ライフサイエンスコーパス: perforant path

1 inal input to the ipsilateral dentate gyrus (perforant path).

2 tial after high-frequency stimulation of the perforant path.

3 it was restricted to synapses of the lateral perforant path.

4 dopaminergic control of transmission in the perforant path.

5 stimulation (HFS) was applied to the medial perforant path.

6 nduced through electrical stimulation of the perforant path.

7 perforant path projections, but not lateral perforant path.

8 uated in rats kindled from olfactory bulb or perforant path.

9 escence on glutamatergic axons of the medial perforant path.

10 ols indicating atrophy at this branch of the perforant path.

11 the parahippocampal gyrus that includes the perforant path.

12 arizations in response to stimulation of the perforant path.

13 paired-pulse paradigm was determined in the perforant path.

14 ls prepared with bilateral knife cuts of the perforant path, a major afferent hippocampal fiber bundl

15 ion predict that blocking mossy-fiber and/or perforant path activity to CA3 would cause impairments i

16 revealed that high-frequency stimulation of perforant path afferents induced a robust STP and LTP of

17 separating the associational/commissural and perforant path afferents.

18 ating and recording electrodes placed in the perforant path and dentate gyrus, respectively.

19 mals prepared with chronic electrodes in the perforant path and dentate gyrus.

20 in cortical interneurons, in the hippocampal perforant path and mossy fiber pathways, and in the glob

21 ia a decrease in glutamate release from both perforant path and mossy fiber terminals.

22 ed on the established importance of both the perforant path and N-methyl-D-aspartate (NMDA) receptors

23 nputs to hippocampal CA1 neurons through the perforant path and Schaffer collateral synapses, respect

24 Synaptic input from granule cells (GCs), perforant path, and CA3 inputs onto hilar border interne

25 he associational-commissural pathway, medial perforant path, and lateral perforant path, respectively

26 tribution of the main excitatory inputs, the perforant path, and Schaffer collaterals during theta an

27 ing, we quantified both the integrity of the perforant path as well as dentate/CA3 dendritic changes

28 nd among somatostatin (SOM)-containing hilar perforant path-associated (HIPP) interneurons.

29 rbours were contained within the SO; and one perforant path-associated cell with axonal and dendritic

30 Hilar-perforant-path-associated interneurons (HIPP cells) have

31 high frequency (400 Hz) train bursts to the perforant path at a moderate stimulus intensity and I/O

32 nesthetized rats and with stimulation of the perforant path at the peak of theta in both anesthetized

33 vels in entorhinal cortex neurons, where the perforant path axons originate, were stable through adul

34 (1) the middle molecular layer (MML), where perforant path axons synapse with dentate granule cells,

35 n by increasing afterdischarge thresholds in perforant path (but not olfactory bulb) kindling and cau

36 paired long-term potentiation in the dentate perforant path, but not in the CA1 Schaffer collateral p

37 tic input from the entorhinal cortex via the perforant paths, but this input was differentially sensi

38 ring extrinsic CA3 inputs, whereas extrinsic perforant path-CA3 synaptic inputs are attenuated on CA3

39 by high-frequency stimulation of the medial perforant path carried out on each of 4 consecutive days

40 The perforant path carries place and spatial information tha

41 duces long-term synaptic potentiation of the perforant path connection to granule cells of the dentat

42 QX impaired fast excitatory transmission, at perforant-path dentate gyrus synapses in the dorsal hipp

43 so, long-term potentiation was attenuated in perforant path-dentate granular cell synapses.

44 induction of long-term potentiation (LTP) at perforant path-dentate granule cell synapses in ovariect

45 long-term potentiation (LTP) is deficient at perforant path-dentate granule cell synapses.

46 deficits in long-term potentiation at medial perforant path-dentate granule cells synapses in FX mice

47 pal Schaffer collaterals (SC)-CA1 and medial perforant path-dentate gyrus (mPP-DG) synapses in juveni

48 CK increased AMPA receptor-mediated EPSCs at perforant path-dentate gyrus granule cell, CA3-CA3 and S

49 f hippocampal excitability revealed enhanced perforant path-dentate gyrus long-term potentiation (LTP

50 tiation (LTP) could be induced at the medial perforant path-dentate gyrus synapse.

51 a selective impairment restricted to medial perforant path-dentate gyrus synapses of mutant mice.

52 NMDA receptor antagonist CPP on the decay of perforant path-dentate LTP.

53 Second, activation of CA1 neurons by the perforant path depends on the generation of dendritic sp

54 ty (STP) and long-term potentiation (LTP) at perforant path-DG synapses in naive rats.

