ライフサイエンスコーパス: peptidic

1 ral energies are spatially controlled within peptidic 1-D nanostructures to create localized energy g

2 derivative of acetazolamide, a spacer, and a peptidic (99m)Tc chelator, was labeled using sodium pert

3 ancer cells can process and present a shared peptidic Ag to TCR alphabeta+ T cells via a nonclassical

4 the delta receptor by centrally administered peptidic agonists and intravenously administered JOM-13

5 ects without producing convulsions, and some peptidic agonists can increase BDNF mRNA expression, how

6 n of VEK-30 with mK2Pg demonstrated that the peptidic alpha-helical structure increased substantially

7 Peptidic alpha-toxins AahI to AahIV are responsible for

8 When homologous peptidic amide and ester substrates were compared, a ser

9 work investigates the influence of the first peptidic amino acid (P1) on peptide binding to B*2705 an

10 ould be exploited for the development of non-peptidic amyloid-specific inhibitors.

11 own approach to study a series of alpha/beta-peptidic analogs of anginex, a beta-sheet-forming antian

12 NMR spectroscopy of all of the peptidic analogs of BK or HOE-140 revealed a beta-turn a

13 d species with that of the corresponding non-peptidic analogs, reveals that the peptide component enh

14 Other peptidic analogues, chosen because of specific substitut

15 quantitation of translation termination and peptidic analysis identified lncRNAs that produce peptid

16 ernalized DRM proteins show varied lipid and peptidic anchors indicating that, contrary to the prevai

17 nce for overlapping ligand-binding sites for peptidic and nonpeptidic agonists.

18 It also competes weakly with peptidic and nonpeptidic antagonists.

19 We used an array of peptidic and nonpeptidic arginine-glycine-aspartic acid

20 Thus, the CSP approach distinguishes both peptidic and nonpeptidic delta opioid agonists and antag

21 ned models for a structurally diverse set of peptidic and nonpeptidic delta opioid ligands offer good

22 In addition, results indicate that both peptidic and nonpeptidic ligands have the same binding m

23 Because of its critical role in cancer, many peptidic and nonpeptidic ligands with different modes of

24 access to folded objects beyond the reach of peptidic and nucleotidic backbones.

25 have relevance for the development of other peptidic and peptidomimetic drugs such as inhibitors of

26 Peptidic and peptidomimetic hydroxamates are increasingl

27 jor progress has recently been achieved with peptidic and proteinaceous compounds.

28 o binding of Tat protein and of a variety of peptidic and small molecule ligands, indicating that its

29 es a platform for the further development of peptidic and/or small molecule agents directed toward th

30 notoxin GVIA, a well-characterized ICK-motif peptidic antagonist of voltage-gated calcium channels.

31 caconitine, further opens to accommodate the peptidic antagonist, alpha-conotoxin ImI, but wraps arou

32 e recent development of orally available non-peptidic antagonists and genetically modified mice defic

33 I and class II molecules bind to and display peptidic antigens acquired from pathogens that are recog

34 riant T (MAIT) cells recognize microbial non-peptidic antigens presented by non-classical MHC MR1.

35 ructural relationships with other classes of peptidic antimicrotubule agents, or for modeling studies

36 mode of HTI-286, a synthetic analogue of the peptidic antimitotic agent hemiasterlin, to tubulin is p

37 translocation signal is comprised of unique, peptidic (approximately equal to 40-aa) sequences.

38 These peptidic arrays are used to purge self-reactive T cells,

39 ts for human Cdc25A with respect to a set of peptidic, artificial, and natural substrates.

40 To date, a large number of peptidic as well as nonpeptidic SH2 domain inhibitors ha

41 Second, B cells specific to the peptidic B cell epitope in pCol(28-40) were absent among

42 that the anti-GBM Ab was not related to the peptidic B cell epitope nested in pCol(28-40); that is,

43 ACE1 for activity and inhibition by selected peptidic BACE inhibitors.

44 n-2-ylamine], the first orally available non-peptidic BACE1 inhibitor that produces profound Abeta-lo

45 sure to UV light induces an oxidation of its peptidic backbone and a concomitant reduction of the coo

46 multaneously improved by replacing the polar peptidic backbone of the inhibitor with nonpeptidic moie

47 lator natural product, which contains in its peptidic backbone two S-methylated l-cysteine residues.

