ライフサイエンスコーパス: peptide sequence

1 nformative with respect to glycosylation and peptide sequence.

2 f transient nanostructures controlled by the peptide sequence.

3 our orders of magnitude within each distinct peptide sequence.

4 activate caspase-3 enzyme to cleave the DEVD peptide sequence.

5 for alkylation does depend on the Ca(1)a(2)X peptide sequence.

6 ers prepared herein were ligated to the MUC1 peptide sequence.

7 eet assemblies, which in turn depends on the peptide sequence.

8 or more amino acids by a nitrogen atom in a peptide sequence.

9 al acceptor protein or to a biotin-accepting peptide sequence.

10 on, regardless of the residues' location and peptide sequence.

11 d by the positions of the amino acids in the peptide sequence.

12 distribution of cationic residues along the peptide sequence.

13 on of hMSC cultures compared with the native peptide sequence.

14 structures from operon content and precursor peptide sequence.

15 s, yet remarkably tolerant to changes in the peptide sequence.

16 ures of the resultant assemblies through the peptide sequence.

17 CB[8] (MVCB[8]) within a vast pool of cyclic peptide sequences.

18 s a general detector of membrane activity in peptide sequences.

19 LC and then analyzed by LC-MS/MS to identify peptide sequences.

20 he presence of the MMP cleavage sites in the peptide sequences.

21 e to recognize and process a vast variety of peptide sequences.

22 ted monoclonal phages revealed two conserved peptide sequences.

23 nd acetylated peptides to generate 12 larger peptide sequences.

24 tial tri-disulfide peptide (STP) toxins from peptide sequences.

25 ta-strands, helices, reverse turns) in short peptide sequences.

26 amino acid residues, in known antimicrobial peptide sequences.

27 ng on the protease used to release bioactive peptide sequences.

28 ification of specific amino acid residues in peptide sequences.

29 comparing adhesion sequences with scrambled peptide sequences.

30 r the rational design of materials-selective peptide sequences.

31 rofiles to the list motifs formed by similar peptide sequences.

32 position of such amino acid analogues in the peptide sequences.

33 sing 14-3-3 proteins with the target partner peptide sequences.

34 aging-an approach that is applicable to most peptide sequences.

35 y can also give additional confidence on the peptide sequences.

36 hest antioxidant activity contained 15 novel peptide sequences.

37 stinal tract and may contain novel bioactive peptide sequences.

38 with high antioxidant properties and unique peptide sequences.

39 let photodissociation (UVPD) was applied for peptide sequencing.

40 low for high-throughput and accurate de novo peptide sequencing.

41 -energy dissociation (HCD) fragmentation for peptide sequencing.

42 monomer of the MGAT2 enzyme predicted by its peptide sequence, a 76-kDa moiety was detected in SDS-PA

43 Peptide sequencing after MS/MS fragmentation enabled the

44 Alternatively, de novo peptide sequencing algorithms annotate MS/MS spectra and

45 protocols are rapidly advancing, but de novo peptide sequencing algorithms to analyze tandem mass (MS

46 Amongst the 4 cationic peptides, the peptide sequence ALPMHIR, identified as lactokinin and k

47 ) was identified, supported through in-depth peptide sequencing analysis, and found to carry mitochon

48 c limitations of VIP, we modified the native peptide sequence and generated two stable synthetic anal

49 e-like activity significantly depends on the peptide sequence and length.

50 e a multimodal distribution knowing only the peptide sequence and peak intensities from mass spectrom

51 of TMT(C) ion formation is affected by both peptide sequence and peptide ion charge state; we discus

52 lian membranes by systematically varying the peptide sequence and salt concentration.

53 plex, may be amenable for inhibition and the peptide sequence and structure derived from the interact

54 n mobility mass spectrometer for analysis of peptide sequence and structure showing ultraviolet photo

55 and deep-sequenced to identify the enriched peptide sequence and the accompanying cPTM simultaneousl

56 identification platform (MAGIC) to identify peptide sequences and glycan compositions directly from

57 re that generates large virtual libraries of peptide sequences and searches within the resulting inte

58 specific register formed from three distinct peptide sequences and that of all alternative compositio

59 Using immunoprecipitation, ESI-MS/MS-based peptide sequencing and enzymatic assay we further demons

60 tructures lags far behind similar efforts in peptide sequencing and proteomics.

