ライフサイエンスコーパス: peptides

1 and on the expression of ileal antimicrobial peptides.

2 a variety of complexes with short synthetic peptides.

3 ion and packing can adapt to the presence of peptides.

4 by increasing the activity of antimicrobial peptides.

5 y exceeding that of analogous mussel-mimetic peptides.

6 x with the HLA-E molecule presenting the two peptides.

7 made from ribosomally synthesized precursor peptides.

8 e mobile-phase modifiers for the analysis of peptides.

9 le discovery of O-glycosylation on signaling peptides.

10 compatibility complex (MHC) class II binding peptides.

11 from adults only recognize deamidated gluten peptides.

12 m for expressing relaxin/insulin superfamily peptides.

13 idopsis and rice treated with synthetic RaxX peptides.

14 , and stimulated with vaccine-insert-matched peptides.

15 llowing T cells to detect foreign or mutated peptides.

16 secrete some of the Drosophila insulin-like peptides.

17 lished by isotope dilution with labeled AQUA peptides.

18 expression of IL-22-inducible antimicrobial peptides.

19 peptides, in particular tyrosine-containing peptides.

20 digestion to acquire binding information for peptides.

21 to production of longer amyloidogenic Abeta peptides.

22 ing peptide species and their composing free peptides.

23 rentiate when treated with FHs containing L1 peptides.

24 e dissociation and discovery of S-sulfonated peptides.

25 d with resistance to endogenous host-defense peptides.

26 tions in the oligomerization of IAPP-derived peptides.

27 tivity and better therapeutic potential than peptides.

28 e specifically targeted by fusion-inhibitory peptides.

29 nnate immune responses to undigested gliadin peptides.

30 k for developing effective fusion inhibitory peptides.

31 the presence of H3K36me3-containing histone peptides.

32 ionships of 76 different Abeta40 and Abeta42 peptides.

33 city filter that prevents binding of non-NES peptides.

34 red relative changes of denaturation between peptides.

35 h interday CVs < 20% for 80% of the glycated peptides.

36 d the resulting fibrils are composed of both peptides.

37 , and the presence of cationic antimicrobial peptides.

38 rget prediction identified that insulin-like peptides 7 and 8 (ilp7 and ilp8) are putative targets of

39 enabled the identification of 116 different peptides; 74 of them originated from beta-casein, 4 from

40 irmed BD2-mediated association to histone H3 peptides acetylated at lysine 14 (H3K14Ac), validating t

41 Several endogenous vasoactive peptides act as adaptive mechanisms, and their augmentat

42 determine activity against S/T/Y-containing peptides; additionally, label-free quantitation is used

43 atorial reflections, suggesting that the two peptides adopt distinct lateral packing of the diffracti

44 The behavior of peptides after this chemical modification was simulated

45 S. aureus uses secreted cyclic autoinducing peptides (AIPs) and the accessory gene regulator (agr) o

46 face-to-face stacking of DNA nanosheets with peptides aligned perpendicularly to the sheet surfaces.

47 Application to peptides allowed expedient preparations of alpha-amino b

48 omparisons of the binding preferences of 400 peptides allowed us to construct a position-specific sco

49 ate ssDNA bind to the same three A3G tryptic peptides (amino acids 181-194, 314-320, and 345-374) tha

50 f STP-C1 using UPLC-MS/MS identified sixteen peptides/amino acids.

51 Many organisms rely on antimicrobial peptides (AMPs) as a first line of defense against patho

52 Antimicrobial peptides (AMPs) represent a promising therapeutic altern

53 usion inhibitors by dimerizing the F-derived peptides and conjugating them to cholesterol.

54 l-gated technology is amenable to endogenous peptides and has been successfully demonstrated on the p

55 D) is accumulation of misfolded amyloid-beta peptides and hyperphosphorylated tau protein in the brai

56 e reported for the detected peptide queries, peptides and inferred proteins.

57 hR complex, and is extendable to other toxin peptides and ion channels.

58 Tom1 interacts with aberrant nascent peptides and is essential to limit their accumulation an

59 A correlation between host skin peptides and microbiota suggests a mechanism of host-dir

60 cepted by amine reactants to generate amides/peptides and o-mercaptobenzamides.