48 Here we report a new type of unnatural peptidic backbone, containing alpha-, beta-, and gamma-a

49 y-D-glucitol-gamma-glutamate subunits into a peptidic backbone, was synthesized.

50 are seen also in helices formed by unnatural peptidic backbones, e.g., those containing beta- or gamm

51 e 1 were conceived as "minimalist" mimics of peptidic beta-turn structures.

52 t reported crystal structure of a two-tailed peptidic bilayer reveals similarities in thickness to a

53 , a strategy for the iterative conversion of peptidic blockers of protein-protein interactions into p

54 the A' pocket of the groove, whereas its two peptidic branches protrude along the F' pocket to the ou

55 ers of 4-hydroxyphenylglycine as non-natural peptidic building blocks synthesized via a copper-comple

56 We investigated the effect of the peptidic C3 inhibitor, compstatin Cp40, and its long-act

57 c binding of the substrate; hydration of the peptidic carbonyl by an active site water; proton transl

58 n amine-containing PS forms amide bonds with peptidic cargo, a thiol derivative is designed for conju

59 conjugation of a small receptor ligand to a peptidic carrier to potentially facilitate transport acr

60 ates has predominantly focused on the use of peptidic carriers to deliver the phosphotyrosine moiety

61 Incubation of the cells with the peptidic caspase inhibitor z-valine-alanine-asparagine-C

62 ort peptides, the design and optimization of peptidic catalysts by rational structural modifications

63 In recent years, numerous versatile peptidic catalysts have been developed that bear Xaa-Pro

64 stereoselectivity of H-Pro-Pro-Xaa-NH2-type peptidic catalysts in conjugate addition reactions.

65 diastereoselectivity of structurally related peptidic catalysts.

66 ool to optimize the catalytic performance of peptidic catalysts.

67 radiography and compared with an established peptidic CCK agonist radioligand.

68 rom these studies revealed not only that the peptidic CCK2R ligands were unstable in vivo but also th

69 s of the Lck SH2 domain which are reduced in peptidic character and in which the three carboxyl group

70 o acid residues of 1 with moieties with less peptidic character was done with retention of BACE enzym

71 ncy of this lead, as well as attenuating its peptidic character, an analogue program was undertaken.

72 h higher conformational definition and lower peptidic character.

73 and KGHK-Rev, which also contain N-terminal peptidic chelators (ATCUN motifs), were studied for comp

74 activity can be conveniently monitored with peptidic chromogenic or fluorogenic substrates, with cer

75 e site specificity (PICS), we identified 286 peptidic cleavage sites spanning from P6 to P6' from whi

76 stent with the kinetic data, the affinity of peptidic competitive inhibitors is diminished at acidic

77 hese studies yield new insight into critical peptidic components composing one side of the prion repl

78 and robustly with PrP(Sc), likely represent peptidic components of one flank of the prion replicativ

79 Defensins are peptidic components of the innate immune system of plant

80 d was specific for structure of the acyl and peptidic components of these antigens.

81 of 70.37%, was characterised in terms of its peptidic composition using mass spectrometry and 1882 pe

82 This peptidic compound, termed LirAzo, possesses an azobenzen

83 These peptidic compounds and their advantageous biological pro

84 have constructed and tested a library of 45 peptidic compounds based on this loop sequence.

85 LACE as an effective strategy for converting peptidic compounds to more pharmaceutically relevant com

86 (including apamin, scyllatoxin and newer non-peptidic compounds) showed these homomeric SK3 channels

87 ity, nonreceptor-mediated interaction of the peptidic conantokins with synaptic membranes in conjunct

88 t a study on MMP-12 inhibitors with a common peptidic core but different ZBGs.

89 ss-section EM to reveal a nanostructure with peptidic core.

90 pharmacokinetic properties relative to their peptidic counterparts.

91 cleoside amino acid fragment was followed by peptidic coupling of the two components, leading to the

92 onalized pyrolytic graphite electrodes using peptidic coupling.

93 r antagonist, and alpha-helical CRH(9-41), a peptidic CRHR1/CRHR2 antagonist to attempt to determine

94 Previously documented peptidic cross-linking strategies remain operative in th

95 and the synthesis of our first series of non-peptidic cyclophilin ligands, along with the preliminary

96 present study examined whether a variety of peptidic delta agonists, DPDPE, JOM-13, a systemically a

97 TEEI (4), VYGGG (5), and YGFGG (6) to afford peptidic derivatives for exploring pentapeptide-based hy

98 process and convert exogenous antigens into peptidic determinants capable of interaction with MHC cl

99 own to be very efficacious at insertion into peptidic disulfide bonds.