61 This automated, deep efficient peptide sequencing and quantification mass spectrometry

62 We confirmed IRES activity by both peptide sequencing and ribosome profiling in muscle from

63 isoforms have a conserved N-terminus (signal peptide sequence) and are dissimilar in amino acid seque

64 omatic component, (ii) linker segment, (iii) peptide sequence, and (iv) C-terminus.

65 rbitrap mass spectrometer with HCD-MS/MS for peptide sequencing, and MaxQuant bioinformatics tool for

66 ning an alternate and non-protease-cleavable peptide sequence are stable in both in vitro and in vivo

67 Intriguingly, many of the new peptide sequences are attributable to antibody variable

68 Because the peptide sequences are completely random, the assay is ef

69 ow that other extracellular domain HER-2/neu peptide sequences are consistently processed by the prot

70 Peptide sequences are known to recognize and bind differ

71 und that peak widths encompassing 95% of all peptide sequences are substantially smaller than previou

72 Peptide sequences are usually achieved using tandem mass

73 ycopeptides, with the glycan attached to the peptide sequence, are characterized by tandem mass spect

74 Using the consensus substrate-peptide sequence as a starting point, we optimized the l

75 both sheet folding encoded by a parent alpha-peptide sequence as well as nativelike side-chain displa

76 erties of the glycopeptides depending on the peptide sequence as well as the size and charges of the

77 te reveals great potential for DEAdcCE-caged peptide sequences as selective drug carriers in the cont

78 ered the underlying grammar of antimicrobial peptide sequences, as demonstrated by the experimentally

79 e fragment ions to improve the confidence of peptide sequence assignment in proteomic analyses and ex

80 processing was performed to obtain confident peptide sequence assignments, allowing the detection of

81 This transition depends on nascent peptide sequence at specific tunnel locations.

82 oped strong serum reactivity against mutated peptide sequences at the site of these glycosylations, a

83 r conserved cysteine residues; it also has a peptide sequence (AT-hook) at its C terminus that binds

84 53 that has a glutamic acid-rich amphipathic peptide sequence attached to N-terminal of bZIP53 leucin

85 rate feasibility, we have (i) generated 1536 peptide sequences based on the parallel dimeric coiled-c

86 We describe a strategy for de novo peptide sequencing based on matched pairs of tandem mass

87 We describe a new method for peptide sequencing based on the mapping of the interpret

88 The identical peptide sequence bearing an amide terminus did not bind

89 Thus, the amphipathic peptide sequences become available to disrupt the endoso

90 mixtures of glycosylated and nonglycosylated peptides, sequence both glycan and peptide moieties simu

91 ration could provide not only information on peptide sequence but also on the localization of the dis

92 e binding was observed in the Trp-containing peptide sequence but not the other tested sequences.

93 lden color upon the cleavage of the specific peptide sequence by the Listeria protease.

94 e proteins and obtained 43 de novo-generated peptide sequences by tandem MS.

95 De novo peptide sequencing by mass spectrometry represents an im

96 tion, reversible formaldehyde cross-linking, peptide sequencing by mass spectrometry, and analysis of

97 of this method resides in the fact that the peptide sequence can be used to identify the microbial s

98 Hence, only minor changes in the peptide sequence can decide between agonism and inverse

99 nge of oligomers that a single amyloidogenic peptide sequence can form, but also how mutation can alt

100 hydrolytic stability of functional, natural peptide sequences can be improved by two orders of magni

101 Here, we describe a short peptide (sequence CAQK) identified by in vivo phage disp

102 The marker peptide sequences chosen were those found to be present

103 Alanine scanning of the peptide sequence, combined with preliminary in silico mo

104 roat infections, and T cells that respond to peptide sequences common to streptococcal M proteins and

105 demonstrate that a carboxyl-terminated RXXR peptide sequence, conjugated to liposomes at a concentra

106 Hyp of model substrate acceptors having AGP peptide sequences, consisting of non-contiguous Hyp resi

107 Due to the enormously large number of peptide sequences contained in global peptide profiles g

108 we have designed and tested a number of new peptide sequences containing the key CxC or CxxC motifs.

