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2 6), low CSF to blood glucose ratio (HR, 1.16 per 0.10 decrease; 95% CI, 1.04-1.30), CSF culture posit
5 nce rates with 95% confidence intervals (CI) per 1,000 person-years were as follows: non-biologic, 14
8 We defined incident CKD as eGFR<60 ml/min per 1.73 m(2) and >/=30% eGFR decline at the third visit
9 participants with baseline eGFR >/=60 ml/min per 1.73 m(2) At baseline, mean age was 55 years old, 37
10 ipants were men, and mean eGFR was 94 ml/min per 1.73 m(2) Over a median follow-up of 8 years, 228 (6
14 f using observed values (47.7 vs 38.6 mL/min per 1.73 m, P < 0.001) and was superior based on observe
15 andard cleaning strategies (n=76; 33.9 cases per 10 000 exposure days; relative risk [RR] 0.70, 95% C
16 , and presented them as excess relative risk per 10 mug/m(3) increase in particulate ambient air poll
17 F neutrophil counts (hazard ratio [HR], 1.10 per 10% increase; 95% confidence interval [CI], 1.04-1.1
21 vCDR asymmetry >/=0.20 are 1.44 times higher per 10-year increase in age (odds ratio [OR], 1.44; 95%
22 and gender-adjusted annual incidence of 1.8 per 100 000 (95% confidence interval, 1.3-2.2) between 1
23 d incidence rate of anaphylaxis was 26 cases per 100 000 person-years and the one-year period prevale
24 ly for men and women, by 7% (from 358 to 332 per 100 000 person-years; adjusted incidence ratio 0.93,
25 h the short-course regimen and 4.3 (2.9-7.6) per 100 000 population with continued use of longer ther
26 would be 3.3 (95% uncertainty range 2.2-5.6) per 100 000 population with the short-course regimen and
27 omes of the model were changes in life-years per 100 000 total population over 40 years (to 2050).
29 incidence of VF on second-line ART was 12.9 per 100 person-years (n = 23), and prevalence of VF at c
30 ow-grade dysplasia (95% CI 1.5-7.2), and 7.3 per 100 person-years among patients with baseline high-g
31 0 person-years overall (95% CI 3.3-8.2); 3.3 per 100 person-years among patients with baseline low-gr
32 cidence rate of dysplasia recurrence was 5.2 per 100 person-years overall (95% CI 3.3-8.2); 3.3 per 1
34 ons resulted in an overall incidence of 22.6 per 100 PYO (95% confidence interval [CI], 20.4-25.0).
38 cidence for these infants by 58%, from 1,878 per 100,000 subsequent children under age 2 months (IQR,
41 ated to academic performance in adolescents (per 100-g increase in birth weight, -0.004 grade, 95% CI
42 ween predicted (hospital mean of 6.18 deaths per 1000 admissions based on preimplementation trends) a
44 ith diabetic retinal disease in 2009 to 13.6 per 1000 in 2015) while that of ranibizumab initially in
49 of follow-up, indicating an incidence of 8.9 per 1000 person-years: 6.9 for SVR and 21.6 for NSVR per
50 er in the commercial population (weighted RD per 1000, -0.08; 95% CI, -0.51 to 0.36) or the Medicare
52 were statistically significantly increased, per 10000 person-years, for gallbladder disease (30 more
54 days of birth) were rare in all periods (5.2 per 100000 births in the baseline period, 1.9 per 100000
55 00000 births in the learning period, and 5.3 per 100000 births in the EOS calculator period) and did
56 er 100000 births in the baseline period, 1.9 per 100000 births in the learning period, and 5.3 per 10
57 rates were 1.49 per 100000 in the lung, 3.56 per 100000 in gastroenteropancreatic sites, and 0.84 per
59 2012), the highest incidence rates were 1.49 per 100000 in the lung, 3.56 per 100000 in gastroenterop
61 d nearly 6-fold from 2001 to 2014 (from 0.26 per 100000 person-years to 1.51 per 100000 person-years)
62 4441) who experienced an increase from 55.1 per 100000 person-years to 99.7 per 100000 person-years
64 in the US population sample was 0.10%, or 98 per 100000 persons (95% CI, 97-99 per 100000 persons).