100 cerning the rate by which TCEP reduces other peptidic disulfide bonds.

101 s an engineered nanocontainer for delivering peptidic drugs across the BBB encapsulating the analgesi

102 ffector molecule, resembles the mechanism of peptidic entry inhibitors based on portions of the gp41

103 tion of gluten and gliadin 33-mer equivalent peptidic epitopes (33EPs) in human feces.

104 oach can become a tool for rapid creation of peptidic expression domains in a eukaryotic environment.

105 ot substrates for farnesylation, do not have peptidic features, and have no hydrolyzable bonds.

106 ioid receptors, for which relatively few non-peptidic fluorescent probes currently exist.

107 In this respect, peptidic foldamers are perhaps the best-characterized sy

108 We describe efforts to develop peptidic foldamers that bind to the irregular receptor-r

109 Peptidic foldamers, consisting of various amino acid bas

110 mes to stabilize the folding in a variety of peptidic foldamers.

111 bundles composed of either alpha-peptides or peptidic foldamers.

112 The peptidic fraction of carotenoproteins (PFCP) contained 8

113 s and in vitro antioxidative activity of the peptidic fraction of carotenoproteins from shrimp (Parap

114 Results from this study suggest that the peptidic fraction of carotenoproteins is a good source o

115 rties of Pacific hake hydrolysates and their peptidic fractions varying in molecular size were assess

116 (procyanidin B3) and different wheat-derived peptidic fractions.

117 is stabilized by hydrogen bonds between the peptidic fragment and the sugar.

118 restrictive properties of media differing in peptidic fragment content and reveal unusual signalling

119 markedly enhanced production of informative peptidic fragment ions during CID that dramatically incr

120 CLIP is substituted by exogenous peptidic fragments in an exchange reaction catalyzed by

121 were obtained for isolated protein domains, peptidic fragments, or mutants.

122 with MALDI-TOF MS analysis of the resulting peptidic fragments.

123 can be widely used to improve the potency of peptidic fusion inhibitors against other enveloped virus

124 cretagogue receptor 1a (ghrelin receptor), a peptidic G-protein-coupled receptor.

125 Peptidic glucagon antagonists have been shown to lower b

126 All peptidic guests in all solvent systems have association

127 Macrocyclization could also provide a less peptidic HCV inhibitor.

128 ins DS40M6 and DS40M8, each contain a unique peptidic head group that coordinates iron(III) and an ap

129 tin has the same Tris-hydroxamate-containing peptidic headgroup composed of three ornithine residues

130 rection for the discovery of more potent non-peptidic HIV protease inhibitors as potential therapeuti

131 Our broad screening program to discover non-peptidic HIV protease inhibitors previously identified c

132 re made of selected steroidal components and peptidic hormones in blood serum, and cognitive and phys

133 uretic peptides (PNPs), are a novel class of peptidic hormones that signal via guanosine 3',5'-cyclic

134 No specific peptidic hydrolysed bond was detected.

135 acterize the engagement of hTS with one such peptidic inhibitor in cell lysates.

136 ng and subsequent removal of a high affinity peptidic inhibitor increased the apparent molecular mass

137 Fasciculin, a selective peptidic inhibitor of acetylcholinesterase, is a member

138 A peptidic inhibitor of caspase-3, Z-Asp-Glu-Val-Asp-fluor

139 Aclacinomycin A is the first described non-peptidic inhibitor showing discrete selectivity for the

140 nerated viruses with resistance to VIR165, a peptidic inhibitor that binds the fusion peptide of the

141 The non-peptidic inhibitor tipranavir is distinctive in its cons

142 ee cases the enzyme forms a complex with the peptidic inhibitor U-89360E.

143 A synthetic peptidic inhibitor, diphenyl N alpha-benzoxycarbonyl-l-A

144 Recently, we successfully developed a peptidic inhibitor, RRYGTSKYQ ("SKY" peptide), that show

145 association of acetylcholinesterase with its peptidic inhibitor, the neurotoxin fasciculin.

