ライフサイエンスコーパス: peptide nucleic acid

1 nto oligomeric strands that are analogous to peptide nucleic acid.

2 -(2-aminoethyl)glycine (AEG), a backbone for peptide nucleic acids.

3 very of conventional and chemically-modified peptides nucleic acids.

4 sed by reduction in the cytoplasm, including peptide nucleic acids, a cyclic peptide (phalloidin), an

5 mobilized anthraquinone-labeled pyrrolidinyl peptide nucleic acid (acpcPNA) probe was successfully de

6 ection system using immobilized pyrrolidinyl peptide nucleic acid (acpcPNA) probes.

7 ssay for DNA detection based on pyrrolidinyl peptide nucleic acid (acpcPNA)-induced nanoparticle aggr

8 sensor was developed based on a pyrrolidinyl peptide nucleic acid (acpcPNA)/polypyrrole (PPy)/silver

9 ethylenediamine portion of aminoethylglycine peptide nucleic acids (aegPNAs) with one or more (S,S)-t

10 We have shown that antigene peptide nucleic acids (agPNAs) and antigene duplex RNAs

11 The resulting alpha-helical peptide nucleic acids (alpha PNAs) are composed of a rep

12 Peptide nucleic acid and 2'-O-MeRNA oligomers inhibit te

13 We report that peptide nucleic acid and locked nucleic acid antisense o

14 Here we use triplex-forming peptide nucleic acids and donor DNA in biodegradable pol

15 itions adjacent to the lambda operators with peptide nucleic acids and monitored their movement by te

16 here is a brief introduction to the field of peptide nucleic acids and their potential benefits as pr

17 y method is described based on surface-bound peptide nucleic acids and water-soluble cationic conjuga

18 More specifically, proteins, peptides, nucleic acids and polysaccharides serve as vit

19 made with triplex-forming oligonucleotides, peptide nucleic acids, and polyamides, but substantial e

20 biomimetics, molecular imprinting polymers, peptide nucleic acids, and ribozymes were encompassed as

21 miR-690 knockdown using peptide nucleic acid-antagomiR was able to unblock and s

22 ments using two triplex-forming molecules, a peptide nucleic acid-antennapedia (PNA-Antp), and a TFO

23 We find that the attachment of peptide nucleic acid antimiRs to a peptide with a low pH

24 Peptide nucleic acids are a class of nondegradable oligo

25 Finally recent results on the use of peptide nucleic acids as oligonucleotides surrogate are

26 The platform was developed using peptide nucleic acids as probes on gold electrode surfac

27 Herein, we show that peptide nucleic acids, as short as six nucleobases, bind

28 s, stemless and stem-containing DNA and PNA (peptide nucleic acid) beacons, in Tris-buffer solutions

29 Bis-peptide nucleic acid (bis-PNA) binding results in D-loop

30 emplated chemical transformation of bifacial peptide nucleic acid (bPNA) fragments directed by an abi

31 We demonstrate herein that bifacial peptide nucleic acid (bPNA) hybrid triplexes functionall

32 tative NMR spectral parameters for proteins, peptides, nucleic acids, carbohydrates and ligands or co

33 cally labeled using a fluorescein-conjugated peptide nucleic acid clamp.

34 hanism and kinetic specificity of binding of peptide nucleic acid clamps (bis-PNAs) to double-strande

35 We demonstrate that peptide nucleic acid 'clamps' (bis-PNAs) bind strongly a

36 Peptide nucleic acids containing thymidine and 2-aminopy

37 ces, followed by highlights of ways by which peptide nucleic acids could benefit a number of establis

38 The T414G mutation was analyzed by peptide nucleic acid directed clamping PCR.

39 The activity of the peptide nucleic acids does not involve inhibition of tra

40 We show that systemic delivery of antisense peptide nucleic acids encapsulated in unique polymer nan

41 ever, "ligand" molecules, included proteins, peptides, nucleic acids, etc. are expensive and vulnerab

42 diffusivity between a free ferrocene-labeled peptide nucleic acid (Fc-PNA) and a Fc-PNA hybridized wi

43 The utility of peptide nucleic acid fluorescence in situ hybridization

44 These newer tests, peptide nucleic acid fluorescence in situ hybridization

45 carensis and C. nivariensis species-specific peptide nucleic acid fluorescence in situ hybridization

46 cation of Candida albicans blood isolates by peptide nucleic acid fluorescence in situ hybridization

47 A novel rapid peptide nucleic acid fluorescence in situ hybridization

48 Peptide nucleic acid fluorescence in situ hybridization

49 valuate the performance of a new three-color peptide nucleic acid fluorescence in situ hybridization

50 A shortened protocol for two peptide nucleic acid fluorescence in situ hybridization

51 in blood culture bottles within 2.5 h using peptide nucleic acid fluorescence in situ hybridization.