61 er anticancer agents and nanoparticles using peptides and other affinity ligands may represent a gene

62 tagonists, the field has relied on synthetic peptides and pepducins to describe protease-activated re

63 MaxQuant was used to identify peptides and proteins and quantify heavy/light lysine ra

64 Peptides and proteins are not orally bioavailable in mam

65 an islet amyloid polypeptide and prions, the peptides and proteins associated with Alzheimer's, Parki

66 l-suited for activation and fragmentation of peptides and proteins in ion trap mass spectrometers, bu

67 thermal decomposition reactions that cleave peptides and proteins specifically at the C-terminus of

68 (oxetane) can be readily grafted into native peptides and proteins through site-selective bis-alkylat

69 Bacteria exploit an arsenal of antimicrobial peptides and proteins to compete with each other.

70 in the presence of macromolecules, including peptides and proteins, is reviewed, with a focus on inte

71 ional ensembles for intrinsically disordered peptides and proteins.

72 bonds between C-terminal residues of lentil peptides and residues of the ACE catalytic site.

73 , induced between low molecular weight (LMW) peptides and sucrose, was studied.

74 ted structural analogy with cell-penetrating peptides and that both the entire protein and the peptid

75 that is broadly applicable to cysteine-rich peptides and the influence of a fourth disulfide bond on

76 e demonstration of correlating assemblies of peptides and the relevant protein epitopes, this work il

77 lihood of capturing these modified signaling peptides and to provide improved sequence coverage and a

78 es for differentiation regulators (e.g., CLE peptides) and pectin/cell wall modification.

79 abeled (SIL) tryptic peptides, cleavable SIL peptides, and a full-length SIL protein were compared fo

80 The resource will be extended to >1 million peptides, and all data will be shared with the community

81 xes, bacteria, viruses, cytokines, hormones, peptides, and drugs.

82 posttranslational modification of ribosomal peptides, and transferases from various biosynthesis pat

83 oth classic characteristics of antimicrobial peptides, and we observed that IFN-beta can directly kil

84 are present in human plasma, and some of the peptides are capable of distinguishing CPT-11 from its m

85 Antimicrobial peptides are components of the innate immune systems in

86 Therapeutic applications of peptides are currently limited by their proteolytic inst

87 Our data suggest that NCR peptides are host determinants of symbiotic specificity

88 ally bioavailable in mammals, although a few peptides are intestinally absorbed in small amounts.

89 Bioactive antioxidant peptides are more and more attracting the attention of f

90 Large amounts of peptides are naturally generated in foods through the pr

91 nsors based on screen-printed electrodes and peptides are promising alternatives for molecular diagno

92 ties of food derived protein hydrolysates or peptides are related to the amino acid composition, sequ

93 ity, and challenge the view that stimulatory peptides are the ultimate gatekeepers of puberty.

94 Thiopeptides (or more formally thiazolyl peptides) are a class of thiazole-containing, highly mod

95 that such peptides, which we have termed DO peptides, are involved in disulfide-dithiol exchange rea

96 This study aimed to identify small peptides arising from actin proteolysis, as influenced b

97 obably a helix barrel that contains eight D4 peptides arranged in parallel.

98 f commutability of tryptic and cleavable SIL peptides as internal calibrators across various bottom-u

99 Using these peptides as substrates, we confirm the biochemical activ

100 All peptides, as well as full length Sap6, demonstrated amyl

101 applied to synthesize both linear and cyclic peptides, as well as peptides composed of natural and no

102 in particular, binds to amyloid-beta (Abeta) peptides at residues 12-28 of Abeta and this binding mod

103 te walk test, and measurement of natriuretic peptides before and 1 year after AVR.

104 t-parenting solitary adults and quantify 133 peptides belonging to 18 neuropeptides.

105 to a structure similar to other sea anemone peptides belonging to structural group 9a.

106 rediction of human leukocyte antigen-binding peptides by in silico algorithms, but the predictive pow

107 d due to rapid proteolysis of apelin-derived peptides by proteases, including neprilysin (NEP).

108 o membrane disrupting cationic antimicrobial peptides (CAMPs), such as polymyxins.