55 s, but neither LTP nor LTD was evoked at the perforant path-DG synapses.

56 nonspatial (visual object) information from perforant path efferents in a unique manner that is cons

57 at a maximal stimulus intensity through the perforant path electrode, and input/output (I/O) functio

58 ferences were observed in characteristics of perforant path evoked field potentials or in paired puls

59 reduction in the conductance of polysynaptic perforant path-evoked fast and slow inhibitory postsynap

60 LTP of lateral perforant path-evoked field EPSPs was induced selectivel

61 to granule cells, paired-pulse depression of perforant path-evoked granule cell population spikes was

62 here was no post-traumatic alteration in the perforant path-evoked monosynaptic excitatory postsynapt

63 CG-IV also suppressed feedback inhibition of perforant path-evoked population spikes.

64 cts were not accompanied by major changes in perforant path-evoked responses or paired-pulse inhibiti

65 ntaneous synaptic events, and stimulation of perforant path fibers revealed direct, facilitating syna

66 synaptic potentials evoked by stimulation of perforant path fibers revealed increased excitatory tran

67 ed either by intermittent stimulation of the perforant path for 30 min (PPS) or by injection of lithi

68 cus (SSSE) in response to stimulation of the perforant path for periods too brief to have any effect

69 xcitability, and LTP induction in the medial perforant path-granule cell synapse of freely moving rat

70 or kappa) regulate LTP induction at lateral perforant path-granule cell synapses and (2) to test the

71 TP that can be sustained over days at medial perforant path-granule cell synapses in awake mice.

72 mined, we studied synaptic plasticity at the perforant path-granule cell synapses in the dentate gyru

73 g tests indicated that intact LTP at lateral perforant path-granule cell synapses is either redundant

74 te gyrus to stimulus pulses delivered to the perforant path in an ascending intensity series.

75 lices from untreated rats by stimulating the perforant path in the presence of bicuculline and 6 mM K

76 plasticity via electrical stimulation of the perforant path in vivo, MKRN1-short specifically accumul

77 ls to unilateral complete transection of the perforant path in vivo, we tracked these cells using tra

78 ssural projections following interruption of perforant path in Wlds mutant mice and in normal (C57BL/

79 The perforant path input (pp) is a major direct source of sp

80 Overall, these data show that the perforant path input from the entorhinal cortex to the D

81 ntate gyrus granule cells, which receive the perforant path input from the entorhinal cortex, relativ

82 routing, which is homologous to the original perforant path input to the dentate gyrus of the hippoca

83 litation in field CA1 but not in the lateral perforant path input to the dentate gyrus.

84 s long-term potentiation (LTP) at the direct perforant path input to the distal dendrites of CA1 pyra

85 of the parahippocampal gyrus (origin of the perforant path input to the hippocampal formation in the

86 s triggered a long-lasting impairment of the perforant path input-output operation in epileptic denta

87 cal circuit alters information processing of perforant path inputs constituting the major excitatory

88 and also for the role of the mossy fiber and perforant path inputs to hippocampal area CA3.

89 asticity rule in which stimulation of distal perforant path inputs to hippocampal CA1 pyramidal neuro

90 dritic morphology, intrinsic properties, and perforant path inputs were similar to those of dentate g

91 First, activation of CA1 neurons by the perforant path is limited, a result of the long distance

92 The perforant path is the principal route of entry from cort

93 These data suggest that perforant path kindling causes a persistent increase in

94 The present study examined the effects of perforant path kindling on 0-Mg(2+)-induced epileptiform

95 memory deficits in performance accompanying perforant path knife cuts.

96 deposits are dynamic structures and that the perforant path lesion alters the equilibrium between Abe

97 tate gyrus granule cells 2, 5, and 9 d after perforant path lesions.

98 ransmitter release at synapses in the medial perforant path linking stellate neurons located in layer

99 Perforant path long-term potentiation (LTP) in intact mo

100 -commissural projections than in the lateral perforant path (LPP), an effect associated with distinct

101 ion relayed to the structure via the lateral perforant path (LPP).

102 lded mossy cells as potentially critical for perforant path LTP and the GAP-43 in these cells as impo

103 ype and AC1 mutant mice exhibited comparable perforant path LTP recorded in the dentate gyrus as well

104 caused a long-lasting attenuation of medial perforant path (MPP) inputs to the young DGCs, but also

105 ng-dependent plasticity (STDP) of the medial perforant path (mPP) synapse onto dentate granule cells.

