ライフサイエンスコーパス: pericentriolar

1 omprises a reticulum of linked stacks in the pericentriolar and often in the juxtanuclear regions of

2 Tfn then accumulated in the pericentriolar cluster of recycling vesicles (RVs).

3 f recycling cargo typically accumulates in a pericentriolar cluster of tubules and vesicles.

4 by which the duplicated centrosomes recruit pericentriolar components and increase their microtubule

5 s possess increased levels of centriolar and pericentriolar components including gamma-tubulin and th

6 The pericentriolar components, gamma tubulin and dynactin, a

7 rotein vimentin to form a cage surrounding a pericentriolar core of aggregated, ubiquitinated protein

8 le formation, and lysosomes are recruited to pericentriolar cytoplasmic inclusion bodies by a process

9 n epithelia converge in an apically located, pericentriolar endosomal compartment termed the apical r

10 (MDCK), antibodies to Rab11a label an apical pericentriolar endosomal compartment that is dependent o

11 lls has been shown to be concentrated in the pericentriolar endosomal recycling compartment and to pl

12 To better characterize this pericentriolar endosome population, we determined the di

13 However, although these pericentriolar endosomes contained Cbvn, they were strik

14 istributed along centriolar cylinders and on pericentriolar fibers, at least some of which constitute

15 At the onset of mitosis, the pericentriolar Golgi apparatus of mammalian cells is con

16 or without lethal factor, converts stacks of pericentriolar Golgi membranes into smaller fragments co

17 Based on our findings, we suggest that the pericentriolar Golgi organization is a sensor for contro

18 The pericentriolar Golgi stacks are fragmented and found dis

19 ivated protein kinase 1 (MEK1) fragments the pericentriolar Golgi stacks in mammalian cells.

20 ed P23H accumulates in aggresomes, which are pericentriolar inclusion bodies that require an intact m

21 Sequestration of misfolded proteins into pericentriolar inclusions called aggresomes is a means t

22 l) binding proteins (SAS-6 and CPAP) and the pericentriolar localization of gamma-tubulin.

23 d by nocodazole, although the characteristic pericentriolar location of the population was not mainta

24 as is common for JBTS proteins, and also in pericentriolar locations.

25 dc14A overexpression induces the loss of the pericentriolar markers pericentrin and gamma-tubulin fro

26 nherited centrioles and maternally inherited pericentriolar material (PCM) [1].

27 a coiled-coil protein that localizes within pericentriolar material (PCM) and in the immediate vicin

28 hat the centrioles play instructive roles in pericentriolar material (PCM) assembly and that the PCM

29 nherent capacity to duplicate or to organize pericentriolar material (PCM) but acquired both after mi

30 pproximately 5-8 h after ablation, clouds of pericentriolar material (PCM) containing gamma-tubulin a

31 which the centriole forms but the centrosome pericentriolar material (PCM) fails to assemble, actin m

32 Furthermore, pericentriolar material (PCM) formation is abnormal in s

33 cells depleted of Asl, we found that, while pericentriolar material (PCM) function is mildly affecte

34 centrosomal protein required for organizing pericentriolar material (PCM) in mitosis.

35 Pericentriolar material (PCM) mediates the microtubule (

36 pair of centrioles surrounded by a matrix of pericentriolar material (PCM) that assembles from cytopl

37 onsist of a pair of centrioles surrounded by pericentriolar material (PCM) that expands dramatically

38 entrioles surrounded by a protein network of pericentriolar material (PCM) that is essential for the

39 Centrioles are surrounded by pericentriolar material (PCM), which is proposed to prom

40 two centrioles embedded in the proteinaceous pericentriolar material (PCM).

41 air of centrioles surrounded by an amorphous pericentriolar material (PCM).

42 nded by an amorphous protein mass called the pericentriolar material (PCM).

43 amma-TuRCs) embedded within the centrosome's pericentriolar material (PCM).

44 ther' and 'daughter' centriole surrounded by pericentriolar material (PCM).

45 ists of a pair of centrioles and surrounding pericentriolar material (PCM).

46 comprise a pair of centrioles surrounded by pericentriolar material (PCM).

47 localizes to centrosomes and stabilizes the pericentriolar material (PCM).

48 rioles surrounded by an amorphous network of pericentriolar material (PCM).

49 air of centrioles surrounded by an amorphous pericentriolar material (PCM).

50 bules (MTs) is a property of the surrounding pericentriolar material (PCM).