52 We investigated a 2.5-h peptide nucleic acid-fluorescence in situ hybridization

53 A blinded comparison of peptide nucleic acid-fluorescence in situ hybridization

54 In this work, two 28S rRNA-directed peptide nucleic acid-fluorescence in situ hybridization

55 ichment broths by the use of subculture, GBS peptide nucleic acid fluorescent in situ hybridization (

56 selective Streptococcus agar (SSA), and by a peptide nucleic acid fluorescent in situ hybridization (

57 nce of the Candida albicans/Candida glabrata peptide nucleic acid fluorescent in situ hybridization (

58 on of a biofilm in vivo was visualized using peptide nucleic acid fluorescent in situ hybridization (

59 ch probes could be used as an alternative to peptide nucleic acids for investigating the dynamics of

60 mides, triplex-forming oligonucleotides, and peptide nucleic acids for recognition of chromosomal DNA

61 ntly, we have considered the use of DNAs and peptide nucleic acids for this purpose because oligomers

62 how that conformationally preorganized gamma-peptide nucleic acid (gamma-PNA) containing an acridine

63 opipette and an assay of complementary gamma-peptide nucleic acid (gamma-PNA) probes conjugated to po

64 eparing optically pure guanidine-based gamma-peptide nucleic acid (gammaGPNA) monomers for all four n

65 the mRNA and a complementary gamma-modified peptide nucleic acid (gammaPNA) sequence with a noncompl

66 Over the past three decades, peptide nucleic acids have been employed in numerous che

67 Guanine-rich peptide nucleic acids have been previously shown to hybr

68 These synthetic compounds model peptide-nucleic acid heteroconjugates encountered in ant

69 thymine [2+2] dimer repair in DNA and in DNA/peptide nucleic acid hybrid duplexes.

70 othiadiazole) dibromide]), and neutral PNA (peptide nucleic acid) hybridization probes.

71 ansfer (FRET) between fluorescently labelled peptide nucleic acids, hybridized to defined single stra

72 midate (MO) 20mer or hydroxyprolyl-phosphono peptide nucleic acid (HypNA-pPNA) 16mer antisense oligon

73 eukaryotic histones, synthetic peptides, or peptide nucleic acids may be limited by high production

74 Before RNA-based organisms arose, peptide nucleic acids may have been used to transmit gen

75 The peptide nucleic acid-mediated 5 nuclease real-time polym

76 from 97 baseline blood samples by our novel peptide nucleic acid-mediated 5 nuclease real-time polym

77 rference with these lncRNAs using complement peptide nucleic acid molecules down-regulated the active

78 can be successfully targeted by an antisense peptide nucleic acid oligomer named PNA(PR2).

79 Peptide nucleic acid oligomers (PNAs) have a remarkable

80 sequences are superior to those of analogous peptide nucleic acid oligomers, emphasizing the value of

81 ring probe) is threaded, with the aid of two peptide nucleic acid openers, between the two strands of

82 nucleotide, its analog or its mimic (such as peptide nucleic acid, or PNA).

83 e, we report the use of pseudo-complementary peptide nucleic acids (pcPNAs) for intracellular gene ta

84 aluates the potential of pseudocomplementary peptide nucleic acids (pcPNAs) for sequence-specific mod

85 ere, we demonstrate that pseudocomplementary peptide nucleic acids (pcPNAs) represent a class of vers

86 utations in AS, we developed allele-specific peptide nucleic acid-PCR assays.

87 ore stably bound to plasmid DNA than similar peptide nucleic acid (PNA) 'clamps' for procedures such

88 nce-specific DNA-templated polymerization of peptide nucleic acid (PNA) aldehydes.

89 Poly(A) DNA, RNA and peptide nucleic acid (PNA) all form these assemblies.

90 etrating peptide (CPP) conjugates of a 16mer peptide nucleic acid (PNA) analogue targeted to the apic

91 lly cationic and chiral C(gamma)-substituted peptide nucleic acid (PNA) analogues have been synthesiz

92 Here, we test the hypothesis that antisense peptide nucleic acid (PNA) and locked nucleic acid (LNA)

93 based on the strand replacement of dsDNA by peptide nucleic acid (PNA) and the in situ growth of ele

94 systemic barriers for in vivo application of peptide nucleic acid (PNA) anti-microRNA therapeutics.

