ライフサイエンスコーパス: peptidyl transferase center

1 to the E site but remains temporarily in the peptidyl transferase center.

2 re with another activity associated with the peptidyl transferase center.

3 n establishing the tertiary structure of the peptidyl transferase center.

4 ics on the scale of seconds at the ribosomal peptidyl transferase center.

5 the L27 N-terminus, which protrudes into the peptidyl transferase center.

6 is located in the immediate vicinity of the peptidyl transferase center.

7 is known to be a component of the ribosomal peptidyl transferase center.

8 ial for the successful assembly of ribosomal peptidyl transferase center.

9 via tertiary interactions to features of the peptidyl transferase center.

10 f the acceptor end of the A-site tRNA at the peptidyl transferase center.

11 within domains IV and V, which contains the peptidyl transferase center.

12 o position helices 77 and 78 relative to the peptidyl transferase center.

13 oning the activated ends of tRNAs within the peptidyl transferase center.

14 f the A-tRNA from entering the A site of the peptidyl transferase center.

15 omal tunnel to the exit port, ~100A from the peptidyl transferase center.

16 S rRNA A-loop, an essential component of the peptidyl transferase center.

17 are elongated, one residue at a time, at the peptidyl transferase center.

18 he modern ribosome this remnant includes the peptidyl transferase center.

19 esidue was separated by 14 residues from the peptidyl transferase center.

20 l RNA (rRNA) that includes hairpin 92 of the peptidyl transferase center.

21 y conserved GGQ motif packs tightly into the peptidyl transferase center.

22 ents are normally performed in the ribosomal peptidyl transferase center.

23 23S ribosomal RNA, an important part of the peptidyl transferase center.

24 somal subunit in the cleft that contains the peptidyl transferase center.

25 the RNA-mediated catalysis of the ribosomal peptidyl transferase center.

26 interplay between the nascent chain and the peptidyl transferase center.

27 3S rRNA at three sites, all located near the peptidyl transferase center.

28 inhibition of TnaC-tRNA(Pro) cleavage at the peptidyl transferase center.

29 he subunit interface, and junctions near the peptidyl transferase center.

30 as a function of the distance away from the peptidyl transferase center.

31 f the ribosome such as the tRNA path and the peptidyl transferase center.

32 Nucleotide A2572 is in the ribosomal peptidyl transferase center.

33 binding sites of several antibiotics in the peptidyl transferase center.

34 e accommodation of decoding factors into the peptidyl transferase center.

35 m to pause before allowing entrance into the peptidyl transferase center.

36 may generalize to other aaRS, as well as the peptidyl transferase center.

37 entified group thought to reside in the rRNA peptidyl transferase center.

38 that docks the catalytic GGQ motif into the peptidyl-transferase center.

39 s access to both the decoding center and the peptidyl-transferase center.

40 RNAs containing deleterious mutations in the peptidyl transferase center (25S NRD).

41 Thus, eIF5B interaction with the peptidyl transferase center A loop increases the accurac

42 ther universally conserved nucleotide in the peptidyl transferase center, A2451.

43 itionally, a nucleotide located close to the peptidyl transferase center, A2572, which was protected

44 All three are at or have been linked to the peptidyl transferase center according to the literature.

45 eptide exit tunnel at some distance from the peptidyl transferase center agrees with the proposed mod

46 contributes to the tertiary structure of the peptidyl transferase center and influences the conformat

47 he C-terminal domain of EF4 reaches into the peptidyl transferase center and interacts with the accep

48 the protein that interacts with the ribosome peptidyl transferase center and mimics the 3'-acceptor s

49 Both antibiotics bind at the peptidyl transferase center and sterically occlude the C

50 nd the subsequent expansions that shaped the peptidyl transferase center and the conserved core.

51 n of essential functional sites, such as the peptidyl transferase center and the decoding site.

52 end in tRNA interactions with the ribosomal peptidyl transferase center and the elongation factor Tu

53 ubunit along the path it follows between the peptidyl transferase center and the exit site on the dis

54 Two hydrophobic crevices, one at the peptidyl transferase center and the other at the entranc

55 a catalytic water can be coordinated in the peptidyl transferase center and, together with previous

56 d helix 44 of 18S rRNA, domain 4 is near the peptidyl-transferase center and its helical subdomain co

57 omain V (which is known to be a component of peptidyl transferase center) and a loop of the helix 35

58 the A loop and P loop, respectively, of the peptidyl transferase center, and G1735A, mapping near a

59 , including the neighborhood surrounding the peptidyl transferase center, and stable association of r

60 d that the ribosome dynamics detected at the peptidyl transferase center are highly inhomogeneous.

61 es of tRNA substrate located in the ribosome peptidyl transferase center around the 2-fold axis, we h

62 oRNA binding causes little distortion of the peptidyl transferase center but do provide suggestive ev

63 fined to the nascent peptide residues in the peptidyl transferase center but not to the peptide segme

64 e ribosome is catalyzed in the large subunit peptidyl transferase center by release factors on recogn

65 ons of two other nucleotide positions in the peptidyl transferase center, C2471 and U2519 (C2452 and

66 centers in the large subunit, including the peptidyl-transferase center, for unnatural polymer synth

67 confirm the topographical separation of the peptidyl transferase center from the E site domain.

68 S rRNA nucleotides in the 2585 region of the peptidyl transferase center, G2583A and U2584C, were obs

69 bosomal subunits and the conformation of the peptidyl transferase center in the context of the intact

70 nd peptidyl-D-aa-tRNA can trap the ribosomal peptidyl-transferase center in a conformation in which p

71 onstruct that comprises much of the 23S rRNA peptidyl transferase center, including the central loop

72 ce of these results for the structure of the peptidyl transferase center is considered.

