ライフサイエンスコーパス: pericentric

1 that bw can be simultaneously acted upon by pericentric and distal blocks of heterochromatin.

2 the functional centromere within an enlarged pericentric and heterochromatic region.

3 illustrated by the formation of concentric, pericentric and multicompartment liposomes.

4 g from canonical heterochromatic function at pericentric and telomeric regions to exclusive localizat

5 and establish ATRX as a major determinant of pericentric beta-heterochromatin identity.

6 85 but not ATRX125 is highly concentrated in pericentric beta-heterochromatin of the X chromosome in

7 , ATRX185 is required for HP1a deposition in pericentric beta-heterochromatin of the X chromosome.

8 of inner kinetochores contract, whereas the pericentric chromatin and cohesin that encircle spindle

9 rochromatin-associated HP1beta and Ikaros at pericentric chromatin and expressed low levels of Ezh2 a

10 domain also reduces cohesin turnover within pericentric chromatin and permits establishment of Wapl-

11 Pericentric chromatin forms an intramolecular loop that

12 the kinetochore promotes the organization of pericentric chromatin into a cruciform in mitosis such t

13 ritical features of how these complexes mold pericentric chromatin into a functional spring.

14 pite its increased spatial distribution, the pericentric chromatin is less dynamic.

15 To understand how pericentric chromatin is packaged and resists tension, w

16 ntromere DNA-looping complexes positions the pericentric chromatin loops and stabilizes the dynamic p

17 metric alteration of all 16 kinetochores and pericentric chromatin reflect global changes in the peri

18 er chromatids toward opposite poles, whereas pericentric chromatin resists with contractile springlik

19 Linking of pericentric chromatin through cohesin, condensin, and ki

20 eometry and dynamics of kinetochores and the pericentric chromatin upon reduction of microtubule dyna

21 hese findings indicate that H2A.Z-containing pericentric chromatin, as in higher eukaryotes with regi

22 rotein complexes are concentrated within the pericentric chromatin, but whether they contribute to te

23 phosphorylation and Sgo1 recruitment to the pericentric chromatin, rather than microtubule dynamics.

24 or the increased association of cohesin with pericentric chromatin, which is required to resist micro

25 th are governed in part by the stretching of pericentric chromatin.

26 e4-containing centromeric nucleosome, but in pericentric chromatin.

27 activity also reduce turnover of cohesin on pericentric chromatin.

28 displaced from the spindle axis and confines pericentric chromatin.

29 s and is responsible for axial compaction of pericentric chromatin.

30 al studies that, in animals heterozygous for pericentric chromosomal inversions, loop formation is gr

31 ts in the eu-heterochromatin junction in the pericentric chromosome regions.

32 ereas coordinated stretching is dependent on pericentric cohesin and Cin8.

33 Pericentric cohesin and condensin contribute to spindle

34 Depletion of pericentric cohesin or condensin has been shown to incre

35 Pericentric condensin contributes to chromatin compactio

36 e results also show a down-regulation of the pericentric constitutive heterochromatin mark, histone H

37 Pericentric DNA is related to heterochromatin and gene i

38 r kinetochore complex (CBF3) is required for pericentric DNA looping at the Cse4p-containing nucleoso

39 ng kinetochore complexes are not involved in pericentric DNA looping but are required for the geometr

40 microtubules, the kinetochore, and organized pericentric DNA loops.

41 We demonstrate that pericentric enrichment of condensin is mediated by inter

42 Reinstating the pericentric enrichment of Sgo1p alleviates the mitotic d

43 HP1 binds predominantly to pericentric genes and transposable elements.

44 report on the role of KLLN in maintenance of pericentric H3K9 trimethylation (H3K9me3) and genomic st

45 lation of histone H3K9 trimethylation at the pericentric HC after DNA damage.

46 As anticipated, the pericentric heterochromatin and chromosome 4 are on aver

47 r second chromosome, at the boundary between pericentric heterochromatin and euchromatin.