95 We showed previously that peptide nucleic acid (PNA) anti-miRs containing a few at

96 sociated CD40 protein expression by use of a peptide nucleic acid (PNA) antisense inhibitor, ISIS 208

97 n charge transfer in double-stranded DNA and peptide nucleic acid (PNA) are investigated.

98 ly and sequence-specifically to pDNA using a peptide nucleic acid (PNA) as a linker molecule.

99 Peptide nucleic acid (PNA) as a novel DNA-binding reagen

100 (2'-O-MOE) phosphorothioate, morpholino and peptide nucleic acid (PNA) backbones was investigated us

101 Peptide nucleic acid (PNA) building blocks, bearing a fl

102 ivities of a cell-permeable, guanidine-based peptide nucleic acid (PNA) called GPNA.

103 lo domain partitioning of the palmitoylated peptide nucleic acid (PNA) can be influenced by formatio

104 Here we demonstrate how peptide nucleic acid (PNA) can be used to control the as

105 a gold electrode coated with charge neutral peptide nucleic acid (PNA) capture probes (CPs) is first

106 itoneal injection of an unmodified antisense peptide nucleic acid (PNA) complementary to mRNA of the

107 opolymer microgel based on protein, DNA, and peptide nucleic acid (PNA) components.

108 ense imaging agent comprised of an iodinated peptide nucleic acid (PNA) conjugated to a monoclonal an

109 sonant mechanism of charge transfer in short peptide nucleic acid (PNA) duplexes obtained through ele

110 hroughput microarray screening process using peptide nucleic acid (PNA) encoding technology, allowing

111 e tube coagulase test (TCT) read at 4 h, and peptide nucleic acid (PNA) fluorescence in situ hybridiz

112 easts on Gram stain using a Candida albicans peptide nucleic acid (PNA) fluorescent in situ hybridiza

113 "reporter and miRNA" and "reporter and miRNA-peptide nucleic acid (PNA) hybrid", which yields two sig

114 esized that scintigraphic detection of CCND1 peptide nucleic acid (PNA) hybridization probes with a (

115 ations, using allele-specific, mass-labeled, peptide nucleic acid (PNA) hybridization probes, and dir

116 We designed a CCND1-specific peptide nucleic acid (PNA) hybridization sequence (CTGGT

117 ng RNA function in living cells that we call peptide nucleic acid (PNA) interference mapping.

118 Peptide nucleic acid (PNA) is a DNA mimic in which the n

119 Peptide nucleic acid (PNA) is a DNA mimic with improved

120 Peptide nucleic acid (PNA) is a DNA/RNA mimic that offer

121 Peptide nucleic acid (PNA) is a promising precursor to R

122 Peptide nucleic acid (PNA) is a synthetic analogue of DN

123 Peptide nucleic acid (PNA) is a synthetic DNA mimic with

124 Peptide nucleic acid (PNA) is a synthetic mimic of DNA a

125 s of molecular dynamics simulations of small peptide nucleic acid (PNA) molecules, synthetic analogs

126 uration of the target plasmid sample using a peptide nucleic acid (PNA) oligomer as the probe is desc

127 A peptide nucleic acid (PNA) oligomer, an analogue of DNA,

128 Peptide nucleic acid (PNA) oligomerization of the 5,6-be

129 nes in two mutually complementary mixed-base peptide nucleic acid (PNA) oligomers are substituted wit

130 Guanine-rich peptide nucleic acid (PNA) oligomers bind to homologous

131 Snap-to-it probes were prepared from peptide nucleic acid (PNA) oligomers by modifying each t

132 Peptide nucleic acid (PNA) oligomers have been reported

133 Peptide nucleic acid (PNA) oligomers targeted to guanine

134 A series of partially self-complementary peptide nucleic acid (PNA) oligomers was prepared.

135 ere, we show that a short antisense chimeric peptide nucleic acid (PNA) oligonucleotide conjugated to

136 Steric blocking peptide nucleic acid (PNA) oligonucleotides have been us

137 led telomeric repeat complementing (CCCTAA)3 peptide nucleic acid (PNA) probe coupled with cardiac-sp

138 va telomeric sequence d(G(4)T(4)G(4)) with a peptide nucleic acid (PNA) probe having a homologous rat

139 iameter polystyrene beads to which uncharged peptide nucleic acid (PNA) probe molecules have been con

140 cribed were internally functionalized with a peptide nucleic acid (PNA) probe specific for a gene tra

141 of a target genomic DNA and a complementary peptide nucleic acid (PNA) probe.