51 ments of two centrosome-associated proteins, pericentriolar material 1 (PCM-1) and pericentrin, in pr

52 ariation in brain morphology associated with pericentriolar material 1 (PCM1) alleles was examined us

53 ed the extent of centrosomal localization of pericentriolar material 1 (PCM1) in SH-SY5Y cells.

54 eover, SDCCAG8 interacts and cotraffics with pericentriolar material 1 (PCM1), a centriolar satellite

55 on and differentiation of NPCs by repressing pericentriolar material 1 (PCM1).

56 s requires the interaction between Hook3 and Pericentriolar Material 1 (PCM1).

57 e also find that the targeting protein PCM1 (pericentriolar material 1) localizes CaMKIIbeta to the c

58 aside from their role as an anchor point for pericentriolar material and as basal bodies of flagella

59 ls, SSX2IP knockdown caused fragmentation of pericentriolar material and chromosome segregation error

60 separate, but only one is active, retaining pericentriolar material and forming a "dominant centroso

61 osomes consist of two centrioles embedded in pericentriolar material and function as the main microtu

62 ves asymmetric, organizing varying levels of pericentriolar material and microtubules.

63 DCCAG8 regulates centrosomal accumulation of pericentriolar material and neuronal polarization and mi

64 Such MTOCs had pericentriolar material and the centriolar protein Sas-4

65 Gle1 assembles into the toroid-shaped pericentriolar material around the mother centriole.

66 ancer target that is critical for regulating pericentriolar material cohesion during bipolar spindle

67 rmed maturation, involves the recruitment of pericentriolar material components via an as-yet unknown

68 ma-tubulin ring complex and, possibly, other pericentriolar material components, thus promoting their

69 ucleus, also preferentially localizes to the pericentriolar material in interphase cells.

70 kely microtubule nucleation sites within the pericentriolar material of isolated centrosomes.

71 mma-tubulin and other proteins that form the pericentriolar material on centrosomes during G2/prophas

72 We propose that Gle1 assembly into the pericentriolar material positions the DEAD-box protein r

73 Our results suggest that the pericentriolar material promotes daughter centriole form

74 at brain-8A, centrosomal protein of 290 kDa, pericentriolar material protein 1, and polycystin-2, as

75 We link Cdk5rap2 function to the pericentriolar material protein pericentrin, loss of fun

76 Thus, both centriolar and pericentriolar material proteins contribute to centriole

77 uring G2/M, where it associates with various pericentriolar material proteins, including Polo-like ki

78 assembly assay to examine the roles of three pericentriolar material proteins: SPD-5, the kinase auro

79 We also find that Asl is not essential for pericentriolar material recruitment or centrosome functi

80 composed of a single centriole surrounded by pericentriolar material that was studded with ring-shape

81 Centrioles organize pericentriolar material to form centrosomes and also tem

82 The KASH protein Nesprin-1alpha recruits pericentriolar material to the surface of myotube nuclei

83 These structures and associated pericentriolar material undergo fragmentation.

84 Significantly, the presence of excess pericentriolar material was associated with the highest

85 luded 1) supernumerary centrioles, 2) excess pericentriolar material, 3) disrupted centriole barrel s

86 a pair of centrioles surrounded by amorphous pericentriolar material, and centrosome duplication is c

87 poles of dd4 cells have irregular amounts of pericentriolar material, but also that they can have abn

88 In addition to residing on the pericentriolar material, GABARAP marks a subtype of PCM1

89 nsists of two centrioles and the surrounding pericentriolar material, is the primary microtubule-orga

90 -inflammatory stimuli lead to recruitment of pericentriolar material, specifically pericentrin and ga

91 ericentrin antibodies decorate the amorphous pericentriolar material, while the Cdc2 antibodies also

92 ression in both the Wee1 mRNA 3' UTR and the pericentriolar material-1 (Pcm-1) mRNA 3' UTR in immatur

93 ng a protective role for Polo kinase and the pericentriolar material.

94 binding occurs at the outer boundary of the pericentriolar material.

95 oles surrounded by an ill-defined "cloud" of pericentriolar material.

96 ves the interaction of tubulin subunits with pericentriolar material.

97 regulates the recruitment of GABARAP to the pericentriolar material.

98 ication of the centriole and organization of pericentriolar material.

99 consists of a pair of centrioles embedded in pericentriolar material.

100 s on assembly of protein components into the pericentriolar material.

101 nsists of a pair of centrioles surrounded by pericentriolar material.