109 Stable isotopically labeled (SIL) tryptic peptides, cleavable SIL peptides, and a full-length SIL

110 phosphorylated central or distal C-terminal peptides competed for association with beta-arrestin 2.

111 monstrated that central or distal C-terminal peptides competed for the CB1R association with CRIP1a,

112 both linear and cyclic peptides, as well as peptides composed of natural and non-natural amino acid

113 of this study was to demonstrate whether L1 peptides conjugated to FHs promote tissue regeneration i

114 a,gamma,alpha-tripeptides, being superior to peptides containing a cyclobutane beta-amino acid residu

115 We show that unstructured peptides containing alternating N--trifluoroacetyllysine

116 iques to separate and sequence de novo proto-peptides containing broader combinations of prebioticall

117 he majority of studies in the field focus on peptides containing only one or two types of amino acids

118 tigate protease activities/specificities for peptides containing post-translationally modified amino

119 Vaccination of mice with peptides containing the 13B5 target sequence resulted in

120 Cyclic peptides containing the Arg-Gly-Asp (RGD) sequence have

121 ins are cysteine-rich cationic antimicrobial peptides contributing to the innate immunity in plants.

122 Peptides corresponding to transmembrane domain (TMD)1, 2

123 Although cationic cell-penetrating peptides (CPPs) are able to bind to cell membranes, thus

124 Various chloroplast transit peptides (CTP) have been used to successfully target som

125 In contrast to most antimicrobial peptides, cWFW neither permeabilizes the membrane nor tr

126 centrations in vivo, d-amino acid containing peptides (DAACPs) are crucial to many life processes.

127 nteractions between two short highly charged peptides-deca-arginine (R10) and deca-lysine (K10).

128 al isotope distributions for the majority of peptides, demonstrating an asymmetric configuration of t

129 he literature for all instances of bioactive peptides derived from milk proteins from any mammalian s

130 llographic and solution-state NMR studies of peptides derived from residues 11-17 of IAPP that assemb

131 the binding site, we used a series of decoy peptides derived from the primary amino acid sequence in

132 escence spectroscopy we here show that short peptides designed in silico by a recently developed algo

133 From the peptides designed, RR4 and its D-enantiomer, D-RR4, emer

134 s), HLA-F tetramers bound with human-derived peptides differentially stained leukocytes, suggesting p

135 The results confirm that the peptides do not absorb randomly, but follow the ion-indu

136 The other motif peptides do not induce lipid flip-flop, suggesting an al

137 ference, both two and three disulfide-bonded peptides drove proliferation of a human cholangiocyte ce

138 the production of multi-functional bioactive peptides due to the hydrolysis of whey proteins.

139 nning, as typically observed for amphiphilic peptides embedded near the polar/apolar bilayer interfac

140 The mechanism by which such peptides emerge from linear precursor proteins has recei

141 asma from cancer patients and discovered two peptides encoded by the peptidyl-prolyl cis-trans isomer

142 r electrode prepared from wild-type M13, Y3E peptides engineered M13 and without M13.

143 ve to unmodified peptides, optimized stapled peptides exhibit increased structural stability, binding

144 dipeptidyl peptidase IV (DPP-IV) inhibitory peptides (FLQY, FQLGASPY, ILDKEGIDY, ILELA, LLQLEAIR, LP

145 erotonin, the use of distinct neuroendocrine peptides for each output may be one means to achieve phe

146 aves invariant chains and produces antigenic peptides for loading onto major histocompatibility compl

147 ormation upon interaction with RCD1, whereas peptides from ANAC013 and ANAC046 formed different struc

148 ns a trypsin-like protease that can generate peptides from casein that have a bacteriostatic effect.

149 ng the HX-MS signal intensities of myoglobin peptides from crowded samples containing 300 g L(-1) Fic

150 pecific bpy-diol ligand protects unprotected peptides from Cu(II) -mediated oxidative damage through

151 s responding weakly to hundreds of MHC-bound peptides from graft-derived leukocytes.

152 reign MHC class II molecule type loaded with peptides from leukocytes from the graft.

153 s a promising method to analyze proteins and peptides from natural sources, recombinant expression, o

154 tides are ultra-stable cyclic disulfide-rich peptides from plants.