109 s of growing interest, particularly as short peptide sequences continue to play important roles as bi

110 cher spectra and substantially increases the peptide sequence coverage and confidence in peptide iden

111 ment ions in AI-ETD+ substantially increases peptide sequence coverage while also improving peptide i

112 med within approximately 60 s, yielding 100% peptide sequence coverage.

113 A 19-mer peptide sequence covering the core of the immunodominant

114 urther truncates of PaaP leader and follower peptide sequences demonstrate the different impacts of t

115 ophages in a time-, dose-, temperature-, and peptide sequence-dependent endocytotic process.

116 r five orders-of-magnitude versus the native peptide sequence depending on staple placement.

117 ILA1 CD8(+) T-cell clone that responds to a peptide sequence derived from human telomerase reverse t

118 Rats were immunized with a peptide sequence derived from the third extracellular lo

119 show that p12 proteins engineered to encode peptide sequences derived from known viral tethering pro

120 Peptide sequences derived from the well-defined CARM1 su

121 Short lipidated peptide sequences derived from various intracellular loo

122 This stapling modification performed on a peptide sequence designed to bind the C-terminal domain

123 The 6706 uniquely identified peptide sequences determined with a conservative Mascot

124 d hydrophilic (such as Lys) side-chains in a peptide sequence determines the orientation of the pepti

125 ific for AGPs because substrates lacking AGP peptide sequences did not act as acceptors.

126 Replacement of this linker with flexible peptide sequences did not restore DhNik1p activity.

127 er of the oppositely charged residues in the peptide sequence differ, such that they have different c

128 SILAC partner spacing and filters candidate peptide sequences during a database search using this in

129 d 972 bp, respectively and the corresponding peptide sequences each contained several conserved motif

130 d strategy provides high-performance de novo peptide sequencing, enabling the de novo sequencing of t

131 in a sequence-dependent manner, resulting in peptide sequence-encoded properties such as UV absorbanc

132 clear analogue conjugated to an octaarginine peptide sequence exhibited some cytotoxicity over 24 h,

133 Polymers displayed a GKRK peptide sequence for targeting p32, a protein often over

134 synthetic polymeric substrates containing a peptide sequence for that MMP.

135 The inhibitors are based on a characteristic peptide sequence for the inhibition of the cysteine prot

136 yet extensive survey of key short bioactive peptide sequences for a range of applications ranging fr

137 l imaging because of the high specificity of peptide sequences for their biomolecular targets.

138 D-IM-MS analysis serves both as a method for peptide sequencing for peptides of similar (or identical

139 Antibodies were prepared against a unique peptide sequence found in the N terminus of the protein.

140 ld be identified in addition to 33854 unique peptide sequences found.

141 e of the Brd4 ET domain bound to a conserved peptide sequence from the C terminus of murine leukemia

142 teractions, we show using a newly identified peptide sequence from the Clr3 histone deacetylase and a

143 A total of 29 peptide sequences from peptide fraction of <10 kDa were

144 N-linked carbohydrate is to shield conserved peptide sequences from recognition by humoral immunity.

145 blies in nature are dimeric, we select short peptide sequences from the interface of a heterodimer of

146 dentified approximately 2,500 unique de novo peptide sequences from the ostrich sample with over 900

147 -MS together to enable the identification of peptide sequence, glycosylation site and the structure o

148 is remarkable biointerface, several of these peptide sequences have found extensive use in creating f

149 esting new finding is that aggregation prone peptide sequences have similar properties to signal pept

150 periodontal pathogens contain antigens with peptide sequences having homology to beta2GPI.