73 ce of these results for the structure of the peptidyl transferase center is considered.

74 s to block assembly at a late stage when the peptidyl transferase center is formed, indicating a poss

75 The ribosomal peptidyl transferase center is responsible for two funda

76 gest that the positioning of Pro-tRNA in the peptidyl transferase center is the major determinant for

77 nity for CCdApPuro comparable to that of the peptidyl transferase center itself (Kd approximately 10

78 Three additional sites were at the peptidyl transferase center itself.

79 -bound tRNAs, whose 3' termini reside in the peptidyl transferase center, label primarily nucleotides

80 in 23S rRNA, which is situated close to the peptidyl transferase center, may participate in one or m

81 to interact with nucleotide residues in the peptidyl transferase center of domain V.

82 to pseudouridine (Psi) in a stem-loop at the peptidyl transferase center of Escherichia coli 23S rRNA

83 lmN and Cfr, both methylate A2503 within the peptidyl transferase center of prokaryotic ribosomes, yi

84 ance of pseudouridine formation (Psi) in the peptidyl transferase center of rRNA was examined by depl

85 These findings directly implicate the peptidyl transferase center of the 50S subunit in the me

86 on binding sites of the 30S subunit with the peptidyl transferase center of the 50S subunit via rRNA-

87 , inhibit protein synthesis by targeting the peptidyl transferase center of the bacterial ribosome.

88 has been implicated as a constituent of the peptidyl transferase center of the Escherichia coli 50 S

89 The action of the peptidyl transferase center of the large ribosomal unit

90 ffectively an unbranched tube connecting the peptidyl transferase center of the large subunit and the

91 lation of an adenosine nucleotide within the peptidyl transferase center of the ribosome mediated by

92 ired for introducing specific changes in the peptidyl transferase center of the ribosome that activat

93 This nucleotide is positioned within the peptidyl transferase center of the ribosome, which is a

94 catalytically productive orientation in the peptidyl transferase center of the ribosome.

95 o acids are polymerized into peptides in the peptidyl transferase center of the ribosome.

96 This modification is located in the peptidyl transferase center of the ribosome.

97 of domain V, which forms a major part of the peptidyl transferase center of the ribosome.

98 ndividual point mutations, in either the 25S peptidyl transferase center or 18S decoding site, that a

99 aphic structures of antibiotics bound to the peptidyl transferase center or the exit tunnel of archae

100 Such placement, near the peptidyl transferase center, provides a rationale for th

101 beling, and mutational analyses revealed the peptidyl transferase center (PTC) as the focal point of

102 its peptide-bond formation in the ribosome's peptidyl transferase center (PTC) during its own transla

103 The effect of AAP and Arg on ribosome peptidyl transferase center (PTC) function was analyzed

104 ribosomal exit tunnel and the A-site of the peptidyl transferase center (PTC) in halting translation

105 the CCA-end of the A-site tRNA away from the peptidyl transferase center (PTC) is functionally signif

106 Here we demonstrate that the ribosomal peptidyl transferase center (PTC) is supported by a fram

107 x RNA helicase specifically activated by the peptidyl transferase center (PTC) of 23S rRNA.

108 Peptide bond formation is catalyzed at the peptidyl transferase center (PTC) of the large ribosomal

109 protein synthesis inhibitors that target the peptidyl transferase center (PTC) on the large subunit o

110 nding of neither nucleotide (ATP or ADP) nor peptidyl transferase center (PTC) RNA, the presumed phys

111 ribosomal RNA (rRNA) helix 89 of the nascent peptidyl transferase center (PTC) through Nsa2.

112 tion axes for both subunits pass through the peptidyl transferase center (PTC), indicating a tendency

113 and catalyzing peptide bond formation at the peptidyl transferase center (PTC).

114 none molecule within its binding site in the peptidyl transferase center (PTC).

115 l differences are in the conformation of the peptidyl-transferase center (PTC) and the interface betw

116 the sarcin/ricin loop (SRL) and A2531 in the peptidyl-transferase center (PTC) has adverse effects on

117 owing a disruption of the A-site side of the peptidyl-transferase center (PTC).

118 discovered near the decoding center and the peptidyl transferase center, respectively.

119 es specific nucleotides within the ribosomal peptidyl transferase center that appear to be essential

120 mes, and their effect on conformation in the peptidyl transferase center, the GTPase-associated cente

121 erichia coli 23S rRNA, 14 are located in the peptidyl transferase center, the main antibiotic target

122 iary interactions between nucleotides in the peptidyl transferase center, the SRD, and the GTPase-ass

123 e essential macromolecular components of the peptidyl transferase center to 23S rRNA and ribosomal pr

124 s a hydrolytic reaction in the large subunit peptidyl transferase center to release the finished poly

125 subunit surface, connecting the tRNA in the peptidyl transferase center to the distally located nasc

126 changes occur at several nucleotides in the peptidyl transferase center upon alterations in pH, temp

127 es of 8 rRNA-modifying enzymes targeting the peptidyl transferase center were individually inactivate

128 reates a free tryptophan-binding site in the peptidyl transferase center, where bound tryptophan inhi

129 tRNAs for binding in the A-site cleft in the peptidyl-transferase center, which is universally conser

130 rom the back of the 50 S particle toward the peptidyl transferase center within the 50 S subunit.

131 ming the three- dimensional structure of the peptidyl transferase center within the ribosome.