48 on, there is increased nuclear clustering of pericentric heterochromatin and extensive changes in pri

49 maintenance of transcriptional silencing in pericentric heterochromatin and in the chromatin-depende

50 on of telomere shelterin components restores pericentric heterochromatin and its functions in RNAi mu

51 protein that is prominently associated with pericentric heterochromatin and mediates the concomitant

52 in replication-linked maintenance of centric/pericentric heterochromatin and suggest a novel means wh

53 osomal protein primarily associated with the pericentric heterochromatin and telomeres in Drosophila.

54 , we found that MeCP2 induced aggregation of pericentric heterochromatin and that its chromatin accum

55 euchromatic genes brought to the vicinity of pericentric heterochromatin and the activation of hetero

56 duce silencing, suggesting that proximity to pericentric heterochromatin and/or a high local TE densi

57 WSTF accumulates in pericentric heterochromatin coincident with the replicat

58 native pathway that loss of CBP leads to the pericentric heterochromatin condensation through ESET ex

59 romocenters are clusters of late-replicating pericentric heterochromatin containing HP1 bound to trim

60 In fission yeast, loss of RNAi causes pericentric heterochromatin defects, compromising gene s

61 ocalization towards spindle poles as well as pericentric heterochromatin domains at the metaphase II

62 me, where it confers epigenetic asymmetry to pericentric heterochromatin during the transition to the

63 chromosome translocations containing ectopic pericentric heterochromatin embedded in euchromatin disp

64 A transposition of the 59E-60A region into pericentric heterochromatin ensnares distal 59E-60A via

65 asmate chromosomes with the normal amount of pericentric heterochromatin exhibit increased nondisjunc

66 On human and fly chromosomes, for example, pericentric heterochromatin flanks single centromeres, w

67 al role for KLLN as a potential regulator of pericentric heterochromatin formation, genomic stability

68 the RNAi machinery is no longer required for pericentric heterochromatin functions.

69 We suggest that late-replicating pericentric heterochromatin helps to maintain embedded c

70 ient cells fail to deacetylate and methylate pericentric heterochromatin histones and to recruit esse

71 , it also displays a strong association with pericentric heterochromatin in diploid cells, where it a

72 ind to methylated H3K9 (H3K9me) and regulate pericentric heterochromatin in fission yeast.

73 Me3K9H3 decorated late-replicating pericentric heterochromatin in mouse cells and sites of

74 The localization of Lrwd1 and Orc2 at pericentric heterochromatin in mouse cells is lost in ce

75 Pericentric heterochromatin is a highly compacted struct

76 e mechanism for transcriptional silencing of pericentric heterochromatin is conserved from fission ye

77 Pericentric heterochromatin is critical for silencing re

78 pose that BRCA1-dependent establishment of X-pericentric heterochromatin is critical for XY body morp

79 K9me3 and that the association of Lrwd1 with pericentric heterochromatin is required for heterochroma

80 Furthermore, we observe defects in pericentric heterochromatin maintenance and assembly.

81 e find that targeting of the Sin3 complex to pericentric heterochromatin may also follow this model.

82 function in concert to methylate H3K9 in the pericentric heterochromatin of all chromosomes, with dG9

83 ele and a yellow transgene inserted into the pericentric heterochromatin of chromosome 2R, while a th

84 nd its murine homologue Np95 are enriched in pericentric heterochromatin of interphase nuclei, and th

85 how that a hybrid lethality factor(s) in the pericentric heterochromatin of the D. mauritiana X chrom

86 een mapped at position 1q21, adjacent to the pericentric heterochromatin on the long arm of chromosom

87 hromosome axes and promotes establishment of pericentric heterochromatin on the X chromosome.