151 or temporarily attaching highly solubilizing peptide sequences ("helping hands") onto insoluble pepti

152 s inserted at the N-terminus in a very short peptide sequence (i.e., PhCO-(R)-Oxo-Azn-L-Ala-Aib-L-Ala

153 were selected from approximately 64 million peptide sequences (i.e., a large unbiased representation

154 The 5B4 epitope corresponds to a peptide sequence (I56-K68) overlapping with the binding

155 To facilitate the subsequent peptide sequence identification by common database searc

156 TBLASTN analysis of the acquired peptide sequences identified a single full-length maize

157 arly cancer detection test based on a set of peptide sequences identified by comparing cancer patient

158 Human vaccine recipients responded to the peptide sequences identified by LC-MS/MS.

159 Based on the peptide sequences identified by mass spectrometry, 30 pr

160 DPP-IV inhibitory peptide sequences identified within camel and bovine mil

161 xcess of enzymatic cleavage sites, nonunique peptide sequences, impaired peptide ionization/separatio

162 thyl-hexanoic acid, and linearization of the peptide sequence improves antibacterial activity and red

163 a single histidine, was engineered into the peptide sequence in order to bind (PPIX)Zn to provide ph

164 ues, which were artificially inserted into a peptide sequence in order to perform native chemical lig

165 Our findings underline a key role for peptide sequence in the ability to assemble and form tox

166 A model peptide sequenced in alpha-gliadin, 33-mer (LQLQPFPQPQLP

167 ficient identification of low molecular mass peptide sequences in food protein hydrolysates.

168 Inserting antigenic peptide sequences in introns that are spliced out before

169 this pathway normally requires two signals: peptide sequences in unassembled outer-membrane proteins

170 Peptide sequences included in fractions with antioxidant

171 The identification of the peptide sequence incorporating the oxidised amino acid p

172 Use of tandem MS data with peptide sequence information increases the specificity o

173 Binary encoding of peptide sequences into differential antimicrobial mechan

174 e combine several key strategies for de novo peptide sequencing into a single high-throughput pipelin

175 The peptide sequences investigated were functionalized with

176 The most abundant and frequent peptide sequence ions were a/x-type products which, impo

177 in both mouse and human cells even when the peptide sequence is not conserved.

178 e)copper(II) and various organelle-targeting peptide sequences is reported.

179 hese proteins interact with PCNA via a short peptide sequence known as a PIP (PCNA interacting protei

180 DNA with or without the mitochondrial signal peptide sequence led to selective expression of the prot

181 mass distributions (AAMDs), the influence of peptide sequence length on parameter sensitivity, and ho

182 he transpeptidase Sortase A (SrtA) for short peptide sequences (LPXTG and GGG).

183 he effect of a cleavable leucine-rich signal peptide sequence (Lucy tag) on OR surface expression in

184 is work, we report the discovery of a unique peptide sequence, M2pep, identified using a subtractive

185 hinders the de novo prediction of the active peptide sequences, making MS-based measurements very val

186 as purified to apparent homogeneity, and the peptide sequence matched that encoded by a recently iden

187 Peptide sequence matching algorithms used for peptide id

188 Introduction of aza-residues into peptide sequences may result in unique structural and ph

189 A new peptide sequence (MB1) has been designed which, in the p

190 rogels of P(MAA-co-NVP) crosslinked with the peptide sequence MMRRRKK were synthesized and tested in

191 tography-tandem mass spectrometry (LC-MS/MS) peptide sequencing (multiplex substrate profiling by mas

192 erivatives based on the metabolically stable peptide sequence NLys-Lys-Pro-Tyr-Tle-Leu suitable for P

193 We report the design of two collagen-mimetic peptide sequences, NSI and NSII, that self-assemble into

194 ull-length maize cDNA clone encoding all the peptide sequences obtained from the purified enzyme.

195 MALDI-TOF study showed a peptide sequence of AFCGGSLVNENKMHSAGHCYKSRIQV at the N-

196 We found that molecules with a peptide sequence of alternating hydrophobic and hydrophi

197 Two proteolytic sites within the GLP1 peptide sequence of dulaglutide were identified using th

198 According to our in silico predictions, the peptide sequence of the exposed extracellular unstructur

199 fect of tubulin carboxy-terminal tails using peptide sequences of alpha-, beta-, or detyrosinated alp

200 FN directly or indirectly, here we identify peptide sequences of growth factor-binding sites in FN.

201 From specific antibodies raised against peptide sequences of scleritin, we obtained immunolabeli

202 Using new generated antibodies to specific peptide sequences of the human betaIII spectrin, we here

203 of the peptide, indicating the influence of peptide sequence on KIR-HLA association.