155 edicted HLA class I- and class II-restricted peptides from rDEN2Delta30 and used them in a gamma inte

156 There is high potential that antioxidative peptides from rice bran might also be produced in the ga

157 ith heterologous H1N1 and H3N2 IAVs and CD8+ peptides from the internal proteins (matrix protein 1 [M

158 We studied host defense peptides from the skin of the South Indian frog and demo

159 Antitumor GO peptides have been designed as dimerization inhibitors o

160 though detailed pictures of Hsp70 bound with peptides have emerged, correspondingly detailed structur

161 been adopted, among which 2A "self-cleaving" peptides have garnered increased interest for their poly

162 oires directed to some immunodominant gluten peptides have previously been described, but the global

163 The limitations of peptides have severely hampered their use in pharmacolog

164 reports on the bioactivity of casein-derived peptides have shown that the beta-casein peptide (193-20

165 Despite these peptides high potency and ability to evade acquired bact

166 a rich source of bioactive molecules such as peptides, hormones, and neurotransmitters, but relativel

167 xtraction due to accumulation of hydrophobic peptides (IC50 between 12 and 21mg/l).

168 om two T1D subjects recognized distinct IGRP peptides, implicating this molecule as a trigger for CD4

169 Gastrointestinal digestion of peptides improved their dual activity (10-14mumol Trolox

170 epitope sequences concatenated with tryptic peptides in a single artificial protein to create intern

171 which are easily multiplexed to target many peptides in a single assay.

172 ed proteolysis is known to produce antigenic peptides in adaptive immunity, our findings demonstrate

173 examination of Abeta- and non-Abeta-derived peptides in complex with heme revealed that the peroxida

174 ion ELISA to measure integrin-binding of RGD-peptides in high-throughput without using cells, ECM-pro

175 ch determines sequence-dependent behavior of peptides in HILIC.

176 suggesting a role for urinary antimicrobial peptides in susceptibility to select uropathogens.

177 Conventional peptides in the 20-40-mer length range are rapidly degra

178 ression pattern, and in vivo function of ELA peptides in the adult cardiovascular system, to seek evi

179 enrichment efficiency with 85% of identified peptides in the enriched fraction as glycated, high sens

180 ne the molecular-level structure(s) of these peptides in the materials adsorbed state.

181 lutamic acid and glutamine, and further with peptides, in A. thaliana cells.

182 otein hydrolysates is caused by a variety of peptides, in particular tyrosine-containing peptides.

183 aches to the investigation of bioactive milk peptides, including bioinformatics, chemometric tools, a

184 In particular, we show that peptides incorporating the amino acid phenylalanine, a f

185 and experiments with 14 synthetic reference peptides indicated that reliable qualitative identificat

186 These peptides induce autophagy at micromolar concentrations i

187 Aggregation of amyloid-beta peptides into fibrils or other self-assembled states is

188 ISR provided fast and easy identification of peptides involved in disulfide bonding from nonreduced p

189 ith adhesive and morphogenetic solid-binding peptides is a promising route for synthesizing hybrid ma

190 Aggregation of amyloid beta (Abeta) peptides is a significant event that underpins Alzheimer

191 The design of the peptides is based on the C-terminal D4 domain of the Esc

192 A large number of bioactive peptides isolated from natural sources are known to play

193 tide as well as on a wide series of modified peptides, leading to an affinity value of 1.6 x 10(9) M(

194 albicans have transporters for farnesylated peptides, like the a-factor pheromone, which could poten

195 The action of these peptides likely relies on tight coupling between membran

196 mulation (gpASIT+) containing Lolium perenne peptides (LPP) and having a short up-dosing phase has be

197 Mitochondrial-derived peptides (MDPs) and their analogs have emerged as wide-s

198 should be suitable for screening compounds, peptides, micro-organisms to identify fungitoxic or anti

199 rent guidelines recommend use of natriuretic peptides (N-terminal pro-B type natriuretic peptide) and

200 and functionally characterized one of these peptides named "avathrin." Avathrin is a fast, tight bin

201 These data indicate that one or several peptides need to be degraded for MTM and LTM.

202 dified to produce a panoply of antimicrobial peptides now known.

