptional

174 elicited by phosphate were clustered in the peptide motifs that comprise the active site.

175 hat lead to Taxol resistance-we selected for peptide motifs that confer resistance to Taxol-induced c

176 Hox protein evolution, and that pleiotropic peptide motifs that contribute quantitatively to several

177 from >1,000 peptides, we characterized novel peptide motifs that include dominant anchor residues ext

178 ing-phage random peptide library selects for peptide motifs that localize to different intracellular

179 that PDZ domains can recognize some internal peptide motifs that occur within a specific secondary st

180 ichia coli, we identified additional nascent peptide motifs that stall ribosomes.

181 Zinc fingers are small DNA-binding peptide motifs that were discovered in this laboratory.

182 On the basis of this peptide motif, the present study aimed at identifying th

183 nce for the membrane compartmentalization of peptide motifs thought to target to lipid rafts.

184 T-Ag and E1A each contains an LXCXE-peptide motif through which binding to the conserved 'A/

185 tylproteins was used to identify a potential peptide motif, TMDX1-12AAC(C)A (TMD, transmembrane domai

186 me with an M13KE phage that delivers a small peptide motif to an F(+), alpha-complementing strain of

187 ruses exploit a capsid-associated small PPxY peptide motif to manipulate the autophagic machinery to

188 beta4GalNAc-T4 are able to utilize the same peptide motif to selectively add GalNAc to beta1,6-linke

189 Conjugation of beta-sheet peptide motif to the CHP results in self-assembly of non

190 conserved H(abc) domain, which connects an N-peptide motif to the SNARE core domain and is thought to

191 for ClpX, in that both proteins use related peptide motifs to bind to the N-terminal domain of ClpX,

192 eceptors based on similarity of the selected peptide motifs to mouse proteins.

193 ing (VPS) pathway to bud from cells, and use peptide motifs to recruit specific class E VPS factors.

194 all intrinsically disordered or unstructured peptide motifs to regulate the specific activity of a pr

195 ent an approach for the efficient docking of peptide motifs to their free receptor structures.

196 Here, we identified a peptide motif, TPKTSVT, that homes to the yolk sac, indu

197 In addition to peptide motifs, ubiquitination of cytosolic lysine resid

198 peptide display and one ZIP kinase consensus peptide motif was identified in p21(WAF1).

199 Ralpha ligand-binding domain and coactivator peptide motifs was comparable to PPARalpha agonists, but

200 Although interactions with the consensus peptide motif were conserved in all structures, flanking

201 of four CAMHC peptides containing the -KXXS- peptide motif were found to be immunogenic.

202 Specific substitutions within the 3S peptide motif were prepared by directed mutagenesis.

203 Different peptide motifs were recovered from each of these tissues

204 me sequence showed that these EF-P-dependent peptide motifs were represented in flagellar genes.

205 ar receptors preferentially bind to an LXXLL peptide motif which is highly conserved throughout the 3

206 in containing the C-terminal Asp-Pro nascent peptide motif (which interferes with translation termina

207 We designed and screened minimal peptide motifs whose conjugates with polyethylene glycol

208 vivo B. subtilis reporter system identified peptide motifs whose efficient synthesis was most depend

209 ubiquitin-interacting motif (UIM) is a short peptide motif with the dual function of binding ubiquiti

210 R)-fold, a module that typically binds short peptide motifs, with three TPR alpha-helical repeats.

211 between the KLC2(TPR) domain and a conserved peptide motif within an unstructured region of the molec

212 lex in vivo Previously we identified a short peptide motif within H3 that binds to the TPR domain of

213 racts with alphabeta-tubulin through a small peptide motif within its MT-binding domain.

214 ing mutational analysis, we show that a WRPW peptide motif within the Otx2 protein is required for ph

215 bunit to specific phosphotyrosine-containing peptide motifs within activated cytoplasmic receptor dom

216 eparase recognizes and cleaves two conserved peptide motifs within Scc1.

217 de microarray screening of C3 identified two peptide motifs within the beta chain of fibrinogen (resi

218 elimits residues within two highly conserved peptide motifs within the tail that are required (KKCRAR

219 ese activators, and short acidic-hydrophobic peptide motifs within these subdomains.

220 mediated by seven conserved diaromatic penta-peptide motifs (WXXX(F/Y) motifs) in the N-terminal half