88 SUV39H1 methylates H3K9 at the pericentric heterochromatin region and participates in t

89 MT1 complexes are recruited independently to pericentric heterochromatin regions, they are both requi

90 entify a new compaction pathway of mammalian pericentric heterochromatin relying on Tip60 that might

91 DNA in pericentric heterochromatin replicates late in S phase,

92 activity is required for the fine-tuning of pericentric heterochromatin replication relative to othe

93 during mid S phase, which is coincident with pericentric heterochromatin replication.

94 ctivity, splitting an F-box and relocating a pericentric heterochromatin segment in juxtaposition wit

95 hylation, and DNA methylation in maintaining pericentric heterochromatin structure throughout cell di

96 ite repeat sequence-derived transcripts from pericentric heterochromatin that accumulate at different

97 MeCP2 at chromocenters, regions of extensive pericentric heterochromatin that can be imaged by fluore

98 led to reduced accumulation of H4K20me3 onto pericentric heterochromatin that coincided with abnormal

99 ults indicate that the Lrwd1 is recruited to pericentric heterochromatin through binding to H3K9me3 a

100 Pericentric heterochromatin transcription has been impli

101 We demonstrate that mammalian pericentric heterochromatin transcription is linked to c

102 ce and are disproportionately represented in pericentric heterochromatin, a feature potentially explo

103 of the A- and B-type lamins, alterations in pericentric heterochromatin, abnormally clustered centro

104 of satellite transcription, decompaction of pericentric heterochromatin, and defects in chromosome s

105 es an essential role in the establishment of pericentric heterochromatin, and genetic ablation of mSd

106 with mitotic chromosomes is concentrated at pericentric heterochromatin, and is encoded, in part, by

107 proteins are preferentially targeted to the pericentric heterochromatin, and mice lacking both Suv39

108 s reveals distinct profiles for euchromatin, pericentric heterochromatin, and the 4th chromosome.

109 SMARCAD1 ensures that silenced loci, such as pericentric heterochromatin, are correctly perpetuated.

110 transposable elements and tandem repeats at pericentric heterochromatin, as well as incomplete chrom

111 BMI1 was highly enriched at intergenic and pericentric heterochromatin, co-immunoprecipitated with

112 domains surrounding the centromere, known as pericentric heterochromatin, histone modifications, part

113 exts, PTRs confer no targeting, targeting to pericentric heterochromatin, or targeting to the periphe

114 are essential for targeting these enzymes to pericentric heterochromatin, probably via a mechanism ot

115 NAi pathway is required for the formation of pericentric heterochromatin, proper chromosome segregati

116 tightly associates with actively replicating pericentric heterochromatin, suggesting a role in its as

117 la melanogaster localized principally in the pericentric heterochromatin, telomeres, and fourth chrom

118 gaster, carrying a silenced transgene in the pericentric heterochromatin, to investigate in detail th

119 tone acetyltransferase Tip60 is recruited to pericentric heterochromatin, where it mediates acetylati

120 Pericentric heterochromatin, while often considered as "

121 h loss of KLLN resulting in dysregulation of pericentric heterochromatin, with consequent chromosomal

122 es such as the initiation and maintenance of pericentric heterochromatin, X-inactivation, and germ ce

123 y and the deposition or maintenance of major pericentric heterochromatin-associated histone marks, in

124 a central role in initiating the cascade of pericentric heterochromatin-specific modifications neces

125 aused aberrant HP1alpha distribution only to pericentric heterochromatin-surrounding nucleoli.

126 an promote genetic instability via defective pericentric heterochromatin.

127 ted CenH3, and transcriptional quiescence of pericentric heterochromatin.

128 Lys-9 were both selectively enriched within pericentric heterochromatin.

129 me that harbors large amounts of centric and pericentric heterochromatin.

130 centromere-kinetochore complexes, including pericentric heterochromatin.

131 to methylate the major satellite repeats at pericentric heterochromatin.

132 ains are required for their association with pericentric heterochromatin.