203 The cardiac natriuretic peptides (NPs), atrial NP and B-type NP, regulate fluid

204 one or more WW domains and WT or PPXY mutant peptides of eVP40.

205 spectrometry to detect and quantify specific peptides of interest.

206 infiltrating MCs and the effects of gliadin peptides on intestinal MCs indicated an increase in proi

207 approach, we successfully incorporate (D)CDX peptides onto the surface of RBCNPs without compromising

208 Relative to unmodified peptides, optimized stapled peptides exhibit increased s

209 obtain direct information for membrane-bound peptides or proteins by measuring RDCs using magic-angle

210 patient sample on average, with two or more peptides per protein and starting from as little as 200

211 ow cytometry experiments confirmed that both peptides permeabilize the bacterial cell membrane but su

212 -derived TCRs exhibited strong selection for peptides presented in a highly diverse pHLA-A( *)02:01 l

213 They recognize defective cells by binding to peptides presented on the cell surface by MHC class I mo

214 antigens, which are tumour-specific, mutated peptides presented on the surface of cancer cells.

215 DP(84Gly) constitutively presents endogenous peptides processed by the proteasome and transported to

216 ng factor (EPF) family of secreted signaling peptides regulate the frequency of stomatal development

217 Thus, amino acids/peptides released during digestion may show antioxidant

218 , we analyzed the individual responses of 38 peptides reporting for 25 proteins of interest in 170 or

219 Nonribosomal peptides represent a large class of metabolites with pha

220 Mitochondrially derived peptides represent a new class of circulating signalling

221 any applications based on using graphene and peptides require peptides to interact with (e.g., noncov

222 These are by far the largest variant peptides resolved by any method, some with PTM contribut

223 es showed that 52% and 48% of the identified peptides, respectively, were affected by PTMs, with a to

224 tor-binding affinities, with three candidate peptides retaining full cardiovascular activities for po

225 Many proteins and peptides self-associate into highly ordered and structur

226 However, these peptides should be absorbed intact through the intestina

227 The same peptides significantly altered a nicotinic receptor indu

228 2-residue spontaneous membrane translocating peptides (SMTPs) selected from the library contained a 5

229 pH positively affected peptides, soluble phenolic compounds and antioxidant act

230 ation and study its effects on generation of peptides, soluble phenolics and bioactivities.

231 frequency of these residues generates short peptides, some of which are too small or uninformative f

232 ecombinant wildtype Cyp c 1, and overlapping peptides spanning the Cyp c 1 sequence.

233 predicted to bind these self- and microbial peptides strongly, and these responses were more common

234 Such biomolecules include amyloidogenic peptides, such as the well-known amyloid-beta peptide in

235 e a retention dataset of approximately 30000 peptides, sufficient for identifying the major sequence-

236 predicted, with simulation of virion-derived peptides suggesting that efficient processing of Gag can

237 presentation, preferentially of DRiP-derived peptides, suggesting that the processing of DRiPs is in

238 nge the preconceptions about 'antimicrobial' peptides, supporting the notion that their role in bioti

239 e observed relative to ESI for all drugs and peptides tested at flow rates from 15 to 55 muL min(-1).

240 es excellent sequence coverage of the larger peptides that are often less well characterized by tradi

241 at cancer neoantigens, a class of HLA-bound peptides that arise from tumour-specific mutations.

242 Here we construct simple peptides that assemble into well-defined amyloid phases

243 Peptides that contained only two native disulfide bonds

244 Hydrocarbon-stapled peptides that display key residues of the p53 transactiv

245 The system involves creating an array of 100 peptides that have been selected for broad capability to

246 Nexvax2 is an adjuvant-free mix of three peptides that include immunodominant epitopes for gluten

247 Here, we identified a series of peptides that interact specifically with the DNA binding

248 idence for two populations of PmB molecules: peptides that lie flat on the membranes, and an inserted

249 ected mutagenesis and by inhibition by small peptides that mimic the loop residues.