204 complexes were obtained by assembling small peptide sequences on the surface of cationic self-assemb

205 recognize and bind to tyrosyl-phosphorylated peptide sequences on their target proteins, and thereby

206 LRRK2 kinase activity, combining a reported peptide sequence optimized for LRRK2 binding and an esta

207 Given a peptide sequence (or elemental formula) and charge state

208 atic interactions in the center of the Abeta peptide sequence play a crucial role in the three-dimens

209 ion of UHM domains by UHM ligand motif (ULM) peptide sequences plays important roles during early ste

210 er cell lines and also discovered unexpected peptide sequence polymorphisms (pSPs).

211 cale screening, resulting in vast amounts of peptide sequences, potentially containing information on

212 However, no recurrent neoantigen peptide sequences predicted responder patient population

213 We show that long peptide sequences, producing precursors with up to five

214 ly modified amino acid sequences to evaluate peptide sequence properties influencing binding to C. al

215 analyzed by MALDI mass spectrometry, and the peptide sequences read directly from the resulting spect

216 d peptide array libraries to investigate the peptide sequence recognition specificity of murine HEMK2

217 tiation Ags gp100 and TRP-2, whereas altered peptide sequences recruited gp100-specific CD8 T cells f

218 ad specificity the generation of overlapping peptide sequences reduces the number of identified prote

219 With that in mind, this work investigates peptide-sequence-related factors that influence curvatur

220 stems of disease-relevant mutant protein and peptide sequences relates to the IPOD and JUNQ patterns

221 The degree of hydrolysis reached and the peptide sequences released over time were evaluated.

222 allation of interlocked dicarba bridges into peptide sequences requires the development of a regiosel

223 -D-Oxd-Tri-CO motif may be introduced in any peptide sequence requiring the presence of a stable beta

224 Proteolytic cleavage of the peptide sequence results in a shift in wavelength of the

225 ay combined with reengineering of the signal peptide sequence results in display levels 24-fold above

226 Crystallographic analysis of 35 different peptide sequences revealed a range of conformational sta

227 Protein/peptide sequencing revealed 1kDa peptides with the prese

228 by coating FDA-approved PLGA-PEG NP with the peptide sequence RGD, which binds with high affinity to

229 Peptide sequences rich in either glutamic acid (E: E3Cys

230 Peptide sequence scrambling during mass spectrometry-bas

231 ur results strongly support the mechanism of peptide sequence scrambling via b ion cyclization, and p

232 ion, we demonstrate that addition of a short peptide sequence selected for binding to the gut of the

233 y to diagnose propagation-related TUPS among peptide sequences selected by phage display.

234 solated from organisms and material-specific peptide sequences selected from combinatorial molecular

235 he shells by fusion to a predicted targeting peptide sequence, setting the stage for the use of these

236 The peptide sequence shows no homology to any previously des

237 SVM is used to search the undiscovered peptide sequence space and identify Pareto-optimal candi

238 Here we report a methodology that allows the peptide sequence space to be searched for self-assemblin

239 These tools, which enable the peptide sequence space to be searched for supramolecular

240 e a variant TEV protease with altered target peptide sequence specificities.

241 Peptide sequencing studies performed on the cleaved-off

242 these inteins is context-dependent: certain peptide sequences surrounding their ligation junction (c

243 enzoic acid separately into an amyloidogenic peptide sequence, synthesized alpha/beta, alpha/gamma an

244 Tag-based methods extract peptide sequence tags from a tandem mass spectrum and us

245 andem peptide (TP) consisting of 2 connected peptide sequences targeting the DSG adhesive interface t

246 tential utility offered by a high-throughput peptide sequencing technology.

247 sed medium, also includes a unique synthetic peptide sequence that acts as a traceable "code" to iden

248 e MDA-7 has a potential 28 amino acid signal peptide sequence that can target it for active secretion

249 ptide library screening to design an optimal peptide sequence that enhanced functional activation of

250 iviral activity of a parainfluenza F-derived peptide sequence that inhibits both parainfluenza and Ni

251 dified their N and/or C termini with a short peptide sequence that interacts with FcRn.