133 and Dnmt3b are particularly concentrated in pericentric heterochromatin.

134 as used to show enrichment of the protein in pericentric heterochromatin.

135 ected H3 Lys9 trimethylation specifically at pericentric heterochromatin.

136 trast, trimethylated H3 Lys9 was enriched at pericentric heterochromatin.

137 and heterochromatin protein 1 binding at the pericentric heterochromatin.

138 2 (HP2), which codistributes with HP1 in the pericentric heterochromatin.

139 lization is preferentially within Drosophila pericentric heterochromatin.

140 ionary and functional genomics of satDNAs in pericentric heterochromatin.

141 for Prod protein to its target satellite in pericentric heterochromatin.

142 20 of histone H4 (H4K20me3)) and localize to pericentric heterochromatin.

143 ittle impact on the localization of Lrwd1 on pericentric heterochromatin.

144 (alphoid) DNA array, where it is flanked by pericentric heterochromatin.

145 alleles at levels comparable to that seen on pericentric heterochromatin.

146 similar to that involved in the formation of pericentric heterochromatin.

147 s well known as a silencing protein found at pericentric heterochromatin.

148 ontributes to HP1-dependent variegation at a pericentric insertion site, as demonstrated by a decreas

149 mates (now found in the Bornean orangutan) a pericentric inversion and centromere shift leads to the

150 a model where an ancestral human-chimpanzee pericentric inversion and the ancestral chromosome 2 fus

151 nce in situ hybridization, five evolutionary pericentric inversion breakpoints present on the chimpan

152 n Genome Project, have been used to identify pericentric inversion breakpoints seen when comparing th

153 The pericentric inversion disrupts a gene (ACOD4) on chromos

154 n 5AL/4AL translocation and a putative small pericentric inversion in chromosome 5A.

155 A possible pericentric inversion in chromosome 7D was detected.

156 omolog, and a fission of chromosome 21 and a pericentric inversion is needed to derive the Bornean or

157 r Great Apes, that a cytogenetically cryptic pericentric inversion may have been involved in the form

158 GLI mapping reveals that a pericentric inversion occurred in the HSA chromosome 12

159 describe an 8-year-old boy who has a de novo pericentric inversion of chromosome 12, with breakpoints

160 We identified a pericentric inversion of chromosome 4, inv(4)(p13q21) th

161 signs of PMD, cytogenetic analysis showed a pericentric inversion of the X chromosome.

162 s indicated the possible presence of a small pericentric inversion on chromosome 2B.

163 Crossover within a pericentric inversion produces reciprocal recombinant ch

164 A pericentric inversion specific to the rice lineage was d

165 haracterize the breakpoints defining a large pericentric inversion that occurred some time after the

166 ts confirm the earlier putative claim that a pericentric inversion took place in HSA chromosome 11 an

167 nding in which it was proposed that only one pericentric inversion was needed.

168 omic changes in B. stricta likely involved a pericentric inversion, a chromosomal fusion, and two rec

169 equent chromosomal rearrangement, especially pericentric inversion, increases the probability of gene

170 (p23.1q22.1), and is derived from a parental pericentric inversion, inv(8)(p23.1q22.1).

171 s from its homologues in the great apes by a pericentric inversion.

172 and (3) in this family DMD is caused by the pericentric inversion.

173 o be important in the origin of species, and pericentric inversions account for the majority of evolu

174 Paracentric and pericentric inversions are easily recovered when two ele

175 repeated events of unequal crossing over and pericentric inversions during chromosome 9 evolution.

176 The use of loci-specific probes to decipher pericentric inversions has proved to be a formidable app

177 anges (both involving centromeres) and three pericentric inversions have been identified between chic

178 Cases of AS resulting from translocations or pericentric inversions have been observed to be associat

179 These pericentric inversions in PTR and GGO may have occurred

180 Pericentric inversions may have been important for the e

181 is heteromorphic in 6-8% of humans, whereas pericentric inversions occur in more than 1% of the popu

182 ylogenotic markers, was used to decipher the pericentric inversions of human chromosomes 11 and 12.