146 The potent peptidic inhibitor, Y1, of the basic residue-specific ye

147 The designed peptidic inhibitors are 12-amino-acids-long and target t

148 the importance of evaluating the potency of peptidic inhibitors at physiologically relevant pH value

149 in-coupled receptors, for which chemical and peptidic inhibitors have been extensively explored, few

150 vel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases.

151 esis and in vitro characterization of potent peptidic inhibitors of dengue virus protease that incorp

152 This is the first report on peptidic inhibitors of heme oxygenase.

153 We recently discovered new, unconventional peptidic inhibitors of hTS that are active against cance

154 Potent and selective non-peptidic inhibitors of human endothelin-converting enzym

155 A series of P2-modified, orally active peptidic inhibitors of human neutrophil elastase (HNE) a

156 gn and structural characterization of potent peptidic inhibitors of influenza hemagglutinin.

157 trated that the rational design of small non-peptidic inhibitors of large protein-protein interfaces

158 e of action of Elec410 as one of the largest peptidic inhibitors targeting the acetylcholinesterase p

159 benzamide, belongs to a family of potent non-peptidic inhibitors that have large P1' groups.

160 y demonstrates the feasibility of developing peptidic inhibitors to functionally relevant sites on PC

161 With the caspases fully inactivated by peptidic inhibitors, GrB induced in Jurkat cells growth

162 Using this assay, we found that the peptidic inhibitors, leupeptin and aprotinin, exhibited

163 Structure-based design of potent non-peptidic inhibitors, utilizing crystal structures of HIV

164 to give irreversible cruzain inhibition for peptidic inhibitors.

165 as a starting structure to rationally design peptidic inhibitors.

166 y classified as either peptidomimetic or non-peptidic inhibitors.

167 ied structurally diverse small molecule (non-peptidic) inhibitors (SMNPIs) of the botulinum neurotoxi

168 re were employed to mine small molecule (non-peptidic) inhibitors from the National Cancer Institute'

169 nd a domain motion enabling enclosure of the peptidic ligand and formation of specific hydrogen bonds

170 in was recently identified as the endogenous peptidic ligand for human APJ.

171 that targets the ATP-binding cleft and (2) a peptidic ligand that enhances selectivity between kinase

172 settled in the apo-cluster and the PR-957 (a peptidic ligand) complex in the pep-cluster.

173 he potency of a recently described linear SE peptidic ligand.

174 subunits of the unliganded species with the peptidic liganded forms demonstrates a greatly enhanced

175 The manner by which peptidic ligands bind and activate their corresponding G

176 Peptidic ligands can be used for specific cell targeting

177 In contrast, peptidic ligands failed to promote expression or rescue

178 ve biopanning for isolation of high affinity peptidic ligands for a single cancer type and expands th

179 One of the better characterized peptidic ligands is the chemotactic cytokine complement

180 r phylogeny has accelerated the discovery of peptidic ligands targeted to ion channels and receptors.

181 pioid efficacy pharmacophore, is extended to peptidic ligands using replica exchange molecular dynami

182 rcine pancreatic elastase (PPE) complexed to peptidic ligands, we have developed a new series of nonp

183 residues is compared with that of biotin and peptidic ligands.

184 iopanning for the isolation of TM transiting peptidic ligands.

185 and the pep-cluster comprises complexes with peptidic ligands.

186 H1-hinge domains of mAb2 are fused through a peptidic linker to the N terminus of mAb1 H chain, and p

187 the latter, the two peptides are joined via peptidic linkers of variable lengths to produce a range

188 glycosidic attachment of thymine at C-1, and peptidic linking of the C-6 amine with the 1,2-aminocycl

189 peptides proved efficient in the ligation to peptidic, lipidic and fluorescently labeled amines and i

190 cule modulators of CXCR7 have been reported, peptidic macrocycles may provide advantages in terms of

191 We produced a series of peptidic macrocycles that incorporate an N-linked peptoi

192 ning the activity and physical properties of peptidic macrocycles.

193 ate and selectively redissolve CS versus the peptidic material and (3) the selective purification and

194 Administration of peptidic MC4R antagonists (usually by intracerebro ventr

195 alternatives, we replaced one or both of the peptidic membrane anchors of exocytic vesicle (v)- and t

196 ndocaensis results in the discovery of three peptidic metabolites (cahuitamycins A-C), with cahuitamy

197 effectively mine microbial strains for novel peptidic metabolites.