67 ic masseter and temporalis muscle activities per 20-N bite-force (T20 N, microV), which defined thres
68 34% (IQR, 24% to 42%) (P < .001) (rate -3.3% per 5 years; IQR, -8.9% to 1.2%), indicating large inter
69 95% CI, 1.0 to 5.1; P = .04) and > 5 mitoses per 50 high-power fields (AHR, 2.5; 95% CI, 1.1 to 6.0;
73 e of p-STAT3(+) CD11c(+) cells was higher in Per a 10-administered mice and was reduced upon PAR-2 bl
78 dge gaps regarding the land-sea transport of per- and polyfluoroalkyl substances (PFASs) through rive
79 d with an estimated demand of one metric ton per annum for the prodrug, provides a compelling mandate
82 s were used to establish 3 predictive models per binning configuration: one model based on a combinat
83 OSTAT food balance sheets for Australia, the per capita availability of added or refined sugars and s
87 argest inpatient and outpatient cost impacts per case, followed by "other" cancer, whereas NMSC impac
89 e showed that the number of infection events per cell during cell-free HIV-1 infection follows a nega
91 ethod detected 21 798 CGIs (76% of all CGIs) per cell, and the number of CGIs consistently detected f
92 PM2.5 pollution in 2007 worldwide, about 12 per cent (411,100 deaths) were related to air pollutants
93 at in which the death occurred, and about 22 per cent (762,400 deaths) were associated with goods and
94 rt the detection of substantial (8.3 +/- 0.8 per cent from our most conservative simulation), variabl
98 entromere sequences typically occurring once per chromosome, a finding that helps to resolve nuclear
99 rth system climate sensitivity is K (1sigma) per CO2 doubling, which is notably higher than fast-feed
100 nge (10(2) 10(6)cells/mL) was 4.55x10(-2)muA per concentration decade, with the lowest detection limi
102 utron density in near-Earth space-2 x 10(-9) per cubic centimetre-confirming theoretical estimates.
103 ndicate that energy use and carbon footprint per cubic meter of wastewater treated, varies markedly w
104 remely high number density (more than 10(24) per cubic metre) and small size (about 2.7 +/- 0.2 nanom
105 uzumab ozogamicin (starting dose 1.8 mg/m(2) per cycle [0.8 mg/m(2) on day 1; 0.5 mg/m(2) on days 8 a
107 s of adjunctive rifampicin (600 mg or 900 mg per day according to weight, oral or intravenous) versus
109 ient self-reported, estimates of steps taken per day correlated with smartphone data (surrogates: n =
113 topically to a designated target lesion once per day for 4 consecutive days on days 1 through 4, 8 th
114 e placebo or hydrocortisone (0.5 mg/kg twice per day for 7 days, followed by 0.5 mg/kg per day for 3
115 In wild-type (WT) mice, LY2828360 (3 mg/kg per day i.p. x 12 days) suppressed chemotherapy-induced
117 y translated into standard drink equivalents per day of different countries, the WHO risk levels coul
118 otentially, targets will be consumed at 1 M per day per reactor, demanding a 5000x unit cost reducti
120 DSM criteria), smoking 10 or more cigarettes per day, and a willingness to attempt smoking cessation.
123 LY) gained, pound372 207 (268 162-1 903 385) per death averted, and pound628 874 (434 902-4 740 724)
124 n significant positive growth trends of 1-2% per decade for the full period, and 3-7% since 1950.
125 lians, increasing age (odds ratio [OR], 1.72 per decade) and having not had an eye examination within
126 glycemia with a blood glucose level of 55 mg per deciliter (3.1 mmol per liter) or below was signific
128 nsistent with binding of one molecule of 11m per dimer interface, contrary to most benzothiadiazine d
129 n estimate of US$94 (95% CrI: US$51, US$166) per Disability Adjusted Life Year (DALY) averted, PMI-fu
131 transitions and emission of several photons per excitation comprise a very attractive feature of sem
133 lihood of complete clinical success (OR 0.95 per extra year, 0.93-0.98; p<0.001) and clinical benefit
136 sters (SiPcs, 1-7) with non-, partially- and per-fluorinated aliphatic (linear or branched at the alp
139 ng with its extremely low cost (about 3 cent per gram), simplicity of fabrication and environment-fri
143 ecision making (mean, 9.70 vs 2.77 instances per hour, P = .03) and failure to progress (mean, 1.20 v
144 re to progress (mean, 1.20 vs 0.13 instances per hour, P = .04) were addressed, and they were more th
146 inistration of antibiotics (odds ratio, 1.04 per hour; 95% CI, 1.03 to 1.06; P<0.001) but not a longe
147 sted in-hospital mortality (odds ratio, 1.04 per hour; 95% confidence interval [CI], 1.02 to 1.05; P<
148 adjusted to one or two biotin binding sites per immobilized SAv by choosing appropriate surface chem
150 ces in running speed, as the firing rates of PER interneurons did not show significant velocity modul