106 n field CA1 are not operative in the lateral perforant path: multiple lines of evidence indicate that

107 of electrodes into the dentate gyrus and the perforant path of the hippocampus in vivo.

108 synapses on dentate granule cells but not at perforant path or associational-commissural synapses.

109 Stimulation of the perforant path or the commissural system was used to eli

110 ated hippocampus that incorporate either the perforant path or the trisynaptic loop.

111 Medial perforant path plasticity can be attenuated by 2-amino-5

112 aleric acid (APV) infusions, whereas lateral perforant path plasticity can be attenuated by naloxone

113 cortex contains the cells of origin for the perforant path, plays a critical role in memory processi

114 Theta burst stimulation of the perforant path potentiated responses throughout the mole

115 Stimulation of the MR 40 ms prior to perforant path (PP) activation significantly increased t

116 input from the entorhinal cortex through the perforant path (PP) and from CA3 through Schaffer collat

117 porally precise pairing of direct entorhinal perforant path (PP) and hippocampal Schaffer collateral

118 m the entorhinal cortex directly through the perforant path (PP) and indirectly through Schaffer coll

119 Perforant path (PP) axon terminals within the dentate gy

120 ibition with paired-pulse stimulation of the perforant path (PP) in vitro.

121 le effect on SC synapses, but suppresses CA1 perforant path (PP) inputs.

122 timing of inputs to hippocampal CA1 from the perforant path (PP) of the entorhinal cortex and the Sch

123 which the cortical excitatory drive from the perforant path (PP) recruits GABAergic interneurons that

124 The perforant path (PP) undergoes synaptic changes in the co

125 itatory input from entorhinal cortex via the perforant path (PP), but the role of this cortical input

126 In wild-type mice, stimulation of the medial perforant path produced paired-pulse depression of inter

127 ized sensory input to the hippocampus is the perforant path projection from layer II of entorhinal co

128 The perforant-path projection to the hippocampus forms synap

129 report that high frequency activation of the perforant path projections to the dentate gyrus causes n

130 High-frequency stimulation of the perforant path projections to the dentate gyrus, which t

131 targeted to synaptic sites by activating the perforant path projections to the dentate gyrus.

132 sociational-commissural afferents and medial perforant path projections, but not lateral perforant pa

133 arriving at distal CA1 synapses through the perforant path provide compartmentalized, instructive si

134 pathway, medial perforant path, and lateral perforant path, respectively.

135 No changes in medial perforant path responses occurred.

136 Unilateral transection of the excitatory perforant path results in the acute deafferentation of a

137 w-frequency, single-shock stimulation of the perforant path revealed an early granule cell hyperexcit

138 vitro paired-pulse stimulation of the mixed perforant path revealed beta-estradiol-induced augmentat

139 tion of long-term potentiation in the medial perforant path, showing that the upregulated alpha4* rec

140 charge (AD) evoked from the dentate gyrus by perforant path simulation, whereas GalOE had increased t

141 mbria-fornix-transected (5 days), as well as perforant path-stimulated Sprague-Dawley rats fixed in 5

142 on of a single afterdischarge (AD) evoked by perforant path stimulation (0.1 ms pulse duration, 5 Hz,

143 ats undergoing self-sustaining SE induced by perforant path stimulation (PPS) at the ages of postnata

144 We examined the duration of intermittent perforant path stimulation (PPS) needed to induce self-s

145 (SSSE) induced in rats by brief intermittent perforant path stimulation (PPS) was examined with regar

146 , there was a decline in LTP in the DG after perforant path stimulation and impairment in contextual

147 creased the excitability of granule cells to perforant path stimulation both within and outside of th

148 a transient period during GC maturation when perforant path stimulation can generate a high probabili

149 Intermittent perforant path stimulation for 24 hours induced acute de

150 Here we found that perforant path stimulation in rat hippocampal slices evo

151 tials, paroxysmal discharges, were evoked by perforant path stimulation in the dentate gyrus of EL mi

152 Recently, we reported in the perforant path stimulation model another neuroplastic ch

153 opensity to develop status epilepticus after perforant path stimulation or systemic kainic acid, as w

154 eaker paired-pulse inhibition in response to perforant path stimulation relative to suprapyramidal re

155 Although perforant path stimulation resulted in a larger [K+]o el

156 Induction of hippocampal seizure activity by perforant path stimulation resulted in an increase in SG

157 gyrus molecular layer in response to lateral perforant path stimulation was shifted to the left in hi

158 t, field potential responses to paired-pulse perforant path stimulation were obtained from the dorsal

159 ale offspring and field potentials evoked by perforant path stimulation were recorded from the dentat

160 6 months of age), field potentials evoked by perforant path stimulation were recorded in the dentate

161 As adults, field potentials evoked by perforant path stimulation were recorded in the dentate

162 nger-lasting depolarizations, in response to perforant path stimulation, in the presence of the GABAA

163 ged trains of action potential discharges to perforant path stimulation.