198 These results suggest that all peptidic mimics of Tat induce the same dynamics in TAR w

199 talling isosteric chemical substituents in a peptidic model system and using NMR spectroscopy, X-ray

200 of the myristoyl chain and repulsion of the peptidic moiety from the phospholipid headgroup region.

201 a1-selective peptidomimetic, or an RGD/PHSRN peptidic molecule.

202 As peptidic molecules find increasing value in therapeutic

203 e energy associated with the transfer of the peptidic molecules from water to membrane.

204 ade to develop technologies for selection of peptidic molecules that act as substrates or binders to

205 o link the acids to DNA major groove-binding peptidic motifs known to adopt alpha-helical conformatio

206 xylation of conserved prolyl residues within peptidic motifs present in the HIFalpha family members.

207 second and fourth amino acid residues in the peptidic mu opioid lead agonist Dmt-d-Arg-Phe-Lys-NH(2)

208 s, we show that intraarticular delivery of a peptidic nanoparticle complexed to NF-kappaB siRNA signi

209 This peptidic natural product exhibited an amino acid sequenc

210 A number of seemingly structurally disparate peptidic natural products inhibit tubulin polymerization

211 y towards high-throughput discovery of novel peptidic natural products.

212 endothelin-A (ET(A)) receptor; however, its peptidic nature leads to poor oral absorption characteri

213 nvironmental responsiveness, morphology, and peptidic nature make this hydrogel a possible material c

214 The peptidic nature of pantocin B facilitated a series of st

215 lic dipeptide moiety would also decrease the peptidic nature of the inhibitors.

216 ochemistry was employed to detect changes in peptidic neurotransmitter expression in identified dural

217 amics simulations were performed with 13 non-peptidic neurotransmitters (NTs) in three different memb

218 methylmalonyl CoA is hydrogen bonded to the peptidic NH group of Gly 110 and the imidazole ring of H

219 The oxyanion hole, formed by peptidic NH groups from Gly121, Gly122, and Ala204, is a

220 d between the carbonyl oxygen of ACh and the peptidic NH groups of Gly121 and Gly122.

221 the inhibitors are mediated through backbone peptidic NH groups, carbonyl oxygens, and/or solvents.

222 gen bonds with backbone carbonyl oxygens and peptidic NH groups.

223 that the stimulatory compounds were neither peptidic nor lipidic but instead were composed of sulfur

224 structure prediction and design of five non-peptidic oligomer scaffolds (noncanonical backbones), ol

225 Peptidic oligomers that contain both alpha- and beta-ami

226 The peptidic opioid delta(1) agonist [D-Pen(2),D-Pen(5)]enke

227 ibitors relies on a core zinc chelator and a peptidic or nonpeptidic scaffold that provides supplemen

228 letely novel set of antibacterial compounds, peptidic or peptidomimetic, if the interacting bacterial

229 is first halogenated and then elaborated by peptidic or polyketide extensions.

230 een used to screen approximately 150,000 non-peptidic organic compounds in a molecular data base and

231 ecule that occupies the same position as the peptidic oxygen in the tetrahedral intermediate.

232 On the contrary, we identified the non-peptidic part as the determining factor of differences b

233 n classes of rhodesain inhibitors, including peptidic, peptidomimetic, and nonpeptidic structures, em

234 zed by conjugating fluorescent dyes to a non-peptidic, pharmacophore-based ligand, based on a molecul

235 alpha,beta-unsaturated ketones catalyzed by peptidic phosphine ligands and (CuOTf)(2).C(6)H(6).

236 While the peptidic portion of these compounds serves an enzyme tar

237 ligand can bind simultaneously to a flexible peptidic PPI recognition motif and to a well-structured

238 downregulation in cancer cells by designing peptidic precursors as the substrates of both carboxyles

239 ) in complex with a substrate analogue and a peptidic product to 2.5 and 2.7 A, respectively, and com

240 A similar configuration was evident for the peptidic product, although decreasing electron density t

241 ompared efficacy and safety of the novel non-peptidic protease inhibitor tipranavir co-administered w

242 a well-known family of aldehyde-containing, peptidic protease inhibitors, including antipain, chymos

243 fluence of (EH)3 on the biodistribution of 2 peptidic radiopharmaceuticals, Glu-urea-Lys(Ahx)-HBED-CC

244 to improve the pharmacokinetic properties of peptidic radiopharmaceuticals, leading to reduced uptake

245 Here we investigate the ability of such peptidic receptor ligands to target the liver.

246 and their bioderivatization with a selective peptidic receptor modified with a SERS transducer.