151 stimating equations estimated relative risks per interquartile-range increment for pollutants and hig
154 = 1.31 [95% confidence interval = 1.05-1.63] per kJ/m(2)) and minimum (1.25 [1.06-1.47] per kJ/m(2))
156 ypically from tens to hundreds of dead trees per km(2) , rising dramatically during the fourth year o
157 seline platelet count (<10 x 10(9) platelets per L vs >/=10 x 10(9) platelets per L) and disease (MDS
159 let count of lower than 30 x 10(9) platelets per L, aged at least 18 years, with refractoriness, inel
160 ucose level of 55 mg per deciliter (3.1 mmol per liter) or below was significantly lower in the sotag
162 sistence time for species by a factor of 6.8 per location or approximately 2,272 years, on average, r
164 els were identified (median 2; quartiles 1-3 per map), although this represented LR in only n=7 out o
167 es at levels ranging from 0.1 to 10(5) parts per million (weight/weight), worked equally well on diff
168 sociated with NSVT runs at a rate >200 beats per minute (adjusted hazard ratio, 15.63; 95% confidence
169 ) mL/kg per minute to 16.1 (13.2-18.6) mL/kg per minute (P=0.009 for within-group changes), whereas n
170 ment in peak Vo2 from 14.5 (10.5-16.6) mL/kg per minute to 16.1 (13.2-18.6) mL/kg per minute (P=0.009
173 ion of participants with less than 50 copies per mL of plasma HIV-1 RNA at week 48 (by the US Food an
174 UTIs with 10(3) or more colony-forming units per mL of vaccine-serotype E coli was noted in the vacci
176 logical suppression (<50 copies of HIV-1 RNA per mL) on a stable regimen for at least 6 months, CD4 c
177 % or greater reduction in mean migraine days per month, change in the number of days of use of acute
180 D4 count decreased by a median of -130 cells per muL (range -472 to 266) with little change in CD4 ce
181 s with CD4 cell count of more than 500 cells per muL assigned to immediate ART or deferral until thei
182 t 6 months, CD4 count of more than 100 cells per muL, and no history of resistance to elvitegravir, e
185 s of active pharmaceutical ingredients (API) per nano-liposome that enable therapeutically viable API
187 receive either two intranasal doses (0.25 mL per nostril) of LAIV H5N2 (101 participants) or placebo
188 ck Study, multivariable adjusted risk ratios per one-SD higher log miR-122 were 1.60 (95% CI 1.30-1.9
189 ctive, and liberates more than 120 equiv NH3 per Os center in a single batch experiment using Cp*2Co
190 (odds ratio [OR]: 0.992; 95% CI 0.984-1.000 per pack-year) and positively with obesity: OR: 1.97 [1.
193 ere the difference of total episode payments per patient between lowest and highest quintile hospital
194 nged survival; the mean number of life-years per patient was 19.4 in the scenario with IR compared wi
197 d 19 rotor domains in 10 patients (1.8+/-1.1 per patient; 7 in the right atrium versus 12 in the left
199 e resource settings yields 0.008 fewer QALYs per person, but saves US$204 compared to monitoring ever
202 after applying a 3-year lag period (OR, 1.09 per procedure; 95% CI, 1.03-1.14 and OR when exposure fr
203 most smoking-related cancer cases (OR, 1.10 per procedure; 95% CI, 1.05-1.16 and OR when exposure fr
207 = 0.09) and a significant -3.8% reduction in per-protocol analysis (P = 0.043).Independent of other l
212 e primary efficacy endpoint, analysed in the per-protocol population, was pathological complete respo
214 id our primary and secondary analyses in the per-protocol set, which excluded patients with non-compl
215 io (ICER) was euro6840.75 (95% CI 2545-2759) per QALY gained for a treatment efficacy of 20% and euro
217 ost US$18,000 (95% CI: US$14,000, US$24,000) per QALY gained, 50% NSP coverage could avert up to 35,0
218 cost US$25,000 (95% CI: US$7,000, US$76,000) per QALY gained, 50% Test & Treat coverage could avert u
219 ost US$27,000 (95% CI: US$15,000, US$48,000) per QALY gained, and 50% PrEP coverage could avert up to
222 tiveness ratios (ICERs) in 2015 U.S. dollars per quality-adjusted life year (QALY) gained and number
223 incremental cost-effectiveness ratios (cost per quality-adjusted life year gained) from the societal
224 2 201 (95% credible interval 12 662-132 452) per quality-adjusted life-year (QALY) gained, pound372 2
225 tly estimate the number of DNA target copies per reaction partition, lambda, where the partitions are
226 ly, targets will be consumed at 1 M per day per reactor, demanding a 5000x unit cost reduction to $
227 ciative learning (-0.140 standard deviations per risk factor, p < 0.0001) and remained significant af
228 via multiparametric MR imaging (31 mutations per sample +/- 15), and high-grade cancer (33 mutations
230 l via histopathologic analysis (34 mutations per sample +/- 19), mildly suspicious via multiparametri