102 nsists of a pair of centrioles and amorphous pericentriolar material.

103 f CDK5RAP2, centrosomin (Cnn), maintains the pericentriolar matrix (PCM) around centrioles during mit

104 ent required for assembly of all other known pericentriolar matrix (PCM) proteins to achieve microtub

105 of two centrioles surrounded by an amorphous pericentriolar matrix (PCM), but it is unknown how centr

106 pair of centrioles surrounded by an ordered pericentriolar matrix (PCM).

107 hair bundles, accompanied by defects in the pericentriolar matrix and microtubule organization.

108 at pericentrin, an integral component of the pericentriolar matrix of the centrosome that has been sh

109 GABARAP is on the pericentriolar matrix, and this dynamic pool contributes

110 ioles surrounded by a relatively ill-defined pericentriolar matrix, provide the ciliary centriole-kin

111 e, in a microtubule-dependent manner, to the pericentriolar matrix.

112 n to the centrosome center creates a dynamic pericentriolar matrix.

113 We find that ZW10 localizes to pericentriolar membranous structures during interphase a

114 cell whole mounts show the centrioles and a pericentriolar network of filaments.

115 a small GTP-binding protein enriched in the pericentriolar plasma membrane recycling systems.

116 tosis and may provide an explanation for the pericentriolar position of the mammalian Golgi apparatus

117 n by RNA interference led to the loss of the pericentriolar positioning and dispersal of the Golgi ap

118 y the p150 Glued subunit of dynactin and the pericentriolar protein PCM-1.

119 MGC1203 encodes a pericentriolar protein that interacts and colocalizes wi

120 ) lack cilia, although mother centrioles and pericentriolar proteins are detected.

121 ype Caenorhabditis elegans zygotes, maternal pericentriolar proteins are not recruited to the sperm c

122 Kinesin prevents recruitment of pericentriolar proteins by coating the sperm DNA and cen

123 In the zygote, the centrioles recruit pericentriolar proteins from the egg to form a mature ce

124 ssemble gamma-tubulin, pericentrin, or other pericentriolar proteins into an organized PCM.

125 rt mitochondria to MTOCs independent of core pericentriolar proteins that regulate MT assembly at cen

126 r, GFP-AKAP350A(2691-3907) recruited several pericentriolar proteins to MTNCs, including gamma-tubuli

127 ion of the trans-Golgi network (TGN) and the pericentriolar recycling compartment (PRC).

128 at the TR and GLUT4 are transported from the pericentriolar recycling compartment in separate vesicle

129 report that PI3K-C2alpha is enriched in the pericentriolar recycling endocytic compartment (PRE) at

130 king of beta-catenin/E-cadherin complexes to pericentriolar recycling endosomes (PCREs).

131 ndosomes, and subsequently with Rab11-GFP in pericentriolar recycling endosomes.

132 mbrane trafficking through early/sorting and pericentriolar recycling endosomes.

133 early/sorting endosomes, as well as Rab11 on pericentriolar recycling endosomes.

134 somes and tubular recycling endosomes in the pericentriolar region followed by their reappearance at

135 antly to an intracellular compartment at the pericentriolar region of the cell.

136 n-Ig, which at steady state accumulated in a pericentriolar region similar to rhodamine-transferrin.

137 to produce fragmented Golgi membranes in the pericentriolar region that is characteristic of macfarla

138 embranes are subsequently dispersed from the pericentriolar region.

139 d that protein 4.1 epitopes localized in the pericentriolar region.

140 ollapse of the lysosomal population into the pericentriolar region.

141 ance of the resulting Golgi fragments in the pericentriolar region.

142 es, associates with centrosome/centriole and pericentriolar satellites in human cells and forms a com

143 Here we demonstrate that trafficking of pericentriolar satellites requires the interaction betwe

144 d the nucleus in C. elegans, is recruited to pericentriolar satellites through interaction with PCM1,

145 c assembly is mediated by the trafficking of pericentriolar satellites, which are comprised of centro

146 s inclusions or virus factories that form at pericentriolar sites close to the microtubule organizing

147 mation underneath the plasma membrane and at pericentriolar sites, concurrent with decreased particle

148 The pericentriolar stacks of Golgi cisternae undergo extensi

149 croscopy suggest that Skp1 forms an extended pericentriolar structure that may function to organize t

150 aded CFTR molecules accumulate at a distinct pericentriolar structure which we have termed the aggres

151 constitutively active form of Arl3 (Q71L) on pericentriolar vesicle transport.