247 potential to interact with broad surfaces of peptidic receptors rather than within their narrow folds

248 Boronic acid based peptidic receptors, derived from a combinatorial library

249 we biochemically generated the potential Tg peptidic repertoire available to HLA-DR3 by separately t

250 ot affect the binding of the four C-terminal peptidic residues to PDZ, as revealed by the crystal str

251 he catalytic domain of human MMP9 bound to a peptidic reverse hydroxamate inhibitor as well as the co

252 The introduction of non-peptidic scaffolds into macrocycles is highly desirable

253 unit of the ligand and the AA2 moiety of the peptidic segment of the chiral ligand associates and del

254 yields highly conjugated backbones when the peptidic segment of the PAs has a linear, as opposed to

255 , we further identified within this region a peptidic segment that exhibits membrane interaction prop

256 olism through their binding, via a conserved peptidic sequence, into a universally conserved pocket.

257 A discrete peptidic sequence, termed the amyloid-converting motif (

258 rupting the DNA stretch encoding a conserved peptidic sequence.

259 pine nucleus is introduced internally to the peptidic sequence.

260 s of beta-sheet folding and design for alpha-peptidic sequences are well established, while those for

261 ere, we used phage display to identify novel peptidic sequences that bind Cx43CT and modify Cx43 regu

262 s further exemplified in combining optimized peptidic sequences with effective N-terminal capping gro

263 dels or, as in previous studies, zinc finger peptidic sequences.

264 novo-designed bioactive beta- or alpha,beta-peptidic sequences.

265 ile substantially different from that of the peptidic series, particularly with regard to the require

266 the membrane permeability of matched sets of peptidic small molecules bearing natural or bioisosteric

267 Our approach relies on the use of non-peptidic small molecules, which selectively bind fungal

268 inus of VEK30 (VEK32) maintained a monomeric peptidic structure, but exhibited similar K2hPg binding

269 eation of rationally designed and functional peptidic structures, the roles of these forces on purely

270 ma-imino)triphosphate), but not ADP, or of a peptidic substrate induces depolymerization of FLAG-BiP.

271 proteolysis rate of the folded protein and a peptidic substrate mimicking the sequence at the cleavag

272 iabetic compound such a the organic vanadate peptidic substrate was possible the toxicity problems cu

273 Ligand interactions, as reported in one peptidic substrate, are favorable so that complementarit

274 ic phosphate derivatives, the more realistic peptidic substrates allow evaluating substrate specifici

275 e results also suggest the design of optimal peptidic substrates and inhibitors.

276 re efficient substrates than the most potent peptidic substrates ever reported for VHR.

277 employing 3-nitrophosphotyrosine containing peptidic substrates is described.

278 ytic efficiency than glycan-free KLK2 toward peptidic substrates with P2-Phe, the situation was rever

279 nown to process a large variety of different peptidic substrates, although the mechanism behind this

280 ng enzyme (IDE) cleaves insulin, among other peptidic substrates, but its function in insulin signali

281 In contrast to peptidic substrates, Cdc25A and dN25A are highly active

282 ction from 3-nitrophosphotyrosine containing peptidic substrates, which are accepted by many PTPs.

283 atases-tailoring the number of phosphates on peptidic substrates-is able to regulate the rate of mole

284 onfirms a mode of binding similar to that of peptidic substrates.

285 aturation and are capable of acting on large peptidic substrates.

286 e show that gp33 variants substituted at the peptidic termini at the putative CDR1 contact regions sh

287 e and robust synthesis of highly substituted peptidic thiazole derivatives using Ugi-multicomponent r

288 ctivating regions characterized thus far are peptidic, this function can be served by other kinds of

289 MII, isolated from Conus magus, is a potent peptidic toxin which specifically targets the mammalian

290 , it is likely that the discovery of similar peptidic toxins will rapidly expand to existing and emer

291 Endothelin-1 is the most potent peptidic vasoconstrictor discovered to date.

292 h 7 daily subcutaneous injections of VIPhyb (peptidic VIP-antagonist) or phosphate-buffered saline (P