231 via multiparametric MR imaging (37 mutations per sample +/- 21), intermediately suspicious via multip
232 assays that produce hundreds of measurements per sample are powerful tools for quantifying cell-mater
234 azard ratios (HRs) for incident parkinsonism per SD decrease in global cognition, adjusted for age, s
236 othripsis and associated with poor prognosis per se and not merely by association with other adverse
237 red with younger subjects, chronological age per se did not correlate with rationality measures withi
239 did not impair spatial learning or retrieval per se, but impaired the ability to follow changing spat
241 velocity offsets of less than 600 kilometres per second and linear offsets of less than 100 kiloparse
242 We present an all-plasmonic 116-gigabits per second electro-optical modulator in which all the el
245 SNPs with low LLD have significantly larger per-SNP heritability and that roughly half of this effec
246 al existing methods when there is one allele per species, although STELLS2 is slower than these metho
247 imab maintenance therapy at a dose of 375 mg per square meter of body-surface area administered every
248 gold foil with a sheet resistance of 7 ohms per square showed only a 4% increase in resistance after
250 CAPZB, present at approximately 100 copies per stereocilium, concentrated at stereocilia tips as ha
254 d number of unnecessary treatments generated per TB death averted, if standard Xpert were switched to
256 sition allows standard uncertainties of 0.18 per thousand and 0.48 per thousand to be achieved for de
257 cross the entire analytical procedure is 0.6 per thousand for delta(15)N and 0.5 per thousand for del
259 uncertainties of 0.18 per thousand and 0.48 per thousand to be achieved for delta(13)C and delta(18)
261 ption and the known role of PDF in enhancing PER/TIM stability occur via independent pathways downstr
262 A content can produce about 50 kg of alkenes per tonne of suspended solids treated, with a significan
263 tal tree burden of summation operator26PFASs per tree was up to 11 mg for birch and 1.8 mg for spruce
264 o of mean tumor to bone marrow absorbed dose per unit administered activity of (131)I, after THW and
268 n PAWP were measured to calculate the DPD as per usual practice (diastolic pulmonary artery pressure-
269 E (MMAE) significantly increase loading on a per-vehicle basis as compared to antibody-drug conjugate
273 CI, -0.15 to 0.92) or metabolic equivalents per week (3 studies; standardized mean differences, 0.11
274 once weekly at 8 and 10 mg/kg, or two times per week at 4 and 6 mg/km on weeks 1 and 2 of 3-week rep
275 nterventions significantly increased minutes per week of metabolic equivalents (4 studies; standardiz
276 nterval [CI], 1.44 to 2.69), but not minutes per week of MVPA (13 studies; standardized mean differen
278 2010 to calculate the hospitalization costs per year attributed to misdiagnosed lower extremity pseu
279 ard of mortality remained, but decreased 14% per year for DDKT recipients (0.830.860.89, P < 0.001) a
280 recipients (0.830.860.89, P < 0.001) and 9% per year for LDKT recipients (0.850.910.98, P < 0.001).
281 ging utilization went from 0.43 examinations per year in 2007 to 0.34 examinations per year in 2013,
282 ations per year in 2007 to 0.34 examinations per year in 2013, a decrease of 21.33% (P < .0001).
283 D) SMR was 0.46 (1.06) vs 0.50 (1.50) events per year in the every 4 weeks vs every 12 weeks groups (
285 ed in delayed-start patients (from -2.26 g/L per year to -1.26 g/L per year), but no significant diff
286 patients during this time period (-1.51 g/L per year to -1.63 g/L per year), thus in early-start pat
287 dily increased yields by about 1% (13 kg/ha) per year while increasing temperatures decreased yields
288 K9 inhibitors in the United States (>$14,500 per year) are >100x higher than generic statins, and onl
289 rate (mean number of skeletal-related events per year), and, in a subset of 553 patients, suppression
290 tients (from -2.26 g/L per year to -1.26 g/L per year), but no significant difference was seen in the
291 time period (-1.51 g/L per year to -1.63 g/L per year), thus in early-start patients the efficacy was
293 rine ecosystems, fix up to 27.4 Tg of carbon per year, and provide important structural components fo
298 ere significantly reduced (40 deaths [0.025% per year] v 94 deaths [0.038% per year]; HR, 0.65; 95% C
299 deaths [0.025% per year] v 94 deaths [0.038% per year]; HR, 0.65; 95% CI, 0.45 to 0.94; P = .02) by t
300 ed forests and, unexpectedly, increased 4.9% per yr from 1996 to 2014, likely indicating a recovery f
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