252 III)-binding motif with a lanthanide-binding peptide sequence that is known to selectively recognize

253 ater elimination and the formation of larger peptide sequences that are characterized by subsequent i

254 Discriminative n-grams are short peptide sequences that are highly frequent in one class

255 anning we have also identified several short peptide sequences that bind to the E-box used by the sup

256 s, which in turn explains the large array of peptide sequences that can function as NESs.

257 Cell-penetrating peptides (CPPs) are short peptide sequences that can translocate across cellular p

258 We designed stable beta-peptide sequences that generated globally amphiphilic (G

259 Minimotifs are short contiguous peptide sequences that have a known function in at least

260 of an iterative peptide library to identify peptide sequences that have the following two properties

261 the ability of multifunctional RecA to bind peptide sequences that serve as substrates for eukaryoti

262 When fused to a cargo carrying peptide sequence this BCL-3-derived peptide, but not a m

263 een the two cysteine residues present in the peptide sequence to generate a dimeric molecule potentia

264 arise because of the inability of an altered peptide sequence to properly engage protein homeostasis

265 ides a graphical user interface for aligning peptide sequences to protein sequences.

266 is often of interest to compare the selected peptide sequences to the natural protein binding partner

267 ter programs use a protein database to match peptide sequences to the observed spectra.

268 guously that antibodies with specificity for peptide sequences underlying gp41 carbohydrates can effe

269 n between isomeric leucine and isoleucine in peptide sequencing utilizes multistage electron transfer

270 Clone A2, with peptide sequence VTPNDDTFDPFR, showed the best response

271 alleles led to the identification of a short peptide sequence, W(83)KY, that is necessary for proper

272 Consequently, the peptide sequence was obtained manually by ESI-MS spectra

273 the SCHOOL approach and the SARS-CoV fusion peptide sequence, we rationally designed a novel immunom

274 Using rationally designed short peptide sequences, we determined that the charge type an

275 The identified peptide sequences were analysed for their structural con

276 Peptide sequences were assembled on solid-phase.

277 By using PEAKS studio, 511 peptide sequences were first shortlisted based on their

278 onmental cycling protocol, hundreds of proto-peptide sequences were formed over a mere 4 d of reactio

279 ed from MS/MS spectra of their own and their peptide sequences were identified by the MS(3) spectra o

280 Thirteen peptide sequences were identified following UPLC-ESI MS/

281 A number of novel PEP inhibitory peptide sequences were identified in this study, includi

282 Thirteen potential peptide sequences were identified to be present in the c

283 specific regions in the Amyloid beta (Abeta) peptide sequence where variations cause enhanced toxicit

284 eling was effective for determination of the peptide sequence, which could be used to provide informa

285 of these CEST effects were dependent on the peptide sequence, which demonstrated the sensitivity of

286 oxisomal matrix proteins is encoded by short peptide sequences, which have been characterized as pero

287 inhibition effect of EGCG is specific to the peptide sequence, while those of resveratrol and curcumi

288 uots: The first is digested with trypsin for peptide sequencing, while the second has its ratio of (1

289 The peptide sequence with the highest sensitivity and select

290 B. pseudomallei FliC contained several peptide sequences with ability to bind multiple HLA clas

291 Four peptide sequences with existing biochemical applications

292 conformational preferences of three-residue peptide sequences with implications on the role played b

293 by LC-ESI-MS/MS allowed identification of 8 peptide sequences with potential antioxidant properties.

294 interaction is shown to require only a short peptide sequence within the central domain of these bact

295 polyclonal antibody to a 13-amino-acid-long peptide sequence within the receptor-binding domain of t

296 ll attachment through multivalent binding to peptide sequences within the extracellular matrix, and o

297 epitopes and maximizing the content of human peptide sequences without disrupting protein structure a

298 ing of Sil3 is not dependent on a particular peptide sequence, yet a lysine-rich 12-14-amino acid pep

299 Furthermore, analyses of the peptide sequences yield information on the specificity o

300 A panel of six unique peptide sequences yielded 85% sensitivity and 91% specif