164 and loss of paired-pulse inhibition (29%) to perforant path stimulation.

165 o granule cell layer stimulation but also to perforant path stimulation.

166 mature brain from the excitotoxic affects of perforant path stimulation.

167 lt neurogenesis-reduced dentate responses to perforant-path stimulation and shifted EPSP-spike coupli

168 l recordings 5-16 d after seizure induction, perforant-path stimulation now evoked glutamatergic inpu

169 Intracellularly recorded responses to single perforant path stimuli also exhibited prolonged and larg

170 eature of the prolonged response to a single perforant path stimulus was a predominantly biphasic fie

171 esynaptic expression of HCN1 channels in the perforant path, suggesting that network activity contrib

172 tive mGluR2-mediated responses at the medial perforant path synapse and that this effect of forskolin

173 nels enhances the low efficacy of release at perforant path synapses by increasing the contribution o

174 naptic plasticity at Schaffer collateral and perforant path synapses in the hippocampus.

175 that the efficacy of transmitter release at perforant path synapses is lower than at Schaffer collat

176 Surprisingly, at perforant path synapses kainate receptor activation enha

177 netic induction of long-term potentiation at perforant path synapses of dentate gyrus engram cells re

178 r-dependent long-term potentiation at medial perforant path synapses onto dentate granule cells and d

179 ng cold stress is not due to an inability of perforant path synapses to express LTP.

180 expression of long-term depression at medial perforant path synapses, increased granule cell and CA1

181 ion of glutamatergic inputs originating from perforant path synapses, resulting in reduced spike tran

182 r collateral synapses but not of that of the perforant path synapses.

183 ion spike LTP and EPSP-spike potentiation at perforant path synapses.

184 now elicited frank LTD of synaptic EPSPs at perforant path synapses.

185 firing output, and long-term potentiation of perforant path synapses.

186 2+) channels at the Schaffer collateral than perforant path synapses.

187 ior and experience-dependent modification of perforant path synaptic function through NMDAR activatio

188 abetes impairs hippocampus-dependent memory, perforant path synaptic plasticity and adult neurogenesi

189 ranule cell and pyramidal cell excitability, perforant path synaptic plasticity, and spatial memory.

190 Perforant path synaptic strength, measured in the in vit

191 on postsynaptic mechanisms regulating medial perforant path synaptic strength.

192 , but surprisingly not in granule cells, the perforant path target.

193 erved in a neuronal cell line and in lateral perforant path terminals naturally expressing mGlu2 and

194 ociated interneurons (n = 6) innervating the perforant path termination zone in stratum lacunosum-mol

195 icotine-induced synaptic potentiation of the perforant path that was found to underlie nicotine-condi

196 nels were localized to axon terminals of the perforant path (the major hippocampal afferent pathway)

197 originating from the entorhinal cortex (the perforant path, the alvear pathway, and the commissural

198 During a 1 Hz stimulus train applied to the perforant path, the magnitude and duration of the negati

199 med by the temporoammonic (TA) branch of the perforant path, the major cortical input to the hippocam

200 way, with little or no expression within the perforant path, the Schaffer collaterals, or neuronal ce

201 uperficial entorhinal afferents (part of the perforant path) to dentate granule cells, dentate mossy

202 -term depression, are dysregulated at medial perforant path-to-dentate gyrus synapses of young Nse-Cr

203 In contrast, stimulation of the perforant path using patterns of stimulation that induce

204 spike, following tetanic stimulation of the perforant path, was observed in all strains.

205 bility elicited by stimulation of the medial perforant path, was obtained for each vigilance state at

206 tate gyrus in response to stimulation of the perforant path were assessed under urethane anesthesia.

207 ever, place units that were activated by the perforant path were prevalent in the model and were cruc

208 as demonstrated by stimulation of the medial perforant path, which induced normal synaptic potentiati

209 Lesioning of the perforant path, which innervates the outer two-thirds of