142 ry after labeling with an S. aureus-specific peptide nucleic acid (PNA) probe.

143 n situ hybridization (FISH) method that uses peptide nucleic acid (PNA) probes for identification of

144 nce in situ hybridization (FISH) method with peptide nucleic acid (PNA) probes for identification of

145 Peptide nucleic acid (PNA) probes have been synthesized

146 report demonstrates the use of high-affinity peptide nucleic acid (PNA) probes in labeling mRNA trans

147 Comparison with published data for DNA and peptide nucleic acid (PNA) probes is carried out to look

148 Peptide nucleic acid (PNA) probes targeting APP, combine

149 orescence in situ hybridization (FISH) using peptide nucleic acid (PNA) probes targeting Staphylococc

150 Briefly, thiolated peptide nucleic acid (PNA) probes were firstly immobiliz

151 Peptide nucleic acid (PNA) probes were used to capture R

152 on by using cationic conjugated polymers and peptide nucleic acid (PNA) probes with ultrafast pump-du

153 A strategy employing a combination of peptide nucleic acid (PNA) probes, an optically amplifyi

154 nologies: rapid cycling PCR thermal cyclers, peptide nucleic acid (PNA) probes, and a new double-stra

155 zation biosensor, based on thiol-derivatized peptide nucleic acid (PNA) probes, offers unusual in sit

156 ensitize the emission of a dye on a specific peptide nucleic acid (PNA) sequence for the purpose of h

157 A peptide nucleic acid (PNA) targeting a splice junction o

158 ted nucleosome within the polymer by using a peptide nucleic acid (PNA) targeting compound.

159 mycin B (ring II) was conjugated to a 16-mer peptide nucleic acid (PNA) targeting HIV-1 TAR RNA.

160 ew DNA diagnostic is based on combination of peptide nucleic acid (PNA) technology, rolling circle am

161 tic approach to develop an embedded chimeric peptide nucleic acid (PNA) that effectively enters the c

162 nt studies describe the production of 16-mer peptide nucleic acid (PNA) that is antisense around the

163 n 3D nucleic acid-amino acid complexes using peptide nucleic acid (PNA) to assemble peptides inside a

164 Using a peptide nucleic acid (PNA) trap assay, we show that G4R1

165 e energy transfer (FRET) measurements with a peptide nucleic acid (PNA) trap.

166 Briefly, mercapto-terminated peptide nucleic acid (PNA) was firstly immobilized onto

167 A modified M918 peptide conjugated to a peptide nucleic acid (PNA) was shown to silence lucifera

168 A peptide nucleic acid (PNA) with improved strand-displace

169 The modification of peptide nucleic acid (PNA) with unnatural nucleobases en

170 We show here that the hybridization of a peptide nucleic acid (PNA) within or adjacent to the pro

171 C locked nucleic acid (LNA) residues, and a peptide nucleic acid (PNA), inhibit Tat-dependent in vit

172 molecules, each linked to a short strand of peptide nucleic acid (PNA), synthetic polymers that use

173 o acid is used as a building block for a new peptide nucleic acid (PNA), which exhibits excellent DNA

174 A bis-peptide nucleic acid (PNA)-anthraquinone imide (AQI) con

175 Using the recently developed peptide nucleic acid (PNA)-assisted assay, which makes i

176 The peptide nucleic acid (PNA)-assisted identification of RB

177 We have developed the peptide nucleic acid (PNA)-assisted identification of RB

178 We report on the peptide nucleic acid (PNA)-directed design of a DNA-nick

179 DNA samples are first amplified using peptide nucleic acid (PNA)-directed PCR clamping reactio

180 The peptide nucleic acid (PNA)-directed PCR clamping techniq

181 teraction between a cationic cyanine dye and peptide nucleic acid (PNA)-DNA duplexes.

182 ave found that it is possible to use labeled peptide nucleic acid (PNA)-oligomers as probes in pre-ge

183 was to synthesize and evaluate radiolabeled peptide nucleic acid (PNA)-peptide conjugates targeting

184 We describe the synthesis of peptide nucleic acid (PNA)-titanium dioxide (TiO(2)) nan

185 ividual bases are added to abasic sites of a peptide nucleic acid (PNA).