250 evealed that the expression of antimicrobial peptides that play a vital role in insect immune system

251 on sites were also identified on a subset of peptides that were palmitoylated, demonstrating for the

252 With aromatic guest-host peptides, the 50% conducting intermediate oscillated wit

253 Despite enhanced sensitivity to host defense peptides, the Y. pseudotuberculosis DeltarfaH strain was

254 Tat-Beclin peptides therefore represent a new family of viral trans

255 for infection that involve translocation of peptides through capsid pores are associated with a subt

256 he emergence of extensively different cyclic peptides through short mutational paths based on indels.

257 brates by binding and presenting immunogenic peptides to cytotoxic T lymphocytes.

258 ory polypeptide (GIP), as proof-of-principle peptides to demonstrate the value of thioamide substitut

259 des mobile EPIDERMAL PATTERNING FACTOR (EPF) peptides to enforce stomatal spacing.

260 ncreased IL-1beta boosts local antimicrobial peptides to facilitate microbiota remodelling.

261 based on using graphene and peptides require peptides to interact with (e.g., noncovalently bind to)

262 undamental challenges of docking large toxin peptides to ion channel homology models, as exemplified

263 s consistently capturing and presenting more peptides to Tfh cells than other lineages of more specif

264 Several motif variant peptides translocate into synthetic vesicles with rates

265 Peptides undergo changes in conformation and aggregation

266 driven by the spatial orientation of tryptic peptides upon interaction with the negatively charged su

267 cquisition (DIA)-MS workflow to identify HCP peptides using automatically combined targeted and untar

268 for identifying target-binding cystine-dense peptides using mammalian surface display, capable of int

269 igate the presence and colocalization of the peptides vasoactive intestinal polypeptide (VIP), calcit

270 reus that is more sensitive to antimicrobial peptides was killed more efficiently by IFN-beta than wa

271 The limit of detection for these peptides was less than 50 attomole.

272 or linear epitope prediction, a set of seven peptides was successfully selected as potential Cry1A(b)

273 receptor-blocking antibodies and activation peptides, we determined that thrombin-mediated injury de

274 phosphopeptide enrichment of isotope-labeled peptides, we examined the dynamic of the CD147 microenvi

275 When tested against all cluster-related M peptides, we found that 9 of 17 (53%) paired sera had a

276 All peptides were collagen fragments, suggesting that these

277 Gag peptides were detectable in both cell lysates and supern

278 These peptides were extended at the C terminus (POmega) and co

279 Multiple peptides were identified from HAV capsid proteins (53.7%

280 In this Accretion Model, small RNAs and peptides were subsumed onto subunit surfaces, gradually

281 Furthermore, 4E native peptides were used as additive to deposit Au nanostructu

282 these tools to dock larger ligands, such as peptides, which are molecules of growing interest in can

283 ing proteins by LC-MS is to digest them into peptides, which can serve as surrogates of the protein.

284 We also observed intermolecular cross-linked peptides, which indicated Atg18 oligomerization.

285 photoreceptor-EGF, glia produce insulin-like peptides, which induce lamina neuronal differentiation.

286 odimer bound to DNA, ligands and coactivator peptides, which shows that NR quaternary architectures a

287 an intrinsic ability to discriminate between peptides, which varies in efficiency between allotypes,

288 It is expected that such peptides, which we have termed DO peptides, are involved

289 ces biodistribution and the half-life of the peptides, while integration into the target cell membran

290 MHC I molecules typically bind peptides with 9 amino acids in length with both ends tuc

291 Five Pinto bean peptides with alpha-amylase and angiotensin converting e

292 ow allows the screening of large macrocyclic peptides with diverse modifications thereby expanding th

293 Several peptides with DPP-IV inhibitory features or known activi

294 at restored transport activity to Tat signal peptides with inactivating twin arginine substitutions.

295 , high sensitivity for detection of glycated peptides with LOD and LOQ at 1.2 and 2.4 pg, respectivel

296 icable and could be used to develop meditope peptides with low nanomolar affinity for other therapeut

297 oors to developing applications that utilize peptides with membrane-permeabilizing activities that ar

298 ine Xaa-Pro aminopeptidases, which hydrolyze peptides with proline at the second position (P1').

299 Peptides with smaller MW possessed higher antioxidant ac

300 on of nanoparticles directly from functional peptides would therefore offer a versatile and robust pl