183 AL2 and ZAL2(m) differ by a pair of included pericentric inversions that we estimate span at least 98

184 No pericentric inversions were detected.

185 translocations, 10 paracentric inversions, 2 pericentric inversions, and 4 disassociations or associa

186 (n = 7) through an unusually high number of pericentric inversions.

187 mating the frequency of recombination within pericentric inversions.

188 changes in heterochromatin distribution and pericentric inversions.

189 esis, intrachromatid crossing-over generated pericentric inversions.

190 ion of cohesin (SMC3), condensin (SMC4), and pericentric LacO arrays within the spindle.

191 f heterochromatic genes that depend on their pericentric localization for maximal transcriptional act

192 To account for the ubiquity and pericentric localization of satellites, we propose that

193 DNA within the pericentric loop occupies a spatially confined area that

194 er chromosome segregation, and repression of pericentric meiotic recombination.

195 ation increases Chp1 and decreases Chp2/Swi6 pericentric occupancy and exhibits centromeric desilenci

196 specifically regulating interactions between pericentric origins.

197 ttenuated H3-Sgo1p interaction essential for pericentric recruitment of Sgo1p.

198 is pigmentosa (adRP) phenotype linked to the pericentric region of chromosome 8 is associated with mu

199 der branchio-oto-renal syndrome (BOR) to the pericentric region of chromosome 8q.

200 ported an insertion of 270-kb mtDNA into the pericentric region on the short arm of chromosome 2.

201 hl4 are necessary for Sgo1 to associate with pericentric regions but less so for Sgo1 to associate wi

202 merase II in euchromatin but its increase in pericentric regions in piwi mutants.

203 at reducing RNA polymerase II recruitment to pericentric regions is essential for maintaining heteroc

204 RNA polymerase II (RNAPII) occupancy at the pericentric regions is only modestly increased, while pr

205 Finally, H1 is essential for organization of pericentric regions of all polytene chromosomes into a s

206 ar position or replication timing of any non-pericentric regions of the genome, nor did it affect pro

207 reveals a preferential binding of cohesin to pericentric regions over cohesin-associated regions (CAR

208 rossovers between markers in heterochromatic pericentric regions that underwent demethylation.

209 atin protein Swi6, which is redistributed to pericentric regions through RNAi-independent heterochrom

210 regions and less abundant in crossover-poor pericentric regions were identified.

211 ated in mutant germ cells, tandem repeats in pericentric regions were methylated normally.

212 of the heterochromatin is distributed in the pericentric regions with some rice chromosomes containin

213 1 onto heterochromatin or the methylation of pericentric regions, possibly owing to a compensating in

214 We also found KLLN to localize to pericentric regions, with loss of KLLN resulting in dysr

215 s more frequent in telomeric regions than in pericentric regions.

216 ced affect on histone modification status at pericentric repeats or methylation of centromeric DNA.

217 histone H3K9 dimethylation at the endogenous pericentric repeats.

218 omatin is accompanied by an up-regulation of pericentric satellite III repeat transcripts.

219 enhancers of position-effect variegation at pericentric sites whereas the gain-of-function JIL-1(Su(

220 ergistic interaction displaces HP1gamma from pericentric sites, inducing changes in chromatin structu

221 omal telomere-telomere fusion resulting in a pericentric translocation of a chromosome segment or an

222 within an HBB BAC bias a competition between pericentric versus peripheral heterochromatin targeting

223 ar, six inversions, five paracentric and one pericentric, were revealed in chromosomes 4, 5 and 7.

224 on in a three-generation family with a large pericentric X chromosome inversion, inv(X)(p21.1q26), in

225 Our results indicate that (1) pericentric X chromosome inversions result in reduction