186 her self-folding polymers, including DNA and peptide nucleic acid (PNA).

187 ch the 15mer DNA was replaced by a strand of peptide nucleic acid (PNA).

188 displaced strand with a nucleic acid mimic, peptide nucleic acid (PNA).

189 rves as a trap was replaced with a strand of peptide nucleic acid (PNA).

190 mbled with the aid of a DNA synthetic mimic, peptide nucleic acid (PNA).

191 screening with less flexible, self-assembled peptide nucleic acid (PNA).DNA complexes uncovered a wel

192 An approach is described for predicting peptide nucleic acid (PNA):DNA duplex stability from bas

193 ying lengths by hybridization of n-alkylated peptide nucleic acids (PNA amphiphiles) to the products,

194 Peptide nucleic acids (PNA) are mimics with normal bases

195 d whether tunable-surface bead chemistry and peptide nucleic acids (PNA) could enhance the recovery a

196 Peptide nucleic acids (PNA) mimic DNA and RNA by forming

197 The discovery that peptide nucleic acids (PNA) mimic DNA and RNA by forming

198 The ability of peptide nucleic acids (PNA) to form specific higher-orde

199 logues, which also include compounds such as peptide nucleic acids (PNA), in surface hybridization ap

200 Utilizing the neutral backbone of peptide nucleic acids (PNA), our method is based on the

201 Toward such applications using peptide nucleic acids (PNA), we herein report the chemic

202 In the current study, we describe a peptide nucleic acids (PNA)-based approach to block the

203 Here we show that ssODNs made of peptide nucleic acids (PNA-ssODNs) can achieve gene repa

204 rrelating with gene knockdown, we employed a peptide-nucleic acid (PNA) hybridization assay.

205 obes: anneal-inhibiting blocking primers and peptide-nucleic acid (PNA) oligonucleotide blockers.

206 equently, molecularly-imprinted polymers and Peptide nucleic acid (PNAs) were developed as an attract

207 the field - locked nucleic acids (LNAs) and peptide nucleic acids (PNAs) - significantly increase th

208 Here, we show that antisense peptide nucleic acids (PNAs) alter splicing of the IL-5R

209 chanics calculations suggest that strands of peptide nucleic acids (PNAs) and complementary oligonucl

210 Peptide nucleic acids (PNAs) are a DNA mimic in which th

211 Peptide nucleic acids (PNAs) are a new class of DNA mimi

212 Peptide nucleic acids (PNAs) are a potentially powerful

213 Peptide nucleic acids (PNAs) are a powerful tool for rec

214 Peptide nucleic acids (PNAs) are analogs of nucleic acid

215 lamide (HPMA) polymers grafted with multiple peptide nucleic acids (PNAs) are crosslinked upon additi

216 Peptide nucleic acids (PNAs) are DNA analogs containing

217 Peptide nucleic acids (PNAs) are engineered uncharged ol

218 Although peptide nucleic acids (PNAs) are neutral by themselves,

219 Peptide nucleic acids (PNAs) are nonionic DNA/RNA mimics

220 Peptide nucleic acids (PNAs) are uncharged analogs of DN

221 es for a successful and broad application of peptide nucleic acids (PNAs) as antisense therapeutics.

222 eport the development of chemically modified peptide nucleic acids (PNAs) as probes for qualitative a

223 Peptide nucleic acids (PNAs) can bind to homopurine/homo

224 Peptide nucleic acids (PNAs) can bind to single-stranded

225 validity of such an approach we synthesised peptide nucleic acids (PNAs) complementary to human mtDN

226 assembled monolayers of single-stranded (ss) peptide nucleic acids (PNAs) containing seven nucleotide

227 Here, we show that peptide nucleic acids (PNAs) efficiently block a key ind

228 Peptide nucleic acids (PNAs) have also been extensively

229 Gold nanocrystals modified with peptide nucleic acids (PNAs) have been prepared and appl

230 forming oligonucleotides and triplex-forming peptide nucleic acids (PNAs) have been shown to stimulat

231 plex-forming DNA oligonucleotides (TFOs) and peptide nucleic acids (PNAs) have been shown to stimulat

232 Peptide nucleic acids (PNAs) have stronger affinity and

233 To determine the effectiveness of peptide nucleic acids (PNAs) in vivo, we designed and sy

234 verning the inhibition of gene expression by peptide nucleic acids (PNAs) inside cells.

235 Peptide nucleic acids (PNAs) offer a distinct option for

236 Peptide nucleic acids (PNAs) present a novel method to t

237 Here we report that triplex-forming peptide nucleic acids (PNAs) substituted at the gamma po

238 e imaged in a mouse by PET with 64Cu-labeled Peptide nucleic acids (PNAs) tethered to the permeation

239 induce G-quadruplex formation, we used short peptide nucleic acids (PNAs) that bind to the complement

240 use high-affinity recognition by overlapping peptide nucleic acids (PNAs) to identify nucleotides wit

241 The remarkable stability of peptide nucleic acids (PNAs) towards enzymatic degradati

242 In this communication, we show that peptide nucleic acids (PNAs) with lengths of 15-20 nucle

243 Peptide nucleic acids (PNAs), analogs of DNA or RNA whic

244 The ability of DNA oligonucleotides, neutral peptide nucleic acids (PNAS), and oligonucleotide conjug

245 triplex-forming oligonucleotides (TFOs) and peptide nucleic acids (PNAs), can be utilized to introdu

246 ergence of triplex-forming oligonucleotides, peptide nucleic acids (PNAs), minor groove binding polya

247 sical properties, we explore the assembly of peptide nucleic acids (PNAs), which are short DNA mimics

248 ments for efficient and nontoxic delivery of peptide nucleic acids (PNAs).

249 ligands and as a modified backbone unit for peptide nucleic acids (PNAs).

250 with temperature gradient focusing (TGF) and peptide nucleic acids (PNAs).

251 ies superior to those possessed by analogous peptide nucleic acids (PNAs).

252 e inhibition of human telomerase activity by peptide nucleic acids (PNAs).

253 tion of G-quadruplexes could be induced with peptide nucleic acids (PNAs).

254 gress with triplex-forming oligonucleotides, peptide nucleic acids, polyamides, and other approaches,

255 Peptide nucleic acids possess enormous potential because

256 In each case, fluorescence intensity of a peptide nucleic acid probe specific for telomeric sequen

257 ocked by electrophoretically mobilized bead-(peptide nucleic acid probe) conjugates upon hybridizatio

258 rt 21 base-long RNA target to an immobilized peptide nucleic acid probe, while fragmented mRNA target

259 retreatment T790M resistance mutation with a peptide nucleic acid probe-based real-time PCR.

260 ysis or flow-FISH with a fluorescein-labeled peptide nucleic acid probe.

261 al nucleic acid sensors based on fluorogenic peptide nucleic acid probes embedded in permeable, physi

262 oligonucleotide-templated reactions between peptide nucleic acid probes embedded within permeable ag

263 lization, hybridization of cellular DNA with peptide nucleic acid probes with cells intact, and analy

264 d-tube PCR analysis using a quencher-labeled peptide nucleic acid (Q-PNA) probe.

265 at provide small molecular mimics to explore peptide-nucleic acid recognition have been prepared.

266 utic applications, intracellular delivery of peptide nucleic acids remains a challenge.

267 so delivered a biotinylated 18-mer antisense peptide-nucleic acid specific for the rev gene of HIV-1

268 ransfer (CT) properties are compared between peptide nucleic acid structures with an aminoethylglycin

269 f the net increase in negative charge at the peptide nucleic acid surface that occurs upon single-str

270 A model peptide-nucleic acid system is presented here to clarify

271 pecific motif sites with fluorescent bisPNA (Peptide Nucleic Acid) tags.

272 First, using a peptide nucleic acid templated system, we identified the

273 Using L-lysine gamma-substituted peptide nucleic acids, the multivalent effects of an int

274 n of isotopomer tandem nucleic acid mass tag-peptide nucleic acid (TNT-PNA) conjugates is described a

275 can generally be used to effectively deliver peptide nucleic acids to adipose tissue.

276 he progress that has been made in delivering peptide nucleic acids to intracellular targets.

277 simple oligo-dipeptide backbones [thioester peptide nucleic acids (tPNAs)] and undergoes dynamic seq

278 A-norbornyl monomers to yield poly-PNA (poly(peptide nucleic acid)) via ring-opening metathesis polym

279 -MOE)-phosphorothioate and PNA-4K oligomers (peptide nucleic acid with four lysines linked at the C t